JP2017505311A5 - - Google Patents

Info

Publication number

JP2017505311A5

JP2017505311A5 JP2016548192A JP2016548192A JP2017505311A5 JP 2017505311 A5 JP2017505311 A5 JP 2017505311A5 JP 2016548192 A JP2016548192 A JP 2016548192A JP 2016548192 A JP2016548192 A JP 2016548192A JP 2017505311 A5 JP2017505311 A5 JP 2017505311A5

Authority

JP

Japan

Prior art keywords

seq

breast cancer

antibody

light chain

igf

Prior art date

2015-01-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 206010006187 Breast cancer Diseases 0.000 claims 19
• 206010055113 Breast cancer metastatic Diseases 0.000 claims 15
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 12
• 239000008194 pharmaceutical composition Substances 0.000 claims 11
• 102000013275 Somatomedins Human genes 0.000 claims 10
• 102000015694 estrogen receptors Human genes 0.000 claims 8
• 108010038795 estrogen receptors Proteins 0.000 claims 8
• 102000003998 progesterone receptors Human genes 0.000 claims 8
• 108090000468 progesterone receptors Proteins 0.000 claims 8
• 229940044551 receptor antagonist Drugs 0.000 claims 8
• 239000002464 receptor antagonist Substances 0.000 claims 8
• BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 claims 6
• 208000026310 Breast neoplasm Diseases 0.000 claims 6
• 229960000255 exemestane Drugs 0.000 claims 6
• HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 4
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 4
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 4
• 229960002932 anastrozole Drugs 0.000 claims 4
• YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 claims 4
• 239000003886 aromatase inhibitor Substances 0.000 claims 4
• 229940046844 aromatase inhibitors Drugs 0.000 claims 4
• 229960005167 everolimus Drugs 0.000 claims 4
• 229960003881 letrozole Drugs 0.000 claims 4
• HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims 4
• 230000003637 steroidlike Effects 0.000 claims 4
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
• 102000038455 IGF Type 1 Receptor Human genes 0.000 claims 3
• 108010031794 IGF Type 1 Receptor Proteins 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 2
• 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 2
• 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 210000000481 breast Anatomy 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1