JP2017205537A - 透析液中の物質を検出するための感知システム - Google Patents
透析液中の物質を検出するための感知システム Download PDFInfo
- Publication number
- JP2017205537A JP2017205537A JP2017130353A JP2017130353A JP2017205537A JP 2017205537 A JP2017205537 A JP 2017205537A JP 2017130353 A JP2017130353 A JP 2017130353A JP 2017130353 A JP2017130353 A JP 2017130353A JP 2017205537 A JP2017205537 A JP 2017205537A
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- JP
- Japan
- Prior art keywords
- gas
- dialysate
- ammonia
- sensing system
- detector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Landscapes
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Abstract
【解決手段】透析液中の物質を検出するための感知システムであって、透析液中の物質がガスに対して平衡を保つことを可能にすることができる疎水性バリア150と、ガスを検出することができる検出器141と、疎水性バリアと検出器の間に配置され、ガスの流体連通を可能にするように構成されたインタフェース40a、40bと、ガスを疎水性バリアから検出器まで運搬することができる1又は2以上の送達機構とを含む感知システムを提供する。
【選択図】図1A
Description
に使用されている透析の形態は血液透析である。血液透析は、大量の血液を濾過ユニットすなわち透析器に通すことによって患者の血液から毒素を直接に除去する体外システムの使用を含む。血液透析治療は一般に数時間続き、医療専門家の監視の下で週に3回ないし4回実施しなければならず、このことは患者の移動性及び生活の質を大幅に低下させる。さらに、血液透析は連続的にではなく周期的に実行されるため、汚染物質を除去する「治療サイクル」が完了した瞬間から患者の健康は悪化し始める。
wearable, peritoneal-based artificial kidney)は、腎不全の患者を助け、代謝老廃
物を除去する方法の一部である。こうした方法のいくつか、例えば「24/7」稼働の腹膜ベースの着用可能な人工腎臓(WAK)は、吸着剤カートリッジ技術を使用して透析液を連続的に再生することによって、尿毒症性の毒素を最適に取り除くことができる。
アンモニアを感知する材料/部分が、使い捨て/単回使用である;
使用するには、患者がカートリッジを組み立てる必要がある;
きわめて近い/若しくは直接接触するセンサが、透析液の浸出を引き起こし、生体適合性の問題をまねく可能性がある;
誤って組み立てられる可能性があり、そのために不正確になることがある。
本明細書で使用される以下の語及び用語は以下に示す意味を有する。
本発明の一態様は、透析液中の物質を検出するための感知システムを提供する。感知システムは、透析液中の物質がガスに対して平衡を保つことを可能にすることができる疎水性バリアと、ガスを検出することができる検出器と、疎水性バリアと検出器の間に配置され、ガスの流体連通を可能にするように構成されたインタフェースと、ガスを疎水性バリアから検出器まで輸送することができる1又は2以上の送達機構とを含むことができる。
性有機化合物である。
する、及び/又はその測定値が所定の閾値を超えているときに警報を発するように構成される。
て、強化溶液が強化溶液リザーバ(121)内へ逆流しないことを保証する。強化モジュール(120)は次いで、電解質、浸透圧剤、栄養素、薬物などの所望の物質を含む予め選択された量の強化溶液を、逆止め弁(102)及び導管(130)を通して透析液導管(20)内へ分配する。
(51)を介して移動させる。透析液は、逆止め弁(100)を通って、剛性区画(180)内に位置する蓄積室(70)へ流れる。圧力室(80)内において予め選択された負圧を確立するため、及び腹膜腔(60)から抜き取っている透析液の圧力が安全限界内にあるかどうかを判定するために、ポンプ(90)と動作可能に連通した圧力センサ(170)が配置されている。
れた透析液は、逆止め弁(409)及び出口(415)を通って使い捨てのハウジングを出る。
蓄積室(70)から前記吸着剤ゾーン(110)へ流れることを可能にし、さらに、前記汚染物質を実質的に含まない透析液が腹膜腔(60)へ再び戻ることを可能にするように構成されている。
プ(670)に流体結合する。
。強化モジュール(620)上のコネクタ(622)は、使い捨てのハウジング(601)上に位置するコネクタ(623)によって穴をあけることができる栓(800)を備える。図8bでは、栓(800)に穴をあけるために、強化モジュール上のコネクタ(622)が、使い捨てのハウジング(601)上のコネクタ(623)と対合している。
圧力の緩和なしでポンプのオンとオフを切り換えて、圧力を400mmHg(流入)又は−100mmHg(流出)に維持する通常の流れ制御に対する代表的な動作シナリオを仮定した。その結果によれば、容量が2250mA時の電池は、ファームウェアによって10.5Vで運転が停止されるまでに、上記の動作を18時間維持することができた。図13は、この実験における電池の電圧降下を動作時間に対して示したグラフを示す。
第2の試験では、流入サイクルと流出サイクルの全動作の間、ポンプが常にオンであるワーストケースシナリオを仮定した。その結果によれば、この電池は、ファームウェアによって10.5Vで運転が停止されるまでに、14.5時間機能し続けることができる。この実験における電池の電圧降下を動作時間に対して示したグラフを以下に示す。
互いに結合させると、溝(1704)の中にピン(1705)が受け取られ、コントローラ(1702)によってフレームが変形し、破壊される(1708)(図17B)。
の特定の利用条件を必要とすることを認識している。
compound)、又はCO2 O2、SO2、HCN、NOxなど、医学的状態の検出に使
用される他のバイオマーカを検出するように構成することができる。
する。
、polyvinyl chloride)、アクリロニトリルブタジエンスチレン(ABS、acrylonitrile butadiene styrene)、ポリエチレン(PE、polyethylene)及びポリプロピレン(P
P、polypropylene)が含まれる。
含む。透析液の流路2008が、アンモニアガス発生器2002によってガス流路2006から分離される。アンモニア検出器2014及びポンプ2050は、ガス流路2006に動作可能に接続される。ポンプ2050は、ガスをガス流路2006の中で前後に移動させる二方向ポンプとすることができる。この実施形態において、ガスの前後の動きによって提供される循環型ポンプにまさる利点は、ガスが疎水性バリア上で押されると、ガスが、生じる可能性のあるバリアを妨げる微小な液滴を改善するのを助けることである。この構成により、試験用の構成では、循環の構成に比べて凝縮が低減される。この実施形態では、ガスの前後の動きは、循環型ポンプにまさる1つの利点を有する。ガスが、疎水性バリア上で押されると、ガスが、生じる可能性のあるバリアを妨げる微小な液滴を改善するのを助ける。この構成により、試験用の構成では、循環の構成に比べて凝縮が低減する。
、主要なポンプ2150を経て主要なシステムの排気装置(図25 2158)へ流れる。
2506/2508/2510、ポンプ2512、圧力センサ2514、安全スクリーン2516及び排出手段2518を備える。一実施形態では、安全スクリーン2516は、限定的ではないが例として、5μmの金属スクリーンとすることができる。
いが、アセトンを含む揮発性有機化合物(VOC)、CO2 O2、SO2、HCN、NOxなどを検出するように構成することができる。
Claims (19)
- 透析液中の物質を検出するための感知システムであって、
前記透析液中の前記物質がガスに対して平衡を保つことを可能にすることができる疎水性バリアと、
前記ガスを検出することができる検出器と、
前記疎水性バリアと前記検出器の間に配置され、前記ガスの前記疎水性バリアと前記検出器の間の流体連通を可能にするように構成されたインタフェースと、
前記ガスを前記疎水性バリアから前記インタフェースを通って前記検出器まで輸送することができる1又は2以上の送達機構と
を含み、
前記物質がアンモニウムを含み、前記ガスがアンモニアガスであり、前記ガスが前記透析液中で前記物質とpH依存の平衡状態にある、
前記感知システム。 - 1又は2以上の送達機構が、ガスを疎水性バリアから検出器まで輸送することができる駆動力を提供する、請求項1に記載の感知システム。
- 駆動力がガスをインタフェース内で循環させる、請求項2に記載の感知システム。
- 駆動力がガスをインタフェース内で前後に移動させる、請求項2に記載の感知システム。
- 駆動力を制御するように構成された電子制御手段をさらに含む、請求項2〜4のいずれかに記載の感知システム。
- 1又は2以上の送達機構がキャリアガスを含む、請求項1〜5のいずれかに記載の感知システム。
- インタフェースが約1cm〜50cmの長さである、請求項1〜6のいずれかに記載の感知システム。
- 疎水性バリアが、透析液中のアンモニウムをインタフェース内のアンモニアガスから分離することができる、請求項1〜7のいずれかに記載の感知システム。
- 疎水性バリアが脱ガスバリアを含む、請求項1〜8のいずれかに記載の感知システム。
- 疎水性バリアが細菌フィルターを含む、請求項1〜9のいずれかに記載の感知システム。
- インタフェースが、1又は2以上のアンモニアガスに適合する材料を含む、請求項1〜10のいずれかに記載の感知システム。
- インタフェースが非多孔性材料を含む、請求項1〜11のいずれかに記載の感知システム。
- インタフェースが、インタフェース内に凝縮低減手段を含む、請求項1〜12のいずれかに記載の感知システム。
- 検出器に電気的に接続された電子プロセッサをさらに含み、前記電子プロセッサが、前記検出器から測定値を得て、前記測定値を処理する、及び/又は前記測定値が所定の閾値を超えているときに警報を発するように構成される、請求項1〜13のいずれかに記載の感知システム。
- アンモニアの勾配を使用して消耗を検出するように構成される、請求項1〜14のいずれかに記載の感知システム。
- 請求項1〜15のいずれかに記載の感知システムを含む透析装置。
- 腹膜透析装置を含む、請求項16に記載の透析装置。
- 血液透析装置を含む、請求項16に記載の透析装置。
- 以下のステップを含む、透析液中のアンモニウムを検出する方法であって、
前記透析液中のアンモニウムがアンモニアガスに対して平衡を保つことを可能にすることができる疎水性バリアを提供するステップ;
アンモニアガスを検出することができる検出器を提供するステップ;
前記疎水性バリアと前記検出器の間にインタフェースを配置し、前記インタフェースを前記アンモニアガスの前記疎水性バリアと前記検出器の間の流体連通を可能にするように構成するステップ;及び
前記アンモニアガスを前記疎水性バリアから前記インタフェースを通って前記検出器まで輸送することができる1又は2以上の送達機構を提供するステップ;
前記アンモニアガスが前記アンモニウムとpH依存の平衡状態にある、
前記方法。
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DE102018125988A1 (de) | 2017-10-24 | 2019-04-25 | Shimano, Inc. | Controller, von menschen angetriebenes fahrzeugsystem und steuerverfahren |
DE102018125987A1 (de) | 2017-10-24 | 2019-04-25 | Shimano Inc. | Bremssystem |
DE102018125989A1 (de) | 2017-10-24 | 2019-04-25 | Shimano Inc. | Bremssystem |
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AU2011329576A1 (en) | 2013-05-09 |
BR112014010992A2 (pt) | 2017-05-02 |
SG188635A1 (en) | 2013-04-30 |
WO2012067585A1 (en) | 2012-05-24 |
ES2874232T3 (es) | 2021-11-04 |
JP2014500067A (ja) | 2014-01-09 |
US20210205522A1 (en) | 2021-07-08 |
GB201019228D0 (en) | 2010-12-29 |
US11135347B2 (en) | 2021-10-05 |
JP6486416B2 (ja) | 2019-03-20 |
EP2640438A1 (en) | 2013-09-25 |
EP2640438B1 (en) | 2021-05-12 |
RU2013125315A (ru) | 2014-12-27 |
CN103209721B (zh) | 2016-11-16 |
BR112013012075A2 (pt) | 2019-09-24 |
JP5681294B2 (ja) | 2015-03-04 |
TR201909087T4 (tr) | 2019-07-22 |
US20140309584A1 (en) | 2014-10-16 |
TW201225996A (en) | 2012-07-01 |
RU2651130C2 (ru) | 2018-04-18 |
AU2011329576B2 (en) | 2015-09-10 |
CN103209721A (zh) | 2013-07-17 |
US20180147338A1 (en) | 2018-05-31 |
TWI577397B (zh) | 2017-04-11 |
EP2640438A4 (en) | 2018-03-28 |
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