JP2017506527A - ラップを含む外傷性創傷ドレッシングシステム - Google Patents
ラップを含む外傷性創傷ドレッシングシステム Download PDFInfo
- Publication number
- JP2017506527A JP2017506527A JP2016544854A JP2016544854A JP2017506527A JP 2017506527 A JP2017506527 A JP 2017506527A JP 2016544854 A JP2016544854 A JP 2016544854A JP 2016544854 A JP2016544854 A JP 2016544854A JP 2017506527 A JP2017506527 A JP 2017506527A
- Authority
- JP
- Japan
- Prior art keywords
- wrap
- oxygen
- wound
- container
- wound site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000472 traumatic effect Effects 0.000 title description 32
- 239000001301 oxygen Substances 0.000 claims abstract description 148
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 148
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 142
- 239000000843 powder Substances 0.000 claims abstract description 57
- 239000007788 liquid Substances 0.000 claims abstract description 54
- 239000003054 catalyst Substances 0.000 claims abstract description 40
- 239000003708 ampul Substances 0.000 claims abstract description 28
- 239000002243 precursor Substances 0.000 claims abstract description 27
- 230000000975 bioactive effect Effects 0.000 claims description 60
- 239000010410 layer Substances 0.000 claims description 29
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 26
- 238000001804 debridement Methods 0.000 claims description 20
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 18
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 18
- 231100000765 toxin Toxicity 0.000 claims description 17
- 239000002082 metal nanoparticle Substances 0.000 claims description 16
- 229940030225 antihemorrhagics Drugs 0.000 claims description 15
- 239000002874 hemostatic agent Substances 0.000 claims description 15
- 239000002250 absorbent Substances 0.000 claims description 14
- 230000002745 absorbent Effects 0.000 claims description 14
- 239000003242 anti bacterial agent Substances 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 claims description 14
- 239000003112 inhibitor Substances 0.000 claims description 11
- 150000002978 peroxides Chemical class 0.000 claims description 11
- 230000004888 barrier function Effects 0.000 claims description 10
- 239000002131 composite material Substances 0.000 claims description 10
- 239000011241 protective layer Substances 0.000 claims description 10
- -1 mannitol peroxide Chemical class 0.000 claims description 9
- 102000016938 Catalase Human genes 0.000 claims description 7
- 108010053835 Catalase Proteins 0.000 claims description 7
- 239000005749 Copper compound Substances 0.000 claims description 7
- 102000003992 Peroxidases Human genes 0.000 claims description 7
- 239000000853 adhesive Substances 0.000 claims description 7
- 230000001070 adhesive effect Effects 0.000 claims description 7
- 150000001880 copper compounds Chemical class 0.000 claims description 7
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 7
- 108040007629 peroxidase activity proteins Proteins 0.000 claims description 7
- 229930195725 Mannitol Natural products 0.000 claims description 5
- 230000000202 analgesic effect Effects 0.000 claims description 5
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 5
- 239000000594 mannitol Substances 0.000 claims description 5
- 235000010355 mannitol Nutrition 0.000 claims description 5
- 150000001451 organic peroxides Chemical class 0.000 claims description 5
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- 230000003213 activating effect Effects 0.000 claims 1
- 230000002542 deteriorative effect Effects 0.000 abstract description 2
- 208000027418 Wounds and injury Diseases 0.000 description 184
- 206010052428 Wound Diseases 0.000 description 182
- 210000001519 tissue Anatomy 0.000 description 34
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 25
- 229920002413 Polyhexanide Polymers 0.000 description 25
- 229910052709 silver Inorganic materials 0.000 description 19
- 239000004332 silver Substances 0.000 description 19
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 17
- 239000003814 drug Substances 0.000 description 14
- 239000004927 clay Substances 0.000 description 13
- 230000035876 healing Effects 0.000 description 12
- 239000000017 hydrogel Substances 0.000 description 12
- 229940035676 analgesics Drugs 0.000 description 11
- 239000000730 antalgic agent Substances 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 239000000463 material Substances 0.000 description 11
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 10
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 10
- 208000015181 infectious disease Diseases 0.000 description 10
- 230000000844 anti-bacterial effect Effects 0.000 description 9
- 230000006870 function Effects 0.000 description 9
- 239000000376 reactant Substances 0.000 description 9
- 230000029663 wound healing Effects 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 7
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 7
- 239000004599 antimicrobial Substances 0.000 description 7
- 229960003260 chlorhexidine Drugs 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 210000000416 exudates and transudate Anatomy 0.000 description 7
- 238000011282 treatment Methods 0.000 description 7
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 229920002125 Sokalan® Polymers 0.000 description 6
- 230000000740 bleeding effect Effects 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 230000000813 microbial effect Effects 0.000 description 6
- 150000002926 oxygen Chemical class 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 238000013461 design Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 239000011888 foil Substances 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- 208000002847 Surgical Wound Diseases 0.000 description 4
- 230000002421 anti-septic effect Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 210000000170 cell membrane Anatomy 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 230000006835 compression Effects 0.000 description 4
- 239000000645 desinfectant Substances 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 210000004400 mucous membrane Anatomy 0.000 description 4
- 238000002640 oxygen therapy Methods 0.000 description 4
- 230000009885 systemic effect Effects 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000233866 Fungi Species 0.000 description 3
- 229920001340 Microbial cellulose Polymers 0.000 description 3
- 244000061458 Solanum melongena Species 0.000 description 3
- 235000002597 Solanum melongena Nutrition 0.000 description 3
- 239000003570 air Substances 0.000 description 3
- 230000000845 anti-microbial effect Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 210000004379 membrane Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229940093158 polyhexanide Drugs 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 229940032044 quaternium-18 Drugs 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 239000003352 sequestering agent Substances 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000002266 amputation Methods 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000002439 hemostatic effect Effects 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 231100000344 non-irritating Toxicity 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- UEJSSZHHYBHCEL-UHFFFAOYSA-N silver(1+) sulfadiazinate Chemical compound [Ag+].C1=CC(N)=CC=C1S(=O)(=O)[N-]C1=NC=CC=N1 UEJSSZHHYBHCEL-UHFFFAOYSA-N 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 239000003760 tallow Substances 0.000 description 2
- 230000000451 tissue damage Effects 0.000 description 2
- 231100000827 tissue damage Toxicity 0.000 description 2
- 230000000287 tissue oxygenation Effects 0.000 description 2
- 210000005166 vasculature Anatomy 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 230000002407 ATP formation Effects 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000012422 Collagen Type I Human genes 0.000 description 1
- 108010022452 Collagen Type I Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 108090000204 Dipeptidase 1 Proteins 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 102100028314 Filaggrin Human genes 0.000 description 1
- 101710088660 Filaggrin Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000034693 Laceration Diseases 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 206010061225 Limb injury Diseases 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 241000422980 Marietta Species 0.000 description 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical class COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 229920002334 Spandex Polymers 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 208000000558 Varicose Ulcer Diseases 0.000 description 1
- 206010053649 Vascular rupture Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000037374 absorbed through the skin Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 241001148470 aerobic bacillus Species 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 239000002870 angiogenesis inducing agent Substances 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 229940124350 antibacterial drug Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 210000004666 bacterial spore Anatomy 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960005274 benzocaine Drugs 0.000 description 1
- 102000006635 beta-lactamase Human genes 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000008081 blood perfusion Effects 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 230000009087 cell motility Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- MYPYJXKWCTUITO-KIIOPKALSA-N chembl3301825 Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)C(O)[C@H](C)O1 MYPYJXKWCTUITO-KIIOPKALSA-N 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229940096422 collagen type i Drugs 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000023753 dehiscence Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000002222 downregulating effect Effects 0.000 description 1
- 210000000959 ear middle Anatomy 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000000416 hydrocolloid Substances 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 239000012705 liquid precursor Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 210000002418 meninge Anatomy 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229960003085 meticillin Drugs 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 231100000065 noncytotoxic Toxicity 0.000 description 1
- 230000002020 noncytotoxic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 229960001807 prilocaine Drugs 0.000 description 1
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 229940101631 quaternium-18 hectorite Drugs 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008521 reorganization Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 230000009919 sequestration Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 229940099261 silvadene Drugs 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000004759 spandex Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
- 239000002759 woven fabric Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
- A61F13/0206—Adhesive bandages or dressings with fluid retention members with absorbent fibrous layers, e.g. woven or non-woven absorbent pads or island dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
- A61F13/0226—Adhesive bandages or dressings with fluid retention members characterised by the support layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0273—Adhesive bandages for winding around limb, trunk or head, e.g. cohesive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/05—Bandages or dressings; Absorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00314—Wound bandages with surface treatments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
- A61L2300/212—Peroxy acids, peracids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
本願は、2014年1月24日に出願された米国仮特許出願第61/931,166号に基づく優先権を主張する。当該出願は、全文を引用することを以って本明細書の一部となす。
生物活性粉体は、創部に直接適用することができ、抗菌薬、止血薬、生物毒素抑制薬、鎮痛薬、デブリードマン用薬、及び酸素触媒、例えば、金属ナノ粒子(例えば銀ナノ粒子)、炭酸塩(例えば重炭酸ナトリウム)、銅化合物、カタラーゼ、ペルオキシダーゼ、二酸化マンガン、ヨウ化物、ヨウ化カリウムなどうちの1つ以上を含むことができる。生物活性原料を生体適合性担体に取り入れるか、生体適合性担体と一体化させるか、生体適合性担体に加えることができ、かつ生体適合性担体自体に生物活性特性を持たせることができる。
本発明の外傷性創傷ドレッシングシステムで用いるために、任意の適切な抗菌薬が考えられる。抗菌薬の使用については、以下の文献にさらに実証されかつ説明されており、これらの文献は全て、本明細書と矛盾しない範囲で、引用を以って本明細書の一部となす:米国特許出願公開第2007/0048344号公報(特許文献2)、米国特許出願公開第2007/0048345号公報(特許文献3)、米国特許出願公開第2007/0048356号公報(特許文献4)、米国特許出願公開第2006/0140994号公報(特許文献5)、米国特許第8,203,029号明細書(特許文献6)、及び米国特許第8,551,517号明細書(特許文献7)。本発明で考慮される特定の抗菌薬については、以下に詳細に説明する。
本発明の外傷性創傷ドレッシングシステムで使用することが考えられる1つの抗菌薬は、ポリヘキサメチレンビグアナイド(PHMB)である。PHMB(すなわち、ポリヘキサニド)は、化粧品、例えば、コンタクトレンズ洗浄液、おしぼりなどに使用されてきた長い歴史があるが、創傷ケア用途に使用可能な消毒薬である。PHMBは、洗浄液(ビー・ブラウン社製PRONTOSAN(登録商標))としても、SUPRASORB(登録商標)X+PHMB(ローマン&ラウシャー社製)などのバイオセルロースドレッシングにおいても利用可能である。濃度0.3%(例えば、SUPRASORB(登録商標)X+PHMBにおいて)及び濃度0.1%(例えば、PRONTOSAN(登録商標)において)で、PHMBは、非細胞毒性及び非刺激性であって、感作のリスクが非常に低いことが示された。PHMBは、広範囲の好気性及び嫌気性の細菌に対して、さらには、菌類、カビ、及び酵母に対しても効果的であることが分かっており、メチシリン耐性黄色ブドウ球菌(MRSA)及びバンコマイシン耐性腸球菌(VRE)に対する効果が証明されている。
本発明の外傷性創傷ドレッシングシステムでの使用が考えられる別の抗菌薬または消毒薬は、ビグアニド消毒薬であるクロルヘキシジンである。クロルヘキシジンは、消毒剤及び消毒薬溶液によく用いられてきた。クロルヘキシジン消毒薬溶液は、主として泌尿器科、婦人科、歯科において、及び創傷の治療において用いられる。これは殺菌性が高い。創傷洗浄用に約0.02%の濃度を用いることができる。他の研究では、クロルヘキシジンは創傷治癒時間を減少させることを示していた。クロルヘキシジン含有リンスもまた、術中に施行した場合には微生物の合併症を減少させるのに効果的であることを示していた。クロルヘキシジンは、2つの形態で、すなわち、創清浄用の0.05%希釈液と、術前皮膚消毒液及びハンドスクラブとして用いるための4%溶液とが作製される。最近になって、術前皮膚消毒用に2%溶液が利用可能になった。
本発明の外傷性創傷ドレッシングシステムでの使用が考えられる別の抗菌薬は、銀である。治療における銀の潜在力は長い間認識されていた。銀の広範な殺菌作用と、細菌レベルが特定の閾値を超えると創傷治癒が妨げられるという理解とにより、創傷治癒を助けるために銀をベースにした製品が多数開発されてきた。そのような製品には、銀を含む塗り薬(テネシー州ブリストルに本社を置くキング・ファーマシューティカル社製スルファジアジン銀Silvadene)や、様々な種類の銀含有ドレッシング、例えば、フォームドレッシング(ジョージア州マリエッタに本社を置くコロプラスト社製Contreet Ag)、ハイドロコロイドドレッシング(コロプラスト社製Contreet H)、ハイドロファイバドレッシング(ニュージャージー州スキルマンに本社を置くコンバテック社製アクアセル(登録商標)Ag)、アルギン酸塩ドレッシング(マサチューセッツ州クインシーに本社を置くシスタジェニックス社製SILVERCEL(登録商標))、フィルムポリマードレッシング(イリノイ州マンデレインに本社を置くメドライン社製ARGLAES(登録商標))、またはナノ結晶銀を含むポリエチレンメッシュタイプのドレッシング(英国ハル市に本社を置くスミス・アンド・ネフュー社製ACTICOAT(登録商標)フレックス7)が含まれる。これらの製品は、反応性銀陽イオン[Ag+]の放出によって機能し、それによって、細胞の細胞壁の成分を崩壊させ、電子伝達系の微生物の呼吸酵素及び要素を阻害し、DNA及びRNAの合成及び機能を低下させ得る。
止血薬もまた、本発明の外傷性創傷ドレッシングシステムでの使用が考えられ、血流損失防止及び/または凝固の恩恵を得るために止血薬を用いることができる。有用な止血薬は、ポリアクリル酸ポリマー、改質粘土及び、ポリアクリル酸ポリマーマトリックス中のCaCl2を含む。これら及び他の止血薬の使用については、以下の文献にさらに実証されかつ説明されており、これらの文献は全て、本明細書と矛盾しない範囲で、引用を以って本明細書の一部となす:米国特許第7,335,713号明細書(特許文献42)、及び米国特許第6,822,135号明細書(特許文献43)。
毒素隔離剤もまた、本発明の外傷性創傷ドレッシングシステムでの使用が考えられる。毒素隔離剤は、改質粘土技術と、創部及び周辺組織との生物毒素相互作用を低下させるかまたはなくす任意の他の薬剤とを含む。これら及び他の毒素隔離剤の使用については、以下の文献にさらに実証されかつ説明されており、これらの文献は全て、本明細書と矛盾しない範囲で、引用を以って本明細書の一部となす:米国特許第6,551,607号明細書(特許文献44)、米国特許第6,521,241号明細書(特許文献45)、米国特許第6,485,733号明細書(特許文献46)、米国特許第6,517,848号明細書(特許文献47)、及び米国特許第8,110,215号明細書(特許文献48)。
鎮痛薬は公知であり、当分野で既知の任意の適切な局所性または全身性の鎮痛薬を本発明の外傷性創傷ドレッシングシステムにおいて用いることができる。適切な例には、リドカイン、ベンゾカイン、またはプリロカインが含まれるが、これらに限定されるものではない。
本発明の外傷性創傷ドレッシングシステムは、1若しくは複数のデブリードマン用薬の使用も考慮する。デブリードマン用薬を使用することによって、救護所に到着次第すぐにデブリードマンを促進することができる。そのようなデブリードマン用薬群は、構造化界面活性剤技術と、創部及び周辺組織の洗浄及びデブリードマンを可能にする薬剤とを含む。これら及び他のデブリードマン用薬の使用については、以下の文献にさらに実証されかつ説明されており、これらの文献は全て、本明細書と矛盾しない範囲で、引用を以って本明細書の一部となす:米国特許第7,268,104号明細書(特許文献49)、米国特許第7,666,824号明細書(特許文献50)、米国特許第8,545,951号明細書(特許文献51)、及び米国特許第6,764,988号明細書(特許文献52)。
本発明の外傷性創傷ドレッシングシステムは、改質粘土の使用も考慮する。改質粘土の使用については、以下の文献にさらに実証されかつ説明されており、これらの文献は全て、本明細書と矛盾しない範囲で、引用を以って本明細書の一部となす:米国特許第6,551,607号明細書(特許文献44)、米国特許第6,521,241号明細書(特許文献45)、米国特許第6,517,848号明細書(特許文献47)、及び米国特許第6,485,733号明細書(特許文献46)。いくつかの実施形態では、本発明の粘土は、有機親和改質粘土または非有機親和改質粘土であってよい。有機親和改質粘土とは、天然材料の表面に比較的疎水性の材料を加えることによって、天然に存在する電荷を著しく減少させたものを意味する。例えば、粘土の変性は、フェノール、第4級アンモニウム、メタクリル酸メチル化合物による誘導体化を含む様々な技術を用いて実現されている。例えば、本発明の外傷性創傷ドレッシングの有機親和改質粘土成分を作製する際に用いることができる第4級アンモニウム化合物は、1つか2つの長鎖置換基、例えば14〜20炭素原子と、2つか3つの短鎖置換基、例えばメチル基とを有し得る。1つの特に適切な第4級アンモニウム化合物は、ジメチル二水素化牛脂アンモニウムクロリドである。牛脂は、18炭素原子を含むステアリン酸の大部分を含んでいるので、結果として得られる粘土は、クオタニウム18粘土、例えば、クオタニウム18ベントナイトやクオタニウム18ヘクトライトと呼ばれることが多い。そのような有機親和性粘土の組成及び作製は公知である。一実施形態では、本発明に用いられる有機親和改質粘土は、クオタニウム18ベントナイトである。その一方で、1価及び2価の陽イオン、例えば、リチウム、ナトリウムまたはカリウムなどの無機対イオンを付加するなどの他の若干の処理変更によって、非有機親和改質粘土が形成される。
生物活性粉体成分を含むことに加えて、本発明の外傷性創傷ドレッシングシステムは、液体成分も含む。外傷性創傷ドレッシングシステムを用いて創傷部位を被覆する前に、本発明の外傷性創傷ドレッシングのラップの中央に位置する易壊性アンプルまたは任意の他の適切な格納容器内に生物活性液体を収容しておくことができる。ラップを創傷部位に適用する前にラップに液体を染み込ませることができるように、アンプルまたは他の格納容器を破壊するかまたは別な方法で開封することができる。
生物活性粉体成分及び生物活性液体成分を含むことに加えて、本発明の外傷性創傷ドレッシングシステムは、ラップも含む。ラップまたはドレッシングは、吸水性を有することができ、かつ圧力を加えることによって創傷部位を固定しかつ少量の出血を最小限に抑えることによる圧迫を強化する利益をもたらすような弾性特性を有することができる。一実施形態では、ラップは不織布複合材料の形態をとることができる。上記したように、健常組織上に最初にラップを配置することを容易にするために、ラップの一端に粘着性細長片を提供することができる。一実施形態では、ラップに金属ナノ粒子(例えば銀ナノ粒子)を含浸させることができる。金属ナノ粒子は、易壊性アンプル破壊時に導入される酸素前駆体液体がラップと接触したときに酸素を発生させるための酸素触媒として機能することができるが、これについての詳細は後述する。別の実施形態では、酸素触媒は、例えば、炭酸塩(例えば重炭酸ナトリウム)、銅化合物、カタラーゼ、ペルオキシダーゼ、二酸化マンガン、ヨウ化物、またはヨウ化カリウムなどの、任意の他の適切な酸素触媒であってよい。
本発明の外傷性創傷ドレッシングシステムの別の特徴は、ラップ内で酸素を発生させるとともにその後引き続きこの酸素を創部及び周辺組織に運搬する能力である。
Claims (24)
- 創傷ドレッシングシステムであって、
創傷部位に接触させ、または創傷部位を取り囲むべく構成されたラップと、
酸素触媒と、
酸素前駆体を有する易壊性アンプルとを含み、
前記酸素触媒及び前記酸素前駆体が、互いに組み合わせられたときに酸素を発生させるように構成されていることを特徴とするシステム。 - 前記ラップが内側吸収層を含み、該内側吸収層が、前記ラップが前記創傷部位に適用されたときに前記創傷部位に隣接して配置されるように構成されていることを特徴とする請求項1に記載のシステム。
- 前記ラップが外側保護層を含むことを特徴とする請求項1に記載のシステム。
- 前記ラップが、弾性層、通気性バリア層、またはそれらの組合せを含むことを特徴とする請求項1に記載のシステム。
- 前記ラップの一端部が粘着剤を含むことを特徴とする請求項1に記載のシステム。
- 前記ラップが不織布複合材料であることを特徴とする請求項1に記載のシステム。
- 前記ラップが前記酸素触媒を含むことを特徴とする請求項1に記載のシステム。
- 前記酸素前駆体が過酸化物を含むことを特徴とする請求項1に記載のシステム。
- 前記過酸化物が、過酸化水素、過酸化マンニトール、過酸化尿素、有機過酸化物、またはそれらの組合せを含むことを特徴とする請求項8に記載のシステム。
- 前記酸素触媒が、金属ナノ粒子、炭酸塩、銅化合物、カタラーゼ、ペルオキシダーゼ、二酸化マンガン、ヨウ化物、ヨウ化カリウム、またはそれらの組合せを含むことを特徴とする請求項1に記載のシステム。
- 前記金属ナノ粒子が銀ナノ粒子を含むことを特徴とする請求項10に記載のシステム。
- 創傷ドレッシングシステムであって、
容器と、
前記容器内に配置されており、前記容器が作動状態にされたときに前記容器から創傷部位に撒布可能となる粉体と、
前記粉体から分離された状態で前記容器内に配置されており、かつ創傷部位に接触させ、または創傷部位を取り囲むべく構成されたラップと、
酸素触媒と、
前記容器内に配置され、酸素前駆体を含む液体を有し、該液体を前記容器の作動時に前記ラップに接触させるように構成された易壊性アンプルとを含み、
前記酸素触媒及び前記酸素前駆体が、互いに組み合わせられたときに酸素を発生させるように構成されていることを特徴とするシステム。 - 前記粉体が、止血薬、抗菌薬、生物毒素抑制薬、鎮痛薬、デブリードマン用薬、酸素触媒、またはそれらの組合せを含むことを特徴とする請求項12に記載のシステム。
- 前記液体が、止血薬、抗菌薬、生物毒素抑制薬、鎮痛薬、デブリードマン用薬、またはそれらの組合せを含むことを特徴とする請求項12に記載のシステム。
- 前記ラップが内側吸収層を含み、該内側吸収層が、前記ラップが前記創傷部位に適用されたときに前記創傷部位に隣接して配置されることになり、
前記ラップがさらに外側保護層を含むことを特徴とする請求項12に記載のシステム。 - 前記ラップが、弾性層、通気性バリア層、またはそれらの組合せを含むことを特徴とする請求項12に記載のシステム。
- 前記ラップの一端部が粘着剤を含むことを特徴とする請求項12に記載のシステム。
- 前記ラップが不織布複合材料であることを特徴とする請求項12に記載のシステム。
- 前記ラップが前記酸素触媒を含むことを特徴とする請求項12に記載のシステム。
- 前記酸素前駆体が過酸化物を含むことを特徴とする請求項12に記載のシステム。
- 前記過酸化物が、過酸化水素、過酸化マンニトール、過酸化尿素、または有機過酸化物であることを特徴とする請求項20に記載のシステム。
- 前記酸素触媒が、金属ナノ粒子、炭酸塩、銅化合物、カタラーゼ、ペルオキシダーゼ、二酸化マンガン、ヨウ化物、ヨウ化カリウム、またはそれらの組合せを含むことを特徴とする請求項12に記載のシステム。
- 前記金属ナノ粒子が銀ナノ粒子であることを特徴とする請求項22に記載のシステム。
- 生物活性粉体と、酸素前駆体を含む生物活性液体と、容器内に配置されかつ酸素触媒を含むラップとを含む創傷ドレッシングシステムを創傷部位に適用する方法であって、
容器を作動状態にすることによって、生物活性粉体を創傷部位に撒布しかつ前記容器の内部の易壊性アンプルを破壊して生物活性液体を撒布するステップと、
十分な時間をかけて前記生物活性液体をラップに吸収させて、前記生物活性液体と前記ラップとの接触によって酸素を発生させるステップと、
前記創傷部位の周りに前記ラップを巻き付けるステップとを含むことを特徴とする方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461931166P | 2014-01-24 | 2014-01-24 | |
US61/931,166 | 2014-01-24 | ||
PCT/US2015/012600 WO2015112807A1 (en) | 2014-01-24 | 2015-01-23 | Traumatic wound dressing system with wrap |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017506527A true JP2017506527A (ja) | 2017-03-09 |
JP6554474B2 JP6554474B2 (ja) | 2019-07-31 |
Family
ID=52450635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016544854A Expired - Fee Related JP6554474B2 (ja) | 2014-01-24 | 2015-01-23 | ラップを含む外傷性創傷ドレッシングシステム |
Country Status (7)
Country | Link |
---|---|
US (1) | US10327956B2 (ja) |
EP (1) | EP3096726B1 (ja) |
JP (1) | JP6554474B2 (ja) |
AU (1) | AU2015209240B2 (ja) |
CA (1) | CA2937344A1 (ja) |
MX (1) | MX2016008555A (ja) |
WO (1) | WO2015112807A1 (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11511094B2 (en) | 2006-11-21 | 2022-11-29 | Mark R. Moore | Apparatus and method for deploying a surgical preparation |
MX369133B (es) | 2014-01-24 | 2019-10-30 | Avent Inc | Sistema de vendaje para heridas traumaticas con cubierta de conformacion. |
EP3464708B1 (en) | 2016-06-07 | 2021-10-06 | Battelle Memorial Institute | Coating materials, and personal protective clothing items coated with the coating materials |
CN107874913A (zh) * | 2017-12-19 | 2018-04-06 | 大连海事大学 | 一种基于液体材料供氧的伤口敷料及其生产方法 |
WO2020040785A1 (en) * | 2018-08-24 | 2020-02-27 | Avent, Inc. | Formulations for generating oxygen |
US11696962B2 (en) | 2019-10-16 | 2023-07-11 | Mark R. Moore | Apparatus and method for deploying a preoperative skin disinfection device with integrated drape |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5792090A (en) * | 1995-06-15 | 1998-08-11 | Ladin; Daniel | Oxygen generating wound dressing |
JP2003512095A (ja) * | 1999-10-20 | 2003-04-02 | オキシバイオ・インコーポレイテッド | 傷用包帯への抗感染活性の付与 |
US6767342B1 (en) * | 2001-04-23 | 2004-07-27 | Evelyna D. Cantwell | Oxygen bandage system |
US20060121101A1 (en) * | 2004-12-08 | 2006-06-08 | Ladizinsky Daniel A | Method for oxygen treatment of intact skin |
JP2006527044A (ja) * | 2003-06-09 | 2006-11-30 | インセンス・リミテッド | オキシドレダクターゼ酵素を含有する皮膚用包帯 |
US7160553B2 (en) * | 1999-12-30 | 2007-01-09 | Acrymed | Matrix for oxygen delivery to compromised tissues |
JP2008508321A (ja) * | 2004-07-30 | 2008-03-21 | アクリメッド インコーポレイテッド | 抗菌銀組成物 |
WO2009102487A2 (en) * | 2008-02-13 | 2009-08-20 | Oxygen Biotherapeutics, Inc. | Gas based wound and tissue therapeutics |
JP2009543644A (ja) * | 2006-07-19 | 2009-12-10 | インセンス・リミテッド | 過酸化水素送達システム |
JP2014510602A (ja) * | 2011-04-13 | 2014-05-01 | キンバリー クラーク ワールドワイド インコーポレイテッド | 生体吸収性創傷治療装置、その製造プロセスおよび使用方法 |
JP2014527041A (ja) * | 2011-07-29 | 2014-10-09 | キンバリー クラーク ワールドワイド インコーポレイテッド | 2部分酸素発生系 |
Family Cites Families (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4861652A (en) | 1987-10-13 | 1989-08-29 | Kimberly-Clark Corporation | Diaper article with elasticized waist panel |
US4798603A (en) | 1987-10-16 | 1989-01-17 | Kimberly-Clark Corporation | Absorbent article having a hydrophobic transport layer |
US5030375A (en) | 1988-05-03 | 1991-07-09 | Kimberly-Clark Corporation | Powder-coated laundry detergent sheet |
CA2073783A1 (en) | 1992-03-12 | 1993-09-13 | Kimberly-Clark Corporation | Elastomeric metallized fabric and process to make the same |
GB9515807D0 (en) | 1995-08-02 | 1995-10-04 | Cantwell Evelyna D | Topical hyperbaric bandage |
US6103647A (en) | 1996-03-14 | 2000-08-15 | Kimberly-Clark Worldwide, Inc. | Nonwoven fabric laminate with good conformability |
US6020047A (en) | 1996-09-04 | 2000-02-01 | Kimberly-Clark Worldwide, Inc. | Polymer films having a printed self-assembling monolayer |
US6111163A (en) | 1996-12-27 | 2000-08-29 | Kimberly-Clark Worldwide, Inc. | Elastomeric film and method for making the same |
US6015764A (en) | 1996-12-27 | 2000-01-18 | Kimberly-Clark Worldwide, Inc. | Microporous elastomeric film/nonwoven breathable laminate and method for making the same |
US5730994A (en) | 1997-01-10 | 1998-03-24 | Medlogic Global Corporation | Methods for draping surgical incision sites |
US6172276B1 (en) | 1997-05-14 | 2001-01-09 | Kimberly-Clark Worldwide, Inc. | Stabilized absorbent material for improved distribution performance with visco-elastic fluids |
US6045900A (en) | 1997-09-15 | 2000-04-04 | Kimberly-Clark Worldwide, Inc. | Breathable filled film laminate |
US6605751B1 (en) | 1997-11-14 | 2003-08-12 | Acrymed | Silver-containing compositions, devices and methods for making |
US6348258B1 (en) | 1998-06-25 | 2002-02-19 | Kimberly-Clark Worldwide, Inc. | Breathable film having organic filler |
US6649099B2 (en) | 1998-10-30 | 2003-11-18 | Kimberly-Clark Worldwide, Inc. | Method of incorporating fluid treatment agents into absorbent composites |
CO5150202A1 (es) | 1998-12-31 | 2002-04-29 | Kimberly Clark Co | Composicion de tisu facial y metodo para usarla para el secuestro de irritantes de la piel de la secrecion nasal |
US7004923B2 (en) | 1999-07-19 | 2006-02-28 | I-Flow Corporation | Catheter for uniform delivery of medication |
US6350253B1 (en) | 1999-07-19 | 2002-02-26 | I-Flow Corporation | Catheter for uniform delivery of medication |
US7547302B2 (en) | 1999-07-19 | 2009-06-16 | I-Flow Corporation | Anti-microbial catheter |
US6794024B1 (en) | 1999-11-01 | 2004-09-21 | Kimberly-Clark Worldwide, Inc. | Styrenic block copolymer breathable elastomeric films |
US6653524B2 (en) | 1999-12-23 | 2003-11-25 | Kimberly-Clark Worldwide, Inc. | Nonwoven materials with time release additives |
EP1255640B1 (en) | 1999-12-28 | 2008-05-21 | Kimberly-Clark Worldwide, Inc. | Controlled release anti-microbial wipe for hard surfaces |
US6916480B2 (en) | 1999-12-28 | 2005-07-12 | Kimberly-Clark Worldwide, Inc. | Wiper containing a controlled-release anti-microbial agent |
US6627564B1 (en) | 2000-08-31 | 2003-09-30 | Kimberly-Clark Worldwide, Inc. | Composite elastic in one direction and extensible in another direction |
US6797856B1 (en) | 2000-10-27 | 2004-09-28 | Kimberly-Clark Worldwide Inc. | Microbial management in swimwear |
US7041868B2 (en) | 2000-12-29 | 2006-05-09 | Kimberly-Clark Worldwide, Inc. | Bioabsorbable wound dressing |
US6764988B2 (en) | 2001-04-18 | 2004-07-20 | Kimberly-Clark Worldwide, Inc. | Skin cleansing composition incorporating anionic particles |
ES2287275T3 (es) | 2001-06-01 | 2007-12-16 | I-Flow Corporation | Dispositivo para bolo de gran volumen. |
US6663584B2 (en) | 2001-08-27 | 2003-12-16 | Kimberly-Clark Worldwide Inc. | Elastic bandage |
US6887496B2 (en) | 2001-12-20 | 2005-05-03 | Kimberly-Clark Worldwide, Inc. | Products for controlling microbial organic compound production |
US8043287B2 (en) | 2002-03-05 | 2011-10-25 | Kimberly-Clark Inc. | Method of treating biological tissue |
US7578997B2 (en) | 2002-04-30 | 2009-08-25 | Kimberly-Clark Worldwide, Inc. | Metal ion modified high surface area materials for odor removal and control |
US6822135B2 (en) | 2002-07-26 | 2004-11-23 | Kimberly-Clark Worldwide, Inc. | Fluid storage material including particles secured with a crosslinkable binder composition and method of making same |
US20040120915A1 (en) | 2002-12-19 | 2004-06-24 | Kaiyuan Yang | Multifunctional compositions for surface applications |
US7381666B2 (en) | 2002-12-20 | 2008-06-03 | Kimberly-Clark Worldwide, Inc. | Breathable film and fabric having liquid and viral barrier |
US7582308B2 (en) | 2002-12-23 | 2009-09-01 | Kimberly-Clark Worldwide, Inc. | Odor control composition |
US6936035B2 (en) | 2002-12-31 | 2005-08-30 | I-Flow Corporation | Patient controlled drug administration device |
US7014630B2 (en) | 2003-06-18 | 2006-03-21 | Oxyband Technologies, Inc. | Tissue dressing having gas reservoir |
US20060200100A1 (en) | 2003-06-18 | 2006-09-07 | Rosati Coni F | Method and apparatus for supplying gas to an area |
US7762045B2 (en) | 2003-06-18 | 2010-07-27 | Oxyband Technologies, Inc. | Method and apparatus for supplying gas to an area |
US7470266B2 (en) | 2003-09-16 | 2008-12-30 | I-Flow Corporation | Fluid medication delivery device |
US7268104B2 (en) | 2003-12-31 | 2007-09-11 | Kimberly-Clark Worldwide, Inc. | Color changing liquid cleansing products |
US7666824B2 (en) | 2004-04-22 | 2010-02-23 | Kimberly-Clark Worldwide, Inc. | Liquid cleanser compositions |
US8529548B2 (en) | 2004-04-27 | 2013-09-10 | Smith & Nephew Plc | Wound treatment apparatus and method |
US8110215B2 (en) | 2004-04-30 | 2012-02-07 | Kimberly-Clark Worldwide, Inc. | Personal care products and methods for inhibiting the adherence of flora to skin |
EP1750790A1 (en) | 2004-05-17 | 2007-02-14 | Applied Tissue Technologies Llc | Wound chamber with remote access portal |
US20060003654A1 (en) | 2004-06-30 | 2006-01-05 | Lostocco Michael R | Dispersible alcohol/cleaning wipes via topical or wet-end application of acrylamide or vinylamide/amine polymers |
US8361553B2 (en) | 2004-07-30 | 2013-01-29 | Kimberly-Clark Worldwide, Inc. | Methods and compositions for metal nanoparticle treated surfaces |
CN101010004B (zh) | 2004-07-30 | 2012-10-03 | 金伯利-克拉克环球有限公司 | 抗微生物的装置和组合物 |
US7642397B2 (en) | 2004-08-10 | 2010-01-05 | Kimberly-Clark Worldwide, Inc. | Absorbent articles comprising a bodily exudate modifying agent and a skin care formulation |
US7265257B2 (en) | 2004-08-10 | 2007-09-04 | Kimberly-Clark Worldwide, Inc. | Absorbent articles comprising a bodily exudate modifying agent and a film-forming skin care formulation |
EP1809264B1 (en) | 2004-09-20 | 2016-04-13 | Avent, Inc. | Antimicrobial amorphous compositions |
US20060067964A1 (en) | 2004-09-30 | 2006-03-30 | Kimberly-Clark Worldwide, Inc. | Decal that includes synergistic antimicrobials for treating surfaces |
US20060140994A1 (en) | 2004-12-27 | 2006-06-29 | Bagwell Alison S | Application of an antimicrobial agent on an elastomeric article |
US20060147502A1 (en) | 2004-12-30 | 2006-07-06 | Kimberly-Clark Worldwide, Inc. | Methods for controlling microbial pathogens on currency and mail |
US20070048344A1 (en) | 2005-08-31 | 2007-03-01 | Ali Yahiaoui | Antimicrobial composition |
US7845351B2 (en) | 2005-08-31 | 2010-12-07 | Kimberly-Clark Worldwide Inc. | Germicidal face mask |
US20070048345A1 (en) | 2005-08-31 | 2007-03-01 | Kimberly-Clark Worldwide, Inc. | Antimicrobial composition |
US20070048356A1 (en) | 2005-08-31 | 2007-03-01 | Schorr Phillip A | Antimicrobial treatment of nonwoven materials for infection control |
US7335713B2 (en) | 2005-12-02 | 2008-02-26 | Stockhausen, Inc. | Method for preparing a flexible superabsorbent binder polymer composition |
US20070134303A1 (en) | 2005-12-14 | 2007-06-14 | Ali Yahiaoui | Protective and therapeutic article |
US7985209B2 (en) | 2005-12-15 | 2011-07-26 | Kimberly-Clark Worldwide, Inc. | Wound or surgical dressing |
US7422712B2 (en) | 2005-12-15 | 2008-09-09 | Kimberly-Clark Worldwide, Inc. | Technique for incorporating a liquid additive into a nonwoven web |
US20070149435A1 (en) | 2005-12-28 | 2007-06-28 | Kimberly-Clark Worldwide, Inc. | Cleansing composition including microencapsulated delivery vehicles |
US20070148459A1 (en) | 2005-12-28 | 2007-06-28 | Kimberly-Clark Worldwide, Inc. | Microencapsulated delivery vehicles |
US8293965B2 (en) | 2006-04-28 | 2012-10-23 | Kimberly-Clark Worldwide, Inc. | Antimicrobial site dressings |
US9808611B2 (en) | 2006-05-19 | 2017-11-07 | Oxyband Technologies, Inc. | Systems and methods for enhancing gas and vapor transfer for tissue treatment devices |
US7813807B2 (en) | 2006-08-15 | 2010-10-12 | Oxyband Technologies, Inc. | Systems and methods for treatment of retinopathy and other eye diseases |
US8623842B2 (en) | 2006-09-27 | 2014-01-07 | Hemostasis, Llc | Hemostatic agent and method |
US8318654B2 (en) | 2006-11-30 | 2012-11-27 | Kimberly-Clark Worldwide, Inc. | Cleansing composition incorporating a biocide, heating agent and thermochromic substance |
US8192841B2 (en) | 2006-12-14 | 2012-06-05 | Kimberly-Clark Worldwide, Inc. | Microencapsulated delivery vehicle having an aqueous core |
US20090014009A1 (en) | 2007-07-13 | 2009-01-15 | Kimberly-Clark Worldwide, Inc. | Toroidal endotracheal cuffs for ventilator associated pneumonia reduction |
US20090099532A1 (en) | 2007-10-15 | 2009-04-16 | Cuevas Brian J | Assembly for lubricating a portion of a medical device |
US20090099531A1 (en) | 2007-10-15 | 2009-04-16 | Griesbach Iii Henry Louis | Packaging for selectivity lubricating part of a medical device |
JP5322002B2 (ja) | 2008-06-19 | 2013-10-23 | アルケア株式会社 | 創傷用器具、及び該創傷用器具を用いた創傷用装置 |
US8075537B2 (en) | 2008-08-15 | 2011-12-13 | Oxyband Technologies, Inc. | Multiple cell therapeutic diffusion device |
US20100038280A1 (en) | 2008-08-15 | 2010-02-18 | Franklin Amie B | Hermetically Sealed Package for A Therapeutic Diffusion Device |
US20100041998A1 (en) | 2008-08-18 | 2010-02-18 | Postel Olivier B | Method for Detecting and/or Monitoring a Wound Using Infrared Thermal Imaging |
US10383985B2 (en) | 2008-09-09 | 2019-08-20 | Oxyband Technologies, Inc. | Methods and apparatus for charging and evacuating a diffusion dressing |
US20100087946A1 (en) | 2008-10-02 | 2010-04-08 | Postel Olivier B | Methods for Automated Fabrication and Dispense of Diffusion Dressings for Use in Tissue Treatment |
JP5638534B2 (ja) | 2008-11-24 | 2014-12-10 | キンバリー クラーク ワールドワイド インコーポレイテッド | 抗菌積層構造体 |
US9004301B2 (en) * | 2008-12-10 | 2015-04-14 | Matthew Wahlstrom | Compartmentalized container |
US8551517B2 (en) | 2008-12-16 | 2013-10-08 | Kimberly-Clark Worldwide, Inc. | Substrates providing multiple releases of active agents |
US20110282259A1 (en) | 2009-03-09 | 2011-11-17 | Postel Olivier B | Methods of manufacture of a diffusion dressing |
US20110135702A1 (en) | 2009-12-09 | 2011-06-09 | Hoffman Douglas R | Sporicidal composition for clostridium difficile spores |
US9974693B2 (en) | 2010-01-22 | 2018-05-22 | Kci Licensing, Inc. | Devices, systems, and methods for instillation of foamed fluid with negative pressure wound therapy |
US20110257610A1 (en) | 2010-03-23 | 2011-10-20 | Franklin Amie B | Therapeutic Diffusion Wound Dressing and Filling Method |
US20110257617A1 (en) | 2010-04-02 | 2011-10-20 | Franklin Amie B | Therapeutic Diffusion Hydrocolloid Wound Dressings |
US8398595B2 (en) | 2010-07-13 | 2013-03-19 | B. Braun Melsungen Ag | Infusion pump |
US20120059301A1 (en) | 2010-08-30 | 2012-03-08 | Franklin Amie B | Therapuetic Diffusion Hydrocolloid Wound Dressings with Methods of Oxygen Level Indication |
US8439862B2 (en) | 2010-12-10 | 2013-05-14 | Kimberly-Clark Worldwide, Inc. | Infusion apparatus with flow indicator |
US8308688B2 (en) | 2010-12-15 | 2012-11-13 | Kimberly-Clark Worldwide, Inc | Large-volume bolus patient controlled drug administration device |
US20120183674A1 (en) | 2011-01-18 | 2012-07-19 | Bonn-Savage Nathan G | Method of Selectively Applying an Antimicrobial Coating to a Medical Device or Device Material |
US8475560B2 (en) | 2011-03-24 | 2013-07-02 | Kimberly-Clark Worldwide, Inc. | Method for producing silver nanofilaments |
US8901188B2 (en) | 2011-06-16 | 2014-12-02 | Kimberly-Clark Worldwide, Inc. | Antimicrobial polyurethane foam and process to make the same |
CN102928931B (zh) | 2011-08-11 | 2015-02-04 | 鸿富锦精密工业(深圳)有限公司 | 光纤连接器及其安装工具 |
EP2747722B1 (en) * | 2011-09-29 | 2019-01-09 | Andover Healthcare, Inc. | System and method for treating leg ulcers |
US20130164334A1 (en) | 2011-12-23 | 2013-06-27 | Roger Bradshaw Quincy, III | Dual Element Odor Control In Personal Care Products |
US8545951B2 (en) | 2012-02-29 | 2013-10-01 | Kimberly-Clark Worldwide, Inc. | Endotracheal tubes and other polymer substrates including an anti-fouling treatment |
US9339638B2 (en) * | 2012-08-08 | 2016-05-17 | Healthpartners Research & Education | Antibiotic delivery system and method |
US9078947B2 (en) | 2013-03-15 | 2015-07-14 | Kimberly-Clark Worldwide, Inc. | Composition for forming a porous absorbent structure |
US10765774B2 (en) * | 2013-07-09 | 2020-09-08 | Ethicon, Inc. | Hemostatic pad assembly kit and method |
MX369133B (es) | 2014-01-24 | 2019-10-30 | Avent Inc | Sistema de vendaje para heridas traumaticas con cubierta de conformacion. |
-
2015
- 2015-01-23 AU AU2015209240A patent/AU2015209240B2/en not_active Ceased
- 2015-01-23 WO PCT/US2015/012600 patent/WO2015112807A1/en active Application Filing
- 2015-01-23 US US15/113,112 patent/US10327956B2/en active Active
- 2015-01-23 MX MX2016008555A patent/MX2016008555A/es active IP Right Grant
- 2015-01-23 EP EP15702929.9A patent/EP3096726B1/en active Active
- 2015-01-23 JP JP2016544854A patent/JP6554474B2/ja not_active Expired - Fee Related
- 2015-01-23 CA CA2937344A patent/CA2937344A1/en not_active Abandoned
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5792090A (en) * | 1995-06-15 | 1998-08-11 | Ladin; Daniel | Oxygen generating wound dressing |
JP2003512095A (ja) * | 1999-10-20 | 2003-04-02 | オキシバイオ・インコーポレイテッド | 傷用包帯への抗感染活性の付与 |
US7160553B2 (en) * | 1999-12-30 | 2007-01-09 | Acrymed | Matrix for oxygen delivery to compromised tissues |
US6767342B1 (en) * | 2001-04-23 | 2004-07-27 | Evelyna D. Cantwell | Oxygen bandage system |
JP2006527044A (ja) * | 2003-06-09 | 2006-11-30 | インセンス・リミテッド | オキシドレダクターゼ酵素を含有する皮膚用包帯 |
JP2008508321A (ja) * | 2004-07-30 | 2008-03-21 | アクリメッド インコーポレイテッド | 抗菌銀組成物 |
US20060121101A1 (en) * | 2004-12-08 | 2006-06-08 | Ladizinsky Daniel A | Method for oxygen treatment of intact skin |
JP2009543644A (ja) * | 2006-07-19 | 2009-12-10 | インセンス・リミテッド | 過酸化水素送達システム |
WO2009102487A2 (en) * | 2008-02-13 | 2009-08-20 | Oxygen Biotherapeutics, Inc. | Gas based wound and tissue therapeutics |
JP2014510602A (ja) * | 2011-04-13 | 2014-05-01 | キンバリー クラーク ワールドワイド インコーポレイテッド | 生体吸収性創傷治療装置、その製造プロセスおよび使用方法 |
JP2014527041A (ja) * | 2011-07-29 | 2014-10-09 | キンバリー クラーク ワールドワイド インコーポレイテッド | 2部分酸素発生系 |
Also Published As
Publication number | Publication date |
---|---|
AU2015209240A1 (en) | 2016-07-07 |
US20170007460A1 (en) | 2017-01-12 |
AU2015209240B2 (en) | 2019-06-13 |
US10327956B2 (en) | 2019-06-25 |
WO2015112807A1 (en) | 2015-07-30 |
MX2016008555A (es) | 2017-01-06 |
EP3096726B1 (en) | 2020-01-01 |
EP3096726A1 (en) | 2016-11-30 |
CA2937344A1 (en) | 2015-07-30 |
JP6554474B2 (ja) | 2019-07-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6688733B2 (ja) | コンフォーマルカバーを含む外傷性創傷ドレッシングシステム | |
JP6554474B2 (ja) | ラップを含む外傷性創傷ドレッシングシステム | |
US10500300B2 (en) | Multi-layer wound care product with perforated release layer | |
EP3558185B1 (en) | Devices for wound treatment | |
US9655840B2 (en) | Wound care products | |
US20030149406A1 (en) | Multi-layer dressing as medical drug delivery system | |
US20080020025A1 (en) | Composition for wound care and method of using same | |
JP6290184B2 (ja) | 創傷ドレッシング | |
KR20220031641A (ko) | 방출가능 항미생물제로 충전된 절개 드레이프를 포함하는 수술 부위 감염을 감소시키기 위한 상처 봉합 시스템 | |
O’Connell et al. | Unique therapies for difficult wounds | |
WO2007143586A2 (en) | Composition for wound care and method of using same | |
Foutsizoglou | A practical guide to the most commonly used dressings in wound care | |
RU2247580C2 (ru) | Многослойный материал пролонгированного лечебного действия для обработки ран, ожогов, язв, пролежней и оказания первой медицинской помощи | |
RU2817920C1 (ru) | Способ лечения гнойных ран | |
Buote | Wound Dressings | |
UA92557U (uk) | Багатошаровий матеріал для аплікацій з біологічно активним покриттям | |
Nather et al. | New Generation Dressings |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180118 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20181116 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20181127 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190221 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190625 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190708 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6554474 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
LAPS | Cancellation because of no payment of annual fees |