JP2017101026A - 高分子硫黄を含む組成物及びその使用 - Google Patents
高分子硫黄を含む組成物及びその使用 Download PDFInfo
- Publication number
- JP2017101026A JP2017101026A JP2016234002A JP2016234002A JP2017101026A JP 2017101026 A JP2017101026 A JP 2017101026A JP 2016234002 A JP2016234002 A JP 2016234002A JP 2016234002 A JP2016234002 A JP 2016234002A JP 2017101026 A JP2017101026 A JP 2017101026A
- Authority
- JP
- Japan
- Prior art keywords
- sulfur
- cysteine
- personal care
- skin
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title claims abstract description 181
- 229910052717 sulfur Inorganic materials 0.000 title claims abstract description 176
- 239000011593 sulfur Substances 0.000 title claims abstract description 176
- 239000000203 mixture Substances 0.000 title claims abstract description 141
- 150000001875 compounds Chemical class 0.000 claims abstract description 18
- 150000003573 thiols Chemical class 0.000 claims abstract description 12
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 22
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 13
- 235000018417 cysteine Nutrition 0.000 claims description 13
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 claims description 12
- 239000003921 oil Substances 0.000 claims description 12
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 12
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 claims description 11
- 239000002537 cosmetic Substances 0.000 claims description 10
- 229920000642 polymer Polymers 0.000 claims description 10
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical group CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims description 9
- 235000001014 amino acid Nutrition 0.000 claims description 8
- 150000001413 amino acids Chemical class 0.000 claims description 8
- 239000004342 Benzoyl peroxide Substances 0.000 claims description 6
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 6
- 235000019400 benzoyl peroxide Nutrition 0.000 claims description 6
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 6
- 229960004889 salicylic acid Drugs 0.000 claims description 6
- 150000002148 esters Chemical class 0.000 claims description 5
- 150000001944 cysteine derivatives Chemical class 0.000 claims description 4
- XWRZKLKALVJDDS-REOHCLBHSA-N (2r)-2-(diaminomethylideneamino)-3-sulfanylpropanoic acid Chemical compound NC(N)=N[C@@H](CS)C(O)=O XWRZKLKALVJDDS-REOHCLBHSA-N 0.000 claims description 3
- JJVXHDTWVIPRBZ-VKHMYHEASA-N (2r)-2-[carboxy(methyl)amino]-3-sulfanylpropanoic acid Chemical compound OC(=O)N(C)[C@@H](CS)C(O)=O JJVXHDTWVIPRBZ-VKHMYHEASA-N 0.000 claims description 3
- XTURYZYJYQRJDO-BNAHBJSTSA-N Acetyl-farnesyl-cysteine Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CSC[C@@H](C(O)=O)NC(C)=O XTURYZYJYQRJDO-BNAHBJSTSA-N 0.000 claims description 3
- 240000008397 Ganoderma lucidum Species 0.000 claims description 3
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims description 3
- IFQSXNOEEPCSLW-DKWTVANSSA-N L-cysteine hydrochloride Chemical compound Cl.SC[C@H](N)C(O)=O IFQSXNOEEPCSLW-DKWTVANSSA-N 0.000 claims description 3
- 229960004308 acetylcysteine Drugs 0.000 claims description 3
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- KCYSKCOUMWIVKR-VKHMYHEASA-N (2R)-2-(hydrazinylmethylideneamino)-3-sulfanylpropanoic acid Chemical compound NN=CN[C@@H](CS)C(=O)O KCYSKCOUMWIVKR-VKHMYHEASA-N 0.000 claims description 2
- BMLMGCPTLHPWPY-REOHCLBHSA-N (4R)-2-oxo-4-thiazolidinecarboxylic acid Chemical compound OC(=O)[C@@H]1CSC(=O)N1 BMLMGCPTLHPWPY-REOHCLBHSA-N 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 36
- 230000000699 topical effect Effects 0.000 abstract description 21
- 235000001508 sulfur Nutrition 0.000 description 169
- 210000003491 skin Anatomy 0.000 description 74
- 208000002874 Acne Vulgaris Diseases 0.000 description 48
- 206010000496 acne Diseases 0.000 description 48
- 238000012360 testing method Methods 0.000 description 26
- 241000894006 Bacteria Species 0.000 description 23
- 210000004027 cell Anatomy 0.000 description 22
- 239000003795 chemical substances by application Substances 0.000 description 19
- 102000004127 Cytokines Human genes 0.000 description 18
- 108090000695 Cytokines Proteins 0.000 description 18
- 230000000770 proinflammatory effect Effects 0.000 description 16
- 208000024891 symptom Diseases 0.000 description 16
- 239000000047 product Substances 0.000 description 15
- 102000004890 Interleukin-8 Human genes 0.000 description 14
- 108090001007 Interleukin-8 Proteins 0.000 description 14
- 208000020154 Acnes Diseases 0.000 description 13
- 239000000463 material Substances 0.000 description 13
- 239000000375 suspending agent Substances 0.000 description 13
- 210000001519 tissue Anatomy 0.000 description 12
- 230000006378 damage Effects 0.000 description 11
- 244000005700 microbiome Species 0.000 description 11
- 239000000523 sample Substances 0.000 description 11
- 210000002374 sebum Anatomy 0.000 description 11
- 239000007787 solid Substances 0.000 description 11
- 238000011282 treatment Methods 0.000 description 11
- 230000002757 inflammatory effect Effects 0.000 description 10
- 239000002245 particle Substances 0.000 description 10
- 201000004700 rosacea Diseases 0.000 description 10
- 239000003974 emollient agent Substances 0.000 description 9
- 238000000338 in vitro Methods 0.000 description 9
- 230000004054 inflammatory process Effects 0.000 description 9
- 210000000265 leukocyte Anatomy 0.000 description 9
- 235000019198 oils Nutrition 0.000 description 9
- 230000000638 stimulation Effects 0.000 description 9
- 206010061218 Inflammation Diseases 0.000 description 8
- 230000000845 anti-microbial effect Effects 0.000 description 8
- 238000003556 assay Methods 0.000 description 8
- 230000008901 benefit Effects 0.000 description 8
- 239000010410 layer Substances 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 208000017520 skin disease Diseases 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 241000186427 Cutibacterium acnes Species 0.000 description 7
- 230000004888 barrier function Effects 0.000 description 7
- 239000006071 cream Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 229920001971 elastomer Polymers 0.000 description 7
- 239000000839 emulsion Substances 0.000 description 7
- 208000015181 infectious disease Diseases 0.000 description 7
- 230000007794 irritation Effects 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- 201000004624 Dermatitis Diseases 0.000 description 6
- -1 cysteine Chemical class 0.000 description 6
- 239000003995 emulsifying agent Substances 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 239000003349 gelling agent Substances 0.000 description 6
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 6
- 210000000987 immune system Anatomy 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 6
- 229940096397 interleukin-8 Drugs 0.000 description 6
- 239000006210 lotion Substances 0.000 description 6
- 230000008591 skin barrier function Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 208000001840 Dandruff Diseases 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 239000004201 L-cysteine Substances 0.000 description 5
- 235000013878 L-cysteine Nutrition 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 5
- 230000006037 cell lysis Effects 0.000 description 5
- 230000003833 cell viability Effects 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 230000000774 hypoallergenic effect Effects 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 239000002674 ointment Substances 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 125000003396 thiol group Chemical group [H]S* 0.000 description 5
- 201000004681 Psoriasis Diseases 0.000 description 4
- 241001303601 Rosacea Species 0.000 description 4
- 239000013543 active substance Substances 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 208000010668 atopic eczema Diseases 0.000 description 4
- 230000033228 biological regulation Effects 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 210000005175 epidermal keratinocyte Anatomy 0.000 description 4
- 210000004209 hair Anatomy 0.000 description 4
- 230000003779 hair growth Effects 0.000 description 4
- 239000002085 irritant Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 208000008742 seborrheic dermatitis Diseases 0.000 description 4
- 206010040872 skin infection Diseases 0.000 description 4
- 125000004434 sulfur atom Chemical group 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- 208000035143 Bacterial infection Diseases 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 206010012438 Dermatitis atopic Diseases 0.000 description 3
- 206010012444 Dermatitis diaper Diseases 0.000 description 3
- 208000003105 Diaper Rash Diseases 0.000 description 3
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 3
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 3
- 239000003463 adsorbent Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000004599 antimicrobial Substances 0.000 description 3
- 201000008937 atopic dermatitis Diseases 0.000 description 3
- 208000022362 bacterial infectious disease Diseases 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 239000000428 dust Substances 0.000 description 3
- 210000001339 epidermal cell Anatomy 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 210000003780 hair follicle Anatomy 0.000 description 3
- 229960000890 hydrocortisone Drugs 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 239000002054 inoculum Substances 0.000 description 3
- 102000009634 interleukin-1 receptor antagonist activity proteins Human genes 0.000 description 3
- 108040001669 interleukin-1 receptor antagonist activity proteins Proteins 0.000 description 3
- 231100000021 irritant Toxicity 0.000 description 3
- 230000007803 itching Effects 0.000 description 3
- 210000002510 keratinocyte Anatomy 0.000 description 3
- 230000002147 killing effect Effects 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 208000035824 paresthesia Diseases 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 229940055019 propionibacterium acne Drugs 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- ZZPKZRHERLGEKA-UHFFFAOYSA-N resorcinol monoacetate Chemical compound CC(=O)OC1=CC=CC(O)=C1 ZZPKZRHERLGEKA-UHFFFAOYSA-N 0.000 description 3
- 229920002379 silicone rubber Polymers 0.000 description 3
- 210000001578 tight junction Anatomy 0.000 description 3
- 230000036572 transepidermal water loss Effects 0.000 description 3
- WCOXQTXVACYMLM-UHFFFAOYSA-N 2,3-bis(12-hydroxyoctadecanoyloxy)propyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC(O)CCCCCC)COC(=O)CCCCCCCCCCC(O)CCCCCC WCOXQTXVACYMLM-UHFFFAOYSA-N 0.000 description 2
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 2
- 208000035985 Body Odor Diseases 0.000 description 2
- 208000035484 Cellulite Diseases 0.000 description 2
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- 206010014989 Epidermolysis bullosa Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000035874 Excoriation Diseases 0.000 description 2
- 206010015946 Eye irritation Diseases 0.000 description 2
- 206010015958 Eye pain Diseases 0.000 description 2
- 206010016936 Folliculitis Diseases 0.000 description 2
- 206010017533 Fungal infection Diseases 0.000 description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 2
- 208000004898 Herpes Labialis Diseases 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 2
- 206010061598 Immunodeficiency Diseases 0.000 description 2
- 208000029462 Immunodeficiency disease Diseases 0.000 description 2
- 206010021531 Impetigo Diseases 0.000 description 2
- 208000006877 Insect Bites and Stings Diseases 0.000 description 2
- 102000004889 Interleukin-6 Human genes 0.000 description 2
- 108090001005 Interleukin-6 Proteins 0.000 description 2
- 208000034693 Laceration Diseases 0.000 description 2
- 239000004594 Masterbatch (MB) Substances 0.000 description 2
- 206010065764 Mucosal infection Diseases 0.000 description 2
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 description 2
- 206010061304 Nail infection Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 206010067152 Oral herpes Diseases 0.000 description 2
- 206010049752 Peau d'orange Diseases 0.000 description 2
- 108010013639 Peptidoglycan Proteins 0.000 description 2
- PLXBWHJQWKZRKG-UHFFFAOYSA-N Resazurin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3[N+]([O-])=C21 PLXBWHJQWKZRKG-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 206010040904 Skin odour abnormal Diseases 0.000 description 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 2
- 208000002847 Surgical Wound Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- 206010064899 Vulvovaginal mycotic infection Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 229960005475 antiinfective agent Drugs 0.000 description 2
- 239000003125 aqueous solvent Substances 0.000 description 2
- 238000013096 assay test Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000000090 biomarker Substances 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- QGJOPFRUJISHPQ-NJFSPNSNSA-N carbon disulfide-14c Chemical compound S=[14C]=S QGJOPFRUJISHPQ-NJFSPNSNSA-N 0.000 description 2
- 239000006143 cell culture medium Substances 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 230000036232 cellulite Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000004927 clay Substances 0.000 description 2
- 239000013068 control sample Substances 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 239000007854 depigmenting agent Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- NJDNXYGOVLYJHP-UHFFFAOYSA-L disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=CC(=O)C=C2OC2=CC([O-])=CC=C21 NJDNXYGOVLYJHP-UHFFFAOYSA-L 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000037336 dry skin Effects 0.000 description 2
- 239000002158 endotoxin Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000004880 explosion Methods 0.000 description 2
- 231100000013 eye irritation Toxicity 0.000 description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
- 230000003325 follicular Effects 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 2
- 206010021198 ichthyosis Diseases 0.000 description 2
- 230000007813 immunodeficiency Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 229940100601 interleukin-6 Drugs 0.000 description 2
- 239000003410 keratolytic agent Substances 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 229920006008 lipopolysaccharide Polymers 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000012982 microporous membrane Substances 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 235000010446 mineral oil Nutrition 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 238000012261 overproduction Methods 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 208000028169 periodontal disease Diseases 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 230000019612 pigmentation Effects 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 230000009759 skin aging Effects 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- 230000036548 skin texture Effects 0.000 description 2
- 239000002195 soluble material Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 208000003265 stomatitis Diseases 0.000 description 2
- 150000003464 sulfur compounds Chemical class 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 210000005166 vasculature Anatomy 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 206010000511 Acne occupational Diseases 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 208000034309 Bacterial disease carrier Diseases 0.000 description 1
- 208000003014 Bites and Stings Diseases 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 238000008157 ELISA kit Methods 0.000 description 1
- 231100000948 EpiDerm Skin Irritation Test Toxicity 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000874889 Euphilotes enoptes Species 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010016260 Fatty acid deficiency Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 229940119178 Interleukin 1 receptor antagonist Drugs 0.000 description 1
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 description 1
- 208000002260 Keloid Diseases 0.000 description 1
- 206010023330 Keloid scar Diseases 0.000 description 1
- 229940124091 Keratolytic Drugs 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 208000009675 Perioral Dermatitis Diseases 0.000 description 1
- 241000186429 Propionibacterium Species 0.000 description 1
- GBFLZEXEOZUWRN-VKHMYHEASA-N S-carboxymethyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CSCC(O)=O GBFLZEXEOZUWRN-VKHMYHEASA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 206010040829 Skin discolouration Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 102000000591 Tight Junction Proteins Human genes 0.000 description 1
- 108010002321 Tight Junction Proteins Proteins 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000159243 Toxicodendron radicans Species 0.000 description 1
- 241000893966 Trichophyton verrucosum Species 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 229940093740 amino acid and derivative Drugs 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000000058 anti acne agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003255 anti-acne Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000000604 anti-edema agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940124340 antiacne agent Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 239000012131 assay buffer Substances 0.000 description 1
- 239000012911 assay medium Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000007707 calorimetry Methods 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000000828 canola oil Substances 0.000 description 1
- 235000019519 canola oil Nutrition 0.000 description 1
- 229960004399 carbocisteine Drugs 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000013553 cell monolayer Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 229910052729 chemical element Inorganic materials 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 210000000172 cytosol Anatomy 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 230000002951 depilatory effect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 210000003560 epithelium corneal Anatomy 0.000 description 1
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000003966 growth inhibitor Substances 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 210000004919 hair shaft Anatomy 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 231100000206 health hazard Toxicity 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000012966 insertion method Methods 0.000 description 1
- 239000012774 insulation material Substances 0.000 description 1
- 239000003407 interleukin 1 receptor blocking agent Substances 0.000 description 1
- 230000019171 interleukin-1 alpha production Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 210000001117 keloid Anatomy 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 230000001530 keratinolytic effect Effects 0.000 description 1
- 239000003350 kerosene Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 210000000282 nail Anatomy 0.000 description 1
- 239000007908 nanoemulsion Substances 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000003658 preventing hair loss Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 238000013040 rubber vulcanization Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000037370 skin discoloration Effects 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000006076 specific stabilizer Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000012719 thermal polymerization Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 238000004073 vulcanization Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/795—Polymers containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/327—Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/38—Percompounds, e.g. peracids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L81/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing sulfur with or without nitrogen, oxygen or carbon only; Compositions of polysulfones; Compositions of derivatives of such polymers
- C08L81/04—Polysulfides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Polymers & Plastics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
【解決手段】 パーソナルケア組成物、及び高分子硫黄Snを含有する組成物を使用する局所皮膚症状を治療する方法。本発明の組成物は好ましくは、チオールなど−SH含有化合物も含むことができる。
【選択図】 図1
Description
低刺激性はBernhoferらのToxicology in Vitro 219〜229(1999)に記載されている皮膚同等モデルを使用して測定され、それは参照により本明細書に組み込まれる。皮膚に対する界面活性剤系の低刺激性を評価するために、このモデルは細胞生存度、細胞溶解及びサイトカイン放出を測定する逐次スクリーニングを利用する。細胞生存度はalamarBlue(登録商標)アッセイを使用して測定されて、それは代謝活性の指標である。細胞溶解は、損傷細胞のサイトソルから放出される乳酸脱水素酵素(LDH)活性を測定することによって検出される。サイトカイン放出(IL−1α及びIL−1raの両方)は、細胞生存度又は細胞溶解の損失を示さない試料群について測定される。
二重盲検式の無作為化した2種類の細胞の調査試験設計を用いて、約38℃の温度で1滴の試料(例えば洗浄組成物の10%希釈物)を被験者の眼内に滴下する。新しい滅菌の使い捨て点眼器が各試料に対して使用されて、1個のみの個人の眼において用いた後に廃棄された。すべての滴下は、研究者によって又は訓練された技術者により実行される。
・刺痛
・0=正常な限界内
・1=マイルド、非常に軽微
・2=中程度
・3=重度
所与の配合物で予想される眼に対する刺激は、Invittoxプロトコルナンバー86、Invittoxプロトコルナンバー86(1994年5月)に記載の「経表皮透過性(TEP)アッセイ」に従って測定される。細胞層を通過するフルオレセインの漏れにより評価されるので、細胞層の透過性への影響を測定することによって、一般に製品の眼への刺激の可能性を評価できる。メイデン−ダービー犬腎臓(MDCK)細胞の単層は、24−ウェルプレート含有培地の微小孔インサート上又は下側ウェルのアッセイ緩衝剤上の合流点まで成長する。本製品の希釈物への15分の暴露後、細胞単層の透過性バリアへの損傷を測定することによって、製品の刺激可能性は評価される。バリア損傷は、30分後下側ウェルを通って漏出したフルオレセインナトリウムの量によって分光光度法で測定されるように評価される。フルオレセイン漏出は、EC50(最大の染料漏出の50%、透過性のバリアに対する50%の損傷、を引き起こす試験材料の濃度)を決定するために、試験材料の濃度に対してプロットされる。より高いスコアは、より低刺激の配合物を示す。
抗菌有効性試験−微小遠心管法
プロピオニバクテリウムアクネス、黄色ブドウ球菌及び大腸菌に対する有効性試験のため、1%試験用試料懸濁液[Wuxi Chemical(中国)製硫黄(S)Sigma又は高分子硫黄(Sn)IS90]は、Butterfield製リン酸塩緩衝液のw/vとして調製された。アリコートは次に、試験微生物への暴露のため微小遠心管内へピペットで移された。アスペルギルス−ブラジリエンシスに対する試験用の10%及び5%濃度は計量されて、微小遠心管で直接希釈された。
抗菌有効性試験−組織培養挿入法
この方法において組織培養挿入物は、微生物を含有する外部流体から硫黄粒子の物理的分離を維持する。組織培養挿入物の底部は透過性(4μm孔)で、流体、溶解した固体及び微生物が出入りできる。
0.01〜3%の高分子硫黄はIL−22誘発IL−8サイトカイン放出を抑制する際、ヒトケラチン生成細胞in vitroで通常の硫黄より効果的であった。
実施例9A:マイルドさ:ヒト皮膚等価物における高分子硫黄(Sn)対通常の硫黄(S)による炎症誘発性サイトカイン放出IL−1αの比較。
生体外でヒト一次ケラチン生成細胞における、高分子硫黄(Sn)対通常の硫黄(S)により生成される、炎症誘発性サイトカインIL−1α及びIL−8の刺激への効果の比較。
(1) 高分子硫黄Snを含むパーソナルケア組成物であって、前記高分子硫黄Snが実質的に非化粧用油を含まない、パーソナルケア組成物。
(2) 前記組成物が−SH部分を含有する化合物を更に含む、実施態様1に記載のパーソナルケア組成物。
(3) nが少なくとも9である、実施態様1に記載のパーソナルケア組成物。
(4) nが少なくとも100である、実施態様3に記載のパーソナルケア組成物。
(5) 前記高分子硫黄Snが線状構造である、実施態様1に記載のパーソナルケア組成物。
(7) 前記チオール含有化合物がアミノ酸及びチオール含有ペプチドからなる群から選択されている、実施態様6に記載のパーソナルケア組成物。
(8) 前記アミノ酸がシステインである、実施態様7に記載のパーソナルケア組成物。
(9) 前記システインが、アセチルシステイン(INN)、N−アセチル−L−システイン、カルボキシメチルシステイン、L−システイン、N−アセチル−2−ヒドロキシベンゾエート(エステル)L−システイン、N−アセチル−L−システイン、N−アセチル−S−[(2E,6E)−3,7,11−トリメチル−2,6,10−ドデカトリエニル]−L−システイン、N−(アミノイミノメチル)−システイン、DL−L−システイン、エチルエステル、塩酸塩(1:1)システイン(INN)、L−システイン、システイン/レイシ果実の抽出物、L−システイン一塩酸塩、L−システイン,S−(カルボキシメチル)−DNA、システイン塩、N−グアニル−L−システイン、オキソアセトアミドカルボシステイン、及びプロシステインからなる群から選択されている、実施態様8に記載のパーソナルケア組成物。
(10) 前記組成物のpHが8未満である、実施態様1に記載のパーソナルケア組成物。
(12) 前記組成物がレゾルシノールを更に含む、実施態様1に記載のパーソナルケア組成物。
(13) 前記組成物が可溶性硫黄を更に含む、実施態様1に記載のパーソナルケア組成物。
(14) 前記組成物がサリチル酸及び過酸化ベンゾイルからなる群から選択される活性成分を更に含む、実施態様1に記載のパーソナルケア組成物。
(15) 高分子硫黄Snを含む組成物の皮膚への適用を含む、局所皮膚症状を治療する方法であって、前記高分子硫黄Snが実質的に非化粧用油を含まない、方法。
(17) 前記皮膚症状が尋常性ざ瘡である、実施態様16に記載の局所皮膚症状を治療する方法。
(18) 前記皮膚症状が炎症である、実施態様16に記載の局所皮膚症状を治療する方法。
(19) 前記硫黄成分が可溶性硫黄及び高分子硫黄を含む、実施態様15に記載の方法。
(20) 前記組成物がレゾルシノール、酢酸レゾルシノール、サリチル酸、過酸化ベンゾイル及びこれらの組み合わせからなる群から選択されるざ瘡治療に有効な成分を更に含む、実施態様15に記載の方法。
(22) 前記皮膚症状が、脂漏性皮膚炎、フケ、癜風、浅在性白癬、疥癬、酒さ、口周囲皮膚炎、毛包虫性皮疹、乾癬、湿疹及びアトピー性皮膚炎を含む皮膚疾患の群に由来している、実施態様16に記載の局所皮膚症状を治療する方法。
(23) バリア機能に対する治療を必要とする皮膚に局所的に適用することを含む、皮膚バリア機能を改良する方法。
(24) 皮膚の老化に対する治療を必要とする皮膚に局所的に適用することを含む、皮膚老化の徴候を治療する方法。
(25) 湿潤に対する治療を必要とする皮膚に局所的に適用することを含む、皮膚の湿潤を改良する方法。
Claims (14)
- 高分子硫黄Snを含むパーソナルケア組成物であって、前記高分子硫黄Snが実質的に非化粧用油を含まない、パーソナルケア組成物。
- 前記組成物が−SH部分を含有する化合物を更に含む、請求項1に記載のパーソナルケア組成物。
- nが少なくとも9である、請求項1に記載のパーソナルケア組成物。
- nが少なくとも100である、請求項3に記載のパーソナルケア組成物。
- 前記高分子硫黄Snが線状構造である、請求項1に記載のパーソナルケア組成物。
- 前記−SH含有化合物がチオール含有化合物である、請求項2に記載のパーソナルケア組成物。
- 前記チオール含有化合物がアミノ酸及びチオール含有ペプチドからなる群から選択されている、請求項6に記載のパーソナルケア組成物。
- 前記アミノ酸がシステインである、請求項7に記載のパーソナルケア組成物。
- 前記システインが、アセチルシステイン(INN)、N−アセチル−L−システイン、カルボキシメチルシステイン、L−システイン、N−アセチル−2−ヒドロキシベンゾエート(エステル)L−システイン、N−アセチル−L−システイン、N−アセチル−S−[(2E,6E)−3,7,11−トリメチル−2,6,10−ドデカトリエニル]−L−システイン、N−(アミノイミノメチル)−システイン、DL−L−システイン、エチルエステル、塩酸塩(1:1)システイン(INN)、L−システイン、システイン/レイシ果実の抽出物、L−システイン一塩酸塩、L−システイン,S−(カルボキシメチル)−DNA、システイン塩、N−グアニル−L−システイン、オキソアセトアミドカルボシステイン、及びプロシステインからなる群から選択されている、請求項8に記載のパーソナルケア組成物。
- 前記組成物のpHが8未満である、請求項1に記載のパーソナルケア組成物。
- 前記組成物が約0.01〜約20重量%の硫黄を含む、請求項1に記載のパーソナルケア組成物。
- 前記組成物がレゾルシノールを更に含む、請求項1に記載のパーソナルケア組成物。
- 前記組成物が可溶性硫黄を更に含む、請求項1に記載のパーソナルケア組成物。
- 前記組成物がサリチル酸及び過酸化ベンゾイルからなる群から選択される活性成分を更に含む、請求項1に記載のパーソナルケア組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/956,883 | 2015-12-02 | ||
US14/956,883 US10238685B2 (en) | 2015-12-02 | 2015-12-02 | Compositions containing polymeric sulfur and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017101026A true JP2017101026A (ja) | 2017-06-08 |
JP6910787B2 JP6910787B2 (ja) | 2021-07-28 |
Family
ID=57471750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016234002A Active JP6910787B2 (ja) | 2015-12-02 | 2016-12-01 | 高分子硫黄を含む組成物及びその使用 |
Country Status (10)
Country | Link |
---|---|
US (2) | US10238685B2 (ja) |
EP (1) | EP3175888B1 (ja) |
JP (1) | JP6910787B2 (ja) |
KR (1) | KR102661585B1 (ja) |
CN (1) | CN106806381A (ja) |
AU (1) | AU2016266017B2 (ja) |
BR (1) | BR102016028260B8 (ja) |
CA (1) | CA2947705C (ja) |
MX (1) | MX368814B (ja) |
RU (1) | RU2016146938A (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108697599A (zh) | 2016-03-24 | 2018-10-23 | 宝洁公司 | 包含恶臭减少组合物的毛发护理组合物 |
WO2019074993A1 (en) | 2017-10-10 | 2019-04-18 | The Procter & Gamble Company | SULFATE FREE TRANSPARENT PERSONAL CLEANING COMPOSITION COMPRISING LOW INORGANIC SALT |
CN114746153A (zh) | 2019-12-06 | 2022-07-12 | 宝洁公司 | 具有增强头皮活性物质沉积的不含硫酸盐的组合物 |
CN115151310A (zh) | 2020-02-27 | 2022-10-04 | 宝洁公司 | 功效和美观性增强的含硫去头皮屑组合物 |
MX2023005963A (es) | 2020-12-04 | 2023-06-07 | Procter & Gamble | Composiciones para el cuidado del cabello que comprenden materiales de reduccion del mal olor. |
US20220378684A1 (en) | 2021-05-14 | 2022-12-01 | The Procter & Gamble Company | Shampoo Compositions Containing a Sulfate-Free Surfactant System and Sclerotium Gum Thickener |
US11986543B2 (en) | 2021-06-01 | 2024-05-21 | The Procter & Gamble Company | Rinse-off compositions with a surfactant system that is substantially free of sulfate-based surfactants |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2460776A (en) | 1945-11-19 | 1949-02-01 | Noned Corp | Bacteriostatic base for medicinal, cosmetic, and toilet preparations |
FR2104969B1 (ja) * | 1970-09-11 | 1973-08-10 | Geigy Ag J R | |
US3755560A (en) | 1971-06-30 | 1973-08-28 | Dow Chemical Co | Nongreasy cosmetic lotions |
GB1541463A (en) | 1975-10-11 | 1979-02-28 | Lion Dentifrice Co Ltd | Process for prparing a multiple emulsion having a dispersing form of water-phase/oil-phase/water-phase |
US4192866A (en) | 1978-10-10 | 1980-03-11 | Ralph Anderson | Anorectal medication |
US4421769A (en) | 1981-09-29 | 1983-12-20 | The Procter & Gamble Company | Skin conditioning composition |
AU609090B2 (en) | 1987-02-18 | 1991-04-26 | Milor Scientific, Ltd. | Composition for treatment of acne |
US4960764A (en) | 1987-03-06 | 1990-10-02 | Richardson-Vicks Inc. | Oil-in-water-in-silicone emulsion compositions |
US5100653A (en) * | 1991-02-08 | 1992-03-31 | Giovanni Campo | Topical compositions for treating mouth tissues |
US5654362A (en) | 1996-03-20 | 1997-08-05 | Dow Corning Corporation | Silicone oils and solvents thickened by silicone elastomers |
US5919437A (en) | 1996-05-24 | 1999-07-06 | Colgate-Palmolive Company | Cosmetic cream composition containing silicone gel material |
US6060546A (en) | 1996-09-05 | 2000-05-09 | General Electric Company | Non-aqueous silicone emulsions |
US5902570A (en) | 1996-10-29 | 1999-05-11 | Procter & Gamble Company | Antiperspirant cream compositions having improved rheology |
US5976514A (en) | 1998-11-20 | 1999-11-02 | Procter & Gamble Company | Low-irritation antiperspirant and deodorant compositions containing a volatile, nonpolar hydrocarbon liquid |
DE19934169A1 (de) | 1999-07-21 | 2001-01-25 | Henkel Kgaa | Kosmetische und/oder dermatologische Zubereitungen |
US6514489B1 (en) | 2000-06-30 | 2003-02-04 | Medicis Pharmaceutical Corp. | Sulfur containing dermatological compositions and methods for reducing malodors in dermatological compositions |
EP1613295A1 (en) * | 2003-04-15 | 2006-01-11 | Unilever N.V. | Use of alkyl resorcinols in the treatment of acne |
US7605194B2 (en) * | 2003-06-24 | 2009-10-20 | Ppg Industries Ohio, Inc. | Aqueous dispersions of polymer-enclosed particles, related coating compositions and coated substrates |
US20080112909A1 (en) * | 2003-06-24 | 2008-05-15 | Ppg Industries Ohio, Inc. | Compositions for providing color to animate objects and related methods |
EP2294123B1 (en) * | 2008-06-30 | 2016-06-01 | Pirelli Tyre S.p.A. | Tyre made of a crosslinkable elastomeric composition comprising an oxetane derivative and an amino acid |
WO2011044568A1 (en) | 2009-10-09 | 2011-04-14 | Mizell Ligon William | Topical skin cream |
EP2755478A4 (en) * | 2011-09-14 | 2015-06-10 | Nuevas Alternativas Naturales S A P I De C V | PREPARATION AND COMPOSITIONS OF HIGH BIOAVAILABILITY ZERO VALENCY ZERO SULFUR AND USES THEREOF |
US9880141B2 (en) * | 2012-05-07 | 2018-01-30 | University Of Manitoba | Detection and recovery of chemical elements from fluids with tectrabrachion |
EP3151671A4 (en) * | 2014-06-03 | 2018-03-07 | Sulfagenix, Inc. | Methods and compositions for treating nitric oxide deficiency disorders and related conditions |
-
2015
- 2015-12-02 US US14/956,883 patent/US10238685B2/en active Active
-
2016
- 2016-11-07 CA CA2947705A patent/CA2947705C/en active Active
- 2016-11-30 RU RU2016146938A patent/RU2016146938A/ru not_active Application Discontinuation
- 2016-11-30 KR KR1020160162107A patent/KR102661585B1/ko active IP Right Grant
- 2016-11-30 AU AU2016266017A patent/AU2016266017B2/en active Active
- 2016-12-01 MX MX2016015896A patent/MX368814B/es active IP Right Grant
- 2016-12-01 JP JP2016234002A patent/JP6910787B2/ja active Active
- 2016-12-01 BR BR102016028260A patent/BR102016028260B8/pt active IP Right Grant
- 2016-12-01 CN CN201611089515.9A patent/CN106806381A/zh active Pending
- 2016-12-02 EP EP16201966.5A patent/EP3175888B1/en active Active
-
2019
- 2019-01-22 US US16/253,387 patent/US20190151355A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
RU2016146938A3 (ja) | 2020-03-27 |
EP3175888B1 (en) | 2021-11-03 |
RU2016146938A (ru) | 2018-05-31 |
US10238685B2 (en) | 2019-03-26 |
US20190151355A1 (en) | 2019-05-23 |
CN106806381A (zh) | 2017-06-09 |
BR102016028260B8 (pt) | 2022-07-26 |
KR20170065004A (ko) | 2017-06-12 |
JP6910787B2 (ja) | 2021-07-28 |
BR102016028260A2 (pt) | 2017-06-06 |
AU2016266017B2 (en) | 2022-09-29 |
EP3175888A1 (en) | 2017-06-07 |
MX368814B (es) | 2019-10-17 |
MX2016015896A (es) | 2018-05-31 |
BR102016028260B1 (pt) | 2021-10-19 |
AU2016266017A1 (en) | 2017-06-22 |
CA2947705C (en) | 2023-11-07 |
US20170157170A1 (en) | 2017-06-08 |
KR102661585B1 (ko) | 2024-04-30 |
CA2947705A1 (en) | 2017-06-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6910787B2 (ja) | 高分子硫黄を含む組成物及びその使用 | |
US11969405B2 (en) | Method of treatment of topical dermatologic acne using a cream composition and method of manufacture | |
US10792258B2 (en) | Antiseptic, antiseborrheic and exfoliating composition to remove or prevent acne | |
EA024483B1 (ru) | Местная композиция для лечения гиперкератотической кожи | |
JP2003531860A (ja) | No合成酵素阻害剤としてのオリーブ種の植物抽出物とその使用 | |
EP2566455B1 (en) | Topical composition and use thereof for the prophylaxis and the treatment of defects connected to inflammatory dermopathies | |
JP4583655B2 (ja) | 抗アレルギー皮膚外用組成物 | |
EP3378475B1 (en) | Composition and kit for the use in the prevention of recurrent onychomycosis | |
WO2016033899A1 (zh) | 一种调节头皮油脂平衡的去屑组合物 | |
FR3025106A1 (fr) | Composition antimicrobienne | |
BR112014017448B1 (pt) | Composição dermocosmética contendo como princípio ativo, uma combinação sinérgica de prata coloidal e ácido desoxirribonucleico e seu uso | |
BR102014030351A2 (pt) | composição dermatológica e seu uso | |
JP5527917B2 (ja) | アルギナーゼ活性促進剤及びそれを含有する皮膚外用剤 | |
CN112999102A (zh) | 一种含碳同素异形体的洗发香波 | |
JP2001288067A (ja) | 皮膚化粧料 | |
WO2018123002A1 (ja) | 外用組成物 | |
JPH0217114A (ja) | 皮膚外用剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20191016 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20201118 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20201124 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210224 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210629 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210707 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6910787 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |