JP7129757B2 - Blood purification device and sterilization method - Google Patents

Description

The present invention relates to a blood purification device and a sterilization method.

So-called dialysis treatment is generally performed using a blood purification device, which includes a blood circuit that supplies the patient's blood to a blood purifier comprising a hollow fiber membrane module or the like and returns it to the patient, and a blood purifier. It is equipped with a dialysate circuit and the like that supplies dialysate to the patient's blood and removes waste products from the patient's blood by taking them into the dialysate through hollow fiber membranes. Further, in order to improve treatment efficiency, the dialysate (replacement fluid) of the dialysate circuit is also supplied to the blood circuit side.

By the way, in the above-mentioned dialysis treatment, therapeutic fluids such as dialysate and replacement fluid are used, and in order to reduce the burden on medical staff, it is desirable that these therapeutic fluids can be continuously and automatically replenished to the blood purification apparatus. (See Patent Document 1).

Japanese Patent No. 4458346 Japanese Utility Model Laid-Open No. 4-61542

Therefore, in hospital facilities, for example, it is common to introduce an RO (Reverse Osmosis) system that purifies tap water or well water, and a dialysate preparation system that generates dialysate by adding undiluted solution to the purified water. is.

However, the dialysate may come into contact with the patient's blood, so even with the water supplied from the RO system described above, countermeasures must be taken inside the device to create a highly clean dialysate. is. For example, it is common practice to install an ETRF (endotoxin trapping filter) for removing endotoxin, or to perform cleaning with a chemical solution at the end of treatment.

However, there is a limit to the sterilization performance of the RO system and the sterilization and sterilization ability on the device, and there are cases where bacteria (biofilm) are generated in the dead space in the RO pipe and the pipe inside the device. This is a well-known fact. In addition, it is feared that bacteria may be mixed from the stock solution bottle for supplying the stock solution of the dialysate, and means for preventing the contamination and growth of bacteria inside the apparatus is very important. In addition, before starting dialysis treatment for a day, between dialysis treatments, after dialysis treatment is finished, etc., a washing process is performed in which a washing liquid such as a chemical solution is supplied to the dialysate circuit of the apparatus for washing. The cleaning liquid must also be thoroughly sterilized.

Therefore, the inventor is considering sterilizing the treatment liquid and cleaning liquid in the liquid circuit such as the dialysate circuit using ultraviolet rays. However, the UV irradiation device used in the conventional dialysis device is of a lamp type (see Patent Document 2) and is a large-sized device. Therefore, it must be installed separately from the blood purification apparatus. As a result, it is necessary to set, operate, and control the ultraviolet irradiation device separately from the blood purification device, which increases the burden on the medical staff. In addition, the large-sized lamp-type ultraviolet irradiating device has restrictions on the place where it can be installed, and cannot be installed in a free place according to the needs of the facility.

In addition, the lamp-type UV irradiation device cannot change the output of UV rays (it can only be turned ON/OFF). is irradiated. As a result, there is a fear that sufficient sterilization ability cannot be obtained due to an insufficient amount of ultraviolet irradiation. In addition, there is a possibility that ultraviolet rays are emitted in excess of the necessary amount of ultraviolet rays, shortening the life of the ultraviolet irradiation device and denaturing the components of the dialysate.

The present application has been made in view of the above points, and one of its objects is to realize a blood purification apparatus equipped with a compact ultraviolet irradiation device capable of changing the amount of ultraviolet irradiation and a control device for controlling the ultraviolet irradiation device. do.

As a result of intensive research conducted by the inventors to achieve the above object, the inventors found that the above problems can be solved by using an ultraviolet irradiation device that emits ultraviolet light from an ultraviolet LED and a control device that controls the irradiation output of the ultraviolet irradiation device. , led to the present invention. That is, the present invention includes the following aspects.
(1) A blood purifier, a blood circuit that supplies blood from a patient to the blood purifier and returns it from the blood purifier to the patient, and a liquid circuit that supplies liquid to at least one of the blood purifier and the blood circuit. an ultraviolet irradiation device for irradiating the liquid in the liquid circuit with ultraviolet light from an ultraviolet LED; and a control device for controlling irradiation output of the ultraviolet irradiation device.
(2) The liquid circuit has a function of mixing an undiluted solution with water to generate a therapeutic liquid, and the ultraviolet irradiation device irradiates at least one of the unmixed water and the therapeutic liquid in the liquid circuit with ultraviolet rays. The blood purification device according to (1).
(3) The liquid circuit has a liquid feed pump that feeds liquid in the liquid circuit, and the control device changes the irradiation output of the ultraviolet irradiation device according to the liquid feed flow rate of the liquid feed pump. The blood purification device according to (1) or (2).
(4) The control device according to (1) or (2), wherein the control device changes the irradiation output of the ultraviolet irradiation device according to the liquid flow rate in the portion of the liquid circuit that is irradiated with the ultraviolet rays by the ultraviolet irradiation device. Blood purifier.
(5) The blood purification apparatus according to any one of (1) to (4), wherein the control device changes the irradiation output of the ultraviolet irradiation device in accordance with a decrease in the output of the ultraviolet irradiation device.
(6) The blood purification apparatus according to (5), which has a sensor that detects the irradiation output of the ultraviolet irradiation device.
(7) The blood purification apparatus according to any one of (1) to (6), wherein the control device changes the irradiation output of the ultraviolet irradiation device according to the water quality of the liquid.
(8) The blood purification apparatus according to (7), which has a water quality sensor that detects water quality of the liquid.
(9) Any one of (1) to (8), further comprising a device housing section containing at least part of the liquid circuit, wherein the ultraviolet irradiation device is built into the device housing section. The blood purification device according to .
(10) The liquid circuit of the apparatus housing section has a mixing section for mixing the undiluted solution with water to generate a therapeutic liquid, and the ultraviolet irradiation device is provided in the liquid circuit on the upstream side of the mixing section. The blood purification device according to (9), wherein
(11) The liquid circuit of the apparatus housing section has a mixing section for mixing the undiluted solution with water to generate a treatment liquid, and the ultraviolet irradiation device is provided in the liquid circuit downstream of the mixing section. The blood purification device according to (9), wherein
(12) further comprising a device housing portion containing at least part of the liquid circuit, wherein the ultraviolet irradiation device is provided in the liquid circuit outside the device housing portion; (1) to ( 8) The blood purification device according to any one of the items.
(13) The liquid circuit has a plurality of positions where the ultraviolet irradiation device can be installed, and the control device changes the irradiation output based on the installation position of the ultraviolet irradiation device, (1) to (8) ).
(14) having an installation position detection sensor that detects an installation position of the ultraviolet irradiation device, wherein the control device changes the irradiation output based on the installation position detected by the installation position detection sensor; A blood purification device as described.
(15) The control device has an installation position input unit for inputting an installation position of the ultraviolet irradiation device, and changes the irradiation output based on the installation position input to the installation position input unit. A blood purification device as described.
(16) The control device has a storage unit that stores the irradiation output conditions in the device status for each installation position of the ultraviolet irradiation device, and changes the irradiation output based on the irradiation output conditions in the device status in the storage unit. The blood purification device according to any one of (13) to (15).
(17) The control device has a storage unit that stores irradiation output conditions in the device status, and changes the irradiation output based on the irradiation output conditions of the device status in the storage unit, (1) to (12) The blood purification device according to any one of 1.
(18) The blood purification apparatus according to (16) or (17), which has an irradiation condition setting unit that sets irradiation output conditions for the apparatus status.
(19) a blood purifier, a blood circuit that supplies blood from a patient to the blood purifier and returns it from the blood purifier to the patient, and a liquid that supplies a treatment liquid to at least one of the blood purifier and the blood circuit a circuit, a cleaning liquid supply device that supplies cleaning liquid to the liquid circuit, an ultraviolet irradiation device that irradiates the cleaning liquid in the liquid circuit with ultraviolet light from an ultraviolet LED, and a control device that controls the irradiation output of the ultraviolet irradiation device. , blood purifier.
(20) The blood purification apparatus according to (19), wherein the control device changes the irradiation output of the ultraviolet irradiation device according to the flow rate of the cleaning liquid in the portion of the liquid circuit irradiated with ultraviolet rays by the ultraviolet irradiation device. .
(21) The blood purification apparatus according to (19) or (20), wherein the control device changes the irradiation output of the ultraviolet irradiation device in accordance with a decrease in the output of the ultraviolet irradiation device.
(22) The blood purification apparatus according to (21), which has a sensor that detects the irradiation output of the ultraviolet irradiation device.
(23) The control device has a storage unit that stores irradiation output conditions in the device status, and changes the irradiation output based on the irradiation output conditions of the device status in the storage unit, (19) to (22). The blood purification device according to any one of 1.
(24) A sterilization method, comprising irradiating the liquid with ultraviolet light from an ultraviolet LED to sterilize the liquid in the liquid circuit of the blood purifier that supplies the liquid to at least one of the blood purifier and the blood circuit.
(25) The sterilization according to (24), wherein in the liquid circuit, an undiluted solution is mixed with water to generate a therapeutic liquid, and at least one of the unmixed water or the therapeutic liquid in the liquid circuit is irradiated with an ultraviolet LED. Method.
(26) A sterilization method comprising irradiating ultraviolet light from an ultraviolet LED to the cleaning liquid supplied to the liquid circuit of the blood purification apparatus that supplies the treatment liquid to at least one of the blood purifier and the blood circuit, thereby sterilizing the liquid circuit.

According to the present invention, it is possible to realize a blood purification apparatus equipped with a compact ultraviolet irradiation device capable of changing the amount of ultraviolet irradiation and a control device for controlling the ultraviolet irradiation device. , there is no need to operate and control, which can reduce the burden on medical personnel. In addition, since a small-sized ultraviolet irradiation device is used, the ultraviolet irradiation device can be installed at an appropriate location including the inside of the device housing according to the needs of the facility. Furthermore, since the irradiation amount of ultraviolet rays can be changed, it is possible to irradiate an appropriate amount of ultraviolet rays so as to perform sufficient sterilization.

1 is a schematic diagram showing an outline of the configuration of a blood purification device; FIG. FIG. 3 is a schematic diagram of a blood purification device having an ultraviolet irradiation device in an upstream circuit inside the device casing. FIG. 2 is a schematic diagram of a blood purification device having an ultraviolet irradiation device in a downstream circuit inside the device casing. 1 is a schematic diagram of a blood purification device equipped with a sensor that detects ultraviolet output; FIG. 1 is a schematic diagram of a blood purification device equipped with a water quality sensor; FIG. 1 is a schematic diagram of a blood purification device equipped with a fluid replacement circuit; FIG. 1 is a schematic diagram of a blood purification device equipped with an installation position sensor; FIG. It is a block diagram of a control device. FIG. 4 is an explanatory diagram showing an example of a display screen; FIG. 11 is an explanatory diagram showing another example of the display screen; FIG. 4 is a block diagram of another aspect of the controller; FIG. 10 is an explanatory diagram showing an example of a display screen with an installation position input section; FIG. 4 is a schematic diagram showing another configuration example of the blood purification device; FIG. 4 is an explanatory diagram showing a cleaning process and an output of ultraviolet rays;

Preferred embodiments of the present invention will be described below with reference to the drawings. The following embodiments are examples for explaining the present invention, and the present invention is not limited only to these embodiments. The same elements are denoted by the same reference numerals, and overlapping descriptions are omitted. In addition, unless otherwise specified, positional relationships such as top, bottom, left, and right in the drawings are based on the positional relationships shown in the drawings. Furthermore, the dimensional ratios of the drawings are not limited to the illustrated ratios.

FIG. 1 is a schematic diagram showing an outline of the configuration of a blood purification device 1 according to this embodiment. In this embodiment, for example, a blood purification apparatus 1 for performing dialysis treatment in a treatment room in a hospital will be described as an example.

The blood purification apparatus 1 includes, for example, a blood purifier 10, a blood circuit 11 that supplies blood from a patient to the blood purifier 10 and returns it from the blood purifier 10 to the patient, and a treatment liquid that is a mixture of water and undiluted dialysate. and the dialysate circuit 12 as a liquid circuit for supplying the dialysate to the blood purifier 10; It has an ultraviolet irradiation device 13 for irradiating ultraviolet rays and a control device 14 . In this specification, the term "liquid" includes at least water, therapeutic liquid, stock solution, and washing liquid, and the term "therapeutic liquid" includes at least dialysate and replacement liquid.

The blood purifier 10 is, for example, a hollow fiber membrane module containing a bundle of hollow fiber membranes. A blood circuit 11 is connected to an inlet/outlet on the primary side 10a of the hollow fiber membrane of the blood purifier 10, and a dialysate circuit 12 is connected to an inlet/outlet on the secondary side 10b of the hollow fiber membrane. The blood purifier 10 uses, for example, the osmotic pressure between the primary side 10a and the secondary side 10b of the hollow fiber membrane to remove waste products in the blood on the primary side 10a of the hollow fiber membrane and the secondary side 10b of the hollow fiber membrane. can be incorporated into the dialysate to purify the blood. A soft tube, for example, is used for the channel portion of the "circuit" in the present embodiment.

The blood circuit 11 is provided with a blood pump 30 and a drip chamber 31 for feeding blood, for example.

The dialysate circuit 12 mixes the raw solution A and the raw solution B with RO water (reverse osmosis water) supplied from a pipe in the wall 40 of the treatment room of the hospital facility to generate a dialysate, and the dialysate is used for blood purification. A dialysate supply circuit 50 that supplies the secondary side 10b of the blood purifier 10, and a dialysate discharge circuit 51 that discharges the dialysate drainage that has passed through the secondary side 10b of the blood purifier 10 to a pipe in the wall 40 of the treatment room. have. In addition, in hospital facilities, for example, tap water is taken from tap water, bacteria are removed from the tap water by a filter using an RO membrane (reverse osmosis membrane) to generate RO water, and the RO water is used for each treatment at the facility. A facility is provided to deliver liquid to the wall 40 of the chamber.

The dialysate supply circuit 50 has, for example, an upstream end connected to a pipe in the treatment room wall 40 and a downstream end connected to the secondary side 10 b of the hollow fiber membrane of the blood purifier 10 . . The dialysate supply circuit 50 has, for example, a first liquid-sending pump 60 and a second liquid-sending pump 61 . Between the first liquid-sending pump 60 and the second liquid-sending pump 61 in the dialysate supply circuit 50, a first circuit 63 for introducing the A undiluted solution from the first supply source 62 into the dialysate supply circuit 50 and , a second circuit 65 for introducing the B stock solution of a second supply source 64 into the dialysate supply circuit 50 is connected. In the present embodiment, for example, in the dialysate supply circuit 50 , the mixing portion 66 is a portion where the RO water is mixed with the A and B undiluted solutions.

The dialysate supply circuit 50 is connected to the first chamber 71 of the metering chamber 70 downstream of, for example, the second liquid feed pump 61, and the hollow fiber membrane of the blood purifier 10 is connected downstream of the first chamber 71. is connected to the secondary side 10b of the

Metering chamber 70 has a septum 73, such as a diaphragm, that is displaceable within a body of constant volume. The interior of the quantitative chamber 70 is divided into a first chamber 71 and a second chamber 72 by a partition wall 73 .

The dialysate discharge circuit 51 has, for example, an upstream end connected to the secondary side 10b of the hollow fiber membrane of the blood purifier 10, and a downstream end connected to a pipe inside the wall 40 of the treatment room. . That is, the downstream side of the secondary side 10b of the hollow fiber membrane of the blood purifier 10 in the dialysate discharge circuit 51 is connected to the second chamber 72 of the quantitative chamber 70, and the downstream side of the second chamber 72 is connected to the facility. is connected to piping in the wall 40 of the A circulation pump 80 is provided between the secondary side 10 b of the blood purifier 10 and the second chamber 72 of the metering chamber 70 . The dialysate discharge circuit 51 also has a water removal circuit 90 that connects from the downstream side of the circulation pump 80 to the downstream side of the metering chamber 70 (the wall 40 of the facility) by bypassing the metering chamber 70 . The water removal circuit 90 has a water removal pump 91 .

The blood purification device 1 includes, for example, a device casing 100 in which various devices and devices are built. The apparatus casing 100 incorporates, for example, a first liquid-sending pump 60, a second liquid-sending pump 61, a metering chamber 70, a circulation pump 80, a water removal pump 91, a blood pump 30, a control device 14, and the like. there is In this specification, the term “built-in” refers to a state of being incorporated inside as a part of the device casing section 100 .

The device housing 100 also contains a portion of the dialysate circuit 12 that passes through the pump. That is, a first internal flow path 110 from the upstream side of the first liquid feed pump 60 in the dialysate supply circuit 50 to the downstream side of the metering chamber 70, and the dialysate discharge circuit 51 from the upstream side of the circulation pump 80 to the metered amount. A second internal flow path 111 is built in to the downstream side of the chamber 70, and ports 112 and 113 connected to the external flow path are provided at both ends of the first internal flow path 110 and the second internal flow path 111, respectively. is provided.

The upstream section from the facility wall 40 to the port 112 of the device housing portion 100 in the dialysate supply circuit 50 is formed by a first external connection flow path 120, and is formed from the port 112 of the device housing portion 100 to the blood purifier 10. A downstream section to the secondary side 10b of is formed by a second external connection channel 121 . That is, the dialysate supply circuit 50 is formed by a first external connection channel 120 , a first internal channel 110 and a second external connection channel 121 . In addition, the upstream section from the secondary side 10b of the blood purifier 10 to the port 113 of the device housing portion 100 in the dialysate discharge circuit 51 is formed by the third external connection flow path 122, The downstream section from port 113 to facility wall 40 is formed by a fourth external connecting channel 123 . That is, the dialysate discharge circuit 51 is formed by the third external connection channel 122 , the second internal channel 111 and the fourth external connection channel 123 .

For example, the blood purifier 10 , the blood circuit 11 and the drip chamber 31 are not built in the device housing 100 and are detachable from the device housing 100 . The blood purifier 10, blood circuit 11 and drip chamber 31 are replaced for each treatment.

The ultraviolet irradiation device 13 is provided, for example, in the first external connection channel 120 outside the device casing 100 . The ultraviolet irradiation device 13 has an ultraviolet LED as a light source, and can irradiate the RO water flowing through the first external connection channel 120 with ultraviolet rays for sterilization. The ultraviolet LED preferably has an irradiation angle of 120 degrees or more, a wavelength range of 250 to 280 nm, and an output of 5 mW or more (when a plurality of ultraviolet LEDs are used, the total output is 5 mW or more). The flow rate of the liquid irradiated with ultraviolet rays by the ultraviolet irradiation device 13 is preferably 300 mL/min or more and 1200 mL/min or less. In addition, the ultraviolet irradiation device 13 may be detachable from the surface of the device housing portion 100 .

The control device 14 is, for example, a computer that controls the overall operation of the blood purification apparatus 1, and includes, for example, the first liquid-sending pump 60, the second liquid-sending pump 61, the metering chamber 70, the circulation pump 80, and the water removal pump 91. , the blood pump 30, the ultraviolet irradiation device 13, and valves (not shown), etc. can be controlled to operate the blood purification device 1 so as to perform the blood purification process.

For example, the control device 14 executes a program stored in the storage unit and varies the irradiation output of the ultraviolet irradiation device 13 according to the liquid feeding flow rate of the first liquid feeding pump 60, for example. For example, when the liquid feeding flow rate is high, the ultraviolet irradiation output is increased, and when the liquid feeding flow rate is low, the ultraviolet irradiation output is decreased. The value of the liquid-feeding flow rate in the first liquid-feeding pump 60 may be grasped by the control device 14 from the set flow rate of the first liquid-feeding pump 60, or may be determined by providing a flow rate sensor in the flow path and obtaining the detected value. , the control device 14 may grasp.

In addition, the control device 14 can control ON/OFF of irradiation of the ultraviolet rays of the ultraviolet irradiation device 13 according to the device status (operation process) of the blood purification device 1 and the output intensity of the LED. For example, the control device 14 can be used to clean the circuit before the start of the blood purification process (for example, a step of flushing the dialysate circuit 12 with cleansing water (RO water)), during the blood purification process, and after the end of the blood purification process. During cleaning (for example, a process of washing by flowing a cleaning liquid (RO water, chemical liquid, etc.) into the dialysate circuit 12), during standby (when neither blood purification processing nor circuit cleaning is being performed), UV rays are emitted depending on the device status. It is possible to switch ON/OFF of the irradiation of the LED and change the output intensity of the LED.

The blood purification apparatus 1 configured as described above performs, for example, the following blood purification process. For example, after the puncture needle (not shown) of the blood circuit 11 is punctured into the patient, the blood pump 30 is activated, and blood is circulated through the blood circuit 11 and the primary side 10a of the hollow fiber membrane of the blood purifier 10. On the other hand, in the dialysate circuit 12 , the first liquid-sending pump 60 and the second liquid-sending pump 61 operate, and the dialysate is stored in the first chamber 71 of the metering chamber 70 . At this time, in the dialysate supply circuit 50 , the RO water flows from the facility wall 40 toward the device housing 100 and is irradiated with ultraviolet rays when passing through the ultraviolet irradiation device 13 . At this time, the flow rate of RO water may be 300 mL/min or more and 1200 mL/min or less. This sterilizes the bacteria in the RO water. It should be noted that the irradiation of ultraviolet rays may be turned on and off according to the turning on and off of the first liquid feed pump 60, for example, when the RO water is flowing. The sterilized RO water flows toward the metering chamber 70 in the device housing 100, and the undiluted solution A and the undiluted solution B are mixed from the first circuit 63 and the second circuit 65 in the mixing unit 66, and are used as the treatment liquid. of dialysate is produced. At this time, for example, first, the first liquid-sending pump 60 is stopped, the second liquid-sending pump 61 is activated, and a predetermined amount of undiluted solution A and undiluted B is introduced into the mixing section 66, and then the first A dialysate having a predetermined concentration may be generated by operating the liquid feed pump 60 to introduce RO water into the mixing section 66 . The produced dialysate is stored in the first chamber 71 of the metering chamber 70 .

When the dialysate is stored in the first chamber 71 of the metering chamber 70, the circulation pump 80 is then activated, and the dialysate in the first chamber 71 is passed through the dialysate supply circuit 50 to the hollow fiber membrane of the blood purifier 10. is supplied to the secondary side 10b of the At this time, the dialysate takes in waste products from the blood flowing through the primary side 10a of the hollow fiber membrane of the blood purifier 10 and purifies the blood.

After passing through the secondary side 10 b of the hollow fiber membrane of the blood purifier 10 , the dialysate drain flows through the dialysate drain circuit 51 into the second chamber 72 of the metering chamber 70 . At this time, the partition wall 73 of the metering chamber 70 moves, and the volume of the second chamber 72 increases by the amount that the volume of the first chamber 71 decreases. In addition, the water removal pump 91 of the water removal circuit 90 also operates, and part of the dialysate is discharged to the downstream side of the dialysate discharge circuit 51 through the water removal circuit 90 without passing through the metering chamber 70 . The amount of dialysis effluent passing through the water removal circuit 90 corresponds to the amount of water removed from the patient's blood in the blood purifier 10 .

Next, the dialysate is again produced from the RO water in the dialysate supply circuit 50, the dialysate is stored in the first chamber 71 of the metering chamber 70, the partition wall 73 is moved along with it, and the second chamber 72 is moved. Dialysate drains through the dialysate drain circuit 51 towards the walls 40 of the facility.

The above steps are repeated to perform dialysis treatment (blood purification treatment).

According to the present embodiment, the ultraviolet irradiation device 13 can be miniaturized by using the ultraviolet irradiation device 13 that irradiates the ultraviolet rays from the ultraviolet LED as the light source. can be incorporated. Therefore, the irradiation output of the ultraviolet irradiation device 13 can be controlled by the control device 14 of the blood purification device 1. As a result, there is no need to set, operate, and control the ultraviolet irradiation device separately from the blood purification device 1. It can reduce the burden on people.

The control device 14 changes the irradiation output of the ultraviolet irradiation device 13 in accordance with the liquid feeding flow rate of the first liquid feeding pump 60. Therefore, when the liquid feeding flow rate is high, for example, the ultraviolet irradiation output is increased to reduce the liquid feeding flow rate. When there is little, the irradiation output of ultraviolet rays can be lowered. As a result, RO water can be sterilized reliably, and unnecessary irradiation can be reduced to reduce costs.

Since the ultraviolet irradiation device 13 is provided in the dialysate circuit 12 outside the device casing 100, maintenance of the ultraviolet irradiation device 13 can be easily performed. In addition, since the ultraviolet irradiation device 13 is provided in the dialysate circuit 12 (first external connection channel 120) upstream of the device housing 100, bacteria enter the device housing 100 and propagate. can be prevented. In addition, it is possible to prevent formation of a biofilm, which is difficult to clean, inside the device casing 100 .

In the above embodiment, the ultraviolet irradiation device 13 may be built in the device casing 100 . In such a case, for example, the ultraviolet irradiation device 13 may be provided in the dialysate circuit 12 on the upstream side of the mixing section 66 as shown in FIG. In this case, the ultraviolet irradiation device 13 may be provided in the first internal channel 110 on the upstream side of the first liquid-sending pump 60 immediately after the port 112 on the upstream side of the device casing 100 . By doing so, the ultraviolet irradiation device 13 is incorporated in the device casing 100, so that the blood purification device 1 including the ultraviolet irradiation device 13 can be slimmed down. In addition, since the ultraviolet irradiation device 13 is located upstream of the device housing 100, it is possible to prevent bacteria from entering and propagating in the device housing 100, and a biofilm that is difficult to clean is formed on the device housing 100. can be prevented. In addition, since the ultraviolet irradiation device 13 is provided inside the device housing 100, it does not interfere with work such as filter replacement and chemical replenishment in the same device. In addition, there is no possibility that ultraviolet rays are emitted to the outside. Furthermore, deterioration of the parts of the device can be suppressed because they are not exposed to sunlight.

Furthermore, as shown in FIG. 3 , the ultraviolet irradiation device 13 may be provided in the dialysate circuit 12 downstream of the mixing section 66 . In such a case, it may be provided in the first internal channel 110 immediately before the port 112 on the downstream side of the device housing section 100 . In this case, the mixed dialysate is irradiated with ultraviolet rays. By doing so, even if the A stock solution or the B stock solution contains bacteria, it is possible to prevent the viable bacteria from entering the blood purifier 10 . Further, the ultraviolet irradiation device 13 may be provided downstream of the mixing section 66 and downstream of the quantification chamber 70 . In this case, the UV irradiation device 13 may be provided, for example, between the metering chamber 70 and the port 112 . In such a case, the dialysate can be efficiently sterilized because the ultraviolet rays are irradiated after the mixture of the RO water and the stock solutions A and B and the flow rate of the mixture are stabilized. Furthermore, if there is a mixing section for promoting mixing of RO water, stock solution A and stock solution B on the downstream side of the quantitative chamber 70, the UV irradiation device 13 may be provided downstream of the mixing section.

In the above embodiment, the control device 14 may change the irradiation output of the ultraviolet irradiation device 13 according to the output reduction of the ultraviolet irradiation device 13 . In such a case, as shown in FIG. 4, the ultraviolet irradiation device 13 is provided with an output sensor (photodiode) 125 for detecting the actual ultraviolet output of the ultraviolet irradiation device 13 . The output sensor 125 is mounted, for example, on the substrate of the ultraviolet LED. A detection result of the output sensor 125 is output to the control device 14 . The control device 14 adjusts the applied current value (irradiation output) to the ultraviolet LED of the ultraviolet irradiation device 13 based on the detection result of the output of ultraviolet rays by the output sensor 125 . For example, when the ultraviolet LED deteriorates and the actual ultraviolet output decreases, the current value applied to the ultraviolet LED of the ultraviolet irradiation device 13 is increased to secure the ultraviolet irradiation amount necessary for sterilization. Also, when the actual output of ultraviolet rays falls below a certain threshold, an alarm is output to prompt the user to replace the ultraviolet LED. The decrease in the output of the ultraviolet irradiation device 13 may not be detected by the output sensor 125, and may be estimated based on, for example, a preset life of the ultraviolet LED. That is, when a predetermined percentage of the life of the ultraviolet LED has passed, it is estimated that the irradiation output of the ultraviolet irradiation device 13 has decreased, and the irradiation output setting of the ultraviolet irradiation device 13 may be increased accordingly. .

In the above embodiment, the control device 14 may change the irradiation output of the ultraviolet irradiation device 13 according to the water quality of the liquid in the dialysate circuit 12 . In such a case, as shown in FIG. 5, the dialysate circuit 12 is provided with a water quality sensor 150 that detects the water quality of the RO water. For the water quality sensor 150, for example, a TOC meter capable of detecting the number of bacteria and the degree of contamination of RO water, a bacteria count measuring device, and a water quality inspection device such as an ET inspection device are used. The water quality sensor 150 is provided upstream of the dialysate circuit 12 , for example, the ultraviolet irradiation device 13 . A detection result of the water quality sensor 150 is output to the control device 14 . The control device 14 adjusts the current value (irradiation output) applied to the ultraviolet LED of the ultraviolet irradiation device 13 based on the detection result of the RO water quality of the water quality sensor 150 . For example, when the quality of RO water is lower than a predetermined lower limit threshold, the irradiation output of the ultraviolet irradiation device 13 is increased to secure the amount of ultraviolet irradiation required for sterilization. Further, when the water quality of the RO water is within a predetermined appropriate range, the ultraviolet irradiation device 13 performs ultraviolet irradiation with a normal irradiation output. The setting location of the water quality sensor 150 can be arbitrarily selected, and the water quality sensor 150 may detect not only the water quality of RO water but also the water quality of the produced dialysate. Note that the water quality of the liquid may be detected without using the water quality sensor 150 . In this case, for example, RO water (from the RO device or RO piping) or dialysate (from the dialysate piping) is periodically sampled, analyzed, and tested for water quality. The control device 14 may change the irradiation output of the ultraviolet irradiation device 13 by inputting to the operation screen (water quality input section).

In the above embodiment, the RO water before mixing and the dialysate after mixing supplied to the blood purifier 10 are irradiated with ultraviolet rays. Ultraviolet rays may be applied to the dialysate or replacement fluid as the treatment fluid. In such a case, for example, the blood purification apparatus 1 has a replacement fluid circuit 130 connected from the dialysate supply circuit 50 to the drip chamber 31 of the blood circuit 11, as shown in FIG. A replacement fluid pump 131 is provided in the replacement fluid circuit 130 . The RO water before mixing, which is finally supplied to the blood circuit 11 through the replacement fluid circuit 130, or the replacement fluid produced by mixing the undiluted fluid may be irradiated with ultraviolet rays. The replacement fluid circuit 130 may be connected to either upstream or downstream of the blood purifier 10 in the blood circuit 11 .

Although the ultraviolet irradiation device 13 is provided at one location, it may be provided at a plurality of locations. For example, the outside of the device housing unit 100 shown in FIG. 1, the dialysate supply circuit 50 on the upstream side of the mixing unit 66 inside the device housing unit 100 shown in FIG. It may be provided in all or any two places of the dialysate supply circuit 50 on the downstream side of the mixing section 66 inside. Moreover, the ultraviolet irradiation device 13 may be provided at another location.

Further, the blood purification apparatus 1 has a plurality of positions where the ultraviolet irradiation device 13 can be installed in the dialysate circuit 12, and the control device 14 changes the irradiation output based on the installation position of the ultraviolet irradiation device 13. can be For example, the blood purification device 1 includes the outside of the device housing portion 100 shown in FIG. It has an installable position in the dialysate supply circuit 50 on the downstream side of the mixing unit 66 inside the device casing 100 , and the user can select the setting position of the ultraviolet irradiation device 13 .

The blood purification apparatus 1 has an installation position detection sensor 160 for detecting the installation position of the ultraviolet irradiation device 13, as shown in FIG. The installation position detection sensor 160 is installed, for example, at a place where the ultraviolet irradiation device 13 is installed, and responds electrically or mechanically when the ultraviolet irradiation device 13 is installed, and can output the information to the control device 14 .

For example, as shown in FIG. 8, the control device 14 includes an irradiation condition setting unit 170 for setting the irradiation output condition of the device status for each installation position of the ultraviolet irradiation device 13 detected by the installation position detection sensor 160, and an irradiation condition setting unit. It has a storage unit 171 that stores the irradiation output conditions of the device status for each installation position of the ultraviolet irradiation device 13 set in 170 .

For example, the irradiation condition setting unit 170 is, for example, a touch panel input screen 180 on the apparatus display as shown in FIGS. It is possible to input output conditions, for example, irradiation output high/low and OFF. The input screen 180 may display the lifetime of the ultraviolet LED and the detection value of the output sensor 125 .

In this case, the control device 14 first detects the installation position of the ultraviolet irradiation device 13 by the installation position detection sensor 160, and based on the installation position of the ultraviolet irradiation device 13, as shown in FIGS. An input screen 180 for device status to be displayed. When the irradiation output condition for each device status is input to the input screen 180 , the control device 14 stores the irradiation output condition for that device status in the storage unit 171 .

Then, the control device 14 changes the irradiation output according to the irradiation output conditions of the device status for each installation position of the ultraviolet irradiation device 13 stored in the storage unit 171 . For example, the control device 14 controls the device status when the circuit is cleaned (priming) before the start of the blood purification process, when the blood purification process (treatment) is performed, when the circuit is cleaned after the completion of the blood purification process, and when the circuit is cleaned during the blood purification process. The irradiation output of the LED is changed according to the irradiation output conditions (High/Low/OFF) of the ultraviolet ray according to the standby time when the UV irradiation is not performed.

For example, when the ultraviolet irradiation device 13 is provided on the downstream side of the mixing section 66, in order to prevent contamination of bacteria from the A and B undiluted solutions, a high output is applied during priming and treatment as shown in FIG. UV rays are applied. The level of the output of ultraviolet rays during treatment may be changed depending on the type of treatment. When the dialysate during treatment is directly supplied to the blood circuit 11, the ultraviolet rays are irradiated at a high output, and the dialysate is supplied to the blood purifier. 10, UV light may be applied at a low power. Further, for example, when the ultraviolet irradiation device 13 is provided upstream of the mixing section 66, as shown in FIG. 10, ultraviolet rays are irradiated at a high output during priming and cleaning, and ultraviolet rays are irradiated at a low output during treatment. be irradiated.

According to this example, the blood purification apparatus 1 has a plurality of positions where the ultraviolet irradiation device 13 can be installed, and the control device 14 changes the irradiation output based on the installation position of the ultraviolet irradiation device 13. While improving the flexibility of the installation position of the irradiation device 13, it is possible to irradiate ultraviolet rays with an output suitable for the installation position.

Since the blood purification apparatus 1 has the installation position detection sensor 160 for detecting the installation position of the ultraviolet irradiation device 13, the installation position of the ultraviolet irradiation device 13 can be detected automatically and accurately.

The control device 14 has a storage unit 171 that stores the irradiation output conditions in the device status for each installation position of the ultraviolet irradiation device 13, and changes the irradiation output based on the irradiation output conditions in the device status of the storage unit 171. . Thereby, the irradiation of the ultraviolet LED can be optimized, and the life of the ultraviolet LED can be extended. In addition, when UV irradiation is not desirable, for example, in equipment status where cleaning is performed using a chemical solution that increases chemical attack due to UV irradiation, chemical attack can be prevented by avoiding UV irradiation or suppressing irradiation output. .

Since the blood purification apparatus 1 has the irradiation condition setting unit 170 for setting the irradiation output conditions of the apparatus status, the user's operability can be improved. For example, the degree of cleanliness (dirtyness) of RO water and undiluted dialysate solution differs from facility to facility. In facilities where the water is highly clean, it is possible to set the lighting only for equipment statuses that are likely to cause the growth of bacteria (such as before nighttime shutdown). Therefore, irradiation output conditions can be customized for each facility.

In the above embodiment, the control device 14 has an installation position input unit 190 for inputting the installation position of the ultraviolet irradiation device 13 as shown in FIG. The irradiation output may be changed. In such a case, the installation position input unit 190 can be manually selected on an input screen 180 of a touch panel as shown in FIG. 12, for example. In such a case, user operability can be improved. In addition, since it is not necessary to provide an installation position sensor, the cost of the device can be reduced accordingly.

In the above embodiment, the control device 14 changes the irradiation output for each installation position of the ultraviolet irradiation device 13 based on the irradiation output conditions of the device status. Regardless, as shown in FIG. 8, a storage unit 171 for storing the irradiation output conditions in the device status may be provided, and the irradiation output may be changed based on the irradiation output conditions in the device status in the storage unit 171. . In this case, the control device 14 may also include an irradiation condition setting unit 170 that sets irradiation output conditions for the device status. As shown in FIGS. 9 and 10, for example, the irradiation output conditions in the apparatus status are set for each of a plurality of apparatus statuses, such as priming, treatment, cleaning, and standby, such as irradiation output level and OFF. It may be set.

In the above-described embodiment, the dialysate circuit 12 is washed by flowing the washing liquid into the dialysate circuit 12 before the start of the blood purification process, during the interruption of the blood purification process, and after the end of the blood purification process. The ultraviolet irradiation device 13 may irradiate the washing liquid flowing through the dialysate circuit 12 with ultraviolet rays during the washing process. Note that the cleaning liquid includes all liquids that flow through the dialysate circuit 12 during the cleaning process, such as RO water, undiluted chemical solutions, and chemical solutions.

For example, as shown in FIG. is connected to the undiluted solution circuit 201 of . This undiluted solution circuit 201 is provided with an opening/closing valve (not shown). In the present embodiment, the cleaning liquid supply device is composed of the undiluted liquid supply source 200, the undiluted liquid circuit 201, and the opening/closing valve.

When the washing process is performed, sterilized RO water is supplied to the dialysate supply circuit 50 of the dialysate circuit 12, and the undiluted chemical solution of the undiluted solution supply source 200 is supplied to the dialysate supply circuit 50 through the undiluted solution circuit 201. , and the undiluted chemical solution and RO water are mixed to generate the chemical solution. At this time, for example, first, the first liquid-sending pump 60 is stopped, the second liquid-sending pump 61 is activated, and a predetermined amount of undiluted chemical solution is introduced into the mixing section 66, and then the first liquid-sending pump is activated. By actuating 60 and introducing RO water into the mixing section 66, a chemical liquid with a predetermined concentration may be generated. The produced chemical solution is stored in the first chamber 71 of the quantitative chamber 70 . After that, the drug solution is discharged without passing through the blood purifier 10 through the first external connection channel 121, a bypass circuit (not shown), or the like.

When the ultraviolet irradiation device 13 is upstream of the mixing unit 66 of the dialysate circuit 12, the RO water before mixing is irradiated with ultraviolet rays, and when it is downstream of the mixing unit 66 of the dialysate circuit 12. , the chemical solution is irradiated with ultraviolet rays. At this time, the irradiation output of the ultraviolet irradiation device 13 is set by the control device 14 according to, for example, the type and flow rate of the cleaning liquid. According to this example, since the cleaning liquid is sufficiently sterilized, the cleaning effect of the cleaning liquid can be ensured. Also, the cleaning effect can be enhanced by irradiating the cleaning liquid with ultraviolet rays. It should be noted that the cleaning liquid does not necessarily need to be generated within the apparatus, and may be generated on the upstream side of the wall 40 or supplied from a cleaning liquid reservoir located on the upstream side of the wall 40. may

The cleaning process may have a plurality of device statuses corresponding to a plurality of cleaning processes, and the LED irradiation output may be changed according to the UV irradiation output conditions of each device status. For example, the control device 14 has a storage unit 171 (shown in FIGS. 8 and 11) that stores the irradiation output conditions in the device status, and changes the irradiation output based on the irradiation output conditions in the device status of the storage unit 171. do. For example, in the cleaning process (cleaning process performed at the end of the day) performed after the end of the blood purification process, as shown in FIG. etc., an acid washing step of washing the circuit with an acid solution (acidic solution) such as an aqueous solution of acetic acid, an aqueous solution of citric acid, or an aqueous solution of peracetic acid, an acid solution storage step of storing the acid solution in the dialysate circuit 12, an acid A post-acid washing step of washing with RO water or the like after washing, a chemical disinfection step of disinfecting the circuit with a chemical solution such as an aqueous solution of sodium hypochlorite, a chemical solution storage step of storing the chemical solution in the dialysate circuit 12, and RO water after the chemical solution disinfection. It has a water washing step after chemical disinfection to wash with etc.

For example, in the water washing process, ultraviolet rays are irradiated with an intermediate output, and in the acid washing process, ultraviolet rays are irradiated with a low output. In the acid liquid storage step, the ultraviolet irradiation is stopped, and in the post-acid cleaning and water washing step, the ultraviolet rays are irradiated with an intermediate output. In the chemical solution disinfection step, ultraviolet rays are irradiated at a low output, in the chemical solution storage step, the irradiation of ultraviolet rays is stopped, and in the washing step after chemical disinfection, the ultraviolet rays are irradiated at a high output.

The reason why ultraviolet rays are irradiated at a low output in the acid washing process and the chemical disinfection process is to prevent chemical attack on the acid solution and the chemical solution by the ultraviolet rays, and the ultraviolet irradiation is stopped in the acid solution storage process and the chemical solution storage process. This is because there is no liquid flow and the sterilization effect is low. In addition, the irradiation of UV rays at a high output in the water washing process after chemical disinfection is because, for example, if live bacteria exist in the RO water stored in the equipment at night, they will proliferate at night and cause equipment contamination (generation of biofilm). This is because the sterilization is actively performed. The intermediate output is an output between a high output and a low output, and is set in the control device 14 as ultraviolet irradiation output conditions (High/Middle/Low/OFF).

In addition, the washing process includes a mode in which only the water washing process is performed, a mode in which after the water washing process, an acid washing process, an acid solution storage process, and a water washing process after acid washing are performed. It may be a mode in which a water washing process is performed, and in this case, the irradiation output of ultraviolet rays may be changed as described above in each process of each mode. Further, the washing may be performed by a hot water washing process or a citric acid hot water washing process.

In this example of irradiating the washing liquid in the dialysate circuit 12 with ultraviolet rays, the control device 14 may change the irradiation output of the ultraviolet irradiation device 14 in accordance with the decrease in the output of the ultraviolet irradiation device 14 as described above. However, at this time, the blood purification apparatus 1 may include a sensor 125 (shown in FIG. 4) that detects the irradiation output of the ultraviolet irradiation device 14 .

In the above embodiment, the control device 14 changes the irradiation output of the ultraviolet irradiation device 13 according to the liquid feeding flow rate of the liquid feeding pump 60, but the dialysate irradiated with ultraviolet rays by the ultraviolet irradiation device 13 The irradiation output of the ultraviolet irradiation device 13 may be changed according to the flow rate of the liquid in the portion of the circuit 12 or the flow rate of the cleaning liquid. In this case, the liquid flow rate of the portion of the dialysate circuit 12 irradiated with ultraviolet rays by the ultraviolet irradiation device 13 may be grasped, for example, by the flow rate of the liquid feed pump 60 or the switching timing of the metering chamber 70, or the dialysate circuit. It may be grasped by a flow meter installed in the irradiation part of 12 ultraviolet rays. When the liquid flow rate in the portion of the dialysate circuit 12 irradiated with ultraviolet rays by the ultraviolet irradiation device 13 is high, the irradiation output of the ultraviolet irradiation device 13 is increased to reduce the liquid flow rate in the portion of the dialysate circuit 12 irradiated with ultraviolet rays. If it is less, the irradiation output of the ultraviolet irradiation device 13 is lowered. In this case, the liquid flowing through the dialysate circuit 12 can be irradiated with an appropriate amount of ultraviolet rays.

For example, the configuration of the blood purification device 1 described in the above embodiments is not limited to this. For example, the dialysate supply circuit 50 may be provided with a filter for removing endotoxins and bacteria in the dialysate. Further, the dialysate generating mechanism for mixing the stock solution with the RO water to generate the dialysate is not limited to this, and other mechanisms and methods may be used to generate the dialysate.

For example, the configuration of the blood purification apparatus 1 is not limited to that of the above embodiments. For example, the dialysate supply circuit 50 is used for the type of blood purification treatment, such as dialysis treatment, continuous hemofiltration (CHF), continuous hemodiafiltration (CHD), continuous hemodiafiltration (CHD), and continuous hemodiafiltration. Depending on dialysis (CHDF: Continuous HemoDiaFiltration), connection to the blood circuit 11, connection to the blood purifier 10, or connection to both of them may be selected. The present invention can also be applied to a blood purification apparatus that performs blood purification treatment other than dialysis treatment.

Although the preferred embodiments of the present invention have been described above with reference to the accompanying drawings, the present invention is not limited to such examples. It is obvious that a person skilled in the art can conceive various modifications or modifications within the scope of the idea described in the claims, and these naturally belong to the technical scope of the present invention. understood as a thing.

INDUSTRIAL APPLICABILITY The present invention is useful in realizing a blood purification apparatus equipped with a compact ultraviolet irradiation device capable of changing the amount of ultraviolet irradiation and a control device for controlling the ultraviolet irradiation device.

1 blood purifier 10 blood purifier 11 blood circuit 12 dialysate circuit 13 ultraviolet irradiation device 14 controller

Claims (22)

blood purifier and
a blood circuit that supplies blood from a patient to the blood purifier and returns it from the blood purifier to the patient;
a liquid circuit for supplying liquid to at least one of the blood purifier and the blood circuit;
an ultraviolet irradiation device for irradiating the liquid in the liquid circuit with ultraviolet light from an ultraviolet LED;
and a control device that controls the irradiation output of the ultraviolet irradiation device,
The blood purification apparatus, wherein the control device has a storage unit that stores irradiation output conditions in the device status, and changes the irradiation output based on the irradiation output conditions of the device status in the storage unit. The liquid circuit has a function of mixing a stock solution with water to generate a treatment liquid,
2. The blood purification apparatus according to claim 1, wherein said ultraviolet irradiation device irradiates at least one of premixed water and treatment liquid in said liquid circuit with ultraviolet rays. The liquid circuit has a liquid transfer pump that transfers liquid in the liquid circuit,
3. The blood purification apparatus according to claim 1, wherein said control device changes the irradiation output of said ultraviolet irradiation device in accordance with the flow rate of liquid sent by said liquid-sending pump. 3. The blood purification apparatus according to claim 1, wherein said control device changes the irradiation output of said ultraviolet irradiation device in accordance with the liquid flow rate of a portion of the liquid circuit irradiated with ultraviolet rays by said ultraviolet irradiation device. 5. The blood purification apparatus according to any one of claims 1 to 4, wherein said control device changes the irradiation output of said ultraviolet irradiation device according to a decrease in the output of said ultraviolet irradiation device. 6. The blood purification apparatus according to claim 5, further comprising a sensor for detecting irradiation output of said ultraviolet irradiation device. 7. The blood purification apparatus according to any one of claims 1 to 6, wherein said control device changes the irradiation output of said ultraviolet irradiation device according to the water quality of said liquid. 8. The blood purification apparatus according to claim 7, further comprising a water quality sensor for detecting water quality of said liquid. further comprising a device housing section containing at least part of the liquid circuit;
The blood purification device according to any one of claims 1 to 8, wherein said ultraviolet irradiation device is built in said device casing. The liquid circuit of the device housing has a mixing section for mixing the stock solution with water to generate the therapeutic liquid,
10. The blood purification apparatus according to claim 9, wherein said ultraviolet irradiation device is provided in a liquid circuit upstream of said mixing section. The liquid circuit of the device housing has a mixing section for mixing the stock solution with water to generate the therapeutic liquid,
10. The blood purification apparatus according to claim 9, wherein said ultraviolet irradiation device is provided in a liquid circuit downstream of said mixing section. further comprising a device housing section containing at least part of the liquid circuit;
The blood purification device according to any one of claims 1 to 8, wherein said ultraviolet irradiation device is provided in a liquid circuit outside said device casing. Having a plurality of installable positions for the ultraviolet irradiation device in the liquid circuit,
The blood purification apparatus according to any one of claims 1 to 8, wherein said control device changes irradiation output based on an installation position of said ultraviolet irradiation device. Having an installation position detection sensor that detects the installation position of the ultraviolet irradiation device,
14. The blood purification apparatus according to claim 13, wherein said control device changes irradiation output based on the installation position detected by said installation position detection sensor. 15. The blood according to claim 14, wherein the control device has an installation position input unit for inputting an installation position of the ultraviolet irradiation device, and changes irradiation output based on the installation position input to the installation position input unit. purifier. 16. The blood purification apparatus according to any one of claims 13 to 15, wherein said storage unit stores irradiation output conditions in apparatus status for each installation position of said ultraviolet irradiation apparatus. The blood purification apparatus according to any one of claims 1 to 16, further comprising an irradiation condition setting unit for setting irradiation output conditions for said apparatus status. blood purifier and
a blood circuit that supplies blood from a patient to the blood purifier and returns it from the blood purifier to the patient;
a liquid circuit that supplies therapeutic liquid to at least one of the blood purifier and the blood circuit;
a cleaning liquid supply device that supplies cleaning liquid to the liquid circuit;
an ultraviolet irradiation device for irradiating the cleaning liquid in the liquid circuit with ultraviolet light from an ultraviolet LED;
and a control device that controls the irradiation output of the ultraviolet irradiation device,
The blood purification apparatus, wherein the control device has a storage unit that stores irradiation output conditions in the device status, and changes the irradiation output based on the irradiation output conditions of the device status in the storage unit. 19. The blood purification apparatus according to claim 18, wherein said control device changes the irradiation output of said ultraviolet irradiation device according to the flow rate of the cleaning liquid in the portion of the liquid circuit irradiated with ultraviolet rays by said ultraviolet irradiation device. 20. The blood purification apparatus according to claim 18, wherein said control device changes the irradiation output of said ultraviolet irradiation device according to a decrease in output of said ultraviolet irradiation device. 21. The blood purification apparatus according to claim 20, comprising a sensor for detecting irradiation output of said ultraviolet irradiation device. 22. The control device according to any one of claims 18 to 21, further comprising a storage section for storing irradiation output conditions in the device status, and changing the irradiation output based on the irradiation output conditions of the device status in the storage section. blood purification device.

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