JP2017173334A5 - - Google Patents
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- Publication number
- JP2017173334A5 JP2017173334A5 JP2017092161A JP2017092161A JP2017173334A5 JP 2017173334 A5 JP2017173334 A5 JP 2017173334A5 JP 2017092161 A JP2017092161 A JP 2017092161A JP 2017092161 A JP2017092161 A JP 2017092161A JP 2017173334 A5 JP2017173334 A5 JP 2017173334A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- fluorouracil
- specimen
- cancer
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 10
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 5
- 239000002246 antineoplastic agent Substances 0.000 claims 5
- 229960002949 fluorouracil Drugs 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 5
- 229960001756 oxaliplatin Drugs 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 230000035945 sensitivity Effects 0.000 claims 3
- OYIFNHCXNCRBQI-UHFFFAOYSA-N 2-aminoadipic acid Chemical compound OC(=O)C(N)CCCC(O)=O OYIFNHCXNCRBQI-UHFFFAOYSA-N 0.000 claims 2
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 claims 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960003180 glutathione Drugs 0.000 claims 1
- 229940029575 guanosine Drugs 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012037448 | 2012-02-23 | ||
| JP2012037448 | 2012-02-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014500945A Division JP6141824B2 (ja) | 2012-02-23 | 2013-02-22 | 併用抗がん剤の感受性判定マーカー |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018140928A Division JP6527994B2 (ja) | 2012-02-23 | 2018-07-27 | 併用抗がん剤の感受性判定マーカー |
| JP2018140929A Division JP2018169409A (ja) | 2012-02-23 | 2018-07-27 | 併用抗がん剤の感受性判定マーカー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017173334A JP2017173334A (ja) | 2017-09-28 |
| JP2017173334A5 true JP2017173334A5 (enExample) | 2017-11-16 |
| JP6381735B2 JP6381735B2 (ja) | 2018-08-29 |
Family
ID=49005852
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014500945A Expired - Fee Related JP6141824B2 (ja) | 2012-02-23 | 2013-02-22 | 併用抗がん剤の感受性判定マーカー |
| JP2017092161A Expired - Fee Related JP6381735B2 (ja) | 2012-02-23 | 2017-05-08 | 併用抗がん剤の感受性判定マーカー |
| JP2018140928A Expired - Fee Related JP6527994B2 (ja) | 2012-02-23 | 2018-07-27 | 併用抗がん剤の感受性判定マーカー |
| JP2018140929A Ceased JP2018169409A (ja) | 2012-02-23 | 2018-07-27 | 併用抗がん剤の感受性判定マーカー |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014500945A Expired - Fee Related JP6141824B2 (ja) | 2012-02-23 | 2013-02-22 | 併用抗がん剤の感受性判定マーカー |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018140928A Expired - Fee Related JP6527994B2 (ja) | 2012-02-23 | 2018-07-27 | 併用抗がん剤の感受性判定マーカー |
| JP2018140929A Ceased JP2018169409A (ja) | 2012-02-23 | 2018-07-27 | 併用抗がん剤の感受性判定マーカー |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9733256B2 (enExample) |
| EP (3) | EP2818870A4 (enExample) |
| JP (4) | JP6141824B2 (enExample) |
| CN (2) | CN104169721A (enExample) |
| WO (1) | WO2013125675A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012127984A1 (ja) * | 2011-03-24 | 2012-09-27 | 学校法人慶應義塾 | 抗がん剤感受性の判定マーカー |
| US9733256B2 (en) | 2012-02-23 | 2017-08-15 | Keio University | Combined anticancer drug sensitivity-determining marker |
| EP3550306B1 (en) * | 2014-08-26 | 2021-03-03 | Keio University | Anti-cancer agent sensitivity-determining marker |
| US20200191772A1 (en) * | 2017-03-31 | 2020-06-18 | Keio University | Combined anticancer agent sensitivity determination marker |
| EP3779451A4 (en) * | 2018-03-29 | 2022-01-12 | Keio University | MARKERS FOR DETERMINING THE SENSITIVITY OF IRINOTECAN-CONTAINING ANTI-CANCER DRUG THERAPY |
| CN112770741A (zh) * | 2018-09-28 | 2021-05-07 | 学校法人庆应义塾 | 并用抗癌剂的感受性的判定标记 |
| KR20230113742A (ko) * | 2020-10-29 | 2023-08-01 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 난소암의 검출 및 치료를 위한 방법 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100569288C (zh) * | 2005-04-06 | 2009-12-16 | 山东蓝金生物工程有限公司 | 一种抗实体肿瘤药物组合物 |
| DE102005051976B4 (de) * | 2005-10-31 | 2009-04-30 | Forschungszentrum Borstel Zentrum für Medizin und Biowissenschaften | Kit für hoch-sensitive Nachweisassays |
| EP2560006A3 (en) * | 2006-09-19 | 2013-06-12 | Metabolon Inc. | Biomarkers for prostate cancer and methods using the same |
| CA2712966A1 (en) * | 2008-01-31 | 2009-08-06 | Kabushiki Kaisha Yakult Honsha | Marker for determination of sensitivity to anti-cancer agent |
| MX2010008496A (es) | 2008-01-31 | 2010-08-30 | Univ Keio | Metodo para la determinacion de sensibilidad a agente anticancerigeno. |
| JP2010038796A (ja) * | 2008-08-06 | 2010-02-18 | Human Metabolome Technologies Inc | 疾患マーカー、および、疾患マーカーの測定方法 |
| CN102597762B (zh) * | 2009-10-30 | 2016-08-03 | 学校法人庆应义塾 | 抗癌剂感受性判定标记 |
| WO2011052749A1 (ja) * | 2009-10-30 | 2011-05-05 | 学校法人慶應義塾 | 抗がん剤の感受性の判定方法 |
| JP2013515270A (ja) * | 2009-12-22 | 2013-05-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 前立腺癌の代謝学的プロファイリング |
| US9733256B2 (en) | 2012-02-23 | 2017-08-15 | Keio University | Combined anticancer drug sensitivity-determining marker |
-
2013
- 2013-02-22 US US14/379,945 patent/US9733256B2/en not_active Expired - Fee Related
- 2013-02-22 CN CN201380010388.7A patent/CN104169721A/zh active Pending
- 2013-02-22 JP JP2014500945A patent/JP6141824B2/ja not_active Expired - Fee Related
- 2013-02-22 WO PCT/JP2013/054488 patent/WO2013125675A1/ja not_active Ceased
- 2013-02-22 EP EP13752246.2A patent/EP2818870A4/en not_active Withdrawn
- 2013-02-22 EP EP17202053.9A patent/EP3326632B1/en active Active
- 2013-02-22 EP EP20214606.4A patent/EP3812009A1/en not_active Withdrawn
- 2013-02-22 CN CN201810228371.3A patent/CN108508168B/zh not_active Expired - Fee Related
-
2017
- 2017-05-08 JP JP2017092161A patent/JP6381735B2/ja not_active Expired - Fee Related
- 2017-06-28 US US15/635,293 patent/US10481160B2/en active Active
-
2018
- 2018-07-27 JP JP2018140928A patent/JP6527994B2/ja not_active Expired - Fee Related
- 2018-07-27 JP JP2018140929A patent/JP2018169409A/ja not_active Ceased
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