JP2017506623A5 - - Google Patents
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- Publication number
- JP2017506623A5 JP2017506623A5 JP2016549334A JP2016549334A JP2017506623A5 JP 2017506623 A5 JP2017506623 A5 JP 2017506623A5 JP 2016549334 A JP2016549334 A JP 2016549334A JP 2016549334 A JP2016549334 A JP 2016549334A JP 2017506623 A5 JP2017506623 A5 JP 2017506623A5
- Authority
- JP
- Japan
- Prior art keywords
- bag3
- vector
- expression
- bcl2
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461934483P | 2014-01-31 | 2014-01-31 | |
| US61/934,483 | 2014-01-31 | ||
| PCT/US2015/013926 WO2015117010A2 (en) | 2014-01-31 | 2015-01-30 | Bag3 as a target for therapy of heart failure |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019191740A Division JP7079761B2 (ja) | 2014-01-31 | 2019-10-21 | 心不全の治療のための標的としてのｂａｇ３ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017506623A JP2017506623A (ja) | 2017-03-09 |
| JP2017506623A5 true JP2017506623A5 (https=) | 2018-05-24 |
| JP6920818B2 JP6920818B2 (ja) | 2021-08-18 |
Family
ID=53757927
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549334A Active JP6920818B2 (ja) | 2014-01-31 | 2015-01-30 | 心不全の治療のための標的としてのｂａｇ３ |
| JP2019191740A Active JP7079761B2 (ja) | 2014-01-31 | 2019-10-21 | 心不全の治療のための標的としてのｂａｇ３ |
| JP2022083707A Active JP7558218B2 (ja) | 2014-01-31 | 2022-05-23 | 心不全の治療のための標的としてのｂａｇ３ |
| JP2024160090A Pending JP2024175055A (ja) | 2014-01-31 | 2024-09-17 | 心不全の治療のための標的としてのｂａｇ３ |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019191740A Active JP7079761B2 (ja) | 2014-01-31 | 2019-10-21 | 心不全の治療のための標的としてのｂａｇ３ |
| JP2022083707A Active JP7558218B2 (ja) | 2014-01-31 | 2022-05-23 | 心不全の治療のための標的としてのｂａｇ３ |
| JP2024160090A Pending JP2024175055A (ja) | 2014-01-31 | 2024-09-17 | 心不全の治療のための標的としてのｂａｇ３ |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US11236389B2 (https=) |
| EP (2) | EP3099333B8 (https=) |
| JP (4) | JP6920818B2 (https=) |
| CA (2) | CA2975258A1 (https=) |
| DK (1) | DK3099333T3 (https=) |
| ES (1) | ES2838804T3 (https=) |
| HU (1) | HUE052814T2 (https=) |
| PT (1) | PT3099333T (https=) |
| SI (1) | SI3099333T1 (https=) |
| WO (1) | WO2015117010A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3099333B8 (en) * | 2014-01-31 | 2020-12-30 | Temple University of the Commonwealth System of Higher Education | Bag3 as a target for therapy of heart failure |
| US20180296703A1 (en) * | 2015-08-17 | 2018-10-18 | Temple University Of The Commonwealth System Of Higher Education | Bag3 compositions and methods |
| CN105769900A (zh) * | 2016-03-22 | 2016-07-20 | 山西大学 | Bag3基因在制备抗膀胱癌药物中的应用 |
| KR101804678B1 (ko) | 2016-05-30 | 2017-12-04 | 가톨릭대학교 산학협력단 | Bis 억제제 스크리닝용 마커, 이를 포함하는 스크리닝 키트 및 이를 이용한 bis 억제제 스크리닝 방법 |
| IT201600069391A1 (it) * | 2016-07-04 | 2016-10-04 | Univ Degli Studi Di Salerno | Uso della proteina bag3 e suoi frammenti peptidici per il controllo dell’omeostasi vascolare |
| MX2019001729A (es) * | 2016-08-11 | 2019-11-12 | Univ Temple | Lesion por isquemia/reperfusion. |
| US20190328836A1 (en) * | 2017-01-09 | 2019-10-31 | Duke University | Methods for treating ischemic injury |
| IT201700113648A1 (it) * | 2017-10-10 | 2019-04-10 | Biouniversa Srl | Anti-BAG3 antibodies as therapeutic reagent in cardiovascular diseases |
| WO2019020734A1 (en) | 2017-07-28 | 2019-01-31 | Biouniversa S.R.L. | ANTI-BAG3 ANTIBODIES AS THERAPEUTIC REAGENTS IN CARDIOVASCULAR DISEASES |
| CN112105630A (zh) * | 2018-02-15 | 2020-12-18 | T·比约尔克隆德 | 经修饰的病毒衣壳 |
| CA3103167A1 (en) * | 2018-06-08 | 2019-12-12 | Temple University - Of The Commonwealth System Of Higher Education | Optimizing bag3 gene therapy |
| IL283004B2 (en) * | 2018-11-08 | 2025-10-01 | Univ Miami | Method for determining response to cell therapy in dilated cardiomyopathy |
| US20220088127A1 (en) * | 2019-01-15 | 2022-03-24 | Temple University - Of The Commonwealth System Of Higher Education | Targeting the bag family for the treatment of neurodegenerative disease |
| CN114450411A (zh) | 2019-04-01 | 2022-05-06 | 特纳亚治疗股份有限公司 | 具有工程化衣壳的腺相关病毒 |
| IL301675A (en) | 2020-10-09 | 2023-05-01 | Tenaya Therapeutics Inc | Methods and preparations for placophilin-2 gene therapy |
| AU2022325237A1 (en) * | 2021-08-12 | 2024-03-21 | Renovacor, Inc. | Retrograde coronary venous or sinus administration of therapeutics |
| CA3235431A1 (en) * | 2021-10-22 | 2023-04-27 | Arthur M. Feldman | Bag3 methods and uses for treatment of inflammation |
| KR20240118855A (ko) * | 2021-12-10 | 2024-08-05 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 바이러스 벡터로 bag-3 관련 심근병증을 치료하는 방법 및 조성물 |
| WO2023147558A2 (en) * | 2022-01-28 | 2023-08-03 | Temple University - Of The Commonwealth System Of Higher Education | Crispr methods for correcting bag3 gene mutations in vivo |
| KR20250012749A (ko) * | 2022-04-22 | 2025-01-24 | 스페이스크래프트 세븐, 엘엘씨 | Aav 벡터를 사용한 b-세포 림프종 2-관련 안타노겐 3(bag3) 유전자 요법 |
| KR20250010008A (ko) * | 2022-05-03 | 2025-01-20 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 뇌에서 bag3 및 단백질 품질 관리 |
| CN120322242A (zh) * | 2022-09-16 | 2025-07-15 | 联邦高等教育系统天普大学 | Bag3用于治疗心脏淀粉样变性的方法和用途 |
| WO2025255576A1 (en) * | 2024-06-07 | 2025-12-11 | The Children's Hospital Of Philadelphia | Compositions and methods for the treatment of neurodegeneration |
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| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| DE3788914T2 (de) | 1986-09-08 | 1994-08-25 | Ajinomoto Kk | Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere. |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5403711A (en) | 1987-11-30 | 1995-04-04 | University Of Iowa Research Foundation | Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved |
| ATE151467T1 (de) | 1987-11-30 | 1997-04-15 | Univ Iowa Res Found | Durch modifikationen an der 3'-terminalen phosphodiesterbindung stabilisierte dna moleküle, ihre verwendung als nukleinsäuresonden sowie als therapeutische mittel zur hemmung der expression spezifischer zielgene |
| US4907603A (en) | 1988-01-04 | 1990-03-13 | Bertha D. Chambers | Safety smoke |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5256775A (en) | 1989-06-05 | 1993-10-26 | Gilead Sciences, Inc. | Exonuclease-resistant oligonucleotides |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US5623065A (en) | 1990-08-13 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Gapped 2' modified oligonucleotides |
| US5459255A (en) | 1990-01-11 | 1995-10-17 | Isis Pharmaceuticals, Inc. | N-2 substituted purines |
| US5149797A (en) | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
| US5220007A (en) | 1990-02-15 | 1993-06-15 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of RNA and production of encoded polypeptides |
| US5218105A (en) | 1990-07-27 | 1993-06-08 | Isis Pharmaceuticals | Polyamine conjugated oligonucleotides |
| US5138045A (en) | 1990-07-27 | 1992-08-11 | Isis Pharmaceuticals | Polyamine conjugated oligonucleotides |
| US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| US5670113A (en) | 1991-12-20 | 1997-09-23 | Sibia Neurosciences, Inc. | Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same |
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| US5652355A (en) | 1992-07-23 | 1997-07-29 | Worcester Foundation For Experimental Biology | Hybrid oligonucleotide phosphorothioates |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| EP0733059B1 (en) | 1993-12-09 | 2000-09-13 | Thomas Jefferson University | Compounds and methods for site-directed mutations in eukaryotic cells |
| WO1995022618A1 (en) | 1994-02-22 | 1995-08-24 | Dana-Farber Cancer Institute | Nucleic acid delivery system, method of synthesis and uses thereof |
| US6015880A (en) | 1994-03-16 | 2000-01-18 | California Institute Of Technology | Method and substrate for performing multiple sequential reactions on a matrix |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5652356A (en) | 1995-08-17 | 1997-07-29 | Hybridon, Inc. | Inverted chimeric and hybrid oligonucleotides |
| NZ532635A (en) | 2001-11-13 | 2007-05-31 | Univ Pennsylvania | A method of identifying unknown adeno-associated virus (AAV) sequences and a kit for the method |
| EP1323733A1 (en) | 2001-12-28 | 2003-07-02 | Arturo Leone | BAG3 nucleotide and protein sequences to be used in research, diagnostics and therapy for cell death-involving diseases |
| US20030175958A1 (en) * | 2002-03-15 | 2003-09-18 | Reed John C. | Methods for using bag expression as a cell differentiation agent and marker |
| KR20100129295A (ko) | 2008-02-19 | 2010-12-08 | 셀라돈 코포레이션 | 심근 내 바이러스 벡터의 흡수를 개선시키기 위한 조성물 |
| WO2010138263A2 (en) * | 2009-05-28 | 2010-12-02 | University Of Massachusetts | Novel aav 's and uses thereof |
| WO2012087835A2 (en) * | 2010-12-22 | 2012-06-28 | Boston Biomedical Research Institute | Compositions and methods for enhancing protein folding |
| WO2012107580A1 (en) | 2011-02-10 | 2012-08-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | In vitro diagnosis method for predicting a predisposition to cardiomyopathy |
| EP3099333B8 (en) | 2014-01-31 | 2020-12-30 | Temple University of the Commonwealth System of Higher Education | Bag3 as a target for therapy of heart failure |
| AU2022325237A1 (en) | 2021-08-12 | 2024-03-21 | Renovacor, Inc. | Retrograde coronary venous or sinus administration of therapeutics |
-
2015
- 2015-01-30 EP EP15743948.0A patent/EP3099333B8/en active Active
- 2015-01-30 CA CA2975258A patent/CA2975258A1/en active Pending
- 2015-01-30 SI SI201531453T patent/SI3099333T1/sl unknown
- 2015-01-30 EP EP20208165.9A patent/EP3812473A1/en active Pending
- 2015-01-30 US US15/115,807 patent/US11236389B2/en active Active
- 2015-01-30 ES ES15743948T patent/ES2838804T3/es active Active
- 2015-01-30 DK DK15743948.0T patent/DK3099333T3/da active
- 2015-01-30 WO PCT/US2015/013926 patent/WO2015117010A2/en not_active Ceased
- 2015-01-30 HU HUE15743948A patent/HUE052814T2/hu unknown
- 2015-01-30 CA CA3228845A patent/CA3228845A1/en active Pending
- 2015-01-30 PT PT157439480T patent/PT3099333T/pt unknown
- 2015-01-30 JP JP2016549334A patent/JP6920818B2/ja active Active
-
2019
- 2019-10-21 JP JP2019191740A patent/JP7079761B2/ja active Active
-
2020
- 2020-05-21 US US15/929,784 patent/US11542555B2/en active Active
-
2022
- 2022-05-23 JP JP2022083707A patent/JP7558218B2/ja active Active
- 2022-10-05 US US17/938,209 patent/US20230073246A1/en active Pending
-
2024
- 2024-09-17 JP JP2024160090A patent/JP2024175055A/ja active Pending
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