JP2017148503A - 擬似色を用いた顕微鏡又は内視鏡などの医用検査装置 - Google Patents
擬似色を用いた顕微鏡又は内視鏡などの医用検査装置 Download PDFInfo
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Abstract
Description
ro=ri+h・(rp−ri)
go=gi+h・(gp−gi)
bo=bi+h・(bp−bi)
となる。つまり、蛍光輝度がf=0の場合、h=0であり、出力ピクセルの色は可視光画像の色に対応する。蛍光画像のピクセルの輝度が増大するにつれて、出力ピクセルの色は擬似色に近づく。
f<fminに対してh=0、かつ、
f>fminに対してh=f
となる。
ro=ri+h・(rp−ri)
go=gi+h・(gp−gi)
bo=bi+h・(bp−bi)
ここで、係数h=f/fmaxであり、fmaxは予測される蛍光最大輝度である
により、計算可能である。
2 対象物
3 照明サブシステム
4 光源
5 照明サブシステムからの光
6 蛍光体
7 照明フィルタ
8 対象物からの反射光又は放出光
9 光学サブシステム
10 撮像サブシステム
11 可視光画像データ
12 蛍光画像データ
13 ビームスプリッタ
14 可視光
15 NIR光
16 可視光撮像アセンブリ
17 蛍光撮像アセンブリ
18 画像処理ユニット
19 画像処理ユニットの出力データ
20 可視光観察フィルタ
21 視野
22 可視光カメラ
23 蛍光観察フィルタ
24 蛍光カメラ
25 蛍光撮像サブシステムのデータインタフェース
26 制御信号
27 制御処理サブシステム
30 コントローラユニット
31 第1の入力セクション
32 第2の入力セクション
33 出力セクション
35 ドキュメンテーションサブシステム
36 モニタリングサブシステム
37 接眼ディスプレイ
38 顕微鏡モニタ
39 ディスプレイインタフェース
41 均一化モジュール
42 均一化フィルタ
43 均一化フィルタを取得するためのキャリブレーション対象物
44 空間分布
45 空間調整モジュール
46 ガンマ補正モジュール
47 閾値調整モジュール
48 擬似色画像発生器
49 可視光画像
50 第1の入力ピクセル
51 蛍光画像
52 第2の入力ピクセル
53 擬似色画像
54 出力ピクセル
60 第1のステップ
61 第2のステップ
62 第3のステップ
63 第4のステップ
64 第5のステップ
70 第1の擬似色
71 第2の擬似色
72 第1の蛍光色
73 第2の蛍光色
Claims (15)
- 画像処理ユニット(18)を含む、顕微鏡又は内視鏡などの医用検査装置(1)であって、
前記画像処理ユニット(18)は、
対象物(2)の可視光画像(49)を表す可視光画像データ(11)を受信するように構成された第1の入力セクション(31)と、
前記対象物(2)の蛍光画像(51)を表す蛍光画像データ(12)を受信するように構成された第2の入力セクション(32)と、
前記対象物(2)の擬似色画像(53)を表す擬似色画像データ(34)を出力するように構成された出力セクション(33)と、
を含み、
前記画像処理ユニット(18)は、前記擬似色画像(53)の出力ピクセル(54)の色(ro,go,bo)を、少なくとも1つの擬似色(rp,gp,bp)と、前記可視光画像(49)の第1の入力ピクセル(50)の色(ri,gi,bi)と、前記蛍光画像(51)の第2の入力ピクセル(52)の輝度(f)と、から計算するように構成されている、
医用検査装置(1)。 - 前記蛍光画像(51)は、少なくとも2つの異なる蛍光発光色(72,73)を含み、
前記画像処理ユニット(18)は、種々異なる擬似色(70,71)を前記異なる蛍光発光色のそれぞれに割り当てるように構成されている、
請求項1に記載の医用検査装置(1)。 - 前記出力ピクセル(54)の色(ro,go,bo)は、色空間(RGB)において、第1の入力ピクセル(50)の色(ri,gi,bi)と前記少なくとも1つの擬似色(rp,gp,bp)との間に線形に配置されており、
前記出力ピクセル(54)の色から前記第1の入力ピクセル(50)の色までの距離は、前記蛍光画像(51)の前記第2の入力ピクセル(52)の輝度(f)に比例する、
請求項1又は2に記載の医用検査装置(1)。 - 前記画像処理ユニット(18)は、均一化モジュール(41)を含み、
前記均一化モジュールは、前記可視光画像(49)及び前記蛍光画像(51)の少なくとも一方における口径食及び不均一な照明の少なくとも一方を補償するように構成されている、
請求項1から3までのいずれか1項に記載の医用検査装置(1)。 - 前記均一化モジュール(41)は、前記可視光画像(49)及びデータと前記蛍光画像(51)とに対して異なる均一化フィルタ(42)を含む、
請求項4に記載の医用検査装置(1)。 - 前記画像処理ユニット(18)は、前記第2の入力ピクセル(52)が閾値(fmin)を下回る輝度(f)を有する場合に、前記蛍光画像(51)の前記第2の入力ピクセル(52)を空白化するように構成された閾値調整モジュール(47)を含む、
請求項1から5までのいずれか1項に記載の医用検査装置(1)。 - 前記画像処理ユニット(18)は、前記可視光画像(49)及び前記蛍光画像(51)を互いに合同となるように移動させるべく構成された空間調整モジュール(45)を含む、
請求項1から6までのいずれか1項に記載の医用検査装置(1)。 - 前記空間調整モジュール(45)は、前記可視光画像(49)及び前記蛍光画像(51)の少なくとも一方に対して、クロップ、回転、シフト及びストレッチのうち少なくとも1つを行うように構成されている、
請求項7に記載の医用検査装置(1)。 - 顕微鏡検査又は内視鏡検査などの、医用検査方法であって、
対象物(2)の可視光画像(49)を表す可視光画像データ(11)を取得するステップと、
前記対象物の蛍光画像(51)を表す蛍光画像データ(12)を取得するステップと、
前記可視光画像データ(11)と前記蛍光画像データ(12)と少なくとも1つの擬似色とを結合して、擬似色画像(53)を表す擬似色画像データ(34)を取得するステップと、
を含み、
前記擬似色画像(53)の出力ピクセル(54)の色(ro,go,bo)は、少なくとも1つの擬似色(rp,gp,bp)と、前記可視光画像(49)の第1の入力ピクセル(50)の色(ri,gi,bi)と、前記蛍光画像(51)の第2の入力ピクセル(52)の輝度(f)と、に依存する、
医用検査方法。 - 種々異なる擬似色(70,71)を前記蛍光画像(51)の種々異なる蛍光発光色(72,73)に割り当てるステップをさらに含む、
請求項9に記載の医用検査方法。 - 結合によって擬似色画像(53)を取得する前記ステップの前に、前記可視光画像(49)及び前記蛍光画像(51)の少なくとも一方を相互に合同となるように移動させるステップをさらに含む、
請求項9又は10に記載の医用検査方法。 - 少なくとも1つの前記可視光画像(49)及び少なくとも1つの前記蛍光画像(51)に対して、前記可視光画像(49)が前記蛍光画像(51)と合同となるように、クロップ、シフト、ストレッチ及び回転のうち少なくとも1つを行う、
請求項11に記載の医用検査方法。 - 前記第2の入力ピクセル(52)の輝度が閾値(fmin)を下回る場合、前記第2の入力ピクセル(52)を前記蛍光画像(51)において空白化する、
請求項9から12までのいずれか1項に記載の医用検査方法。 - 前記出力ピクセル(54)の色(ro,go,bo)を、色空間(RGB)において、前記擬似色(rp,gp,bp)と前記第1の入力ピクセル(50)の色(ri,gi,bi)との間で線形に補間する、
請求項9から13までのいずれか1項に記載の医用検査方法。 - 非一時性のコンピュータで読み出し可能な媒体であって、
医用検査装置(1)に請求項9から14までのいずれか1項に記載の方法を実行させるためのプログラムを記憶した、媒体。
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EP16155625.3A EP3205254B1 (en) | 2016-02-15 | 2016-02-15 | Medical inspection apparatus, such as a microscope or endoscope, using pseudocolors |
EP16155625.3 | 2016-02-15 |
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JP6456416B2 (ja) | 2019-01-23 |
CN107137053B (zh) | 2020-01-14 |
US11330237B2 (en) | 2022-05-10 |
US20170237958A1 (en) | 2017-08-17 |
EP3205254A1 (en) | 2017-08-16 |
EP3205254B1 (en) | 2020-11-18 |
US20210021795A1 (en) | 2021-01-21 |
CN107137053A (zh) | 2017-09-08 |
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