JP2017506511A5 - - Google Patents

Info

Publication number

JP2017506511A5

JP2017506511A5 JP2016551725A JP2016551725A JP2017506511A5 JP 2017506511 A5 JP2017506511 A5 JP 2017506511A5 JP 2016551725 A JP2016551725 A JP 2016551725A JP 2016551725 A JP2016551725 A JP 2016551725A JP 2017506511 A5 JP2017506511 A5 JP 2017506511A5

Authority

JP

Japan

Prior art keywords

medium

ldl

mesenchymal stem

medium according

lipoprotein

Prior art date

2015-02-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
• Discuss

• 239000002609 medium Substances 0.000 claims 24
• 108010007622 LDL Lipoproteins Proteins 0.000 claims 7
• 102000007330 LDL Lipoproteins Human genes 0.000 claims 7
• 210000002901 mesenchymal stem cell Anatomy 0.000 claims 7
• 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 4
• 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 4
• 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 4
• 108010062497 VLDL Lipoproteins Proteins 0.000 claims 4
• 229940126864 fibroblast growth factor Drugs 0.000 claims 4
• 239000001963 growth medium Substances 0.000 claims 4
• 239000002245 particle Substances 0.000 claims 4
• 102000004895 Lipoproteins Human genes 0.000 claims 3
• 108090001030 Lipoproteins Proteins 0.000 claims 3
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 3
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 3
• 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 2
• 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 2
• 108010010234 HDL Lipoproteins Proteins 0.000 claims 2
• 102000015779 HDL Lipoproteins Human genes 0.000 claims 2
• 108010046315 IDL Lipoproteins Proteins 0.000 claims 2
• 102000009618 Transforming Growth Factors Human genes 0.000 claims 2
• 108010009583 Transforming Growth Factors Proteins 0.000 claims 2
• 239000007640 basal medium Substances 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 108091008012 small dense LDL Proteins 0.000 claims 2
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 2
• 102000008100 Human Serum Albumin Human genes 0.000 claims 1
• 108091006905 Human Serum Albumin Proteins 0.000 claims 1
• 108010033266 Lipoprotein(a) Proteins 0.000 claims 1
• 102000057248 Lipoprotein(a) Human genes 0.000 claims 1
• 210000000577 adipose tissue Anatomy 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 210000000988 bone and bone Anatomy 0.000 claims 1
• 210000000845 cartilage Anatomy 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
• 229960003957 dexamethasone Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003102 growth factor Substances 0.000 claims 1
• 229910052711 selenium Inorganic materials 0.000 claims 1
• 239000011669 selenium Substances 0.000 claims 1
• 239000012679 serum free medium Substances 0.000 claims 1
• 210000000130 stem cell Anatomy 0.000 claims 1
• 210000001519 tissue Anatomy 0.000 claims 1
• 230000002792 vascular Effects 0.000 claims 1