JP2017502257A5 - - Google Patents

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JP2017502257A5
JP2017502257A5 JP2016525565A JP2016525565A JP2017502257A5 JP 2017502257 A5 JP2017502257 A5 JP 2017502257A5 JP 2016525565 A JP2016525565 A JP 2016525565A JP 2016525565 A JP2016525565 A JP 2016525565A JP 2017502257 A5 JP2017502257 A5 JP 2017502257A5
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objects
micro
microfluidic device
enclosure
capture micro
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JP6465878B2 (ja
JP2017502257A (ja
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JP2016525565A 2013-10-22 2014-10-22 生体アクティビティをアッセイするための微少流体デバイス Active JP6465878B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201361996969P 2013-10-22 2013-10-22
US201361996962P 2013-10-22 2013-10-22
US201361996973P 2013-10-22 2013-10-22
US61/996,973 2013-10-22
US61/996,969 2013-10-22
US61/996,962 2013-10-22
US201462058658P 2014-10-01 2014-10-01
US62/058,658 2014-10-01
US14/520,510 US9617145B2 (en) 2013-10-22 2014-10-22 Exporting a selected group of micro-objects from a micro-fluidic device
PCT/US2014/061848 WO2015061506A1 (en) 2013-10-22 2014-10-22 Micro-fluidic devices for assaying biological activity
US14/520,510 2014-10-22

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JP2017502257A JP2017502257A (ja) 2017-01-19
JP2017502257A5 true JP2017502257A5 (cg-RX-API-DMAC7.html) 2017-11-30
JP6465878B2 JP6465878B2 (ja) 2019-02-06

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JP2019001195A Active JP6709299B2 (ja) 2013-10-22 2019-01-08 生体アクティビティをアッセイするための微少流体デバイス

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US (3) US9617145B2 (cg-RX-API-DMAC7.html)
EP (2) EP3783094B1 (cg-RX-API-DMAC7.html)
JP (2) JP6465878B2 (cg-RX-API-DMAC7.html)
KR (1) KR102113990B1 (cg-RX-API-DMAC7.html)
AU (2) AU2014340098B2 (cg-RX-API-DMAC7.html)
CA (1) CA2925326C (cg-RX-API-DMAC7.html)
IL (2) IL245253B (cg-RX-API-DMAC7.html)
SG (2) SG11201602336UA (cg-RX-API-DMAC7.html)
WO (1) WO2015061506A1 (cg-RX-API-DMAC7.html)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014340089B2 (en) 2013-10-22 2019-09-26 Berkeley Lights, Inc. Microfluidic devices having isolation pens and methods of testing biological micro-objects with same
US9889445B2 (en) 2013-10-22 2018-02-13 Berkeley Lights, Inc. Micro-fluidic devices for assaying biological activity
US11192107B2 (en) 2014-04-25 2021-12-07 Berkeley Lights, Inc. DEP force control and electrowetting control in different sections of the same microfluidic apparatus
US20150352547A1 (en) 2014-06-06 2015-12-10 Berkeley Lights, Inc. Isolating Microfluidic Structures and Trapping Bubbles
US10058865B2 (en) 2014-12-08 2018-08-28 Berkeley Lights, Inc. Actuated microfluidic structures for directed flow in a microfluidic device and methods of use thereof
KR102369770B1 (ko) 2014-12-08 2022-03-02 버클리 라잇츠, 인크. 측방향/수직 트랜지스터 구조들을 포함하는 미세유체 디바이스 및 그 제조 및 사용 프로세스
CN107223208B (zh) 2014-12-09 2021-04-09 伯克利之光生命科技公司 微流体装置中微物体的自动检测和重新定位
EP3230718B1 (en) 2014-12-09 2022-03-02 Berkeley Lights, Inc. Automated detection of assay-positive areas or of analyte quantities in microfluidic devices
JP2018512875A (ja) 2015-04-22 2018-05-24 バークレー ライツ，インコーポレイテッド マイクロ流体デバイスにおける細胞の凍結及び保管
US10751715B1 (en) 2015-04-22 2020-08-25 Berkeley Lights, Inc. Microfluidic reporter cell assay methods and kits thereof
WO2016172623A1 (en) 2015-04-22 2016-10-27 Berkeley Lights, Inc. Manipulation of cell nuclei in a micro-fluidic device
CA3176018A1 (en) 2015-04-22 2016-10-27 Berkeley Lights, Inc. Microfluidic device for culturing biological cells and methods of use thereof
US10799865B2 (en) 2015-10-27 2020-10-13 Berkeley Lights, Inc. Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
IL299366A (en) 2015-11-23 2023-02-01 Berkeley Lights Inc In situ-generated microfluidic isolation structures, kits and methods of use thereof
CN108603878A (zh) * 2015-12-08 2018-09-28 伯克利之光生命科技公司 微流体设备和试剂盒及其使用方法
IL299835A (en) 2015-12-30 2023-03-01 Berkeley Lights Inc Microfluidic devices for optically activated convection and displacement, and their kits and methods
TWI808934B (zh) 2015-12-31 2023-07-21 美商伯克利之光生命科技公司 經工程化以表現促發炎多肽之腫瘤浸潤細胞
TWI821913B (zh) 2016-01-15 2023-11-11 美商伯克利之光生命科技公司 製造患者專一性抗癌治療劑之方法及使用該治療劑之治療方法
WO2017160991A1 (en) 2016-03-16 2017-09-21 Lavieu Gregory G Methods, systems and devices for selection and generation of genome edited clones
US11285478B2 (en) * 2016-04-04 2022-03-29 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification
CN115184315A (zh) 2016-04-15 2022-10-14 伯克利之光生命科技公司 用于坞内测定的方法、系统和试剂盒
US10675625B2 (en) 2016-04-15 2020-06-09 Berkeley Lights, Inc Light sequencing and patterns for dielectrophoretic transport
WO2017205830A1 (en) 2016-05-26 2017-11-30 Berkeley Lights, Inc. Covalently modified surfaces, kits, and methods of preparation and use
KR102456488B1 (ko) 2016-07-21 2022-10-19 버클리 라잇츠, 인크. 미세유체 디바이스에서의 t 림프구들의 분류
CA3045333A1 (en) * 2016-12-01 2018-06-07 Berkeley Lights, Inc. Automated detection and repositioning of micro-objects in microfluidic devices
EP3551745A4 (en) 2016-12-12 2020-07-15 Xcella Biosciences, Inc. SCREENING METHODS AND SYSTEMS USING MICROCAPILLARY NETWORKS
CA3048645A1 (en) * 2016-12-30 2018-07-05 The Regents Of The University Of California Methods for selection and generation of genome edited t cells
US11156626B2 (en) 2016-12-30 2021-10-26 xCella Biosciences, Inc. Multi-stage sample recovery system
WO2018226900A2 (en) 2017-06-06 2018-12-13 Zymergen Inc. A htp genomic engineering platform for improving fungal strains
EP3721209B1 (en) 2017-10-15 2024-02-07 Berkeley Lights, Inc. Methods for in-pen assays
US11047826B2 (en) 2018-03-15 2021-06-29 Massachusetts Institute Of Technology Chemiresistive sensor and methods of sensing
KR20210018219A (ko) 2018-06-06 2021-02-17 지머젠 인코포레이티드 발효 및 생산 중 곰팡이 형태를 제어하기 위한 신호 전달에 포함된 유전자의 조작
CN108728359B (zh) * 2018-06-08 2022-03-11 天晴干细胞股份有限公司 一种空间站细胞培养瓶及其辅助装置的应用
EP3849705A4 (en) * 2018-09-14 2022-06-01 Berkeley Lights, Inc. Methods for assaying binding affinity
CN109410726B (zh) * 2018-09-17 2020-11-03 中国石油大学(华东) 一种交互式压汞毛管力曲线虚拟仿真测试教学系统及其运行方法
EP3853352A4 (en) 2018-09-21 2022-08-10 Berkeley Lights, Inc. FUNCTIONALIZED TRUCK PLATE, PROCESS FOR ITS MANUFACTURE AND ITS USE
KR20210078510A (ko) 2018-10-11 2021-06-28 버클리 라잇츠, 인크. 최적화된 단백질 생성의 확인을 위한 시스템 및 방법, 및 이를 위한 키트
KR20210089193A (ko) 2018-11-01 2021-07-15 버클리 라잇츠, 인크. 미세유체 디바이스에서 생물학적 세포를 분석하기 위한 방법
EP3883692A4 (en) 2018-11-19 2022-08-31 Berkeley Lights, Inc. MICROFLUID DEVICE WITH PROGRAMMABLE SWITCHING ELEMENTS
US12318775B2 (en) 2018-12-06 2025-06-03 xCella Biosciences, Inc. Lateral loading of microcapillary arrays
WO2020168258A1 (en) * 2019-02-15 2020-08-20 Berkeley Lights, Inc. Laser-assisted repositioning of a micro-object and culturing of an attachment-dependent cell in a microfluidic environment
EP3501658B1 (en) 2019-03-19 2021-04-21 Ace Medical Technology Co., Ltd. Device for sorting bio-particles using a force generated from light-induced dielectrophoresis and operating method thereof
CN116174068A (zh) 2019-04-30 2023-05-30 伯克利之光生命科技公司 用于包封和测定细胞的方法
CN110538680B (zh) * 2019-08-19 2024-08-06 昆山汇先医药技术有限公司 一种微流控样品处理设备
CN114514309B (zh) * 2019-09-26 2024-05-24 京瓷株式会社 细胞检测装置和细胞检测方法
CN110935568B (zh) * 2019-11-15 2022-01-04 Tcl华星光电技术有限公司 粒子分离装置和粒子分离方法
CA3157616A1 (en) 2019-11-17 2021-05-20 Darshan THAKER Systems and methods for analyses of biological samples
US11479779B2 (en) 2020-07-31 2022-10-25 Zymergen Inc. Systems and methods for high-throughput automated strain generation for non-sporulating fungi
WO2023038630A1 (en) * 2021-09-10 2023-03-16 Hewlett-Packard Development Company, L.P. Interface devices with electrodes for digital microfluidics
DE102021211549A1 (de) 2021-10-13 2023-04-13 Robert Bosch Gesellschaft mit beschränkter Haftung Vorrichtung, insbesondere mikrofluidische Kartusche, und Verfahren mit Entnahmekammer und entfernbarer Abdeckung

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997040385A1 (en) 1996-04-25 1997-10-30 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US6942776B2 (en) 1999-05-18 2005-09-13 Silicon Biosystems S.R.L. Method and apparatus for the manipulation of particles by means of dielectrophoresis
EP1194693B1 (en) 1999-06-28 2006-10-25 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US20030007894A1 (en) 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
AU3053002A (en) * 2000-11-28 2002-06-11 Univ California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
ITTO20010411A1 (it) 2001-05-02 2002-11-02 Silicon Biosystems S R L Metodo e dispositivo per l'esecuzione di test e saggi ad alta processivita' ed alto valore biologico su cellule e/o composti.
EP2666849A3 (en) 2002-04-01 2014-05-28 Fluidigm Corporation Microfluidic particle-analysis systems
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US6958132B2 (en) 2002-05-31 2005-10-25 The Regents Of The University Of California Systems and methods for optical actuation of microfluidics based on opto-electrowetting
US7790443B2 (en) * 2002-08-27 2010-09-07 Vanderbilt University Bioreactors with substance injection capacity
JP4328168B2 (ja) 2003-10-02 2009-09-09 ソニー株式会社 毛細管現象を利用する物質間の相互作用検出部と該検出部を用いる方法及びバイオアッセイ用基板
WO2005072399A2 (en) 2004-01-29 2005-08-11 Massachusetts Institute Of Technology Microscale sorting cytometer
US8765454B2 (en) 2004-02-18 2014-07-01 Xiaochuan Zhou Fluidic devices and methods for multiplex chemical and biochemical reactions
KR100597870B1 (ko) * 2004-04-01 2006-07-06 한국과학기술원 고속 스크리닝 또는 고속 분석을 위한 미소 유체 칩
JP2007537729A (ja) 2004-04-12 2007-12-27 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 微粒子及び細胞の操作用の光電子ピンセット
US20060091015A1 (en) 2004-11-01 2006-05-04 Applera Corporation Surface modification for non-specific adsorption of biological material
GB2420850A (en) * 2004-12-03 2006-06-07 Orion Diagnostica Oy Particle based binding assay
EP3029135B1 (en) 2005-07-07 2021-03-17 The Regents of the University of California Apparatus for cell culture array
CA2616504A1 (en) * 2005-08-19 2007-03-01 The Regents Of The University Of California Microfluidic methods for diagnostics and cellular analysis
WO2007102839A2 (en) 2005-10-27 2007-09-13 Applera Corporation Optoelectronic separation of biomolecules
US8124015B2 (en) 2006-02-03 2012-02-28 Institute For Systems Biology Multiplexed, microfluidic molecular assay device and assay method
WO2008119066A1 (en) 2007-03-28 2008-10-02 The Regents Of The University Of California Single-sided lateral-field and phototransistor-based optoelectronic tweezers
ATE554859T1 (de) 2007-05-24 2012-05-15 Univ California Integrierte fluidische vorrichtungen mit magnetischer sortierung
WO2009014143A1 (ja) 2007-07-24 2009-01-29 Panasonic Electric Works Co., Ltd. 充電監視装置
US8961877B2 (en) 2007-08-09 2015-02-24 Massachusetts Institute Of Technology High-throughput, whole-animal screening system
EP2078958A1 (en) 2007-10-25 2009-07-15 Koninklijke Philips Electronics N.V. A reconfigurable microfluidic filter based on eletric fields
JP2011516867A (ja) 2008-04-03 2011-05-26 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア 細胞、小胞、ナノ粒子およびバイオマーカーを分離および単離するためのエキソビボの多次元システム
EP2279238A2 (en) * 2008-04-21 2011-02-02 Cell Kinetics, Ltd. Flat cell carriers with cell traps
KR20100000822A (ko) 2008-06-25 2010-01-06 엘지디스플레이 주식회사 유기전계발광표시장치와 이의 제조방법
US20110275063A1 (en) 2008-07-11 2011-11-10 President And Fellows Of Harvard College Systems and methods of droplet-based selection
GB2464300A (en) * 2008-10-10 2010-04-14 Univ Dublin City Microfluidic multiplexed cellular and molecular analysis device and method
JP2012522518A (ja) * 2009-04-03 2012-09-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 細胞および生体粒子を選別するための方法および装置
US20100273681A1 (en) 2009-04-27 2010-10-28 Wisconsin Alumni Research Foundation Combinatorial chemistry reaction cell with optical tweezers
JP2011000079A (ja) 2009-06-19 2011-01-06 Univ Of Tokyo 粒子を操作する方法及びマイクロ流体装置
US20130118905A1 (en) * 2010-05-26 2013-05-16 Tosoh Corporation Biological sample immobilizing apparatus
CN101947124B (zh) 2010-06-25 2012-07-04 博奥生物有限公司 一种集成式微流控芯片装置及其使用方法
CA2809877C (en) * 2010-09-14 2021-11-23 The Regents Of The University Of California Method and device for isolating cells from heterogeneous solution using microfluidic trapping vortices
SG189160A1 (en) * 2010-09-29 2013-05-31 Massachusetts Inst Technology Device for high throughput investigations of cellular interactions
US20140178854A1 (en) 2010-10-31 2014-06-26 Tocagen Inc. Antisera assays for mlv related viruses in humans and other mammals
WO2012072823A1 (en) 2010-12-03 2012-06-07 Mindseeds Laboratories Srl Rapid screening of monoclonal antibodies
CN103392124B (zh) * 2010-12-03 2016-04-20 塞普莱有限公司 细胞功能的微分析
US8765455B2 (en) * 2011-01-27 2014-07-01 Lawrence Livermore National Security, Llc Chip-based droplet sorting
US9227200B2 (en) 2011-06-03 2016-01-05 The Regents Of The University Of California Microfluidic devices with flexible optically transparent electrodes
CA2842359A1 (en) 2011-08-01 2013-02-07 Denovo Sciences Cell capture system and method of use
US9050593B2 (en) 2011-11-23 2015-06-09 Wisconsin Alumni Research Foundation Self-loading microfluidic device and methods of use
US9770721B2 (en) * 2012-03-27 2017-09-26 The Regents Of The University Of California Continuous whole-chip 3-dimensional DEP cell sorter and related fabrication method
US9857333B2 (en) * 2012-10-31 2018-01-02 Berkeley Lights, Inc. Pens for biological micro-objects
US9403172B2 (en) 2012-11-08 2016-08-02 Berkeley Lights, Inc. Circuit based optoelectronic tweezers
KR102668221B1 (ko) 2013-03-28 2024-05-23 더 유니버시티 오브 브리티쉬 콜롬비아 미세유동 장치 및 분비물의 다세포 검정법에서의 그의 사용 방법

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