JP2017504590A5 - - Google Patents
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- JP2017504590A5 JP2017504590A5 JP2016538745A JP2016538745A JP2017504590A5 JP 2017504590 A5 JP2017504590 A5 JP 2017504590A5 JP 2016538745 A JP2016538745 A JP 2016538745A JP 2016538745 A JP2016538745 A JP 2016538745A JP 2017504590 A5 JP2017504590 A5 JP 2017504590A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- eudragit
- item
- linaclotide
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 174
- KXGCNMMJRFDFNR-WDRJZQOASA-N linaclotide Chemical compound C([C@H](NC(=O)[C@@H]1CSSC[C@H]2C(=O)N[C@H]3CSSC[C@H](N)C(=O)N[C@H](C(N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N2)=O)CSSC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC3=O)C(=O)N[C@H](C(NCC(=O)N1)=O)[C@H](O)C)C(O)=O)C1=CC=C(O)C=C1 KXGCNMMJRFDFNR-WDRJZQOASA-N 0.000 claims description 46
- 108010024409 linaclotide Proteins 0.000 claims description 46
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- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 20
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
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- IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 claims description 5
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims description 5
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- IWVKTOUOPHGZRX-UHFFFAOYSA-N methyl 2-methylprop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.COC(=O)C(C)=C IWVKTOUOPHGZRX-UHFFFAOYSA-N 0.000 claims description 5
- IQSHMXAZFHORGY-UHFFFAOYSA-N methyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound COC(=O)C=C.CC(=C)C(O)=O IQSHMXAZFHORGY-UHFFFAOYSA-N 0.000 claims description 5
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 5
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- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 3
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- 229930182817 methionine Natural products 0.000 description 3
- 102100034605 Atrial natriuretic peptide receptor 3 Human genes 0.000 description 2
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- PLTGTJAZQRGMPP-FXQIFTODSA-N Asn-Pro-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(N)=O PLTGTJAZQRGMPP-FXQIFTODSA-N 0.000 description 1
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- 206010009944 Colon cancer Diseases 0.000 description 1
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- ISWAQPWFWKGCAL-ACZMJKKPSA-N Cys-Cys-Glu Chemical group [H]N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(O)=O)C(O)=O ISWAQPWFWKGCAL-ACZMJKKPSA-N 0.000 description 1
- ALNKNYKSZPSLBD-ZDLURKLDSA-N Cys-Thr-Gly Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(O)=O ALNKNYKSZPSLBD-ZDLURKLDSA-N 0.000 description 1
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 208000032177 Intestinal Polyps Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- CGDZGRLRXPNCOC-SRVKXCTJSA-N Tyr-Cys-Cys Chemical compound SC[C@@H](C(O)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 CGDZGRLRXPNCOC-SRVKXCTJSA-N 0.000 description 1
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- 108010010430 asparagine-proline-alanine Proteins 0.000 description 1
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- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021078445A JP7483656B2 (ja) | 2013-12-11 | 2021-05-06 | リナクロチドの遅延放出組成物 |
| JP2023115832A JP2023126475A (ja) | 2013-12-11 | 2023-07-14 | リナクロチドの遅延放出組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361914952P | 2013-12-11 | 2013-12-11 | |
| US201361914951P | 2013-12-11 | 2013-12-11 | |
| US61/914,951 | 2013-12-11 | ||
| US61/914,952 | 2013-12-11 | ||
| PCT/US2014/069838 WO2015089326A1 (en) | 2013-12-11 | 2014-12-11 | Delayed release compositions of linaclotide |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019029432A Division JP2019073559A (ja) | 2013-12-11 | 2019-02-21 | リナクロチドの遅延放出組成物 |
| JP2021078445A Division JP7483656B2 (ja) | 2013-12-11 | 2021-05-06 | リナクロチドの遅延放出組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017504590A JP2017504590A (ja) | 2017-02-09 |
| JP2017504590A5 true JP2017504590A5 (https=) | 2018-01-25 |
| JP6964380B2 JP6964380B2 (ja) | 2021-11-10 |
Family
ID=52293217
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538745A Active JP6964380B2 (ja) | 2013-12-11 | 2014-12-11 | リナクロチドの遅延放出組成物 |
| JP2019029432A Pending JP2019073559A (ja) | 2013-12-11 | 2019-02-21 | リナクロチドの遅延放出組成物 |
| JP2021078445A Active JP7483656B2 (ja) | 2013-12-11 | 2021-05-06 | リナクロチドの遅延放出組成物 |
| JP2023115832A Pending JP2023126475A (ja) | 2013-12-11 | 2023-07-14 | リナクロチドの遅延放出組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019029432A Pending JP2019073559A (ja) | 2013-12-11 | 2019-02-21 | リナクロチドの遅延放出組成物 |
| JP2021078445A Active JP7483656B2 (ja) | 2013-12-11 | 2021-05-06 | リナクロチドの遅延放出組成物 |
| JP2023115832A Pending JP2023126475A (ja) | 2013-12-11 | 2023-07-14 | リナクロチドの遅延放出組成物 |
Country Status (29)
| Country | Link |
|---|---|
| US (7) | US20160310559A1 (https=) |
| EP (2) | EP3079669B1 (https=) |
| JP (4) | JP6964380B2 (https=) |
| KR (3) | KR102337809B1 (https=) |
| CN (3) | CN115089556A (https=) |
| AU (3) | AU2014362220B2 (https=) |
| CA (1) | CA2933587C (https=) |
| CL (1) | CL2016001424A1 (https=) |
| CY (1) | CY1123953T1 (https=) |
| DK (1) | DK3079669T3 (https=) |
| EA (1) | EA201691216A1 (https=) |
| EC (2) | ECSP16059106A (https=) |
| ES (1) | ES2838007T3 (https=) |
| HR (1) | HRP20201753T1 (https=) |
| HU (1) | HUE052981T2 (https=) |
| IL (2) | IL246155A0 (https=) |
| LT (1) | LT3079669T (https=) |
| MX (2) | MX386584B (https=) |
| NZ (2) | NZ721952A (https=) |
| PE (2) | PE20161373A1 (https=) |
| PH (1) | PH12016501122B1 (https=) |
| PL (1) | PL3079669T3 (https=) |
| PT (1) | PT3079669T (https=) |
| RS (1) | RS61133B1 (https=) |
| SG (2) | SG10201804817TA (https=) |
| SI (1) | SI3079669T1 (https=) |
| SM (1) | SMT202000686T1 (https=) |
| UA (1) | UA119335C2 (https=) |
| WO (2) | WO2015089335A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA119335C2 (uk) * | 2013-12-11 | 2019-06-10 | Айронвуд Фармасьютикалз, Інк. | Композиції лінаклотиду з затриманим вивільненням |
| TW201618783A (zh) | 2014-08-07 | 2016-06-01 | 艾森塔製藥公司 | 以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法 |
| CA2936740C (en) | 2014-10-31 | 2017-10-10 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
| WO2016125064A1 (en) * | 2015-02-02 | 2016-08-11 | Aurobindo Pharma Ltd | Stable compositions comprising linaclotide |
| EP3302440B1 (en) * | 2015-06-05 | 2021-01-06 | Ironwood Pharmaceuticals, Inc. | Modified or targeted release formulations of linaclotide |
| WO2017156214A1 (en) * | 2016-03-11 | 2017-09-14 | Gateway Pharmaceutical LLC | Pharmaceutical compositions for colon-specific delivery |
| US10588864B2 (en) | 2016-03-11 | 2020-03-17 | Gateway Pharmaceuticals LLC | Pharmaceutical compositions for colon-specific delivery |
| JP6957610B2 (ja) * | 2016-10-06 | 2021-11-02 | スキャンポ・アーゲーＳｕｃａｍｐｏ ＡＧ | 医薬品用途のための多層ビーズ |
| MX2019007574A (es) * | 2016-12-21 | 2019-09-04 | Ironwood Pharmaceuticals Inc | Metodos de tratamiento de sindrome de intestino irritable con formulaciones modificadas o de liberacion retardada de linaclotida. |
| KR102227486B1 (ko) * | 2017-06-30 | 2021-03-12 | 롯데정밀화학 주식회사 | 프로톤 펌프 저해제를 포함하는 경구용 고형제제 조성물, 이를 포함하는 경구용 고형제제 및 그 제조방법 |
| CA3095036A1 (en) * | 2018-03-23 | 2019-09-26 | Palatin Technologies, Inc. | Melanocortin receptor-specific peptide formulations and methods for gastrointestinal tract-specific delivery |
| US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
| WO2020251923A1 (en) * | 2019-06-10 | 2020-12-17 | Ironwood Pharmaceuticals, Inc. | Treatment of abdominal pain associated with diarrhea-predominant irritable bowel syndrome |
| KR102104507B1 (ko) * | 2019-08-23 | 2020-04-24 | 브릿지바이오테라퓨틱스(주) | 팔미토일-l-프롤릴-l-프롤릴-글리실-l-타이로신 나트륨을 포함하는 약제학적 제제 및 이의 제조방법 |
| CN110935007B (zh) * | 2019-12-12 | 2023-06-23 | 烟台大学 | 利那洛肽复方组合物、制剂及其用途和制备方法 |
| GB202017863D0 (en) * | 2020-11-12 | 2020-12-30 | Intract Pharma Ltd | Novel compositions |
| WO2022245650A1 (en) * | 2021-05-19 | 2022-11-24 | Alberto Paz | Orally administered compositions for cancer treatment |
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| CN201252259Y (zh) * | 2008-07-24 | 2009-06-03 | 富士康(昆山)电脑接插件有限公司 | 电连接器 |
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| CA2811001A1 (en) * | 2010-09-11 | 2012-03-15 | Ironwood Pharmaceuticals, Inc. | Treatment of constipation-predominant irritable bowel syndrome |
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