JP2017501990A - 肺炎連鎖球菌（Ｓ．ｐｎｅｕｍｏｎｉａｅ）に対して防御的なプロリンリッチペプチド - Google Patents

肺炎連鎖球菌（Ｓ．ｐｎｅｕｍｏｎｉａｅ）に対して防御的なプロリンリッチペプチド Download PDF

Info

Publication number
JP2017501990A
JP2017501990A JP2016536146A JP2016536146A JP2017501990A JP 2017501990 A JP2017501990 A JP 2017501990A JP 2016536146 A JP2016536146 A JP 2016536146A JP 2016536146 A JP2016536146 A JP 2016536146A JP 2017501990 A JP2017501990 A JP 2017501990A
Authority
JP
Japan
Prior art keywords
peptide
proline
chain
amino acids
lipopeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016536146A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017501990A5 (cg-RX-API-DMAC7.html
Inventor
アリン ガスパリアン，
アリン ガスパリアン，
アルマンド スニガ，
アルマンド スニガ，
ニーナ ゲイブ，
ニーナ ゲイブ，
マルコ タンボリーニ，
マルコ タンボリーニ，
マーヤ ユート，
マーヤ ユート，
ゲルト プルシュケ，
ゲルト プルシュケ，
ノダース， アニエブリーズ マルレロ
ノダース， アニエブリーズ マルレロ
ジョン アンソニー ロビンソン，
ジョン アンソニー ロビンソン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schweizerisches Tropen und Public Health Institut
Original Assignee
Schweizerisches Tropen und Public Health Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schweizerisches Tropen und Public Health Institut filed Critical Schweizerisches Tropen und Public Health Institut
Publication of JP2017501990A publication Critical patent/JP2017501990A/ja
Publication of JP2017501990A5 publication Critical patent/JP2017501990A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16023—Virus like particles [VLP]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2016536146A 2013-12-03 2014-12-02 肺炎連鎖球菌（Ｓ．ｐｎｅｕｍｏｎｉａｅ）に対して防御的なプロリンリッチペプチド Pending JP2017501990A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13195402.6 2013-12-03
EP13195402 2013-12-03
PCT/EP2014/076313 WO2015082501A1 (en) 2013-12-03 2014-12-02 Proline-rich peptides protective against s. pneumoniae

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019217485A Division JP2020073487A (ja) 2013-12-03 2019-11-29 肺炎連鎖球菌（Ｓ．ｐｎｅｕｍｏｎｉａｅ）に対して防御的なプロリンリッチペプチド

Publications (2)

Publication Number Publication Date
JP2017501990A true JP2017501990A (ja) 2017-01-19
JP2017501990A5 JP2017501990A5 (cg-RX-API-DMAC7.html) 2019-03-28

Family

ID=49765797

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016536146A Pending JP2017501990A (ja) 2013-12-03 2014-12-02 肺炎連鎖球菌（Ｓ．ｐｎｅｕｍｏｎｉａｅ）に対して防御的なプロリンリッチペプチド
JP2019217485A Pending JP2020073487A (ja) 2013-12-03 2019-11-29 肺炎連鎖球菌（Ｓ．ｐｎｅｕｍｏｎｉａｅ）に対して防御的なプロリンリッチペプチド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019217485A Pending JP2020073487A (ja) 2013-12-03 2019-11-29 肺炎連鎖球菌（Ｓ．ｐｎｅｕｍｏｎｉａｅ）に対して防御的なプロリンリッチペプチド

Country Status (12)

Country Link
US (2) US9943583B2 (cg-RX-API-DMAC7.html)
EP (1) EP3077410B1 (cg-RX-API-DMAC7.html)
JP (2) JP2017501990A (cg-RX-API-DMAC7.html)
KR (1) KR20160088323A (cg-RX-API-DMAC7.html)
CN (1) CN105793276A (cg-RX-API-DMAC7.html)
AU (1) AU2014359292B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016012306A2 (cg-RX-API-DMAC7.html)
CA (1) CA2931570A1 (cg-RX-API-DMAC7.html)
HK (1) HK1225739A1 (cg-RX-API-DMAC7.html)
RU (1) RU2737638C2 (cg-RX-API-DMAC7.html)
WO (1) WO2015082501A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201603962B (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024023357A (ja) * 2019-03-25 2024-02-21 イミュンワーク インク． 金属結合モチーフを有する複合ポリペプチド及びそれを備える分子構築物

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3016815A1 (en) * 2016-03-08 2017-09-14 KeMyth Biotech Co., Ltd. Use of pneumolysin peptides as antagonists against toll-like receptor 4 and methods of treating toll-like receptor 4 related diseases
US11806392B2 (en) * 2016-12-03 2023-11-07 The Uab Research Foundation Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A
RU2019142012A (ru) 2017-06-14 2021-07-14 Вирометикс Аг Циклические пептиды для защиты от респираторно-синцитиального вируса
CN108559784B (zh) * 2018-07-06 2021-08-20 陕西省动物研究所 一种同时检测三种病原菌的三重pcr检测用引物、探针、试剂盒及检测方法
CN113260377B (zh) * 2018-12-20 2025-08-22 维罗米蒂克斯股份公司 脂肽构建块和合成病毒样颗粒
WO2021260176A1 (en) 2020-06-25 2021-12-30 Virometix Ag Synthetic epitopes of betacoronaviruses
US20230355737A1 (en) 2020-09-28 2023-11-09 Dbv Technologies Particle comprising an rsv-f protein for use in rsv vaccination
WO2025012364A1 (en) 2023-07-12 2025-01-16 Virometix Ag Compositions of pneumococcal antigens
WO2025242657A1 (en) 2024-05-21 2025-11-27 Shape Biopharmaceuticals Ag Lipopeptide building blocks and aggregates

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663160A (en) * 1983-03-14 1987-05-05 Miles Laboratories, Inc. Vaccines for gram-negative bacteria
GB8704647D0 (en) 1987-02-27 1987-04-01 Guy S & St Thomas S Hospitals Vaccine
US6592876B1 (en) * 1993-04-20 2003-07-15 Uab Research Foundation Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products
US5391712A (en) 1991-08-30 1995-02-21 Beckman Instruments, Inc. Non-hemolytic streptolysin O variants
GB9202219D0 (en) * 1992-02-03 1992-03-18 Connaught Lab A synthetic heamophilus influenzae conjugate vaccine
US6251405B1 (en) * 1995-06-07 2001-06-26 Connaught Laboratories, Inc. Immunological combination compositions and methods
WO1997037026A1 (en) 1996-04-02 1997-10-09 Smithkline Beecham Corporation Novel compounds
EP0914330A4 (en) 1996-05-14 2002-01-09 Smithkline Beecham Corp NEW TYPE COMPOUNDS
US6096863A (en) 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
DE69739981D1 (de) 1996-10-31 2010-10-14 Human Genome Sciences Inc Streptococcus pneumoniae-Antigene und Impfstoffe
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US6800744B1 (en) 1997-07-02 2004-10-05 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
CA2312900A1 (en) 1997-12-02 1999-06-10 Powderject Vaccines, Inc. Transdermal delivery of particulate vaccine compositions
IT1320157B1 (it) 2000-01-27 2003-11-18 Combistone Italia S P A Piano e/o rivestimento per arredamento e procedimento per la suaproduzione.
EP1328543B1 (en) 2000-10-27 2009-08-12 Novartis Vaccines and Diagnostics S.r.l. Nucleic acids and proteins from streptococcus groups a & b
GB0107658D0 (en) 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
EP1421098A4 (en) 2001-04-13 2006-03-15 Wyeth Corp SURFACE PROTEINS OF STREPTOCOCCUS PYOGENES
GB0210128D0 (en) 2002-05-02 2002-06-12 Chiron Spa Nucleic acids and proteins from streptococcus groups A & B
ES2504166T3 (es) 2002-09-13 2014-10-08 Novartis Vaccines And Diagnostics, Inc. Vacuna de estreptococo del grupo B
RU2352356C2 (ru) 2003-06-26 2009-04-20 Новартис Вэксинес Энд Дайэгностикс, Инк. ИММУНОГЕННАЯ КОМПОЗИЦИЯ НА ОСНОВЕ АНТИГЕНА Chlamydia trachomatis (ВАРИАНТЫ) И ЕЕ ИСПОЛЬЗОВАНИЕ
CA2641220A1 (en) 2006-02-02 2007-08-09 Susan K. Hollingshead Non-coiled protective regions of pneumococcal surface proteins pspa and pspc
SI2121732T1 (sl) * 2006-12-09 2012-12-31 Universitat Zurich Prorektorat Forschung Vijačni svežnji lipopeptidov z ovito vijačnico in sintetični virusu podobni delci
MY163871A (en) * 2011-01-20 2017-10-31 Genocea Biosciences Inc Vaccines and compositions against streptococcus pneumoniae

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARIN GHASPARIAN; TINA RIEDEL; JIMY KOOMULLIL ET AL: "ENGINEERED SYNTHETIC VIRUS-LIKE PARTICLES AND THEIR USE IN VACCINE DELIVERY", CHEMBIOCHEM, vol. VOL:12 NR:1, JPN5016012074, 3 January 2011 (2011-01-03), pages 100 - 109, ISSN: 0004084962 *
BOATO FRANCESCA ET AL: "SYNTHETIC VIRUS-LIKE PARTICLES FROM SELF-ASSEMBLING COILED-COIL LIPOPEPTIDES 以下備考", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. VOL:46 NR:47, JPN5016012073, 12 October 2007 (2007-10-12), DE, pages 9015 - 9018, ISSN: 0003914652 *
INFECTION AND IMMUNITY, vol. 78, no. 5, JPN6018043496, 2010, pages 2163 - 2172, ISSN: 0004084964 *
VACCINE, vol. 30, JPN6018043498, 2012, pages 7157 - 7160, ISSN: 0004084963 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024023357A (ja) * 2019-03-25 2024-02-21 イミュンワーク インク． 金属結合モチーフを有する複合ポリペプチド及びそれを備える分子構築物

Also Published As

Publication number Publication date
KR20160088323A (ko) 2016-07-25
WO2015082501A1 (en) 2015-06-11
EP3077410A1 (en) 2016-10-12
US20160324947A1 (en) 2016-11-10
US9943583B2 (en) 2018-04-17
CA2931570A1 (en) 2015-06-11
US20180256698A1 (en) 2018-09-13
AU2014359292B2 (en) 2019-02-28
RU2737638C2 (ru) 2020-12-01
HK1225739A1 (zh) 2017-09-15
ZA201603962B (en) 2020-02-26
EP3077410B1 (en) 2021-02-03
CN105793276A (zh) 2016-07-20
JP2020073487A (ja) 2020-05-14
AU2014359292A1 (en) 2016-06-23
BR112016012306A2 (pt) 2017-09-26

Similar Documents

Publication Publication Date Title
JP2020073487A (ja) 肺炎連鎖球菌（Ｓ．ｐｎｅｕｍｏｎｉａｅ）に対して防御的なプロリンリッチペプチド
CN110891592B (zh) 用于保护免受呼吸道合胞病毒的环状肽
PT1743027E (pt) Proteínas pneumolisina mutantes
JP7550762B2 (ja) リポペプチドビルディングブロックおよび合成ウイルス様粒子
CA3231684A1 (en) Multivalent pneumococcal vaccines
JP2017160238A (ja) ストレプトコッカス・ニューモニエ（Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｐｎｅｕｍｏｎｉａｅ）に対する融合抗原ワクチンおよび組成物
EP3833387A1 (en) Compositions and methods for preventing and treating virus infection
CA3163999A1 (en) Self-assembling, self-adjuvanting system for delivery of vaccines
CN118891059A (zh) 嵌合多肽
JP5594691B2 (ja) 改変タンパク質
US12048743B2 (en) Glyconjugate vaccines
US20230203103A1 (en) Diagnosis, prevention and treatment of coronavirus infection
WO2009143483A2 (en) PsrP IS A PROTECTIVE ANTIGEN AGAINST PNEUMOCOCCAL INFECTION

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160803

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20171113

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20181113

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20190212

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20190730