JP2017504011A5 - - Google Patents
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- Publication number
- JP2017504011A5 JP2017504011A5 JP2016541297A JP2016541297A JP2017504011A5 JP 2017504011 A5 JP2017504011 A5 JP 2017504011A5 JP 2016541297 A JP2016541297 A JP 2016541297A JP 2016541297 A JP2016541297 A JP 2016541297A JP 2017504011 A5 JP2017504011 A5 JP 2017504011A5
- Authority
- JP
- Japan
- Prior art keywords
- pancreatic cancer
- group
- subject
- biomarker
- biomarkers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000090 biomarker Substances 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 32
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 30
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 30
- 201000002528 pancreatic cancer Diseases 0.000 claims description 30
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 30
- 238000003745 diagnosis Methods 0.000 claims description 8
- 229940106189 ceramide Drugs 0.000 claims description 5
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 4
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 4
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 4
- 238000011156 evaluation Methods 0.000 claims description 4
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 4
- 238000011275 oncology therapy Methods 0.000 claims description 3
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 claims description 2
- 208000000668 Chronic Pancreatitis Diseases 0.000 claims description 2
- 206010033645 Pancreatitis Diseases 0.000 claims description 2
- 206010033649 Pancreatitis chronic Diseases 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 201000002094 pancreatic adenocarcinoma Diseases 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 3
- CWRILEGKIAOYKP-SSDOTTSWSA-M [(2r)-3-acetyloxy-2-hydroxypropyl] 2-aminoethyl phosphate Chemical compound CC(=O)OC[C@@H](O)COP([O-])(=O)OCCN CWRILEGKIAOYKP-SSDOTTSWSA-M 0.000 claims 3
- -1 sphingomyelin Chemical compound 0.000 claims 2
- 150000001783 ceramides Chemical class 0.000 claims 1
- 238000005259 measurement Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13198959 | 2013-12-20 | ||
| EP13198959.2 | 2013-12-20 | ||
| PCT/EP2014/078765 WO2015091962A1 (en) | 2013-12-20 | 2014-12-19 | Means and methods for diagnosing pancreatic cancer in a subject based on a metabolite panel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017504011A JP2017504011A (ja) | 2017-02-02 |
| JP2017504011A5 true JP2017504011A5 (https=) | 2018-02-08 |
Family
ID=49885030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016541297A Pending JP2017504011A (ja) | 2013-12-20 | 2014-12-19 | 代謝物質パネルに基づく被験体において膵臓癌を診断するための手段および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10168333B2 (https=) |
| EP (2) | EP3431998A1 (https=) |
| JP (1) | JP2017504011A (https=) |
| AU (1) | AU2014368412A1 (https=) |
| CA (1) | CA2934012A1 (https=) |
| ES (1) | ES2698374T3 (https=) |
| WO (1) | WO2015091962A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180217125A1 (en) * | 2014-03-26 | 2018-08-02 | Metanomics Health | Means and methods for the determination of the quality of blood samples based on a metabolite panel |
| EP3314264A1 (en) * | 2015-06-25 | 2018-05-02 | Metanomics Health GmbH | Means and methods for diagnosing pancreatic cancer in a subject based on a biomarker panel |
| JP2017067510A (ja) * | 2015-09-29 | 2017-04-06 | 花王株式会社 | 脂質の質量分析方法 |
| KR101937531B1 (ko) | 2016-09-28 | 2019-01-10 | 국립암센터 | 대장암 진단 장치와 대장암 진단 정보 제공 방법 |
| KR102549063B1 (ko) * | 2016-12-15 | 2023-06-28 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 췌관 선암종의 검출 및 치료를 위한 방법 |
| WO2018143336A1 (ja) * | 2017-02-03 | 2018-08-09 | 住友化学株式会社 | 膵臓癌の検査方法 |
| EP3502699A1 (en) * | 2017-12-20 | 2019-06-26 | Metanomics Health GmbH | Methods for diagnosing pancreatic cancer |
| EP3806719B1 (en) * | 2018-06-14 | 2025-08-20 | Metabolomycs, Inc. | Metabolomic signatures for diagnosing and prognosing ovarian cancer |
| CN109288827B (zh) * | 2018-09-29 | 2020-05-26 | 桂林医学院附属医院 | 神经酰胺酶抑制剂D-e-MAPP在制备改善急性胰腺炎的药物中的应用 |
| ES2799973A1 (es) * | 2019-06-19 | 2020-12-22 | Univ Granada | Panel de metabolitos como biomarcadores para el diagnostico de cancer de pancreas |
| WO2022140380A1 (en) * | 2020-12-21 | 2022-06-30 | Pancreomics Llc | Metabolomic signatures for predicting, diagnosing, and prognosing chronic pancreatitis |
| WO2024059549A2 (en) * | 2022-09-12 | 2024-03-21 | Board Of Regents, The University Of Texas System | Methods for the detection and treatment of pancreatic ductal adenocarcinoma |
| TWI859033B (zh) | 2023-12-18 | 2024-10-11 | 安益藥業股份有限公司 | 一種診斷犬科動物胰臟炎的方法與試劑組與一種使用醯基肉鹼作為診斷犬科動物胰臟炎之用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4540884A (en) | 1982-12-29 | 1985-09-10 | Finnigan Corporation | Method of mass analyzing a sample by use of a quadrupole ion trap |
| US5397894A (en) | 1993-05-28 | 1995-03-14 | Varian Associates, Inc. | Method of high mass resolution scanning of an ion trap mass spectrometer |
| JP2005526962A (ja) | 2002-02-28 | 2005-09-08 | メタノミクス ゲーエムベーハー ウント ツェーオー．カーゲーアーアー | 物質の混合物を分析する質量分析方法 |
| SG10201405975VA (en) * | 2009-10-01 | 2014-11-27 | Phenomenome Discoveries Inc | Serum-based biomarkers of pancreatic cancer and uses thereof for diseasedetection and diagnosis |
| EP2415877A3 (en) * | 2010-02-17 | 2012-02-15 | Deutsches Krebsforschungszentrum | Means and methods for diagnosing pancreatic cancer |
| EP3355057A3 (en) | 2010-06-01 | 2018-12-12 | Metanomics Health GmbH | Means and methods for diagnosing pancreatic cancer in a subject |
| ES2638522T3 (es) * | 2010-06-23 | 2017-10-23 | University Of Louisville Research Foundation, Inc. | Procedimientos para detectar cáncer |
| CA2857401A1 (en) | 2011-11-30 | 2013-06-06 | Metanomics Health Gmbh | Device and methods to diagnose pancreatic cancer |
| CN104395758A (zh) | 2012-05-18 | 2015-03-04 | 日东纺绩株式会社 | 用于检测胰腺癌的标志物 |
-
2014
- 2014-12-19 AU AU2014368412A patent/AU2014368412A1/en not_active Abandoned
- 2014-12-19 EP EP18189879.2A patent/EP3431998A1/en not_active Withdrawn
- 2014-12-19 WO PCT/EP2014/078765 patent/WO2015091962A1/en not_active Ceased
- 2014-12-19 US US15/105,970 patent/US10168333B2/en not_active Expired - Fee Related
- 2014-12-19 JP JP2016541297A patent/JP2017504011A/ja active Pending
- 2014-12-19 CA CA2934012A patent/CA2934012A1/en not_active Abandoned
- 2014-12-19 ES ES14815751T patent/ES2698374T3/es active Active
- 2014-12-19 EP EP14815751.4A patent/EP3084443B1/en not_active Not-in-force
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