JP2017505140A5 - - Google Patents
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- JP2017505140A5 JP2017505140A5 JP2016563912A JP2016563912A JP2017505140A5 JP 2017505140 A5 JP2017505140 A5 JP 2017505140A5 JP 2016563912 A JP2016563912 A JP 2016563912A JP 2016563912 A JP2016563912 A JP 2016563912A JP 2017505140 A5 JP2017505140 A5 JP 2017505140A5
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- JP
- Japan
- Prior art keywords
- cell
- cells
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 12
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 6
- 230000004044 response Effects 0.000 claims 4
- 230000022131 cell cycle Effects 0.000 claims 3
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 claims 1
- 102000011727 Caspases Human genes 0.000 claims 1
- 108010076667 Caspases Proteins 0.000 claims 1
- 102000016736 Cyclin Human genes 0.000 claims 1
- 108050006400 Cyclin Proteins 0.000 claims 1
- 230000005778 DNA damage Effects 0.000 claims 1
- 231100000277 DNA damage Toxicity 0.000 claims 1
- 102000007665 Extracellular Signal-Regulated MAP Kinases Human genes 0.000 claims 1
- 108010007457 Extracellular Signal-Regulated MAP Kinases Proteins 0.000 claims 1
- 108010024636 Glutathione Proteins 0.000 claims 1
- 102100039869 Histone H2B type F-S Human genes 0.000 claims 1
- 101001035372 Homo sapiens Histone H2B type F-S Proteins 0.000 claims 1
- 101000950669 Homo sapiens Mitogen-activated protein kinase 9 Proteins 0.000 claims 1
- 206010053961 Mitochondrial toxicity Diseases 0.000 claims 1
- 102100037809 Mitogen-activated protein kinase 9 Human genes 0.000 claims 1
- 108010057466 NF-kappa B Proteins 0.000 claims 1
- 102000003945 NF-kappa B Human genes 0.000 claims 1
- 108091007960 PI3Ks Proteins 0.000 claims 1
- 102000038030 PI3Ks Human genes 0.000 claims 1
- 108700020962 Peroxidase Proteins 0.000 claims 1
- 102000003992 Peroxidases Human genes 0.000 claims 1
- 108091008611 Protein Kinase B Proteins 0.000 claims 1
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 claims 1
- 102000009738 Ribosomal Protein S6 Kinases Human genes 0.000 claims 1
- 108010034782 Ribosomal Protein S6 Kinases Proteins 0.000 claims 1
- ULHRKLSNHXXJLO-UHFFFAOYSA-L Yo-Pro-1 Chemical compound [I-].[I-].C1=CC=C2C(C=C3N(C4=CC=CC=C4O3)C)=CC=[N+](CCC[N+](C)(C)C)C2=C1 ULHRKLSNHXXJLO-UHFFFAOYSA-L 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 230000003833 cell viability Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000004163 cytometry Methods 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 229960003180 glutathione Drugs 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000028709 inflammatory response Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 210000001700 mitochondrial membrane Anatomy 0.000 claims 1
- 231100000296 mitochondrial toxicity Toxicity 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000003642 reactive oxygen metabolite Substances 0.000 claims 1
- 230000003938 response to stress Effects 0.000 claims 1
- 210000003705 ribosome Anatomy 0.000 claims 1
- 230000003595 spectral effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461927247P | 2014-01-14 | 2014-01-14 | |
| US61/927,247 | 2014-01-14 | ||
| PCT/US2015/011441 WO2015109003A1 (en) | 2014-01-14 | 2015-01-14 | Identification of functional cell states |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017505140A JP2017505140A (ja) | 2017-02-16 |
| JP2017505140A5 true JP2017505140A5 (https=) | 2018-02-15 |
| JP6606100B2 JP6606100B2 (ja) | 2019-11-13 |
Family
ID=52440877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016563912A Active JP6606100B2 (ja) | 2014-01-14 | 2015-01-14 | 機能的細胞状態の同定 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20150198584A1 (https=) |
| EP (1) | EP3094974B1 (https=) |
| JP (1) | JP6606100B2 (https=) |
| KR (1) | KR102413041B1 (https=) |
| AU (2) | AU2015206520B2 (https=) |
| CA (1) | CA2972960C (https=) |
| DK (1) | DK3094974T3 (https=) |
| ES (1) | ES2728119T3 (https=) |
| IL (1) | IL246734B (https=) |
| SG (1) | SG11201705495XA (https=) |
| WO (1) | WO2015109003A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102413041B1 (ko) * | 2014-01-14 | 2022-06-23 | 아세다사이언시즈 아게 | 기능성 세포 상태의 확인 |
| US10761011B2 (en) | 2015-02-24 | 2020-09-01 | The University Of Tokyo | Dynamic high-speed high-sensitivity imaging device and imaging method |
| JP6959614B2 (ja) * | 2015-10-28 | 2021-11-02 | 国立大学法人 東京大学 | 分析装置，及びフローサイトメータ |
| US10824693B2 (en) | 2015-12-10 | 2020-11-03 | Reservoir Labs, Inc. | Systems and methods for selective expansive recursive tensor analysis |
| US11205103B2 (en) | 2016-12-09 | 2021-12-21 | The Research Foundation for the State University | Semisupervised autoencoder for sentiment analysis |
| US12300357B2 (en) | 2016-12-14 | 2025-05-13 | FlowJo, LLC | Applied computer technology for management, synthesis, visualization, and exploration of parameters in large multi-parameter data sets |
| ES2980676T3 (es) | 2017-05-25 | 2024-10-02 | Flowjo Llc | Visualización, análisis comparativo y detección de diferencias automatizada para grandes conjuntos de datos multiparamétricos |
| GB2592113B (en) | 2018-06-13 | 2023-01-11 | Thinkcyte Inc | Methods and systems for cytometry |
| EP3969978B1 (en) | 2019-05-14 | 2025-10-01 | University of Pittsburgh - of the Commonwealth System of Higher Education | System and method for characterizing cellular phenotypic diversity from multi-parameter cellular. and sub-cellular imaging data |
| JP7556557B2 (ja) | 2019-12-27 | 2024-09-26 | シンクサイト株式会社 | フローサイトメータ性能評価方法 |
| WO2021200960A1 (ja) | 2020-04-01 | 2021-10-07 | シンクサイト株式会社 | 観察装置 |
| CN121476024A (zh) | 2020-04-01 | 2026-02-06 | 兴科尚株式会社 | 流式细胞仪 |
| EP4189065A4 (en) * | 2020-07-30 | 2024-08-28 | Allen Institute | SYSTEMS, DEVICES AND METHODS FOR SCREENING COMPOUNDS USING PREDICTIVE LABELING |
| WO2023009513A1 (en) | 2021-07-26 | 2023-02-02 | Asedasciences Ag | Improved methods for identification of functional cell states |
| WO2023056481A1 (en) * | 2021-10-01 | 2023-04-06 | CAP Diagnostics, LLC, dba Pathnostics | Automated methods and systems for rapid identification of target particles |
| US12105081B2 (en) | 2021-10-20 | 2024-10-01 | Travera, Inc. | Treatment response assessment using normalized single cell measurements |
| KR20250139846A (ko) | 2023-01-23 | 2025-09-23 | 아세다사이언시즈 아게 | 향상된 인간-컴퓨터 상호작용 시스템 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5544650A (en) | 1988-04-08 | 1996-08-13 | Neuromedical Systems, Inc. | Automated specimen classification system and method |
| AU6024294A (en) * | 1993-01-08 | 1994-08-15 | Coulter Corporation | Method of using preserved control cells in the calibration of fluorescent and light scatter measurements |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| US20050221280A1 (en) * | 1998-02-02 | 2005-10-06 | Odyssey Thera, Inc. | Protein-protein interactions for pharmacological profiling |
| US7166424B2 (en) | 1998-02-02 | 2007-01-23 | Odyssey Thera Inc. | Fragments of fluorescent proteins for protein fragment complementation assays |
| US6801859B1 (en) | 1998-12-23 | 2004-10-05 | Rosetta Inpharmatics Llc | Methods of characterizing drug activities using consensus profiles |
| US6998249B1 (en) * | 1999-09-27 | 2006-02-14 | Pharmacia & Upjohn Company | Toxicity screening method |
| ATE516497T1 (de) | 2000-03-06 | 2011-07-15 | Asterand Acquisition Llc | Screening für funktionshomologien |
| US6834237B2 (en) | 2000-06-02 | 2004-12-21 | Medicometrics Aps | Method and system for classifying a biological sample |
| US7146349B2 (en) | 2000-11-06 | 2006-12-05 | International Business Machines Corporation | Network for describing multimedia information |
| EP1620722A4 (en) | 2003-04-23 | 2008-01-30 | Bioseek Inc | METHODS FOR CHARACTERIZING SIGNALING PATHWAYS AND COMPOUNDS INTERACTING THEREWITH |
| WO2004094992A2 (en) * | 2003-04-23 | 2004-11-04 | Bioseek, Inc. | Methods for analysis of biological dataset profiles |
| WO2008134593A1 (en) | 2007-04-25 | 2008-11-06 | President And Fellows Of Harvard College | Molecular circuits |
| WO2009146036A2 (en) * | 2008-04-01 | 2009-12-03 | Purdue Research Foundation | Quantification of differences between measured values and statistical validation based on the differences |
| US20130226469A1 (en) | 2008-04-01 | 2013-08-29 | Purdue Research Foundation | Gate-free flow cytometry data analysis |
| KR102413041B1 (ko) * | 2014-01-14 | 2022-06-23 | 아세다사이언시즈 아게 | 기능성 세포 상태의 확인 |
-
2015
- 2015-01-14 KR KR1020167022058A patent/KR102413041B1/ko active Active
- 2015-01-14 WO PCT/US2015/011441 patent/WO2015109003A1/en not_active Ceased
- 2015-01-14 SG SG11201705495XA patent/SG11201705495XA/en unknown
- 2015-01-14 JP JP2016563912A patent/JP6606100B2/ja active Active
- 2015-01-14 US US14/596,957 patent/US20150198584A1/en not_active Abandoned
- 2015-01-14 US US15/111,339 patent/US11137388B2/en active Active
- 2015-01-14 DK DK15702063.7T patent/DK3094974T3/da active
- 2015-01-14 AU AU2015206520A patent/AU2015206520B2/en active Active
- 2015-01-14 EP EP15702063.7A patent/EP3094974B1/en active Active
- 2015-01-14 CA CA2972960A patent/CA2972960C/en active Active
- 2015-01-14 ES ES15702063T patent/ES2728119T3/es active Active
-
2016
- 2016-07-12 IL IL246734A patent/IL246734B/en active IP Right Grant
-
2021
- 2021-06-28 AU AU2021204419A patent/AU2021204419A1/en not_active Abandoned
- 2021-08-05 US US17/394,521 patent/US11867690B2/en active Active
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