CN107261236A

CN107261236A - Apparatus for purifying blood and sterilizing methods

Info

Publication number: CN107261236A
Application number: CN201710209589.XA
Authority: CN
Inventors: 土屋瑞穗
Original assignee: Asahi Kasei Medical Co Ltd
Current assignee: Asahi Kasei Medical Co Ltd
Priority date: 2016-03-31
Filing date: 2017-03-31
Publication date: 2017-10-20
Also published as: JP7129757B2; JP2017185218A; CN110801545A

Abstract

The present invention realizes a kind of apparatus for purifying blood, and the apparatus for purifying blood has ultraviolet lamp that is more small-sized and can also changing ultraviolet irradiation amount and the control device for controlling the ultraviolet lamp.Apparatus for purifying blood (1) has：Blood purification (10)；Blood circuit (11), by blood can be supplied to blood purification (10), then send patient back to from blood purification (10) by blood by the blood circuit from patient；Dialysis fluid circuit (12), can by the dialysis fluid circuit toward mixing stoste in water dialyzate is made, and the dialyzate is supplied to blood purification (10)；Ultraviolet lamp (13), it is used for using ultraviolet LED at least any one irradiation ultraviolet radiation in the dialyzate in dialysis fluid circuit (12) and the water before mixing；And control device (14), it is used to control the irradiation of ultraviolet lamp (13) to export.

Description

Apparatus for purifying blood and sterilizing methods

Technical field

The present invention relates to apparatus for purifying blood and sterilizing methods.

Background technology

Generally carry out so-called dialysis treatment using apparatus for purifying blood, the apparatus for purifying blood have blood circuit and Dialysis fluid circuit etc., wherein, can by the blood circuit by the blood supply of patient to being made up of hollow fiber film assembly etc. Blood purification, then send patient back to from the blood purification by blood, by dialyzate can be supplied to blood by the dialysis fluid circuit Liquid purifier, to take away waste from the blood of patient, and makes waste be entered after passing through hollow-fibre membrane in dialyzate, so that Waste is removed from the blood of patient.Moreover, in order to improve therapeutic efficiency, also entering the dialyzate being about in dialysis fluid circuit and (mending Liquid) to blood circuit side supply process.

Incidentally, using the treatment liquid such as dialyzate, fluid infusion in above-mentioned dialysis treatment, here, in order to mitigate doctor The burden for the treatment of personnel, if it is possible to these above-mentioned treatment liquid constantly and are automatically supplemented all right to apparatus for purifying blood (with reference to patent document 1).

Prior art literature

Patent document

Patent document 1：No. 4458346 publications of Japanese Patent Publication No.

Patent document 2：Japanese Patent Publication 4-61542 publications

The content of the invention

Problems to be solved by the invention

Therefore, for example, generally introducing the RO (Reverse for being purified to running water, well water in hospital facility Osmosis) system and for system to be made the dialyzate of dialyzate is made toward adding stoste in the water after purification.

But, because dialyzate is possible to that the blood of patient can be contacted, therefore, supplied even with from above-mentioned RO systems The water come, but in the higher dialyzate of cleanliness factor to be made, it is still necessary to a little countermeasures are taken to device inside.It is used as such example Son, generally carrying out carrying is used to remove the way of endotoxic ETRF (endotoxin capture filter device), medication after treatment is finished Liquid implements the way of cleaning.

It is well known, however, that and also often report has such case in academic conference：What is obtained using RO systems Degerming aspect of performance, device is carried out in itself in terms of degerming, sterilization ability there is also boundary, matching somebody with somebody inside RO pipe arrangements, device Dead angle position in pipe can produce bacterium (biomembrane).Moreover, worrying that bacterium can also be from the stoste of the stoste for supplying dialyzate Bottle is mixed into, it is therefore prevented that bacterium is mixed into inside device, prevents that the means that bacterium breeds inside device are extremely important.Moreover, Before starting one-day dialysis treatment, the time dead between dialysis treatment and dialysis treatment, and in dialysis treatment When waiting after end, to carry out the cleaning fluids such as the supply decoction of the dialysis fluid circuit into device to clean dialysis fluid circuit Cleaning treatment, here, for the cleaning fluid, it is necessary to also must be by fully it is degerming after cleaning fluid.

Therefore, inventor considers a kind of utilization ultraviolet to the treatment liquid in the fluid loops such as dialysis fluid circuit, cleaning The method that liquid is sterilized.But, the ultraviolet lamp used in conventional dialysis apparatus is lamp-based irradiation unit (reference Patent document 2), it is relatively large device.Accordingly, it would be desirable to mutually independently set the ultraviolet to irradiate in addition with apparatus for purifying blood Device.As a result, in addition to being set, be operated to apparatus for purifying blood, be controlled, in addition it is also necessary to ultraviolet is shone again in addition Injection device is set, operated, controlled, and adds the burden of healthcare givers.Shone moreover, large-scale lamp-based ultraviolet can be installed There is also limitation in the place of injection device, it is impossible to which large-scale lamp-based ultraviolet lamp is freely arranged on to the demand with facility Corresponding place.

Moreover, lamp-based ultraviolet lamp can not change the output of ultraviolet, (lamp-based ultraviolet lamp can only be by Unlatching/closing), therefore, sterilizing ability can be caused to reduce during lamp aging, or cause even according to different treatment conditions In the case that analysis flow quantity changes, still it is irradiated with constant energy.Accordingly, there exist such possibility：Ultraviolet irradiates Amount is not enough, it is impossible to obtain sufficient sterilizing ability.Moreover, existing such possible：Beyond required ultraviolet irradiation amount ground mistake Degree ground irradiation ultraviolet radiation, causes the lifetime of ultraviolet lamp, causes dialyzate composition to be denatured.

The present invention is that an object of the present invention is, realize a kind of blood in view of these above-mentioned aspects are made Purifier, the apparatus for purifying blood have ultraviolet lamp more small-sized and that ultraviolet irradiation amount can also be changed and Control device for controlling the ultraviolet lamp.

The solution used to solve the problem

In order to achieve the above object, inventor is carefully studied, and is as a result found, by using utilization ultraviolet LED The ultraviolet lamp of irradiation ultraviolet radiation and the control device that the irradiation of the ultraviolet lamp can be controlled to export, can be solved Certainly above mentioned problem, until completing the present invention.That is, the present invention includes following technical proposals.

(1) a kind of apparatus for purifying blood, wherein, the apparatus for purifying blood has：Blood purification；Blood circuit, can lead to Cross the blood circuit and blood is supplied to the blood purification from patient, then trouble is sent back to from the blood purification by blood Person；Fluid loop, can be supplied a liquid in the blood purification and the blood circuit at least by the fluid loop Any one；Ultraviolet lamp, it is used for using ultraviolet LED to the liquid irradiation ultraviolet radiation in the fluid loop；And Control device, it is used to control the irradiation of the ultraviolet lamp to export.

(2) according to the apparatus for purifying blood described in (1), wherein, the fluid loop has can be by former toward mixing in water Liquid treats the function of liquid to be made, and the ultraviolet lamp can be to the treatment liquid in the fluid loop and the water before mixing In at least any one irradiation ultraviolet radiation.

(3) apparatus for purifying blood according to (1) or (2), wherein, the fluid loop, which has, to be used for toward the liquid The liquid-feeding pump of liquid is conveyed in loop, the control device can correspondingly change the purple with the liquor charging flow in the liquid-feeding pump The irradiation output of outer beam irradiating apparatus.

(4) according to the apparatus for purifying blood described in (1) or (2), wherein, the control device can with it is in fluid loop, The ultraviolet lamp is correspondingly changed by the fluid flow of the part of the ultraviolet lamp irradiation ultraviolet radiation Irradiation output.

(5) apparatus for purifying blood according to any one of (1)~(4), wherein, the control device can be with the purple The output reduction situation of outer beam irradiating apparatus correspondingly changes the irradiation output of the ultraviolet lamp.

(6) apparatus for purifying blood according to (5), wherein, the apparatus for purifying blood, which has, to be used to detect described ultraviolet The sensor of the irradiation output of beam irradiating apparatus.

(7) apparatus for purifying blood according to any one of (1)~(6), wherein, the control device can be with the liquid The water quality of body correspondingly changes the irradiation output of the ultraviolet lamp.

(8) apparatus for purifying blood according to (7), wherein, the apparatus for purifying blood, which has, to be used to detect the liquid Water quality water quality sensor.

(9) apparatus for purifying blood according to any one of (1)~(8), wherein, the apparatus for purifying blood also has dress Housing section is put, the device case portion is built-in with least a portion of the fluid loop, the ultraviolet lamp is built in Described device housing section.

(10) apparatus for purifying blood according to (9), wherein, being located in described device housing section in fluid loop Part has mixing unit, toward mixing stoste in water treatment liquid can be made at the mixing unit, the ultraviolet lamp is set Mixing unit described in ratio in fluid loop leans on the part of upstream side.

(11) apparatus for purifying blood according to (9), wherein, being located in described device housing section in fluid loop Part has mixing unit, toward mixing stoste in water treatment liquid can be made at the mixing unit, the ultraviolet lamp is set The part of mixing unit downstream described in ratio in fluid loop.

(12) apparatus for purifying blood according to any one of (1)~(8), wherein, the apparatus for purifying blood also has Device case portion, the device case portion is built-in with least a portion of the fluid loop, and the ultraviolet lamp is located at The part of the outside positioned at described device housing section in fluid loop.

(13) apparatus for purifying blood according to any one of (1)~(8), wherein, the apparatus for purifying blood is described The position of the ultraviolet lamp can be set with multiple in fluid loop, the control device can be based on described ultraviolet The set location of beam irradiating apparatus exports to change irradiation.

(14) apparatus for purifying blood according to (13), wherein, the apparatus for purifying blood, which has, to be used to detect the purple The set location detection sensor of the set location of outer beam irradiating apparatus, the control device can be based on being examined by the set location The set location that survey sensor is detected exports to change irradiation.

(15) apparatus for purifying blood according to (14), wherein, the control device has set location input unit, energy The set location of the ultraviolet lamp is inputted by the set location input unit, the control device can be based on passing through institute Set location that set location input unit inputted is stated to change irradiation output.

(16) apparatus for purifying blood according to any one of (13)~(15), wherein, the control device, which has, to be deposited Storage portion, the storage part is used to be stored in the ultraviolet irradiation that each position for setting the ultraviolet lamp is set The irradiation output condition of the unit state of device, the control device can be based on the described device state stored in the storage part Irradiation output condition come change irradiation output.

(17) apparatus for purifying blood according to any one of (1)~(12), wherein, the control device has storage Portion, the storage part is used for the irradiation output condition of storage device state, and the control device can be based on storing in the storage part Described device state irradiation output condition come change irradiation output.

(18) apparatus for purifying blood according to (16) or (17), wherein, the apparatus for purifying blood has irradiation condition Configuration part, can set the irradiation output condition of described device state by the irradiation condition configuration par.

(19) a kind of apparatus for purifying blood, wherein, the apparatus for purifying blood has：Blood purification；Blood circuit, can lead to Cross the blood circuit and blood is supplied to the blood purification from patient, then trouble is sent back to from the blood purification by blood Person；Treatment liquid, can be supplied in the blood purification and the blood circuit extremely by fluid loop by the fluid loop Lack any one；Cleaning solution supplying device, it is used to supply cleaning fluid to the fluid loop；Ultraviolet lamp, it is used for Using ultraviolet LED to the cleaning fluid irradiation ultraviolet radiation in the fluid loop；And control device, it is used to controlling described ultraviolet The irradiation output of beam irradiating apparatus.

(20) according to the apparatus for purifying blood described in (19), wherein, the control device can with it is in fluid loop, by institute The flow for stating the cleaning fluid of the part of ultraviolet lamp irradiation ultraviolet radiation correspondingly changes the ultraviolet lamp Irradiation output.

(21) apparatus for purifying blood according to (19) or (20), wherein, the control device can be with the ultraviolet The output reduction situation of irradiation unit correspondingly changes the irradiation output of the ultraviolet lamp.

(22) apparatus for purifying blood according to (21), wherein, the apparatus for purifying blood, which has, to be used to detect the purple The sensor of the irradiation output of outer beam irradiating apparatus.

(23) apparatus for purifying blood according to any one of (19)~(22), wherein, the control device, which has, to be deposited Storage portion, the storage part is used for the irradiation output condition of storage device state, and the control device can be based on depositing in the storage part The irradiation output condition of the described device state of storage exports to change irradiation.

(24) a kind of sterilizing methods, wherein, the sterilizing methods in apparatus for purifying blood, can supply a liquid to At least fluid loop of any one in blood purification and blood circuit, using ultraviolet LED, irradiates ultraviolet to the liquid Line is come the method that is sterilized.

(25) sterilizing methods according to (24), wherein, the sterilizing methods have following step：Toward the fluid loop In water in mix stoste, treatment liquid is made；And at least appointing in the water before the treatment liquid in the fluid loop and mixing One irradiation ultraviolet radiation.

(26) a kind of sterilizing methods, wherein, the sterilizing methods in apparatus for purifying blood, can will treatment liquid supply At least fluid loop of any one into blood purification and blood circuit, using ultraviolet LED, to being fed into the liquid Cleaning fluid irradiation ultraviolet radiation in body loop is come the method that is sterilized.

The effect of invention

Using the present invention, a kind of apparatus for purifying blood can be realized, the apparatus for purifying blood has more small-sized and can also The ultraviolet lamp of ultraviolet irradiation amount and the control device for controlling the ultraviolet lamp are enough changed, therefore, In addition to being set, operated and be controlled to apparatus for purifying blood, without being set again to ultraviolet lamp in addition Fixed, operation and control, can mitigate the burden of healthcare givers.It is additionally, since and uses small-sized ultraviolet lamp, therefore, Appropriate field including correspondingly ultraviolet lamp can be arranged on comprising the position in device case with the demand of facility Institute.Ultraviolet irradiation amount can be changed by being additionally, since, therefore, it is possible to irradiate appropriate ultraviolet, so as to sufficiently be killed Bacterium.

Brief description of the drawings

Fig. 1 is the schematic diagram of the overview for the structure for representing apparatus for purifying blood.

Fig. 2 is that have ultraviolet irradiation dress by upstream end in the part of the inside positioned at device case portion in the loop The schematic diagram of apparatus for purifying blood in the case of putting.

Fig. 3 is that the place downstream in the part of the inside positioned at device case portion in the loop has ultraviolet irradiation dress The schematic diagram of apparatus for purifying blood in the case of putting.

Fig. 4 is with the schematic diagram for being used to detect the apparatus for purifying blood in the case of the sensor of ultraviolet output.

Fig. 5 be with water quality sensor in the case of apparatus for purifying blood schematic diagram.

Fig. 6 be with fluid infusion loop in the case of apparatus for purifying blood schematic diagram.

Fig. 7 be with set location sensor in the case of apparatus for purifying blood schematic diagram.

Fig. 8 is the block diagram of control device.

Fig. 9 is the explanation figure of one for representing display picture.

Figure 10 is the explanation figure of another for representing display picture.

Figure 11 is the another form of block diagram of control device.

Figure 12 is the explanation figure of one of the display picture in the case of representing with set location input unit.

Figure 13 is the schematic diagram for another configuration example for representing apparatus for purifying blood.

Figure 14 is to represent that matting and ultraviolet export the explanation figure of situation.

Embodiment

Below, it is described with reference to the present invention preferred embodiment.In addition, following embodiment is to be used to illustrate The illustration of the present invention, the present invention is not to be only defined in the embodiment.Identical accompanying drawing mark is marked to identical structure member Note, the repetitive description thereof will be omitted.As long as moreover, not specified, just will wait position relationship to be considered as up and down to be based in explanation Position relationship for position relationship shown in the drawings.Moreover, the dimension scale of component is not limited to ratio shown in the drawings.

Fig. 1 is the schematic diagram of the overview of the structure for the apparatus for purifying blood 1 for representing present embodiment.In present embodiment In, for example, for illustrating exemplified by the apparatus for purifying blood 1 of progress dialysis treatment in the therapeutic room in hospital.

Apparatus for purifying blood 1 for example with：Blood purification 10；Blood circuit 11, can be by the blood circuit 11 by blood Liquid is supplied to blood purification 10 from patient, then sends patient back to from blood purification 10 by blood；It is used as the dialysis of fluid loop Liquid loop 12, can be made as treating the dialyzate of liquid by the dialysis fluid circuit 12 toward the stoste of mixing dialyzate in water, And the dialyzate is supplied to blood purification 10；Ultraviolet lamp 13, it is used to return dialyzate using ultraviolet LED At least any one irradiation ultraviolet radiation in the dialyzate obtained after water before mixing and mixing in road 12；And control device 14. In addition, in this manual, " liquid " at least includes water, treatment liquid, stoste, cleaning fluid, " treatment liquid " at least include dialyzate, Fluid infusion.

Blood purification 10 is, for example, the hollow fiber film assembly for being built-in with hollow fiber membrane bundle.In blood purification 10 The primary side 10a of hollow-fibre membrane outlet and entrance be connected with blood circuit 11, goes out in the secondary side 10b of hollow-fibre membrane Mouth and entrance are connected with dialysis fluid circuit 12.Blood purification 10 can for example utilize the primary side 10a and two of hollow-fibre membrane Osmotic pressure between secondary side 10b, hollow-fibre membrane is brought into by waste in the blood in the primary side 10a of hollow-fibre membrane etc. Secondary side 10b in dialyzate in, so as to be purified to blood.The circuit portion in " loop " in present embodiment is for example Soft pipe is used.

In blood circuit 11 provided with blood pump 30, the dropping funnel 31 for example for conveying blood.

Dialysis fluid circuit 12 has：Dialyzate supply circuit 50, can set by the way that the dialyzate supply circuit 50 is past from hospital Mix A stostes and B stostes dialysis is made in the RO water (reverse osmosis water) that pipe arrangement supply in the wall 40 of the therapeutic room applied comes Liquid, and the dialyzate is supplied to the secondary side 10b of blood purification 10；And dialyzate discharge loop 51, the dialysis can be passed through Liquid discharges loop 51 and the dialysis waste liquid after the secondary side 10b of blood purification 10 is discharged in the wall 40 of therapeutic room In pipe arrangement.In addition, for example provided with such equipment in hospital facility：The equipment can obtain running water, and profit from running water pipe Bacterium is removed RO water is made from the running water with the filter made using RO films (reverse osmosis membrane), and the RO water is conveyed To the wall 40 of each therapeutic room of hospital facility.

For example, the end by upstream side of dialyzate supply circuit 50 is connected with the pipe arrangement in the wall 40 of therapeutic room, The end of the downstream of dialyzate supply circuit 50 is connected with the secondary side 10b of the hollow-fibre membrane of blood purification 10. Dialyzate supply circuit 50 is for example with the 1st liquid-feeding pump 60 and the 2nd liquid-feeding pump 61.The 1st in dialyzate supply circuit 50 send The 1st loop 63 and the 2nd loop 65 are connected between the liquid-feeding pump 61 of liquid pump 60 and the 2nd, can be supplied by the 1st loop 63 by the 1st A stostes in source 62 import dialyzate supply circuit 50, can be imported the B stostes in the 2nd supply source 64 by the 2nd loop 65 Dialyzate supply circuit 50.In addition, in the present embodiment, such as by the energy in dialyzate supply circuit 50 toward mixing in RO water The part of A stostes and B stostes is referred to as mixing unit 66.

In dialyzate supply circuit 50 for example than the downstream of the 2nd liquid-feeding pump 61 part and constant room 70 Room the 1st 71 are connected, and the downstream of the 1st Room 71 is connected with the secondary side 10b of the hollow-fibre membrane of blood purification 10.

Constant room 70 has can be freely in partition walls 73 such as the barrier films of main body intrinsic displacement of constant volume.Constant room 70 Inside is divided into the 1st Room 71 and the 2nd Room 72 by partition wall 73.

Loop 51 is discharged on dialyzate, for example its end for leaning on upstream side and the hollow-fibre membrane of blood purification 10 Secondary side 10b is connected, and the end of downstream in dialyzate discharge loop 51 is connected with the pipe arrangement in the wall 40 of therapeutic room Connect.That is, the part of the secondary side 10b downstreams of the hollow-fibre membrane of the ratio blood purification 10 in dialyzate discharge loop 51 It is connected with the 2nd Room 72 of constant room 70, the part of ratio Room the 2nd 72 downstream in dialyzate discharge loop 51 is set with hospital The pipe arrangement in wall 40 applied is connected.It is provided between the secondary side 10b of blood purification 10 and the 2nd Room 72 of constant room 70 Circulating pump 80.Moreover, dialyzate discharge loop 51, which has, removes water loop 90, should be except water loop 90 be from than the downstream of circulating pump 80 Place is bypassed after constant room 70, leads to that side (side of wall 40 of hospital facility) than the downstream of constant room 70.Except water loop 90 have except water pump 91.

Apparatus for purifying blood 1 has device case portion 100, and the device case portion 100 is built-in with for example various equipment, dress Put.Be built-in with device case portion 100 such as the 1st liquid-feeding pump 60, the 2nd liquid-feeding pump 61, constant room 70, circulating pump 80, except water pump 91st, blood pump 30, control device 14 etc..In addition, in this manual, " built-in " refers to the part as device case portion 100 It is assembled into the state of the inside in the device case portion 100.

Device case portion 100 is also built-in with the part of the process said pump of dialysis fluid circuit 12.That is, device case portion 100 It is built-in with being leaned on from than the 1st liquid-feeding pump 60 at upstream side between than the downstream of constant room 70 in dialyzate supply circuit 50 The 1st internal flow path 110 and dialyzate discharge loop 51 in from than circulating pump 80 by upstream side to than constant room 70 on the lower The 2nd internal flow path 111 between side is swum, the connection that can be connected with outer flowpath is provided with the two ends of the 1st internal flow path 110 Mouth 112, the connector 113 that can be connected with outer flowpath is provided with the two ends of the 2nd internal flow path 111.

The wall 40 from hospital facility in dialyzate supply circuit 50 to device case portion 100 the connection by upstream side Upstream interval between mouthfuls 112 is formed by the 1st external connection stream 120, in dialyzate supply circuit 50 from device shell The connector 112 of the downstream in body portion 100 to the downstream interval between the secondary side 10b of blood purification 10 is outside the 2nd Portion's connection formation of stream 121.That is, dialyzate supply circuit 50 is by the 1st external connection stream 120, the 1st internal flow path 110 With the formation of the 2nd external connection stream 121.Moreover, the secondary side 10b from blood purification 10 in dialyzate discharge loop 51 To the upstream interval between the connector 113 by upstream side in device case portion 100 formed by the 3rd external connection stream 122 , connector 113 to the downstream interval between the wall 40 of hospital facility from the downstream in device case portion 100 is by The formation of 4 external connection streams 123.That is, dialyzate discharge loop 51 is by the 3rd external connection stream 122, the 2nd internal flow path The formation of 111 and the 4th external connection stream 123.

For example, blood purification 10, blood circuit 11 and dropping funnel 31 are configured to not be built in device case portion 100, but It can be disassembled freely from device case portion 100.In every progress seance, blood purification 10, blood will be changed Loop 11 and dropping funnel 31.

Ultraviolet lamp 13 is for example located at the 1st external connection stream 120 of the outside positioned at device case portion 100. Ultraviolet lamp 13 has ultraviolet LED as light source, and ultraviolet lamp 13 can be by the 1st external connection The RO water irradiation ultraviolet radiation flowed in stream 120 sterilizes to the RO water.Ultraviolet LED is preferably that irradiating angle is 120 More than degree, wavelength region is 250nm~280nm, and power output (is using multiple ultraviolets for more than 5mW ultraviolet LED In the case of LED, gross output is more than 5mW).It is preferred by the flow of the liquid of the irradiation ultraviolet radiation of ultraviolet lamp 13 For more than 300mL/min, below 1200mL/min.In addition, ultraviolet lamp 13 can also be pacified in the way of disassembly ease Surface mounted in device case portion 100.

Control device 14 is, for example, the computer for being used to control the action of whole apparatus for purifying blood 1, control device 14 If by control the 1st liquid-feeding pump 60, the 2nd liquid-feeding pump 61, constant room 70, circulating pump 80, except water pump 91, blood pump 30, purple The action of outer beam irradiating apparatus 13 and valve (not shown) etc., makes apparatus for purifying blood 1 work, so that apparatus for purifying blood 1 is held Promoting circulation of blood liquid purified treatment.

For example, control device 14 performs the program stored in storage part, with the liquor charging flow phase in such as the 1st liquid-feeding pump 60 Ground is answered to change the irradiation output of ultraviolet lamp 13.For example, in the case where liquor charging flow is more, increasing the photograph of ultraviolet Output is penetrated, in the case where liquor charging flow is less, ultraviolet irradiation output is reduced.In addition, with regard to the liquor charging in the 1st liquid-feeding pump 60 For the value of flow or, control device 14 holds ultraviolet lamp according to the setting flow of the 1st liquid-feeding pump 60 13 output, it is also possible that setting flow sensor in stream, control device 14 is according to the value detected by the sensor come handle Hold the output of ultraviolet lamp 13.

Moreover, control device 14 can correspondingly be controlled with the unit state (operational sequence) of apparatus for purifying blood 1 it is ultraviolet Unlatching/closed mode of the ultraviolet irradiation of beam irradiating apparatus 13, the ultraviolet LED of ultraviolet lamp 13 output are strong Degree.For example, control device 14 can with it is following in the case of unit state correspondingly, unlatching/closing of switching ultraviolet irradiation State, or change ultraviolet LED output intensity.The situation includes：Loop is carried out before blood purification processing starts clear When washing and (such as water for cleaning (RO water) is flowed into dialysis fluid circuit 12 process cleaned to dialysis fluid circuit 12), in blood During liquid purified treatment, loop is cleaned after blood purification processing terminates (for example make cleaning fluid (RO water, decoction Deng) flow into dialysis fluid circuit 12 process cleaned to dialysis fluid circuit 12) when and when standby (both without blood When purified treatment is not also cleaned to loop) etc..

It can be carried out using the apparatus for purifying blood 1 constituted in the above described manner below such as at such blood purification Reason.For example, being penetrated by the puncture needle (not shown) in blood circuit 11 after patient, blood pump 30 is worked, lead to blood Cross the primary side 10a and blood circuit 11 of the hollow-fibre membrane of blood purification 10 and blood is circulated in this way.The opposing party Face, for dialysis fluid circuit 12, makes the 1st liquid-feeding pump 60 and the 2nd liquid-feeding pump 61 work, dialyzate is stored in into constant room 70 In 1st Room 71.Now, in dialyzate supply circuit 50, RO water flows from the wall 40 of hospital facility towards device case portion 100 It is dynamic, RO water illuminated ultraviolet when by ultraviolet lamp 13.The flow of RO water now can also be 300mL/min More than, below 1200mL/min.Thus, the bacterium in RO water can be eliminated.In addition, with regard to ultraviolet irradiation for or, 1st liquid-feeding pump 60 also correspondingly opens ultraviolet irradiation when opening, and ultraviolet is also correspondingly closed when the 1st liquid-feeding pump 60 is closed Irradiation, so as to carry out ultraviolet irradiation when such as RO water flows.RO water after sterilizing is towards positioned at device shell Constant room 70 in body portion 100 is flowed, and A stostes are mixed into from the 1st loop 63 at mixing unit 66, and B is mixed into from the 2nd loop 65 Stoste, so as to be made as treating the dialyzate of liquid.In this case or, for example first stop the 1st liquid-feeding pump 60, The 2nd liquid-feeding pump 61 is worked, the A stostes of ormal weight and B stostes imported into mixing unit 66, afterwards, the 1st liquid-feeding pump 60 is worked, RO water is imported into mixing unit 66, so that the dialyzate normal concentration is made.The dialyzate made is stored in constant room 70 In 1st Room 71.

When dialyzate is stored in the 1st Room 71 of constant room 70, circulating pump 80 is worked, pass through dialyzate Dialyzate in 1st Room 71 is supplied to the secondary side 10b of the hollow-fibre membrane of blood purification 10 by supply circuit 50.Now, Waste is taken away in the blood that dialyzate flows from the primary side 10a of the hollow-fibre membrane in blood purification 10, blood is carried out Purification.

Dialysis waste liquid after the secondary side 10b of the hollow-fibre membrane of blood purification 10 is discharged back by dialyzate Road 51 flows into the 2nd Room 72 of constant room 70.Now, the partition wall 73 of constant room 70 is moved so that the volume of the 1st Room 71 diminishes many Few, the volume of the 2nd Room 72 just becomes big how many.Moreover, also make remove water loop 90 in except water pump 91 works, make the one of dialysis waste liquid Partly without constant room 70, but by being discharged except water loop 90 to the downstream that dialyzate discharges loop 51.The dialysis is given up Liquid passes through liquid measure when removing water loop 90 and the water removal phase in blood purification 10 from the blood of patient during removal waste Correspondence.

Then, dialyzate is made in RO water in dialyzate supply circuit 50 again, the dialyzate is stored in constant room In 70 the 1st Room 71, at the same time, partition wall 73 is moved, and the dialysis waste liquid in the 2nd Room 72 is discharged loop 51 by dialyzate Discharged towards the wall 40 of hospital facility.

Above-mentioned operation is repeated, dialysis treatment (blood purification processing) is carried out.

, can be by using the ultraviolet by the use of the ultraviolet LED illumination ultraviolet as light source using present embodiment Irradiation unit 13, minimize ultraviolet lamp 13, and it is net the ultraviolet lamp 13 can be assembled in into blood Makeup is put in 1.Thus, it is possible to control the irradiation of ultraviolet lamp 13 using the control device 14 of apparatus for purifying blood 1 Output, as a result, in addition to being set, operated to apparatus for purifying blood 1, controlled, without shining again ultraviolet in addition Injection device is set, operated, controlled, and can mitigate the burden of healthcare givers.

Control device 14 can correspondingly change the irradiation of ultraviolet lamp 13 with the liquor charging flow in the 1st liquid-feeding pump 60 Output, thus it is for example possible to which in the case where liquor charging flow is more, increase ultraviolet irradiation output is less in liquor charging flow In the case of, reduce ultraviolet irradiation output.Thereby, it is possible to reliably be sterilized to RO water, and it can reduce meaningless Irradiation, reduce cost.

The part for the outside positioned at device case portion 100 that ultraviolet lamp 13 is located in dialysis fluid circuit 12, because This, easily can safeguard to ultraviolet lamp 13.Moreover, ultraviolet lamp 13 is located at dialysis fluid circuit 12 In than device case portion 100 lean on upstream side part (the 1st external connection stream 120), therefore, it is possible to prevent bacterium enter dress Put housing section 100 and bred in device case portion 100.Moreover, can prevent from forming more difficult clear in device case portion 100 The biomembrane washed.

In the above-described embodiment, ultraviolet lamp 13 can also be built in device case portion 100.In the situation It is lower or, such as shown in Fig. 2 the ratio mixing unit 66 that is located in dialysis fluid circuit 12 of ultraviolet lamp 13 is top Swim the part of side.In this case or, ultraviolet lamp 13 be located at the 1st internal flow path 110 in, immediately following dress Put the part after the connector 112 by upstream side of housing section 100 and be the part that upstream side is leaned on than the 1st liquid-feeding pump 60.It is logical Cross and so do, ultraviolet lamp 13 can be assembled in device case portion 100, therefore, it is possible to make to irradiate with ultraviolet The apparatus for purifying blood 1 of device 13 is more compact.Moreover, ultraviolet lamp 13 is in the upstream portion in device case portion 100, Therefore, it is possible to prevent bacterium from entering device case portion 100 and bred in device case portion 100, so as to prevent in dress Put the biomembrane that housing section 100 forms more difficult cleaning.Moreover, ultraviolet lamp 13 is in device case portion 100, because This, will not hinder the filter changed in same device, supplement the operations such as decoction.Moreover, being scattered to outside in the absence of ultraviolet Possibility.Moreover, will not be arrived by sun, therefore, it is possible to the part aging of restraining device.

Moreover, as shown in figure 3, the ratio mixing unit 66 that ultraviolet lamp 13 can also be located in dialysis fluid circuit 12 is leaned on The part in downstream.In this case or, ultraviolet lamp 13 be located at the 1st internal flow path 110 near dress Part before the connector 112 for the downstream for putting housing section 100.In this case, can be saturating to what is obtained after mixing Analyse liquid irradiation ultraviolet radiation.Even if by doing so it is possible, being mixed into bacterium in A stostes or B stostes, also can prevent the viable bacteria from entering blood Liquid purifier 10.Moreover, ultraviolet lamp 13 can also be located at than at the downstream of mixing unit 66 and be than constant room 70 At downstream.In this case or, ultraviolet lamp 13 is for example located at the company of constant room 70 and downstream Between interface 112.In this case, RO water and A stostes and B stostes mix and wait mixed liquor flow it is relatively stable after Illuminated ultraviolet is just understood, therefore, it is possible to effectively be sterilized to dialyzate.Moreover, at than the downstream of constant room 70 , can also be by ultraviolet lamp 13 in the case of for promoting the mixing unit that RO water and A stostes and B stostes are mixed It is located at than at the mixing unit downstream.

In superincumbent embodiment, control device 14, which can also become, to be dropped with the output of ultraviolet lamp 13 Low situation correspondingly changes the irradiation output of ultraviolet lamp 13.In this case, as shown in figure 4, in ultraviolet irradiation Device 13 is provided for detecting the output transducer (photodiode) of the actual ultraviolet output of ultraviolet lamp 13 125.Output transducer 125 is for example mounted on ultraviolet LED substrate.Output transducer can be exported to control device 14 125 testing result.Control device 14 can be adjusted to purple based on the testing result exported to ultraviolet of output transducer 125 The current value (irradiation output) that the ultraviolet LED of outer beam irradiating apparatus 13 applies.For example cause in ultraviolet LED agings actual In the case that ultraviolet output is reduced, the current value that can be applied by the ultraviolet LED increased to ultraviolet lamp 13, To ensure the ultraviolet irradiation amount needed for sterilization.Moreover, being reduced in actual ultraviolet output than certain threshold value also low degree In the case of, alarm can be exported, to supervise user to change ultraviolet LED.Alternatively, it is also possible to not utilize output transducer 125 Come detect ultraviolet lamp 13 output reduce situation or, such as based on pre-set ultraviolet LED's Life-span estimates the output reduction situation of ultraviolet lamp 13.That is, it can also become：Passing through ultraviolet LED life In requirement ratio period after, estimate the reduced degree of irradiation output of ultraviolet lamp 13, and with this phase Answer the irradiation output setting of ground increase ultraviolet lamp 13.

In superincumbent embodiment, control device 14 can also become water that can be with the liquid in dialysis fluid circuit 12 Matter correspondingly changes the irradiation output of ultraviolet lamp 13.In this case, as shown in figure 5, being set in dialysis fluid circuit 12 Put the water quality sensor 150 of the water quality for detecting RO water.Water quality sensor 150 can for example be used and can detected in RO water The water quality testing meters such as bacterial population, the TOC analyzers of pollution level, bacterial population measurement apparatus, ET detection means.Water quality sensor 150 parts that upstream side is for example leaned on than ultraviolet lamp 13 being located in dialysis fluid circuit 12.Can be defeated to control device 14 Go out the testing result of water quality sensor 150.Control device 14 can the detection knot based on the water quality to RO water of water quality sensor 150 The current value (irradiation output) really applied come the ultraviolet LED adjusted to ultraviolet lamp 13.For example in the water quality of RO water In the case of less than defined lower threshold, irradiation that can be by increasing ultraviolet lamp 13 is exported, to ensure to sterilize institute The ultraviolet irradiation amount needed.Moreover, in the case where the water quality of RO water is in defined proper range, making ultraviolet lamp 13 with irradiation output irradiation ultraviolet under normal circumstances.In addition, for the setting place of water quality sensor 150, Neng Gouxuan Select arbitrary setting place or, water quality sensor 150 can not only detect the water quality of RO water, additionally it is possible to which detection makes Dialyzate water quality.Alternatively, it is also possible to detect the water quality of liquid without using water quality sensor 150.In this case, also may be used To be, such as by regularly being sampled to RO water (from RO devices or RO pipe arrangements), dialyzate (from dialyzate pipe arrangement), Sample is analyzed to carry out water quality detection, and the testing result is inputted to the operation screen (water set in control device 14 Matter input unit) so that, the irradiation output of ultraviolet lamp 13 is changed by control device 14.

In superincumbent embodiment, to being obtained after the RO water before the mixing of blood purification 10 to be fed into or mixing Dialyzate irradiated ultraviolet, but it is also possible to become：To the RO water before the mixing of blood circuit 11 to be fed into or mixed The dialyzate or fluid infusion irradiation ultraviolet radiation as treatment liquid obtained after conjunction.In this case, for example as shown in fig. 6, blood is net Makeup, which puts 1, has fluid infusion loop 130, and the fluid infusion loop 130 is connected to the drop in blood circuit 11 from dialyzate supply circuit 50 Bucket 31.Fluid infusion pump 131 is provided with fluid infusion loop 130.It can also be returned to be finally fed into blood by the fluid infusion loop 130 The fluid infusion irradiation ultraviolet radiation being made after RO water or mixing stoste before the mixing on road 11.In addition, fluid infusion loop 130 can also be connected Ratio blood purification 10 in blood circuit 11 is by the position of upstream side or the position than the downstream of blood purification 10 Optional position.

Ultraviolet lamp 13 has been located at one, but it is also possible to be located at many places.Can also be, for example, first as shown in Fig. 1 As in the outside of device case portion 100, ultraviolet lamp 13 is set, then supply as shown in Figure 2 in dialyzate The ratio mixing unit 66 of the inside positioned at device case portion 100 in loop 50 sets ultraviolet lamp by the part of upstream side 13, and the ratio mixing unit 66 of the inside positioned at device case portion 100 in dialyzate supply circuit 50 as shown in Figure 3 The part of downstream sets ultraviolet lamp 13, or sets ultraviolet to shine at any two in these above-mentioned places Injection device 13.Moreover, ultraviolet lamp 13 can also be located at other places.

Moreover, apparatus for purifying blood 1, which can also become to have in dialysis fluid circuit 12, multiple can set ultraviolet The position of irradiation unit 13, control device 14 can change irradiation output based on the set location of ultraviolet lamp 13.Example Such as, apparatus for purifying blood 1 has in the outside in device case portion 100 as shown in Figure 1 can set ultraviolet irradiation dress Put 13 position, as shown in Figure 2 the ratio of the inside positioned at device case portion 100 in dialyzate supply circuit 50 mix Conjunction portion 66 has by the part of upstream side can set the position of ultraviolet lamp 13, as shown in Figure 3 in dialysis The part of the downstream of ratio mixing unit 66 of the inside positioned at device case portion 100 in liquid supply circuit 50, which has, to be set The position of ultraviolet lamp 13, can select the setting position of ultraviolet lamp 13 for user.

As shown in fig. 7, apparatus for purifying blood 1 has the setting position for the set location for being used to detect ultraviolet lamp 13 Put detection sensor 160.Set location detection sensor 160 is for example arranged on the field of settable ultraviolet lamp 13 Institute, when ultraviolet lamp 13 is arranged on into the place that this is provided with set location detection sensor 160, set location detection Sensor 160 can produce electrically reaction or automatic reaction, and export the information to control device 14.

Control device 14 such as has as shown in Figure 8：Condition configuration par 170 is irradiated, it, which is used to set, is set Ultraviolet that seated position detection sensor 160 is detected, being set in the position of each setting ultraviolet lamp 13 shines The irradiation output condition of the unit state of injection device 13；And storage part 171, it is used to store by irradiating condition configuration par 170 The unit state of ultraviolet lamp 13 setting, being set in the position of each setting ultraviolet lamp 13 Irradiate output condition.

For example, can by irradiate condition configuration par 170 be, for example, as shown in Figure 9 and Figure 10 as device, display On contact panel on input picture 180, can be directed to multiple unit states in each unit state input irradiation it is defeated Go out condition, for example respectively for starting unit state during filling, treatment when unit state, cleaning when unit state, treat Unit state input irradiation output condition during machine, irradiation output condition is, for example, height and the pass of irradiation output of irradiation output Close.In addition, ultraviolet LED life-span, the detected value of output transducer 125 can also be shown in input picture 180.

In this case, control device 14 detects ultraviolet lamp first with set location detection sensor 160 13 set location, and based on the set location of the ultraviolet lamp 13, as shown in Figure 9 and Figure 10, display is with being somebody's turn to do The input picture 180 of the corresponding unit state of the set location of ultraviolet lamp 13.Then, when past input picture 180 During the irradiation output condition of each unit state of middle input, control device 14 stores the irradiation output condition of the unit state to depositing Storage portion 171.

Then, control device 14 is according to the position in each setting ultraviolet lamp 13 stored in storage part 171 The irradiation output condition of the unit state of the ultraviolet lamp 13 installed exports to change irradiation.For example, control device 14 correspondingly change ultraviolet LED's with following unit state according to ultraviolet irradiation output condition (High/Low/OFF) Irradiation output, described device state includes：Dress when being cleaned to loop before blood purification processing starts and (starting filling) Configuration state, carry out blood purification processing (treatment) when unit state, terminate in blood purification processing after to loop carry out clearly Unit state when washing, both handled without blood purification or loop do not cleaned it is standby when unit state.

For example, in the case where ultraviolet lamp 13 is located at than at the downstream of mixing unit 66, it is former from A in order to prevent Liquid, B stostes are mixed into bacterium, as shown in Figure 9, with height output irradiation ultraviolet radiation when when starting filling with treatment.Also may be used Changed with the species according to treatment during treatment ultraviolet output height or, treatment when dialyzate is straight Connect in the case of being supplied to blood circuit 11, with height output irradiation ultraviolet radiation, dialyzate is being supplied to blood purification 10 In the case of, with low output irradiation ultraviolet.Moreover, for example, being located at trip more top than mixing unit 66 in ultraviolet lamp 13 In the case of at side, as shown in Figure 10, with height output irradiation ultraviolet radiation when when starting filling with cleaning, in treatment With low output irradiation ultraviolet.

Using the example, apparatus for purifying blood 1 can set the position of ultraviolet lamp 13, control device with multiple 14 can change irradiation output based on the set location of ultraviolet lamp 13, therefore, it is possible to improve for user The set location in ultraviolet lamp 13 the free degree, and can be purple with the output irradiation mutually fitted with the set location Outside line.

Apparatus for purifying blood 1 has the set location detection sensing for the set location for being used to detect ultraviolet lamp 13 Device 160, therefore, it is possible to automatically and accurately detect the set location of ultraviolet lamp 13.

Control device 14, which has, to be used to be stored in the ultraviolet that each position for setting ultraviolet lamp 13 is set The storage part 171 of the irradiation output condition of the unit state of irradiation unit 13, control device 14 can be based on storing in storage part 171 Unit state irradiation output condition come change irradiation output., can thereby, it is possible to optimize ultraviolet LED irradiation Extend ultraviolet LED life-span.Moreover, in the case where being not intended to illuminated ultraviolet, being such as that use is understood because of ultraviolet In the case of unit state that the decoction for irradiating and making chemical corrosion change strong is cleaned etc., it can be shone by avoiding ultraviolet Penetrate or suppress irradiation output to prevent chemical erosion.

Apparatus for purifying blood 1 has the irradiation condition configuration par 170 of the irradiation output condition for setting device state, because This, it is possible to increase the operability for user.For example, due to RO water, the cleanliness factor (pollution level) of dialyzate stoste It is different and different because of facility, thus, for example in the case of for the cleanliness factor of RO water less high facility, being passed through During water, High usually can be set as, in the case of for the higher facility of the cleanliness factor of RO water, can be set as only easy Ultraviolet is opened (when being waited before at the end of night) during the unit state for causing bacterium to breed.Thus, it is possible to be set for different Apply custom-made irradiation output condition.

In the above-described embodiment, control device 14 can also be become as shown in Figure 11, with for inputting The set location input unit 190 of the set location of ultraviolet lamp 13, control device 14 can be based on defeated by set location Enter set location that portion 190 inputted to change irradiation output.In this case, can be manually in such as Figure 12 Set location input unit 190 is selected in input picture 180 on contact panel as shown.In this case, Neng Gouti Operability of the principle of readjustment, restructuring, consolidation and improvement for user.Furthermore, it is also possible to set location sensor not set, therefore, it is possible to save part dress The cost put.

In the above-described embodiment, control device 14 is based on the position setting in each setting ultraviolet lamp 13 Ultraviolet lamp 13 unit state irradiation output condition come change irradiation output, but it is also possible to become：Control Device 14 is not limited by the set location of ultraviolet lamp 13, but as shown in Figure 8, with for storing dress The storage part 171 of the irradiation output condition of configuration state, control device 14 can the photograph based on the unit state stored in storage part 171 Output condition is penetrated to change irradiation output.Moreover, in this case or, control device 14 have be used for setting device The irradiation condition configuration par 170 of the irradiation output condition of state.For the irradiation output condition of unit state or, As shown in such as Fig. 9 and Figure 10, for each unit state setting irradiation output condition in multiple unit states, For example respectively for start filling when unit state, treatment when unit state, cleaning when unit state, it is standby when dress Configuration state setting irradiation output condition, irradiation output condition is, for example, height and the closing of irradiation output of irradiation output.

In superincumbent embodiment, before one-day blood purification processing is started, in blood purification processing When disconnected, and when being waited after blood purification processing terminates, to make cleaning fluid inflow dialysis fluid circuit 12, to dialysis fluid circuit 12 carry out cleaning treatment.Ultraviolet lamp 13 can also be during cleaning treatment to being flowed in dialysis fluid circuit 12 Cleaning fluid irradiation ultraviolet radiation.In addition, cleaning fluid can flow into dialysis fluid circuit 12 including all during cleaning treatment Liquid, such as including RO water, decoction stoste, decoction.

For example, as shown in figure 13, connecting between the 1st liquid-feeding pump 60 and the 2nd liquid-feeding pump 61 in dialyzate supply circuit 50 It is connected to the stoste loop 201 for the decoction stoste in stoste supply source 200 to be imported to dialyzate supply circuit 50.In the stoste Loop 201 is provided with open and close valve (not shown).In addition, in the present embodiment, by stoste supply source 200, stoste loop 201 and open Valve closing constitutes cleaning solution supplying device.

When carrying out cleaning treatment, the dialyzate that the RO water after sterilizing is supplied in dialysis fluid circuit 12 is supplied back to Road 50, also, the decoction stoste in stoste supply source 200 is supplied to dialyzate supply circuit 50 by stoste loop 201, make Decoction stoste is mixed with RO water, so that decoction is made.In this case or, for example first stop the 1st liquid-feeding pump 60, The 2nd liquid-feeding pump 61 is worked, the decoction stoste of ormal weight is imported into mixing unit 66, afterwards, the 1st liquid-feeding pump 60 is worked, by RO Water imports mixing unit 66, so that the decoction normal concentration is made.The decoction made is stored in the 1st Room 71 of constant room 70 In.Afterwards, decoction is straight without blood purification 10 by the 1st external connection stream 121, bypass circulation (not shown) etc. Connect and be discharged.

Situation of the ratio mixing unit 66 in dialysis fluid circuit 12 by the part of upstream side is in ultraviolet lamp 13 Under, to the RO water irradiation ultraviolet radiations before mixing, the ratio mixing unit 66 in dialysis fluid circuit 12 is in ultraviolet lamp 13 In the case of the part of downstream, to decoction irradiation ultraviolet radiation.In this case, by control device 14, with for example cleaning The species of liquid, flow correspondingly set the irradiation output of ultraviolet lamp 13., can be fully to cleaning fluid using the example Progress is degerming, thereby it is ensured that the cleaning effect brought using cleaning fluid.It can also enough by irradiating purple to cleaning fluid Outside line improves cleaning effect.In addition, to be not necessarily made in device cleaning fluid or, more top than wall 40 Cleaning fluid is made at trip side, or cleaning fluid is supplied from the cleaning fluid reservoir leaned on than wall 40 at upstream side.

Can also, when carrying out above-mentioned cleaning treatment, present the multiple device shapes corresponding with multiple mattings State, when carrying out above-mentioned cleaning treatment, irradiates output condition to change ultraviolet LED photograph according to the ultraviolet of each unit state Penetrate output.For example, control device 14 has storage part 171 (such as Fig. 8 and figure of the irradiation output condition for storage device state Shown in 11.), it is defeated that control device 14 can change irradiation based on the irradiation output condition of the unit state stored in storage part 171 Go out.For example, the cleaning treatment to be carried out (is tied in the processing of one-day blood purification after terminate in blood purification processing The cleaning treatment to be carried out after beam) when, as shown in figure 14, as the process corresponding with unit state, have：Washing step, In the washing step, dialysis fluid circuit 12 (is briefly referred to as in " loop " below using RO water etc..) cleaned；Pickling work Sequence, in the pickling process, is utilized the acid solutions such as acetic acid aqueous solution, aqueous citric acid solution, the peracetic acid aqueous solution (acid decoction) Loop is cleaned；Acid solution stores process, and in acid solution storage process, acid solution is stored in into dialysis fluid circuit 12 In；In washing step after pickling, the washing step after the pickling, RO water etc. is recycled to be cleaned after pickling process； Decoction disinfecting steps, in the decoction disinfecting steps, are carried out disinfection using decoctions such as aqueous sodium hypochlorite solutions to loop；Decoction is store Process is deposited, in decoction storage process, decoction is stored in dialysis fluid circuit 12；And the washing step after decoction sterilization, In washing step after decoction sterilization, RO water etc. is recycled to be cleaned after decoction disinfecting steps.

For example, in washing step, it is ultraviolet with low output irradiation in pickling process with medium output irradiation ultraviolet Line.In acid solution storage process, stop in irradiation ultraviolet radiation, washing step after pickling, it is ultraviolet with medium output irradiation Line.In decoction disinfecting steps, with low output irradiation ultraviolet, in decoction storage process, stop irradiation ultraviolet radiation, in decoction In washing step after sterilization, with height output irradiation ultraviolet radiation.

The reason in pickling process and decoction disinfecting steps with low output irradiation ultraviolet, is, in order to prevent ultraviolet pair Acid solution, decoction cause chemical erosion, the reason for stopping irradiation ultraviolet radiation during acid solution stores process and decoction storage process It is that liquid does not flow, bactericidal effect is relatively low.Moreover, with height output irradiation ultraviolet radiation in the washing step after decoction is sterilized Reason is, if for example, if there is viable bacteria in night, the RO water being stored in device, viable bacteria can breed at night, cause Device is contaminated (generation biomembrane), therefore, energetically to be sterilized.In addition, medium output refer in height output with it is low The output of degree between output, medium output is used as ultraviolet irradiation output condition (High/Middle/Low/OFF) quilt It is set in control device 14.

Moreover, cleaning treatment can also be the pattern for only carrying out washing step, or the progress pickling work after washing step The pattern of washing step after sequence, acid solution storage process and pickling, or progress decoction disinfecting steps, medicine after washing step Liquid stores pattern of washing step etc. after process and decoction sterilization, in this case or, each work in each mode Ultraviolet irradiation output is changed in sequence in the manner described above.Moreover, during cleaning, hot water matting, heat can also be carried out Citric acid water matting.

In addition, in the example of cleaning fluid irradiation ultraviolet radiation in this pair of dialysis fluid circuit 12 or, control device The 14 output reduction situation as described above with ultraviolet lamp 13 correspondingly changes the photograph of ultraviolet lamp 13 Penetrate output, in this case or, apparatus for purifying blood 1 have be used for detect ultraviolet lamp 13 irradiation it is defeated The sensor 125 (as shown in Figure 4) gone out.

In superincumbent embodiment, control device 14 correspondingly changes ultraviolet photograph with the liquor charging flow in liquid-feeding pump 60 The irradiation output of injection device 13, but it is also possible to become：Control device 14 is filled with being irradiated in dialysis fluid circuit 12 by ultraviolet Put the part of 13 irradiation ultraviolet radiations fluid flow or cleaning fluid flow correspondingly change ultraviolet lamp 13 irradiation it is defeated Go out.In this case, held the opportunity that can also be changed according to the flow such as liquid-feeding pump 60 or constant room 70 The fluid flow of the part by the irradiation ultraviolet radiation of ultraviolet lamp 13 in liquid loop 12 is analysed, can also be by dialyzate The flowmeter that the part of the illuminated ultraviolet of energy in loop 12 is set hold in dialysis fluid circuit 12 by ultraviolet The fluid flow of the part of the irradiation ultraviolet radiation of irradiation unit 13.Being irradiated by ultraviolet lamp 13 in dialysis fluid circuit 12 In the case that the fluid flow of the part of ultraviolet is more, the irradiation output of increase ultraviolet lamp 13 is returned in dialyzate In the case that the fluid flow of the part of illuminated ultraviolet in road 12 is less, the irradiation for reducing ultraviolet lamp 13 is defeated Go out.In this case, appropriate ultraviolet can be irradiated to the liquid flowed in dialysis fluid circuit 12.

For example, the structure of the apparatus for purifying blood 1 described in above embodiment is not limited to this.Can also be, for example Dialyzate supply circuit 50 be provided with the endotoxin being used to remove in dialyzate, bacterium filter.Moreover, being used for into RO water Mechanism not limited to this is made the dialyzate of dialyzate is made in mixing stoste, can also be made using other mechanisms, other method Into dialyzate.

For example, the structure of apparatus for purifying blood 1 is not limited to above embodiment.Can also be, for example, and blood purification The species of processing correspondingly, for example with dialysis treatment, continue low formula blood filtration (CHF：Continuous HemoFiltractrion low formula haemodialysis (CHD), is continued：Continuous HemoDiaFiltration), continue Xu Slow formula blood filtration dialysis (CHDF：Continuous HemoDiaFiltration) correspondingly select to make dialyzate supply circuit 50 modes being connected with blood circuit 11, or selection make the side that dialyzate supply circuit 50 is connected with blood purification 10 Formula, or selection make the mode that dialyzate supply circuit 50 is connected with both blood circuit 11 and blood purification 10.Moreover, The present invention can also be applied to carry out the apparatus for purifying blood of the blood purification processing beyond dialysis treatment.

Content is being preferred embodiment illustrated to the present invention, but the present invention is not limited to referring to the drawings above The embodiment.As long as those skilled in the art, just it should be understood that can think in the technology described in patent claims Various modifications or fixed case are associated in the category thought, and can be known, these modifications or fixed case fall within this hair certainly Bright technical scope.

Industrial applicability

The present invention realize it is a kind of have ultraviolet lamp more small-sized and that ultraviolet irradiation amount can also be changed With for controlling the apparatus for purifying blood of the control device of the ultraviolet lamp in terms of be useful.

Description of reference numerals

1st, apparatus for purifying blood；10th, blood purification；11st, blood circuit；12nd, dialysis fluid circuit；13rd, ultraviolet irradiates Device；14th, control device.

Claims

1. a kind of apparatus for purifying blood, wherein,

The apparatus for purifying blood has：

Blood purification；

Blood circuit, by blood can be supplied to the blood purification by the blood circuit from patient, then net from the blood Change device and send blood back to patient；

Fluid loop, can be supplied a liquid in the blood purification and the blood circuit at least by the fluid loop Any one；

Ultraviolet lamp, it is used for using ultraviolet LED to the liquid irradiation ultraviolet radiation in the fluid loop；And

Control device, it is used to control the irradiation of the ultraviolet lamp to export.

2. apparatus for purifying blood according to claim 1, wherein,

The fluid loop has the function that liquid can be treated by being made toward mixing stoste in water,

The ultraviolet lamp can be at least any one photograph in the treatment liquid in the fluid loop and the water before mixing Penetrate ultraviolet.

3. apparatus for purifying blood according to claim 1 or 2, wherein,

The fluid loop has the liquid-feeding pump for being used for that liquid to be conveyed into the fluid loop,

The control device can correspondingly change the irradiation of the ultraviolet lamp with the liquor charging flow in the liquid-feeding pump Output.

4. apparatus for purifying blood according to claim 1 or 2, wherein,

The control device can be with part in fluid loop, by the ultraviolet lamp irradiation ultraviolet radiation liquid flow Amount correspondingly changes the irradiation output of the ultraviolet lamp.

5. according to apparatus for purifying blood according to any one of claims 1 to 4, wherein,

The control device can correspondingly change the ultraviolet with the output reduction situation of the ultraviolet lamp and irradiate The irradiation output of device.

6. apparatus for purifying blood according to claim 5, wherein,

The apparatus for purifying blood has the sensor for being used for the irradiation output for detecting the ultraviolet lamp.

7. according to apparatus for purifying blood according to any one of claims 1 to 6, wherein,

The control device can correspondingly change the irradiation output of the ultraviolet lamp with the water quality of the liquid.

8. apparatus for purifying blood according to claim 7, wherein,

The apparatus for purifying blood has the water quality sensor for the water quality for being used to detect the liquid.

9. according to apparatus for purifying blood according to any one of claims 1 to 8, wherein,

The apparatus for purifying blood also has device case portion, and the device case portion is built-in with least one of the fluid loop Point,

The ultraviolet lamp is built in described device housing section.

10. apparatus for purifying blood according to claim 9, wherein,

The part being located in described device housing section in fluid loop has mixing unit, can be at the mixing unit toward mixing in water Stoste is made treatment liquid,

Mixing unit leans on the part of upstream side described in the ratio that the ultraviolet lamp is located in fluid loop.

11. apparatus for purifying blood according to claim 9, wherein,

The part of mixing unit downstream described in the ratio that the ultraviolet lamp is located in fluid loop.

12. according to apparatus for purifying blood according to any one of claims 1 to 8, wherein,

The part for the outside positioned at described device housing section that the ultraviolet lamp is located in fluid loop.

13. according to apparatus for purifying blood according to any one of claims 1 to 8, wherein,

The apparatus for purifying blood can set the position of the ultraviolet lamp in the fluid loop with multiple,

The control device can change irradiation output based on the set location of the ultraviolet lamp.

14. apparatus for purifying blood according to claim 13, wherein,

The apparatus for purifying blood has the set location detection sensing for the set location for being used to detect the ultraviolet lamp Device,

The control device can change irradiation output based on the set location detected by the set location detection sensor.

15. apparatus for purifying blood according to claim 14, wherein,

The control device has set location input unit, and the ultraviolet irradiation can be inputted by the set location input unit and is filled The set location put, the control device can change photograph based on the set location inputted by the set location input unit Penetrate output.

16. the apparatus for purifying blood according to any one of claim 13~15, wherein,

The control device has storage part, and the storage part is used to be stored in each position for setting the ultraviolet lamp The irradiation output condition of the unit state of the ultraviolet lamp installed, the control device can be based on the storage The irradiation output condition of the described device state stored in portion exports to change irradiation.

17. the apparatus for purifying blood according to any one of claim 1~12, wherein,

The control device has storage part, and the storage part is used for the irradiation output condition of storage device state, the control dress Irradiation output can be changed based on the irradiation output condition of the described device state stored in the storage part by putting.

18. the apparatus for purifying blood according to claim 16 or 17, wherein,

The apparatus for purifying blood has irradiation condition configuration par, can set described device state by the irradiation condition configuration par Irradiate output condition.

19. a kind of apparatus for purifying blood, wherein,

The apparatus for purifying blood has：

Blood purification；

Treatment liquid, can be supplied in the blood purification and the blood circuit extremely by fluid loop by the fluid loop Lack any one；

Cleaning solution supplying device, it is used to supply cleaning fluid to the fluid loop；

Ultraviolet lamp, it is used for using ultraviolet LED to the cleaning fluid irradiation ultraviolet radiation in the fluid loop；And

20. apparatus for purifying blood according to claim 19, wherein,

The control device can be with part in fluid loop, by the ultraviolet lamp irradiation ultraviolet radiation cleaning fluid Flow correspondingly change the ultraviolet lamp irradiation output.

21. the apparatus for purifying blood according to claim 19 or 20, wherein,

22. apparatus for purifying blood according to claim 21, wherein,

23. the apparatus for purifying blood according to any one of claim 19~22, wherein,

24. a kind of sterilizing methods, wherein,

The sterilizing methods in apparatus for purifying blood, can supply a liquid in blood purification and blood circuit extremely Few fluid loop of any one, using ultraviolet LED, the method sterilized to the liquid irradiation ultraviolet radiation.

25. sterilizing methods according to claim 24, wherein,

The sterilizing methods have following step：

Stoste is mixed into the water in the fluid loop, treatment liquid is made；And

To at least any one irradiation ultraviolet radiation in the treatment liquid in the fluid loop and the water before mixing.

26. a kind of sterilizing methods, wherein,

The sterilizing methods in apparatus for purifying blood, can will treatment liquid be supplied in blood purification and blood circuit At least fluid loop of any one, using ultraviolet LED, to the cleaning fluid irradiation ultraviolet radiation being fed into the fluid loop Come the method sterilized.