JP2017186337A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017186337A5 JP2017186337A5 JP2017073900A JP2017073900A JP2017186337A5 JP 2017186337 A5 JP2017186337 A5 JP 2017186337A5 JP 2017073900 A JP2017073900 A JP 2017073900A JP 2017073900 A JP2017073900 A JP 2017073900A JP 2017186337 A5 JP2017186337 A5 JP 2017186337A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- chain variable
- variable region
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000611 antibody drug conjugate Substances 0.000 claims 29
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 29
- 125000003275 alpha amino acid group Chemical group 0.000 claims 27
- 239000000427 antigen Substances 0.000 claims 21
- 102000036639 antigens Human genes 0.000 claims 21
- 108091007433 antigens Proteins 0.000 claims 21
- 239000012634 fragment Substances 0.000 claims 21
- 102000001760 Notch3 Receptor Human genes 0.000 claims 13
- 108010029756 Notch3 Receptor Proteins 0.000 claims 13
- 206010028980 Neoplasm Diseases 0.000 claims 12
- 201000011510 cancer Diseases 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 238000005734 heterodimerization reaction Methods 0.000 claims 2
- 230000036210 malignancy Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 101100074828 Caenorhabditis elegans lin-12 gene Proteins 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 102000005650 Notch Receptors Human genes 0.000 claims 1
- 108010070047 Notch Receptors Proteins 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000000389 T-cell leukemia Diseases 0.000 claims 1
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 230000001908 autoinhibitory effect Effects 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000004477 skin sarcoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261723772P | 2012-11-07 | 2012-11-07 | |
US61/723,772 | 2012-11-07 | ||
US201361889744P | 2013-10-11 | 2013-10-11 | |
US61/889,744 | 2013-10-11 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015540262A Division JP2016505513A (ja) | 2012-11-07 | 2013-11-04 | 抗notch3抗体および抗体−薬物コンジュゲート |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017186337A JP2017186337A (ja) | 2017-10-12 |
JP2017186337A5 true JP2017186337A5 (US07714131-20100511-C00001.png) | 2017-11-24 |
Family
ID=49585464
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015540262A Pending JP2016505513A (ja) | 2012-11-07 | 2013-11-04 | 抗notch3抗体および抗体−薬物コンジュゲート |
JP2017073900A Withdrawn JP2017186337A (ja) | 2012-11-07 | 2017-04-03 | 抗notch3抗体および抗体−薬物コンジュゲート |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015540262A Pending JP2016505513A (ja) | 2012-11-07 | 2013-11-04 | 抗notch3抗体および抗体−薬物コンジュゲート |
Country Status (19)
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8591516B2 (en) | 2006-02-27 | 2013-11-26 | Biomet Manufacturing, Llc | Patient-specific orthopedic instruments |
US9907659B2 (en) | 2007-04-17 | 2018-03-06 | Biomet Manufacturing, Llc | Method and apparatus for manufacturing an implant |
US7967868B2 (en) | 2007-04-17 | 2011-06-28 | Biomet Manufacturing Corp. | Patient-modified implant and associated method |
US8407067B2 (en) | 2007-04-17 | 2013-03-26 | Biomet Manufacturing Corp. | Method and apparatus for manufacturing an implant |
US10278711B2 (en) | 2006-02-27 | 2019-05-07 | Biomet Manufacturing, Llc | Patient-specific femoral guide |
US20150335438A1 (en) | 2006-02-27 | 2015-11-26 | Biomet Manufacturing, Llc. | Patient-specific augments |
US9289253B2 (en) | 2006-02-27 | 2016-03-22 | Biomet Manufacturing, Llc | Patient-specific shoulder guide |
US9339278B2 (en) | 2006-02-27 | 2016-05-17 | Biomet Manufacturing, Llc | Patient-specific acetabular guides and associated instruments |
US9173661B2 (en) | 2006-02-27 | 2015-11-03 | Biomet Manufacturing, Llc | Patient specific alignment guide with cutting surface and laser indicator |
US8377066B2 (en) | 2006-02-27 | 2013-02-19 | Biomet Manufacturing Corp. | Patient-specific elbow guides and associated methods |
US8603180B2 (en) | 2006-02-27 | 2013-12-10 | Biomet Manufacturing, Llc | Patient-specific acetabular alignment guides |
US8568487B2 (en) | 2006-02-27 | 2013-10-29 | Biomet Manufacturing, Llc | Patient-specific hip joint devices |
US9345548B2 (en) | 2006-02-27 | 2016-05-24 | Biomet Manufacturing, Llc | Patient-specific pre-operative planning |
US8092465B2 (en) | 2006-06-09 | 2012-01-10 | Biomet Manufacturing Corp. | Patient specific knee alignment guide and associated method |
US8608748B2 (en) | 2006-02-27 | 2013-12-17 | Biomet Manufacturing, Llc | Patient specific guides |
US9113971B2 (en) | 2006-02-27 | 2015-08-25 | Biomet Manufacturing, Llc | Femoral acetabular impingement guide |
US8535387B2 (en) | 2006-02-27 | 2013-09-17 | Biomet Manufacturing, Llc | Patient-specific tools and implants |
US8608749B2 (en) | 2006-02-27 | 2013-12-17 | Biomet Manufacturing, Llc | Patient-specific acetabular guides and associated instruments |
US9918740B2 (en) | 2006-02-27 | 2018-03-20 | Biomet Manufacturing, Llc | Backup surgical instrument system and method |
US9795399B2 (en) | 2006-06-09 | 2017-10-24 | Biomet Manufacturing, Llc | Patient-specific knee alignment guide and associated method |
WO2007145840A2 (en) * | 2006-06-13 | 2007-12-21 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
WO2008054561A2 (en) * | 2006-07-11 | 2008-05-08 | University Of Medicine And Dentistry Of New Jersey | Proteins, nucleic acids encoding the same and associated methods of use |
GB2442441B (en) * | 2006-10-03 | 2011-11-09 | Biomet Uk Ltd | Surgical instrument |
CA2676008A1 (en) | 2007-01-24 | 2008-07-31 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
KR101413005B1 (ko) | 2007-12-04 | 2014-07-02 | 유니버시티 오브 메디신 앤드 덴티스트리 오브 뉴 저지 | 세포막 재봉합을 조절하기 위한 조성물 및 방법 |
MX2011000233A (es) | 2008-07-08 | 2011-05-19 | Oncomed Pharm Inc | Agentes de union del receptor notch1 y metodos para su uso. |
DE102009028503B4 (de) | 2009-08-13 | 2013-11-14 | Biomet Manufacturing Corp. | Resektionsschablone zur Resektion von Knochen, Verfahren zur Herstellung einer solchen Resektionsschablone und Operationsset zur Durchführung von Kniegelenk-Operationen |
US8632547B2 (en) | 2010-02-26 | 2014-01-21 | Biomet Sports Medicine, Llc | Patient-specific osteotomy devices and methods |
US9271744B2 (en) | 2010-09-29 | 2016-03-01 | Biomet Manufacturing, Llc | Patient-specific guide for partial acetabular socket replacement |
WO2012061793A1 (en) | 2010-11-05 | 2012-05-10 | Trimedicine, Inc. | Serum mg53 as a diagnostic marker for tissue injury |
US9968376B2 (en) | 2010-11-29 | 2018-05-15 | Biomet Manufacturing, Llc | Patient-specific orthopedic instruments |
US9241745B2 (en) | 2011-03-07 | 2016-01-26 | Biomet Manufacturing, Llc | Patient-specific femoral version guide |
US8715289B2 (en) | 2011-04-15 | 2014-05-06 | Biomet Manufacturing, Llc | Patient-specific numerically controlled instrument |
US8668700B2 (en) | 2011-04-29 | 2014-03-11 | Biomet Manufacturing, Llc | Patient-specific convertible guides |
US8956364B2 (en) | 2011-04-29 | 2015-02-17 | Biomet Manufacturing, Llc | Patient-specific partial knee guides and other instruments |
US20140286977A1 (en) * | 2011-05-11 | 2014-09-25 | Riesbeck Healthcare Sweden Ab | Protein F - A Novel Haemophilus Influenzae Adhesin with Laminin and Vitronectin binding Properties |
US8532807B2 (en) | 2011-06-06 | 2013-09-10 | Biomet Manufacturing, Llc | Pre-operative planning and manufacturing method for orthopedic procedure |
US9084618B2 (en) | 2011-06-13 | 2015-07-21 | Biomet Manufacturing, Llc | Drill guides for confirming alignment of patient-specific alignment guides |
US8764760B2 (en) | 2011-07-01 | 2014-07-01 | Biomet Manufacturing, Llc | Patient-specific bone-cutting guidance instruments and methods |
US8597365B2 (en) | 2011-08-04 | 2013-12-03 | Biomet Manufacturing, Llc | Patient-specific pelvic implants for acetabular reconstruction |
US9066734B2 (en) | 2011-08-31 | 2015-06-30 | Biomet Manufacturing, Llc | Patient-specific sacroiliac guides and associated methods |
US9295497B2 (en) | 2011-08-31 | 2016-03-29 | Biomet Manufacturing, Llc | Patient-specific sacroiliac and pedicle guides |
US9386993B2 (en) | 2011-09-29 | 2016-07-12 | Biomet Manufacturing, Llc | Patient-specific femoroacetabular impingement instruments and methods |
EP2770918B1 (en) | 2011-10-27 | 2017-07-19 | Biomet Manufacturing, LLC | Patient-specific glenoid guides |
KR20130046337A (ko) | 2011-10-27 | 2013-05-07 | 삼성전자주식회사 | 멀티뷰 디바이스 및 그 제어방법과, 디스플레이장치 및 그 제어방법과, 디스플레이 시스템 |
US9451973B2 (en) | 2011-10-27 | 2016-09-27 | Biomet Manufacturing, Llc | Patient specific glenoid guide |
US9301812B2 (en) | 2011-10-27 | 2016-04-05 | Biomet Manufacturing, Llc | Methods for patient-specific shoulder arthroplasty |
US9554910B2 (en) | 2011-10-27 | 2017-01-31 | Biomet Manufacturing, Llc | Patient-specific glenoid guide and implants |
US9204977B2 (en) | 2012-12-11 | 2015-12-08 | Biomet Manufacturing, Llc | Patient-specific acetabular guide for anterior approach |
US9060788B2 (en) | 2012-12-11 | 2015-06-23 | Biomet Manufacturing, Llc | Patient-specific acetabular guide for anterior approach |
EP2935330B1 (en) | 2012-12-19 | 2019-04-24 | Aveo Pharmaceuticals, Inc. | Anti-notch3 antibodies |
US9839438B2 (en) | 2013-03-11 | 2017-12-12 | Biomet Manufacturing, Llc | Patient-specific glenoid guide with a reusable guide holder |
US9579107B2 (en) | 2013-03-12 | 2017-02-28 | Biomet Manufacturing, Llc | Multi-point fit for patient specific guide |
US9826981B2 (en) | 2013-03-13 | 2017-11-28 | Biomet Manufacturing, Llc | Tangential fit of patient-specific guides |
US9498233B2 (en) | 2013-03-13 | 2016-11-22 | Biomet Manufacturing, Llc. | Universal acetabular guide and associated hardware |
JP2016514130A (ja) | 2013-03-14 | 2016-05-19 | ノバルティス アーゲー | Notch3に対する抗体 |
US9683039B2 (en) * | 2013-03-14 | 2017-06-20 | New York University | Notch agonists for the treatment of cancer |
US9517145B2 (en) | 2013-03-15 | 2016-12-13 | Biomet Manufacturing, Llc | Guide alignment system and method |
US20150112349A1 (en) | 2013-10-21 | 2015-04-23 | Biomet Manufacturing, Llc | Ligament Guide Registration |
US10282488B2 (en) | 2014-04-25 | 2019-05-07 | Biomet Manufacturing, Llc | HTO guide with optional guided ACL/PCL tunnels |
US9408616B2 (en) | 2014-05-12 | 2016-08-09 | Biomet Manufacturing, Llc | Humeral cut guide |
CN107041139A (zh) * | 2014-05-28 | 2017-08-11 | 艾更斯司股份有限公司 | 海兔脯氨酸‑海兔异亮氨酸肽的衍生物 |
US9839436B2 (en) | 2014-06-03 | 2017-12-12 | Biomet Manufacturing, Llc | Patient-specific glenoid depth control |
US9561040B2 (en) | 2014-06-03 | 2017-02-07 | Biomet Manufacturing, Llc | Patient-specific glenoid depth control |
AU2015319809B2 (en) | 2014-09-28 | 2020-02-06 | The Regents Of The University Of California | Modulation of stimulatory and non-stimulatory myeloid cells |
US9826994B2 (en) | 2014-09-29 | 2017-11-28 | Biomet Manufacturing, Llc | Adjustable glenoid pin insertion guide |
US9833245B2 (en) | 2014-09-29 | 2017-12-05 | Biomet Sports Medicine, Llc | Tibial tubercule osteotomy |
US9820868B2 (en) | 2015-03-30 | 2017-11-21 | Biomet Manufacturing, Llc | Method and apparatus for a pin apparatus |
US10226262B2 (en) | 2015-06-25 | 2019-03-12 | Biomet Manufacturing, Llc | Patient-specific humeral guide designs |
US10568647B2 (en) | 2015-06-25 | 2020-02-25 | Biomet Manufacturing, Llc | Patient-specific humeral guide designs |
EP3448420B1 (en) * | 2016-04-29 | 2022-09-14 | Aveo Pharmaceuticals, Inc. | Anti-notch3 antibody |
CN105968038A (zh) * | 2016-05-09 | 2016-09-28 | 湖北华世通生物医药科技有限公司 | 二肽类化合物的盐酸盐及其制备方法 |
US10722310B2 (en) | 2017-03-13 | 2020-07-28 | Zimmer Biomet CMF and Thoracic, LLC | Virtual surgery planning system and method |
US10858443B2 (en) * | 2017-05-31 | 2020-12-08 | Trustees Of Boston University | Synthetic notch protein for modulating gene expression |
MX2020006213A (es) | 2017-12-12 | 2020-09-14 | Pionyr Immunotherapeutics Inc | Anticuerpos anti-trem2 y metodos relacionados. |
CN108753833B (zh) * | 2018-05-28 | 2021-12-03 | 上海海洋大学 | 斑马鱼notch3基因突变体的制备方法 |
US11912763B2 (en) | 2018-06-17 | 2024-02-27 | L & L Biopharma Co., Ltd. | Antibody targeting CLDN18.2, bispecific antibody, ADC, and CAR, and applications thereof |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
EP0247091B1 (en) | 1985-11-01 | 1993-09-29 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US20040049014A1 (en) | 1988-12-28 | 2004-03-11 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
KR100272077B1 (ko) | 1990-08-29 | 2000-11-15 | 젠팜인터내셔날,인코포레이티드 | 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물 |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
DK1136556T3 (da) | 1991-11-25 | 2005-10-03 | Enzon Inc | Fremgangsmåde til fremstilling af multivalente antigen-bindende proteiner |
US5786158A (en) | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
EP0731106B1 (en) | 1993-10-01 | 2004-11-17 | Teikoku Hormone Mfg. Co., Ltd. | Dolastatin derivatives |
CA2116628A1 (en) | 1994-02-28 | 1995-08-29 | Anne Marie Gisele Joutel | Method for the diagnosis of cadasil |
US5521284A (en) | 1994-08-01 | 1996-05-28 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide amides and esters |
ES2150664T3 (es) | 1995-04-21 | 2000-12-01 | Teikoku Hormone Mfg Co Ltd | Nuevos derivados peptidos. |
EP0780478A1 (en) | 1995-12-21 | 1997-06-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for the indirect genotypic diagnosis of cadasil |
CA2249195A1 (en) | 1996-03-18 | 1997-09-25 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
FR2751986B1 (fr) | 1996-08-01 | 1998-12-31 | Inst Nat Sante Rech Med | Gene implique dans le cadasil, methode de diagnostic et application therapeutique |
US5985837A (en) | 1998-07-08 | 1999-11-16 | Basf Aktiengesellschaft | Dolastatin 15 derivatives |
WO2000020576A2 (en) | 1998-10-02 | 2000-04-13 | The Government Of The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services, The National Institutes Of Health | Methods and compositions for inducing differentiation and apotosis in cells that overexpess the notch protein |
US6323315B1 (en) | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
WO2003020934A1 (en) | 2001-08-31 | 2003-03-13 | Diadexus, Inc. | Compositions and methods relating to colon specific genes and proteins |
US20050137130A1 (en) | 2001-11-14 | 2005-06-23 | Bodmer Mark W. | Medical treatment |
AU2002339157A1 (en) | 2001-11-14 | 2003-05-26 | Lorantis Limited | Inhibitors of the notch signalling pathway for use in the treatment of cancer |
CA2465304A1 (en) | 2001-11-14 | 2003-05-22 | Lorantis Limited | Composition comprising inhibitors of the notch signalling pathway for the modulation of the immune system |
EP2365004B1 (en) | 2002-06-21 | 2016-01-06 | Johns Hopkins University School of Medicine | Membrane associated tumor endothelium markers |
JP2006516089A (ja) | 2002-10-02 | 2006-06-22 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
AU2003284357A1 (en) | 2002-11-01 | 2004-06-07 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
SI1725249T1 (sl) | 2003-11-06 | 2014-04-30 | Seattle Genetics, Inc. | Spojine monometilvalina, sposobne konjugacije na ligande |
JP2007512348A (ja) | 2003-11-26 | 2007-05-17 | ヘルス リサーチ インコーポレイテッド | 形質細胞の治療のためのノッチ経路干渉剤の使用 |
US20070077245A1 (en) | 2004-08-04 | 2007-04-05 | The Brigham And Women's Hospital, Inc. | NOTCH mutations leading to increased receptor signaling |
WO2006053063A2 (en) | 2004-11-05 | 2006-05-18 | The Regents Of The University Of California | Notch-1 assay to detect neurodegenerative diseases |
US20080152660A1 (en) | 2005-03-03 | 2008-06-26 | Bradshaw Curt W | Anti-Angiogenic Compounds |
WO2007008848A2 (en) | 2005-07-07 | 2007-01-18 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus |
WO2007061988A2 (en) | 2005-11-22 | 2007-05-31 | University Of Vermont And State Agricultural College | Methods for determining notch signaling and uses thereof |
US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
US8133857B2 (en) | 2006-03-07 | 2012-03-13 | The Brigham and Women's FHospital, Inc. | NOTCH inhibition in the treatment of atherosclerosis |
WO2008057144A2 (en) * | 2006-05-15 | 2008-05-15 | The Brigham And Women's Hospital, Inc. | Functional negative regulatory domain sequences from human notch1 and 2 and isolated lnr domains from human notch1 |
CN101563366B (zh) | 2006-10-19 | 2012-10-03 | 健泰科生物技术公司 | 抗notch3激动性抗体及其在制备治疗notch3相关疾病的药物中的用途 |
TW200824707A (en) * | 2006-10-19 | 2008-06-16 | Genentech Inc | Anti-Notch3 agonist antibodies and their use in the treatment of Notch3-related diseases |
EP2061814B1 (en) | 2006-10-27 | 2012-06-06 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
AR064388A1 (es) * | 2006-12-18 | 2009-04-01 | Genentech Inc | Anticuerpos antagonistas anti- notch3 y su uso en la prevencion y el tratamiento de enfermedades relacionadas con el receptor notch3 |
WO2009036167A1 (en) | 2007-09-14 | 2009-03-19 | Vanderbilt University | Targeting of notch3 receptor function for cancer therapy |
JP5485897B2 (ja) | 2007-10-12 | 2014-05-07 | シアトル ジェネティクス,インコーポレーテッド | 抗体−薬物複合体の併用療法 |
US8609105B2 (en) | 2008-03-18 | 2013-12-17 | Seattle Genetics, Inc. | Auristatin drug linker conjugates |
EP2947097A1 (en) | 2008-04-07 | 2015-11-25 | Ablynx N.V. | Amino acid sequences directed against the Notch pathways and uses thereof |
MX2011000233A (es) | 2008-07-08 | 2011-05-19 | Oncomed Pharm Inc | Agentes de union del receptor notch1 y metodos para su uso. |
CN102459346B (zh) | 2009-04-27 | 2016-10-26 | 昂考梅德药品有限公司 | 制造异源多聚体分子的方法 |
WO2010141249A2 (en) * | 2009-06-02 | 2010-12-09 | Merck Sharp & Dohme Corp. | Generation, characterization and uses thereof of anti-notch3 antibodies |
PE20121494A1 (es) | 2009-06-18 | 2012-11-01 | Pfizer | Anticuerpos anti notch-1 |
RU2012117619A (ru) * | 2009-09-30 | 2013-11-10 | Дженентек, Инк. | ЛЕЧЕНИЕ ЗЛОКАЧЕСТВЕННЫХ ОПУХОЛЕЙ, УСТОЙЧИВЫХ К ДЕЙСТВИЮ АНТАГОНИСТА Notch1, С ПОМОЩЬЮ АНТАГОНИСТА Notch3 |
WO2011140295A2 (en) | 2010-05-06 | 2011-11-10 | President And Fellows Of Harvard College | Modulators of notch receptor signaling and methods of use thereof |
KR20130050966A (ko) | 2010-07-12 | 2013-05-16 | 씨오브이엑스 테크놀로지스 아일랜드 리미티드 | 다기능적 항체 접합체 |
US20140121123A1 (en) | 2010-10-29 | 2014-05-01 | Kevin Caili Wang | Methods for diversifying antibodies, antibodies derived therefrom and uses thereof |
US9676871B2 (en) | 2010-11-05 | 2017-06-13 | Pfizer Inc. | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
US9603894B2 (en) | 2010-11-08 | 2017-03-28 | President And Fellows Of Harvard College | Materials presenting notch signaling molecules to control cell behavior |
WO2012080891A1 (en) | 2010-12-15 | 2012-06-21 | Rinat Neuroscience Corp. | Anti-notch-1 antibodies |
KR101580726B1 (ko) | 2010-12-15 | 2015-12-29 | 와이어쓰 엘엘씨 | 항-노치1 항체 |
US9358272B2 (en) | 2011-02-17 | 2016-06-07 | The Administrators Of The Tulane Educational Fund | Multicomponent compositions and their uses |
PT2694111T (pt) * | 2011-04-01 | 2016-10-20 | Wyeth Llc | Conjugados de fármaco - anticorpo |
BR112014012609A2 (pt) * | 2011-11-17 | 2020-10-20 | Pfizer Inc | peptídeos citotóxicos e conjungados de droga de anticorpo dos mesmos |
CA2859755C (en) | 2011-12-23 | 2021-04-20 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
-
2013
- 2013-11-04 EP EP13792099.7A patent/EP2917240A1/en not_active Ceased
- 2013-11-04 MX MX2015005810A patent/MX2015005810A/es unknown
- 2013-11-04 BR BR112015010436A patent/BR112015010436A2/pt not_active IP Right Cessation
- 2013-11-04 AU AU2013343045A patent/AU2013343045A1/en not_active Abandoned
- 2013-11-04 TW TW106112626A patent/TW201726746A/zh unknown
- 2013-11-04 TW TW102139960A patent/TW201431880A/zh unknown
- 2013-11-04 JP JP2015540262A patent/JP2016505513A/ja active Pending
- 2013-11-04 WO PCT/IB2013/059893 patent/WO2014072897A1/en active Application Filing
- 2013-11-04 CN CN201380069303.2A patent/CN104903351A/zh active Pending
- 2013-11-04 KR KR1020157015019A patent/KR20150082548A/ko active IP Right Grant
- 2013-11-04 PE PE2015000604A patent/PE20150892A1/es not_active Application Discontinuation
- 2013-11-04 CA CA2890571A patent/CA2890571A1/en active Pending
- 2013-11-04 SG SG11201503469WA patent/SG11201503469WA/en unknown
- 2013-11-04 RU RU2015116480A patent/RU2015116480A/ru not_active Application Discontinuation
- 2013-11-04 TW TW104121691A patent/TWI589590B/zh not_active IP Right Cessation
- 2013-11-06 AR ARP130104060A patent/AR093377A1/es unknown
- 2013-11-06 US US14/073,273 patent/US9433687B2/en active Active
-
2015
- 2015-04-30 IL IL238567A patent/IL238567A0/en unknown
- 2015-05-05 PH PH12015501000A patent/PH12015501000A1/en unknown
- 2015-05-06 SA SA515360395A patent/SA515360395B1/ar unknown
-
2016
- 2016-02-26 HK HK16102254.9A patent/HK1214282A1/zh unknown
- 2016-07-27 US US15/221,049 patent/US20170014526A1/en not_active Abandoned
-
2017
- 2017-04-03 JP JP2017073900A patent/JP2017186337A/ja not_active Withdrawn