JP2017185218A - Blood purification device and sterilization method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To realize a blood purification device comprising a compact ultraviolet irradiation device capable of changing an ultraviolet irradiation amount and a control device for controlling the ultraviolet irradiation device.SOLUTION: A blood purification device 1 comprises: a blood purifier 10; a blood circuit 11 for supplying blood from a patient to the blood purifier 10 and returning the blood from the blood purifier 10 to the patient; a dialysate solution circuit 12 for generating a dialysate solution by mixing a stock solution with water, and supplying the dialysate solution to the blood purifier 10; an ultraviolet irradiation device 13 for irradiating at least one of water before mixing and the dialysate solution in the dialysate solution circuit 12 with an ultraviolet ray by an ultraviolet LED; and a control device 14 for controlling an irradiation output of the ultraviolet irradiation device 13.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a blood purification apparatus and a sterilization method.

  The so-called dialysis treatment is generally performed using a blood purification device, which supplies a patient's blood to a blood purification device including a hollow fiber membrane module and returns the blood to the patient, and a blood purification device. A dialysate circuit is provided for supplying the dialysate to the patient and taking in and removing waste from the patient's blood through the hollow fiber membrane. In order to increase the treatment efficiency, the dialysate (replacement fluid) of the dialysate circuit is also supplied to the blood circuit side.

  By the way, in the above-mentioned dialysis treatment, treatment fluids such as dialysis fluid and replacement fluid are used. However, it is preferable that these treatment fluids can be continuously and automatically replenished to the blood purification apparatus in order to reduce the burden on medical personnel. (See Patent Document 1).

Japanese Patent No. 4458346 Japanese Utility Model Publication No. 4-61542

  Therefore, for example, in hospital facilities, a RO (Reverse Osmosis) system that purifies tap water and well water and a dialysate preparation system that generates a dialysate by adding a stock solution to the purified water are generally introduced. It is.

  However, since the dialysate may come into contact with the blood of the patient, even if the water is supplied from the above-mentioned RO system, it is necessary to take measures inside the device to create a highly clean dialysate. It is. For example, it is generally performed to mount an ETRF (endotoxin supplement filter) for removing endotoxin or to carry out chemical cleaning at the end of treatment.

  However, there are limits to the sterilization performance of the RO system and the sterilization and sterilization capabilities of the equipment, and there are cases in which bacteria (biofilm) are generated in dead spaces in the RO piping and piping inside the equipment. This is a well-known fact. In addition, there is a concern that bacteria may be mixed from a stock bottle for supplying a stock solution of dialysate, and means for preventing the contamination and growth of bacteria inside the apparatus are very important. In addition, before the start of dialysis treatment of the day, between dialysis treatment and after dialysis treatment, etc., after the dialysis treatment is completed, a washing process is performed in which a washing solution such as a chemical solution is supplied to the dialysate circuit of the apparatus for washing. The cleaning solution must also be thoroughly sterilized.

  In view of this, the inventor is considering sterilizing a treatment liquid and a cleaning liquid in a liquid circuit such as a dialysate circuit using ultraviolet rays. However, the ultraviolet irradiation apparatus used in the conventional dialysis apparatus is of a lamp type (see Patent Document 2) and is a large apparatus. For this reason, it is necessary to install separately from the blood purification apparatus. As a result, it is necessary to set, operate and control the ultraviolet irradiation device separately from the blood purification device, which increases the burden on the medical staff. In addition, a large lamp-type ultraviolet irradiation device is limited in the place where it can be attached, and cannot be installed in a free place according to the needs of the facility.

  In addition, the lamp-type UV irradiation device cannot change the UV output (it can only be turned ON / OFF), so even if the sterilization ability decreases due to the deterioration of the lamp or the dialysate flow rate changes depending on the treatment conditions, constant energy is maintained. Irradiation takes place. For this reason, there is a fear that a sufficient sterilizing ability cannot be obtained due to a shortage of ultraviolet irradiation. Moreover, there was a possibility that the life of the ultraviolet irradiation device may be shortened by irradiating the ultraviolet ray in excess of the necessary ultraviolet irradiation amount and the dialysate component may be denatured.

  The present application has been made in view of such a point, and one of the objects is to realize a blood purification apparatus including a small-sized ultraviolet irradiation device that can change the ultraviolet irradiation amount and a control device that controls the ultraviolet irradiation device. To do.

As a result of intensive studies by the inventors to achieve the above object, it has been found that the above problems can be solved by using an ultraviolet irradiation device that irradiates ultraviolet rays with an ultraviolet LED and a control device that controls the irradiation output of the ultraviolet irradiation device. The present invention has been reached. That is, the present invention includes the following aspects.
(1) A blood purifier, a blood circuit that supplies blood to the blood purifier from a patient and returns the blood to the patient, and a liquid circuit that supplies liquid to at least one of the blood purifier and the blood circuit And an ultraviolet irradiation device that irradiates the liquid in the liquid circuit with ultraviolet rays using an ultraviolet LED, and a control device that controls the irradiation output of the ultraviolet irradiation device.
(2) The liquid circuit has a function of generating a treatment liquid by mixing an undiluted solution with water, and the ultraviolet irradiation device irradiates at least one of water and the treatment liquid before mixing in the liquid circuit with ultraviolet rays. The blood purification apparatus according to (1).
(3) The liquid circuit includes a liquid feed pump that feeds liquid in the liquid circuit, and the control device changes an irradiation output of the ultraviolet irradiation device according to a liquid feed flow rate in the liquid feed pump. The blood purification apparatus according to (1) or (2).
(4) The control device according to (1) or (2), wherein the control unit changes an irradiation output of the ultraviolet irradiation device according to a liquid flow rate of a liquid circuit portion irradiated with ultraviolet rays by the ultraviolet irradiation device. Blood purification device.
(5) The blood purification device according to any one of (1) to (4), wherein the control device changes an irradiation output of the ultraviolet irradiation device according to a decrease in output of the ultraviolet irradiation device.
(6) The blood purification apparatus according to (5), further comprising a sensor that detects an irradiation output of the ultraviolet irradiation apparatus.
(7) The blood purification device according to any one of (1) to (6), wherein the control device changes an irradiation output of the ultraviolet irradiation device according to a quality of the liquid.
(8) The blood purification apparatus according to (7), further including a water quality sensor that detects a quality of the liquid.
(9) Any one of (1) to (8), further including a device housing portion including at least a part of the liquid circuit, wherein the ultraviolet irradiation device is built in the device housing portion. The blood purification apparatus according to 1.
(10) The liquid circuit of the device housing unit has a mixing unit that mixes an undiluted solution with water in order to generate a treatment solution, and the ultraviolet irradiation device is provided in a liquid circuit upstream of the mixing unit. The blood purification apparatus according to (9).
(11) The liquid circuit of the device casing includes a mixing unit that mixes a stock solution with water for generation of a treatment solution, and the ultraviolet irradiation device is provided in a liquid circuit downstream of the mixing unit. The blood purification apparatus according to (9).
(12) The apparatus case further includes at least a part of the liquid circuit, and the ultraviolet irradiation device is provided in a liquid circuit outside the apparatus case. The blood purification apparatus according to any one of 8).
(13) The liquid circuit has a plurality of installable positions of the ultraviolet irradiation device, and the control device changes an irradiation output based on an installation position of the ultraviolet irradiation device. ).
(14) An installation position detection sensor for detecting an installation position of the ultraviolet irradiation device is provided, and the control device changes an irradiation output based on the installation position detected by the installation position detection sensor. The blood purification apparatus as described.
(15) The control device includes an installation position input unit that inputs an installation position of the ultraviolet irradiation device, and changes the irradiation output based on the installation position input to the installation position input unit. The blood purification apparatus as described.
(16) The control device includes a storage unit that stores an irradiation output condition in the device status for each installation position of the ultraviolet irradiation device, and changes the irradiation output based on the irradiation output condition of the device status in the storage unit. The blood purification apparatus according to any one of (13) to (15).
(17) The control device includes a storage unit that stores an irradiation output condition in the device status, and changes the irradiation output based on the irradiation output condition of the device status in the storage unit. (1) to (12) The blood purification apparatus according to any one of the above.
(18) The blood purification apparatus according to (16) or (17), further including an irradiation condition setting unit that sets an irradiation output condition of the apparatus status.
(19) A blood purifier, a blood circuit that supplies blood from the patient to the blood purifier and returns the blood to the patient, and a liquid that supplies therapeutic liquid to at least one of the blood purifier or the blood circuit A circuit, a cleaning liquid supply device that supplies a cleaning liquid to the liquid circuit, an ultraviolet irradiation device that irradiates the cleaning liquid in the liquid circuit with ultraviolet light by an ultraviolet LED, and a control device that controls an irradiation output of the ultraviolet irradiation device. , Blood purification device.
(20) The blood purification apparatus according to (19), wherein the control device changes an irradiation output of the ultraviolet irradiation device according to a flow rate of a cleaning liquid in a portion of the liquid circuit irradiated with ultraviolet rays by the ultraviolet irradiation device. .
(21) The blood purification device according to (19) or (20), wherein the control device changes an irradiation output of the ultraviolet irradiation device according to a decrease in output of the ultraviolet irradiation device.
(22) The blood purification apparatus according to (21), further comprising a sensor that detects an irradiation output of the ultraviolet irradiation apparatus.
(23) The control device includes a storage unit that stores an irradiation output condition in the device status, and changes the irradiation output based on the irradiation output condition of the device status in the storage unit. (19) to (22) The blood purification apparatus according to any one of the above.
(24) A sterilization method in which the liquid is sterilized by irradiating the liquid with ultraviolet rays by an ultraviolet LED in a liquid circuit of a blood purification apparatus that supplies the liquid to at least one of a blood purifier and a blood circuit.
(25) The sterilization according to (24), wherein in the liquid circuit, a treatment solution is produced by mixing a stock solution with water, and at least one of water and the treatment solution before mixing in the liquid circuit is irradiated with an ultraviolet LED. Method.
(26) A sterilization method in which in a liquid circuit of a blood purification apparatus for supplying a treatment liquid to at least one of a blood purifier and a blood circuit, the cleaning liquid supplied to the liquid circuit is sterilized by irradiating with ultraviolet light with an ultraviolet LED.

  According to the present invention, it is possible to realize a blood purification device that includes a small-sized ultraviolet irradiation device that can change the ultraviolet irradiation amount and a control device that controls the ultraviolet irradiation device. Therefore, it is not necessary to perform operation and control, and the burden on medical staff can be reduced. Moreover, since a small ultraviolet irradiation device is used, the ultraviolet irradiation device can be installed in an appropriate place including the inside of the device housing according to the needs of the facility. Furthermore, since the irradiation amount of ultraviolet rays can be changed, an appropriate amount of ultraviolet rays can be irradiated so that sufficient sterilization can be performed.

It is a schematic diagram which shows the outline of a structure of the blood purification apparatus. It is a schematic diagram of the blood purification apparatus provided with the ultraviolet irradiation device in the upstream circuit inside the apparatus housing. It is a schematic diagram of the blood purification apparatus provided with the ultraviolet irradiation device in the downstream circuit inside the apparatus casing. It is a schematic diagram of the blood purification apparatus provided with the sensor which detects an ultraviolet-ray output. It is a schematic diagram of the blood purification apparatus provided with the water quality sensor. It is a schematic diagram of the blood purification apparatus provided with the replacement fluid circuit. It is a schematic diagram of the blood purification apparatus provided with the installation position sensor. It is a block diagram of a control apparatus. It is explanatory drawing which shows an example of a display screen. It is explanatory drawing which shows another example of a display screen. It is a block diagram of the other aspect of a control apparatus. It is explanatory drawing which shows an example of the display screen with an installation position input part. It is a schematic diagram which shows the other structural example of the blood purification apparatus. It is explanatory drawing which shows the process of a washing | cleaning, and the output of an ultraviolet-ray.

  Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings. In addition, the following embodiment is an illustration for demonstrating this invention, and this invention is not limited only to the embodiment. The same reference numerals are assigned to the same elements, and duplicate descriptions are omitted. In the drawings, positional relationships such as up, down, left, and right are based on the positional relationships shown in the drawings unless otherwise specified. Furthermore, the dimensional ratios in the drawings are not limited to the illustrated ratios.

  FIG. 1 is a schematic diagram showing an outline of the configuration of blood purification apparatus 1 according to the present embodiment. In the present embodiment, for example, blood purification device 1 that performs dialysis treatment in a treatment room in a hospital will be described as an example.

  The blood purification apparatus 1 includes, for example, a blood purification device 10, a blood circuit 11 that supplies blood to the blood purification device 10 from the patient and returns the blood from the blood purification device 10 to the patient, and a raw solution of dialysate mixed with water as a therapeutic solution. The dialysate circuit 12 as a liquid circuit that supplies the dialysate to the blood purifier 10, and at least one of the water before mixing or the dialysate after mixing in the dialysate circuit 12 is an ultraviolet LED. The ultraviolet irradiation device 13 that irradiates ultraviolet rays by the above and the control device 14 are provided. In the present specification, “liquid” includes at least water, treatment liquid, stock solution, and washing liquid, and “treatment liquid” includes at least dialysate and replacement fluid.

  The blood purifier 10 is, for example, a hollow fiber membrane module containing a hollow fiber membrane bundle. The blood circuit 11 is connected to the inlet / outlet of the primary side 10a of the hollow fiber membrane of the blood purifier 10, and the dialysate circuit 12 is connected to the inlet / outlet of the secondary side 10b of the hollow fiber membrane. The blood purifier 10 uses, for example, the osmotic pressure of the primary side 10a and the secondary side 10b of the hollow fiber membrane to remove waste in the blood on the primary side 10a of the hollow fiber membrane and the secondary side 10b of the hollow fiber membrane. The blood can be purified by taking it into the dialysate. For example, a soft tube is used for the flow path portion of the “circuit” in the present embodiment.

  The blood circuit 11 is provided with, for example, a blood pump 30 and a drip chamber 31 for feeding blood.

  The dialysate circuit 12 mixes the A stock solution and the B stock solution with RO water (reverse osmosis water) supplied from the piping in the wall 40 of the treatment room of the hospital facility to generate a dialysate, and purifies the dialysate into blood. A dialysate supply circuit 50 that supplies the secondary side 10b of the blood vessel 10 and a dialysate discharge circuit 51 that discharges the dialysate drainage that has passed through the secondary side 10b of the blood purifier 10 to a pipe in the wall 40 of the treatment room. Have. In addition, for example, tap water is taken into a hospital facility, bacteria are removed from the tap water using a filter using a RO membrane (reverse osmosis membrane), and RO water is generated. The RO water is used for each treatment in the facility. A facility for feeding liquid to the chamber wall 40 is provided.

  The dialysate supply circuit 50 has, for example, an upstream end connected to a pipe in the treatment room wall 40 and a downstream end connected to the secondary side 10 b of the hollow fiber membrane of the blood purifier 10. . The dialysate supply circuit 50 includes, for example, a first liquid feed pump 60 and a second liquid feed pump 61. A first circuit 63 that introduces the A stock solution of the first supply source 62 into the dialysate supply circuit 50 between the first solution pump 60 and the second solution pump 61 in the dialysate supply circuit 50; A second circuit 65 for introducing the B stock solution of the second supply source 64 into the dialysate supply circuit 50 is connected. In the present embodiment, for example, in the dialysate supply circuit 50, the part where the A stock solution and the B stock solution are mixed with the RO water is the mixing unit 66.

  In the dialysate supply circuit 50, for example, the downstream side of the second liquid feeding pump 61 is connected to the first chamber 71 of the metering chamber 70, and the downstream side of the first chamber 71 is the hollow fiber membrane of the blood purifier 10. Is connected to the secondary side 10b.

  The fixed-quantity chamber 70 has a partition wall 73 such as a diaphragm that can be displaced within a main body having a constant volume. The inside of the fixed amount chamber 70 is divided into a first chamber 71 and a second chamber 72 by a partition wall 73.

  In the dialysate discharge circuit 51, for example, the upstream end is connected to the secondary side 10b of the hollow fiber membrane of the blood purifier 10, and the downstream end is connected to a pipe in the wall 40 of the treatment room. . That is, the downstream side of the secondary side 10b of the hollow fiber membrane of the blood purifier 10 in the dialysate discharge circuit 51 is connected to the second chamber 72 of the metering chamber 70, and the downstream side of the second chamber 72 is the facility It is connected to the piping in the wall 40. A circulation pump 80 is provided between the secondary side 10 b of the blood purifier 10 and the second chamber 72 of the metering chamber 70. The dialysate discharge circuit 51 has a water removal circuit 90 that bypasses the metering chamber 70 from the downstream side of the circulation pump 80 and communicates with the downstream side (facility wall 40) side of the metering chamber 70. The water removal circuit 90 has a water removal pump 91.

  The blood purification apparatus 1 includes, for example, an apparatus housing unit 100 in which various devices and apparatuses are built. In the device housing 100, for example, a first liquid feed pump 60, a second liquid feed pump 61, a metering chamber 70, a circulation pump 80, a water removal pump 91, a blood pump 30, a control device 14 and the like are incorporated. Yes. In the present specification, “built-in” refers to a state of being built in as a component of the apparatus housing unit 100.

  The apparatus housing 100 also includes a part of the dialysate circuit 12 that passes through the pump. That is, the first internal flow path 110 from the upstream side of the first liquid feed pump 60 in the dialysate supply circuit 50 to the downstream side of the metering chamber 70 and the metering from the upstream side of the circulation pump 80 in the dialysate discharge circuit 51. The second internal flow path 111 extending to the downstream side of the chamber 70 is built in, and ports 112 and 113 connected to the external flow paths are respectively provided at both ends of the first internal flow path 110 and the second internal flow path 111. Is provided.

  The upstream section from the facility wall 40 to the port 112 of the apparatus housing unit 100 in the dialysate supply circuit 50 is formed by the first external connection channel 120, and the blood purifier 10 is connected to the port 112 of the apparatus housing unit 100. The downstream section to the secondary side 10b is formed by the second external connection channel 121. That is, the dialysate supply circuit 50 is formed by the first external connection flow path 120, the first internal flow path 110, and the second external connection flow path 121. The upstream section from the secondary side 10b of the blood purifier 10 in the dialysate discharge circuit 51 to the port 113 of the device casing 100 is formed by the third external connection flow path 122, and The downstream section from the port 113 to the facility wall 40 is formed by a fourth external connection flow path 123. That is, the dialysate discharge circuit 51 is formed by the third external connection flow path 122, the second internal flow path 111, and the fourth external connection flow path 123.

  For example, the blood purifier 10, the blood circuit 11, and the drip chamber 31 are not built in the device casing 100 and are configured to be removable from the device casing 100. Blood purifier 10, blood circuit 11, and drip chamber 31 are replaced for each treatment.

  The ultraviolet irradiation device 13 is provided, for example, in the first external connection flow channel 120 outside the device housing unit 100. The ultraviolet irradiation device 13 includes an ultraviolet LED as a light source, and can sterilize the RO water flowing through the first external connection flow channel 120 by irradiating the RO water with ultraviolet rays. The ultraviolet LED preferably has an irradiation angle of 120 degrees or more, a wavelength region of 250 to 280 nm, and an output of 5 mW or more (when using a plurality of ultraviolet LEDs, the total output is 5 mW or more). The flow rate of the liquid irradiated by the ultraviolet irradiation device 13 is preferably 300 mL / min or more and 1200 mL / min or less. The ultraviolet irradiation device 13 may be detachably attached to the surface of the device housing unit 100.

  The control device 14 is, for example, a computer that controls the overall operation of the blood purification device 1. For example, the first liquid feed pump 60, the second liquid feed pump 61, the metering chamber 70, the circulation pump 80, and the water removal pump 91 are used. The blood purification apparatus 1 can be operated so as to execute the blood purification process by controlling the operations of the blood pump 30, the ultraviolet irradiation device 13, and a valve (not shown).

  For example, the control device 14 executes a program stored in the storage unit, and varies the irradiation output of the ultraviolet irradiation device 13 according to, for example, the liquid feeding flow rate in the first liquid feeding pump 60. For example, when the liquid flow rate is large, the ultraviolet irradiation output is increased, and when the liquid flow rate is small, the ultraviolet irradiation output is decreased. In addition, the value of the liquid feeding flow rate in the first liquid feeding pump 60 may be grasped by the control device 14 from the set flow rate of the first liquid feeding pump 60, or a flow rate sensor is provided in the flow path to detect the value. The control device 14 may grasp from the above.

  Further, the control device 14 can control ON / OFF of the irradiation of the ultraviolet rays of the ultraviolet irradiation device 13 according to the device status (operation process) of the blood purification device 1 and the output intensity of the LED. For example, the control device 14 is configured to perform a circuit cleaning before the blood purification process is started (for example, a process in which washing water (RO water) is passed through the dialysate circuit 12 for washing), during the blood purification process, and after the completion of the blood purification process. UV light depending on the device status during washing (for example, washing by flowing a washing solution (RO water, chemical solution, etc.) through the dialysate circuit 12), waiting (when blood purification treatment or circuit washing is not performed), etc. It is possible to switch ON / OFF of irradiation and change the output intensity of the LED.

  In the blood purification apparatus 1 configured as described above, for example, the following blood purification processing is performed. For example, after a puncture needle (not shown) of the blood circuit 11 is punctured by the patient, the blood pump 30 is activated, and blood is circulated through the blood circuit 11 and the primary side 10 a of the hollow fiber membrane of the blood purifier 10. On the other hand, in the dialysate circuit 12, the first liquid feed pump 60 and the second liquid feed pump 61 are operated, and the dialysate is stored in the first chamber 71 of the metering chamber 70. At this time, in the dialysate supply circuit 50, the RO water flows from the facility wall 40 toward the apparatus casing 100 and is irradiated with ultraviolet rays when passing through the ultraviolet irradiation device 13. The flow rate of the RO water at this time may be 300 mL / min or more and 1200 mL / min or less. Thereby, RO underwater bacteria are sterilized. Note that the irradiation of ultraviolet rays may be turned on or off in accordance with the ON / OFF of the first liquid feed pump 60, for example, as performed when the RO water is flowing. The sterilized RO water flows toward the metering chamber 70 in the device casing 100, and the mixing unit 66 mixes the A stock solution and the B stock solution from the first circuit 63 and the second circuit 65, and serves as a treatment solution. Dialysate is produced. At this time, for example, the first liquid feed pump 60 is first stopped and the second liquid feed pump 61 is operated to introduce a predetermined amount of A stock solution and B stock solution into the mixing unit 66, and then the first A dialysate having a predetermined concentration may be generated by operating the liquid feed pump 60 and introducing RO water into the mixing unit 66. The generated dialysate is stored in the first chamber 71 of the metering chamber 70.

  When the dialysate is stored in the first chamber 71 of the metering chamber 70, the circulation pump 80 is then operated, and the dialysate in the first chamber 71 passes through the dialysate supply circuit 50 and the hollow fiber membrane of the blood purifier 10. To the secondary side 10b. At this time, the dialysate takes in waste products from the blood flowing on the primary side 10a of the hollow fiber membrane of the blood purifier 10 and purifies the blood.

  The dialysate drainage that has passed through the secondary side 10 b of the hollow fiber membrane of the blood purifier 10 flows into the second chamber 72 of the metering chamber 70 through the dialysate drain circuit 51. At this time, the partition 73 of the metering chamber 70 moves, and the volume of the second chamber 72 increases as the volume of the first chamber 71 decreases. In addition, the water removal pump 91 of the water removal circuit 90 is also operated, and a part of the dialysate wastewater is discharged to the downstream side of the dialysate discharge circuit 51 through the water removal circuit 90 without passing through the metering chamber 70. The amount of dialysis drainage fluid that passes through the water removal circuit 90 corresponds to the amount of water removed from the blood of the patient in the blood purifier 10.

  Next, the dialysate is again generated from the RO water in the dialysate supply circuit 50, and the dialysate is stored in the first chamber 71 of the metering chamber 70. Dialysate drainage is drained through the dialysate drain circuit 51 toward the facility wall 40.

  The above steps are repeated, and dialysis treatment (blood purification treatment) is performed.

  According to the present embodiment, by using the ultraviolet irradiation device 13 that irradiates ultraviolet rays with an ultraviolet LED that is a light source, the ultraviolet irradiation device 13 can be reduced in size, and this ultraviolet irradiation device 13 is used as the blood purification device 1. Can be incorporated. Therefore, it is possible to control the irradiation output of the ultraviolet irradiation device 13 by the control device 14 of the blood purification device 1. As a result, it is not necessary to set, operate, and control the ultraviolet irradiation device separately from the blood purification device 1, and the medical engagement Can be reduced.

  The control device 14 changes the irradiation output of the ultraviolet irradiation device 13 according to the liquid supply flow rate in the first liquid supply pump 60. For example, when the liquid supply flow rate is high, the ultraviolet irradiation output is increased and the liquid supply flow rate is increased. When there is little, the ultraviolet irradiation output can be lowered. As a result, the sterilization of the RO water can be reliably performed, and the excessive irradiation can be reduced to reduce the cost.

  Since the ultraviolet irradiation device 13 is provided in the dialysate circuit 12 outside the device housing 100, maintenance of the ultraviolet irradiation device 13 can be easily performed. In addition, since the ultraviolet irradiation device 13 is provided in the dialysate circuit 12 (first external connection flow path 120) on the upstream side of the device housing 100, bacteria enter the device housing 100 and propagate. Can be prevented. In addition, it is possible to prevent a biofilm that is difficult to clean from being formed in the apparatus housing 100.

  In the above-described embodiment, the ultraviolet irradiation device 13 may be built in the device casing 100. In such a case, for example, as illustrated in FIG. 2, the ultraviolet irradiation device 13 may be provided in the dialysate circuit 12 upstream of the mixing unit 66. In this case, the ultraviolet irradiation device 13 may be provided in the first internal flow path 110 upstream of the first liquid feeding pump 60 immediately after the port 112 on the upstream side of the device casing 100. By doing so, since the ultraviolet irradiation device 13 is incorporated in the device casing 100, the blood purification device 1 including the ultraviolet irradiation device 13 can be slimmed. Moreover, since the ultraviolet irradiation device 13 is in the upstream portion of the device casing 100, it is possible to prevent bacteria from entering and propagating into the device casing 100, and a biofilm that is difficult to clean is formed in the device casing 100. Can be prevented. Further, since the ultraviolet irradiation device 13 is provided in the device casing 100, it does not get in the way when performing operations such as replacement of a filter in the same device or replenishment of a chemical solution. Moreover, there is no fear that ultraviolet rays are emitted to the outside. Furthermore, since it is not exposed to sunlight, deterioration of the components of the apparatus can be suppressed.

  Furthermore, as shown in FIG. 3, the ultraviolet irradiation device 13 may be provided in the dialysate circuit 12 downstream of the mixing unit 66. In such a case, it may be provided in the first internal flow path 110 immediately before the port 112 on the downstream side of the apparatus housing 100. In this case, the ultraviolet light is irradiated to the dialysate after mixing. By doing so, even if bacteria are mixed in the A stock solution or the B stock solution, the live bacteria can be prevented from entering the blood purifier 10. Furthermore, the ultraviolet irradiation device 13 may be provided downstream of the mixing unit 66 and downstream of the metering chamber 70. In this case, the ultraviolet irradiation device 13 may be provided between the metering chamber 70 and the port 112, for example. In this case, since the ultraviolet light is irradiated after the mixing of the RO water, the A stock solution, and the B stock solution and the flow rate of the mixed solution is stabilized, the dialysate can be sterilized efficiently. Furthermore, when there is a mixing unit that promotes mixing of the RO water, the A stock solution, and the B stock solution on the downstream side of the quantitative chamber 70, the ultraviolet irradiation device 13 may be provided on the downstream side of the mixing unit.

  In the above embodiment, the control device 14 may change the irradiation output of the ultraviolet irradiation device 13 in accordance with a decrease in the output of the ultraviolet irradiation device 13. In this case, as shown in FIG. 4, the ultraviolet irradiation device 13 is provided with an output sensor (photodiode) 125 for detecting the actual ultraviolet light output of the ultraviolet irradiation device 13. The output sensor 125 is mounted on a substrate of, for example, an ultraviolet LED. The detection result of the output sensor 125 is output to the control device 14. The control device 14 adjusts the applied current value (irradiation output) for the ultraviolet LED of the ultraviolet irradiation device 13 based on the detection result of the ultraviolet output of the output sensor 125. For example, when the ultraviolet LED deteriorates and the actual output of the ultraviolet ray decreases, the applied current value to the ultraviolet LED of the ultraviolet irradiation device 13 is increased to ensure the ultraviolet irradiation amount necessary for sterilization. When the actual ultraviolet light output falls below a certain threshold, an alarm is output to prompt the user to replace the ultraviolet LED. Note that the output decrease of the ultraviolet irradiation device 13 may not be detected by the output sensor 125, and may be estimated based on, for example, a preset lifetime of the ultraviolet LED. That is, when a predetermined ratio of the lifetime of the ultraviolet LED has passed, it is estimated that the irradiation output of the ultraviolet irradiation device 13 is lowered, and the irradiation output setting of the ultraviolet irradiation device 13 may be increased accordingly. .

  In the above embodiment, the control device 14 may change the irradiation output of the ultraviolet irradiation device 13 according to the quality of the liquid in the dialysate circuit 12. In such a case, as shown in FIG. 5, the dialysate circuit 12 is provided with a water quality sensor 150 for detecting the quality of the RO water. As the water quality sensor 150, for example, a water quality tester such as a TOC meter capable of detecting the number of bacteria and the degree of contamination of RO water, a bacteria number measuring device, an ET inspection device or the like is used. The water quality sensor 150 is provided upstream of the dialysate circuit 12, for example, the ultraviolet irradiation device 13. The detection result of the water quality sensor 150 is output to the control device 14. The control device 14 adjusts an applied current value (irradiation output) to the ultraviolet LED of the ultraviolet irradiation device 13 based on the detection result of the RO water quality of the water quality sensor 150. For example, when the quality of the RO water is lower than a predetermined lower threshold, the irradiation output of the ultraviolet irradiation device 13 is increased to ensure the ultraviolet irradiation amount necessary for sterilization. In addition, when the water quality of the RO water is within a predetermined appropriate range, the ultraviolet irradiation by the ultraviolet irradiation device 13 is performed with a normal irradiation output. The setting location of the water quality sensor 150 can be arbitrarily selected, and the water quality sensor 150 may detect not only the water quality of the RO water but also the water quality of the generated dialysate. The liquid water quality may be detected without using the water quality sensor 150. In this case, for example, RO water (from the RO device or RO pipe) or dialysate (from the dialysate pipe) is periodically sampled, analyzed for water quality, and the result is provided in the control device 14. The control device 14 may change the irradiation output of the ultraviolet irradiation device 13 by inputting to the operation screen (water quality input unit).

  In the above embodiment, the pre-mixing RO water supplied to the blood purifier 10 and the mixed dialysate were irradiated with ultraviolet rays. However, the pre-mixing RO water supplied to the blood circuit 11 and after mixing The dialysis solution or the replacement fluid as the treatment solution may be irradiated with ultraviolet rays. In such a case, for example, as shown in FIG. 6, the blood purification apparatus 1 has a replacement fluid circuit 130 connected from the dialysate supply circuit 50 to the drip chamber 31 of the blood circuit 11. A replacement fluid pump 131 is provided in the replacement fluid circuit 130. The RO water before mixing finally supplied to the blood circuit 11 through the replacement fluid circuit 130 or the replacement fluid generated by mixing the stock solution may be irradiated with ultraviolet rays. The replacement fluid circuit 130 may be connected to either the upstream side or the downstream side of the blood purifier 10 in the blood circuit 11.

  Although the ultraviolet irradiation device 13 is provided at one place, it may be provided at a plurality of places. For example, the dialysate supply circuit 50 upstream of the mixing unit 66 inside the apparatus casing 100 shown in FIG. 2, the apparatus casing 100 shown in FIG. 3, and the apparatus casing 100 shown in FIG. The dialysate supply circuit 50 on the downstream side of the internal mixing unit 66 may be provided in all or in any two places. Moreover, the ultraviolet irradiation device 13 may be provided in another place.

  Moreover, the blood purification apparatus 1 has a plurality of installable positions of the ultraviolet irradiation device 13 in the dialysate circuit 12, and the control device 14 changes the irradiation output based on the installation position of the ultraviolet irradiation device 13. It may be. For example, the blood purification apparatus 1 includes a dialysate supply circuit 50 upstream of the mixing section 66 inside the apparatus casing 100 shown in FIG. It has a position where it can be installed in the dialysate supply circuit 50 on the downstream side of the mixing unit 66 inside the device casing 100 shown, and the user can select the setting position of the ultraviolet irradiation device 13.

  The blood purification apparatus 1 has an installation position detection sensor 160 that detects the installation position of the ultraviolet irradiation device 13 as shown in FIG. The installation position detection sensor 160 is installed, for example, at a place where the ultraviolet irradiation device 13 is installed. When the ultraviolet irradiation device 13 is installed, the installation position detection sensor 160 reacts electrically or mechanically and can output the information to the control device 14.

  For example, as shown in FIG. 8, the control device 14 includes an irradiation condition setting unit 170 that sets an irradiation output condition of the device status for each installation position of the ultraviolet irradiation device 13 detected by the installation position detection sensor 160, and an irradiation condition setting unit. The storage unit 171 stores the irradiation output condition of the apparatus status for each installation position of the ultraviolet irradiation apparatus 13 set in 170.

  For example, the irradiation condition setting unit 170 is an input screen 180 of a touch panel on the apparatus display as shown in FIGS. 9 and 10, for example, for irradiation of a plurality of apparatus statuses, for example, priming, treatment, washing, and standby. It is possible to input output conditions, for example, irradiation output level and OFF. The input screen 180 may display the lifetime of the ultraviolet LED and the detection value of the output sensor 125.

  In such a case, the control device 14 first detects the installation position of the ultraviolet irradiation device 13 by the installation position detection sensor 160, and responds to it based on the installation position of the ultraviolet irradiation device 13 as shown in FIGS. A device status input screen 180 is displayed. When the irradiation output condition for each device status is input to the input screen 180, the control device 14 stores the irradiation output condition for the device status in the storage unit 171.

  And the control apparatus 14 changes irradiation output according to the irradiation output condition of the apparatus status for every installation position of the ultraviolet irradiation device 13 memorize | stored in the memory | storage part 171. FIG. For example, the control device 14 cleans the circuit at the time of cleaning (priming) of the circuit before the start of blood purification processing, which is the device status, at the time of blood purification processing (treatment), at the time of cleaning of the circuit after completion of the blood purification processing. Depending on the standby time during which the irradiation is not performed, the irradiation output of the LED is changed according to the ultraviolet irradiation output condition (High / Low / OFF).

  For example, when the ultraviolet irradiation device 13 is provided on the downstream side of the mixing unit 66, in order to prevent contamination of bacteria from the A stock solution and the B stock solution, as shown in FIG. Ultraviolet rays are irradiated. The level of the output of ultraviolet rays at the time of treatment may vary depending on the type of treatment. When dialysate at the time of treatment is supplied directly to the blood circuit 11, the ultraviolet light is irradiated at a high output, and the dialysate becomes a blood purifier. 10 may be irradiated with ultraviolet light at a low output. Further, for example, when the ultraviolet irradiation device 13 is provided on the upstream side of the mixing section 66, as shown in FIG. 10, ultraviolet rays are irradiated with high output during priming and washing, and ultraviolet rays are emitted with low output during treatment. Irradiated.

  According to this example, the blood purification apparatus 1 has a plurality of positions where the ultraviolet irradiation device 13 can be installed, and the control device 14 changes the irradiation output based on the installation position of the ultraviolet irradiation device 13. While improving the degree of freedom of the installation position of the irradiation device 13, it is possible to irradiate ultraviolet rays with an output suitable for the installation position.

  Since the blood purification apparatus 1 includes the installation position detection sensor 160 that detects the installation position of the ultraviolet irradiation device 13, the installation position of the ultraviolet irradiation device 13 can be automatically and accurately detected.

  The control device 14 includes a storage unit 171 that stores an irradiation output condition in the device status for each installation position of the ultraviolet irradiation device 13, and changes the irradiation output based on the irradiation output condition of the device status in the storage unit 171. . Thereby, irradiation of ultraviolet LED can be optimized and the lifetime of ultraviolet LED can be extended. In addition, when it is not desirable to irradiate ultraviolet rays, for example, in a device status where cleaning is performed using a chemical solution whose chemical attack becomes stronger by ultraviolet irradiation, chemical attack can be prevented by avoiding ultraviolet irradiation or suppressing irradiation output. .

  Since the blood purification apparatus 1 includes the irradiation condition setting unit 170 that sets the irradiation output condition of the apparatus status, the operability for the user can be improved. For example, since the cleanliness (dirty condition) of RO water and dialysate undiluted solution is different for each facility, for example, a facility where the cleanliness of RO water is not sufficiently high can always be set to High when water is passed. In facilities with high water cleanliness, it is possible to set only the device status (such as before nighttime stoppage) that tends to cause bacterial growth. Therefore, irradiation output conditions can be customized for each facility.

  In the above embodiment, the control device 14 has an installation position input unit 190 that inputs the installation position of the ultraviolet irradiation device 13 as shown in FIG. 11, and based on the installation position input to the installation position input unit 190. The irradiation output may be changed. In such a case, the installation position input unit 190 can be manually selected on an input screen 180 of a touch panel as shown in FIG. 12, for example. In such a case, user operability can be improved. Further, since the installation position sensor need not be provided, the cost of the apparatus can be reduced accordingly.

  In the above embodiment, the control device 14 changes the irradiation output based on the irradiation output condition of the device status for each installation position of the ultraviolet irradiation device 13, but the control device 14 sets the installation position of the ultraviolet irradiation device 13. Regardless, the storage unit 171 for storing the irradiation output condition in the apparatus status as shown in FIG. 8 may be provided, and the irradiation output may be changed based on the irradiation output condition of the apparatus status in the storage unit 171. . In this case, the control device 14 may include an irradiation condition setting unit 170 that sets an irradiation output condition of the apparatus status. For example, as shown in FIGS. 9 and 10, the irradiation output conditions in the apparatus status include a plurality of apparatus statuses, for example, irradiation output conditions such as irradiation output level, for example, priming, treatment, cleaning, and standby. You may make it set.

  In the above-described embodiment, the cleaning liquid is supplied to the dialysate circuit 12 before the start of the blood purification process of the day, when the blood purification process is interrupted, or after the blood purification process is completed, and the cleaning process of the dialysate circuit 12 is performed. The ultraviolet irradiation device 13 may irradiate the cleaning liquid flowing in the dialysate circuit 12 with ultraviolet light during the cleaning process. The cleaning liquid includes all liquids that flow to the dialysate circuit 12 during the cleaning process, and includes, for example, RO water, chemical solution stock, and chemical liquid.

  For example, as shown in FIG. 13, between the first liquid feeding pump 60 and the second liquid feeding pump 61 in the dialysate supply circuit 50, the chemical solution stock solution of the stock solution supply source 200 is introduced into the dialysate supply circuit 50. The undiluted solution circuit 201 is connected. The stock solution circuit 201 is provided with an open / close valve (not shown). In the present embodiment, the cleaning liquid supply device is configured by the raw liquid supply source 200, the raw liquid circuit 201, and the open / close valve.

  When the washing process is performed, sterilized RO water is supplied to the dialysate supply circuit 50 of the dialysate circuit 12, and the chemical solution stock solution of the stock solution supply source 200 passes through the stock solution circuit 201 to the dialysate supply circuit 50. The chemical solution stock solution and the RO water are mixed to produce a chemical solution. At this time, for example, the first liquid feed pump 60 is stopped first, the second liquid feed pump 61 is activated, and a predetermined amount of the chemical solution stock solution is introduced into the mixing unit 66, and then the first liquid feed pump. A chemical solution having a predetermined concentration may be generated by operating 60 and introducing RO water into the mixing unit 66. The generated chemical solution is stored in the first chamber 71 of the metering chamber 70. Thereafter, the drug solution is discharged without passing through the blood purifier 10 through the first external connection flow path 121, a bypass circuit (not shown), or the like.

  When the ultraviolet irradiation device 13 is on the upstream side of the mixing unit 66 of the dialysate circuit 12, the RO water before mixing is irradiated with ultraviolet rays and is on the downstream side of the mixing unit 66 of the dialysate circuit 12. Is irradiated with ultraviolet rays. At this time, the irradiation output of the ultraviolet irradiation device 13 is set by the control device 14 according to, for example, the type and flow rate of the cleaning liquid. According to this example, since the cleaning liquid is sufficiently sterilized, the cleaning effect by the cleaning liquid can be ensured. Further, the cleaning effect can be enhanced by irradiating the cleaning liquid with ultraviolet rays. Note that the cleaning liquid does not necessarily have to be generated in the apparatus, and is generated on the upstream side of the wall 40 or supplied from the cleaning liquid storage section on the upstream side of the wall 40. May be.

  The cleaning process may have a plurality of apparatus statuses corresponding to a plurality of cleaning processes, and change the irradiation output of the LED according to the ultraviolet irradiation output condition of each apparatus status. For example, the control device 14 includes a storage unit 171 (shown in FIGS. 8 and 11) that stores the irradiation output condition in the device status, and changes the irradiation output based on the irradiation output condition of the device status in the storage unit 171. To do. For example, as shown in FIG. 14, in the cleaning process performed after the blood purification process (the cleaning process performed at the end of the day), the dialysate circuit 12 (hereinafter also simply referred to as “circuit”) is RO water as the apparatus status. A washing step for washing with an acid, an acid washing step for washing the circuit with an acid solution (acid chemical solution) such as an acetic acid aqueous solution, a citric acid aqueous solution, a peracetic acid aqueous solution, an acid solution storage step for storing the acid solution in the dialysate circuit 12, Water washing step after acid washing for washing with RO water after washing, chemical liquid disinfecting step for disinfecting the circuit with a chemical solution such as sodium hypochlorite aqueous solution, chemical solution storing step for storing the chemical solution in the dialysate circuit 12, RO water after chemical disinfection It has a water washing process after chemical solution disinfection to wash with etc.

  For example, in the water washing process, ultraviolet rays are irradiated at an intermediate output, and in the acid cleaning process, ultraviolet rays are irradiated at a low output. In the acid solution storage step, the irradiation of ultraviolet rays is stopped, and in the water washing step after the acid cleaning, the ultraviolet rays are irradiated with an intermediate output. In the chemical liquid sterilization process, ultraviolet light is irradiated with low output, in the chemical liquid storage process, irradiation of ultraviolet light is stopped, and in the water washing process after chemical liquid sterilization, ultraviolet light is irradiated with high output.

  The reason why UV light is irradiated at low output in the acid cleaning process and chemical solution disinfection process is to prevent chemical attack on the acid liquid and chemical liquid by UV light, and UV irradiation is stopped in the acid solution storage process and chemical solution storage process. This is because there is no liquid flow and the sterilization effect is low. In addition, UV irradiation with high output in the water washing process after chemical solution disinfection occurs, for example, if there are viable bacteria in the RO water stored in the nighttime device, it will propagate at night, causing contamination of the device (generation of biofilm). Therefore, it is for actively sterilizing. The intermediate output is an output between a high output and a low output, and is set in the control device 14 as an ultraviolet irradiation output condition (High / Middle / Low / OFF).

  Also, the cleaning process is a mode in which only the water washing process is performed, a mode in which the acid washing process, the acid solution storage step and the water washing process after acid washing are performed after the water washing step, a chemical solution disinfection step, a chemical solution storage step and a chemical solution disinfection after the water washing step In this case, the irradiation output of ultraviolet rays may be changed as described above in each step of each mode. The washing may be performed by a hot water washing step and a citric acid hot water washing step.

  In the example of irradiating the washing liquid in the dialysate circuit 12 with ultraviolet rays, as described above, the control device 14 may change the irradiation output of the ultraviolet irradiation device 14 in accordance with the decrease in the output of the ultraviolet irradiation device 14. At this time, the blood purification apparatus 1 may include a sensor 125 (shown in FIG. 4) that detects the irradiation output of the ultraviolet irradiation apparatus 14.

  In the above embodiment, the control device 14 has changed the irradiation output of the ultraviolet irradiation device 13 in accordance with the flow rate of the liquid fed in the liquid feeding pump 60, but the dialysate that is irradiated with ultraviolet rays by the ultraviolet irradiation device 13. You may make it change the irradiation output of the ultraviolet irradiation device 13 according to the flow volume of the liquid of the part of the circuit 12, or the flow volume of the cleaning liquid. In this case, the liquid flow rate of the portion of the dialysate circuit 12 irradiated with ultraviolet rays by the ultraviolet irradiation device 13 may be grasped by, for example, the flow rate of the liquid feeding pump 60 or the switching timing of the metering chamber 70, or the dialysate circuit. You may grasp | ascertain with the flowmeter installed in the irradiation part of 12 ultraviolet rays. When the liquid flow rate in the portion of the dialysate circuit 12 irradiated with ultraviolet rays by the ultraviolet irradiation device 13 is large, the irradiation output of the ultraviolet irradiation device 13 is increased, and the liquid flow rate in the portion of the dialysate circuit 12 irradiated with ultraviolet rays is increased. When the amount is small, the irradiation output of the ultraviolet irradiation device 13 is lowered. In this case, the liquid flowing through the dialysate circuit 12 can be irradiated with an appropriate amount of ultraviolet rays.

  For example, the configuration of the blood purification apparatus 1 described in the above embodiment is not limited to this. For example, the dialysate supply circuit 50 may be provided with a filter for removing endotoxin and bacteria in the dialysate. Moreover, the dialysate production | generation mechanism which mixes a stock solution with RO water and produces | generates a dialysate is not restricted to this, You may produce | generate a dialysate by another mechanism and method.

  For example, the configuration of the blood purification apparatus 1 is not limited to that of the above embodiment. For example, the dialysate supply circuit 50 is a type of blood purification treatment, such as dialysis treatment, continuous gradual hemofiltration (CHF: Continuous HemoFiltractrion), continuous dialysis hemodialysis (CHD), continuous gradual hemofiltration. Depending on dialysis (CHDF: Continuous HemoDiaFiltration), it may be selected whether to connect to the blood circuit 11, connect to the blood purifier 10, or both. The present invention can also be applied to a blood purification apparatus that performs blood purification processing other than dialysis treatment.

  The preferred embodiments of the present invention have been described above with reference to the accompanying drawings, but the present invention is not limited to such examples. It is obvious for those skilled in the art that various modifications or modifications can be conceived within the scope of the idea described in the claims, and these naturally belong to the technical scope of the present invention. It is understood.

  INDUSTRIAL APPLICABILITY The present invention is useful in realizing a blood purification apparatus including a small-sized ultraviolet irradiation device that can change the ultraviolet irradiation amount and a control device that controls the ultraviolet irradiation device.

DESCRIPTION OF SYMBOLS 1 Blood purification apparatus 10 Blood purifier 11 Blood circuit 12 Dialysate circuit 13 Ultraviolet irradiation apparatus 14 Control apparatus

Claims (26)

A blood purifier,
A blood circuit for supplying blood from a patient to the blood purifier and returning the blood purifier to the patient;
A liquid circuit for supplying liquid to at least one of the blood purifier or the blood circuit;
An ultraviolet irradiation device for irradiating the liquid in the liquid circuit with ultraviolet rays by an ultraviolet LED;
A blood purification apparatus comprising: a control device that controls an irradiation output of the ultraviolet irradiation device. The liquid circuit has a function of mixing a stock solution with water to generate a treatment liquid,
The blood purification apparatus according to claim 1, wherein the ultraviolet irradiation device irradiates at least one of water before treatment and treatment liquid in the liquid circuit with ultraviolet rays. The liquid circuit has a liquid feeding pump for feeding liquid in the liquid circuit,
The blood purification device according to claim 1 or 2, wherein the control device changes an irradiation output of the ultraviolet irradiation device in accordance with a liquid supply flow rate in the liquid supply pump.   The blood purification apparatus according to claim 1 or 2, wherein the control device changes an irradiation output of the ultraviolet irradiation device according to a liquid flow rate of a part of a liquid circuit irradiated with ultraviolet rays by the ultraviolet irradiation device.   The blood purification device according to any one of claims 1 to 4, wherein the control device changes an irradiation output of the ultraviolet irradiation device according to a decrease in output of the ultraviolet irradiation device.   The blood purification apparatus according to claim 5, further comprising a sensor that detects an irradiation output of the ultraviolet irradiation apparatus.   The blood purification apparatus according to any one of claims 1 to 6, wherein the control device changes an irradiation output of the ultraviolet irradiation device according to a quality of the liquid.   The blood purification apparatus according to claim 7, further comprising a water quality sensor that detects water quality of the liquid. An apparatus housing part including at least a part of the liquid circuit;
The blood purification apparatus according to any one of claims 1 to 8, wherein the ultraviolet irradiation device is built in the device casing. The liquid circuit of the device casing has a mixing unit that mixes a stock solution with water for the production of a therapeutic solution,
The blood purification apparatus according to claim 9, wherein the ultraviolet irradiation device is provided in a liquid circuit upstream of the mixing unit. The liquid circuit of the device casing has a mixing unit that mixes a stock solution with water for the production of a therapeutic solution,
The blood purification apparatus according to claim 9, wherein the ultraviolet irradiation device is provided in a liquid circuit downstream of the mixing unit. An apparatus housing part including at least a part of the liquid circuit;
The blood purification apparatus according to any one of claims 1 to 8, wherein the ultraviolet irradiation device is provided in a liquid circuit outside the device casing. The liquid circuit has a plurality of installable positions of the ultraviolet irradiation device,
The blood purification apparatus according to any one of claims 1 to 8, wherein the control device changes an irradiation output based on an installation position of the ultraviolet irradiation device. An installation position detection sensor for detecting an installation position of the ultraviolet irradiation device;
The blood purification apparatus according to claim 13, wherein the control device changes an irradiation output based on an installation position detected by the installation position detection sensor.   The blood according to claim 14, wherein the control device includes an installation position input unit that inputs an installation position of the ultraviolet irradiation device, and changes the irradiation output based on the installation position input to the installation position input unit. Purification equipment.   The control device includes a storage unit that stores an irradiation output condition in an apparatus status for each installation position of the ultraviolet irradiation apparatus, and changes the irradiation output based on the irradiation output condition of the apparatus status in the storage unit. Item 16. A blood purification device according to any one of Items 13 to 15.   The said control apparatus has a memory | storage part which memorize | stores the irradiation output condition in apparatus status, and changes irradiation output based on the irradiation output condition of the said apparatus status of the said memory | storage part. Blood purification device.   The blood purification apparatus according to claim 16 or 17, further comprising an irradiation condition setting unit that sets an irradiation output condition of the apparatus status. A blood purifier,
A blood circuit for supplying blood from a patient to the blood purifier and returning the blood purifier to the patient;
A liquid circuit for supplying a treatment liquid to at least one of the blood purifier and the blood circuit;
A cleaning liquid supply device for supplying a cleaning liquid to the liquid circuit;
An ultraviolet irradiation device for irradiating the cleaning liquid in the liquid circuit with ultraviolet light from an ultraviolet LED;
A blood purification apparatus comprising: a control device that controls an irradiation output of the ultraviolet irradiation device.   The blood purification apparatus according to claim 19, wherein the control device changes an irradiation output of the ultraviolet irradiation device in accordance with a flow rate of a cleaning liquid in a portion of a liquid circuit irradiated with ultraviolet rays by the ultraviolet irradiation device.   The blood purification apparatus according to claim 19 or 20, wherein the control device changes an irradiation output of the ultraviolet irradiation device in accordance with a decrease in output of the ultraviolet irradiation device.   The blood purification apparatus according to claim 21, further comprising a sensor that detects an irradiation output of the ultraviolet irradiation apparatus.   The said control apparatus has a memory | storage part which memorize | stores the irradiation output condition in apparatus status, and changes irradiation output based on the irradiation output condition of the said apparatus status of the said memory | storage part. Blood purification device.   A sterilization method in which in a liquid circuit of a blood purification apparatus that supplies liquid to at least one of a blood purifier and a blood circuit, the liquid is sterilized by irradiating the liquid with ultraviolet rays using an ultraviolet LED. In the liquid circuit, the treatment solution is produced by mixing the stock solution with water,
25. The sterilization method according to claim 24, wherein at least one of water and treatment liquid before mixing in the liquid circuit is irradiated with an ultraviolet LED.   A sterilization method in which in a liquid circuit of a blood purification apparatus that supplies a treatment liquid to at least one of a blood purifier and a blood circuit, the cleaning liquid supplied to the liquid circuit is sterilized by irradiating with ultraviolet light with an ultraviolet LED.