JP2017070307A5 - - Google Patents
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- Publication number
- JP2017070307A5 JP2017070307A5 JP2017002170A JP2017002170A JP2017070307A5 JP 2017070307 A5 JP2017070307 A5 JP 2017070307A5 JP 2017002170 A JP2017002170 A JP 2017002170A JP 2017002170 A JP2017002170 A JP 2017002170A JP 2017070307 A5 JP2017070307 A5 JP 2017070307A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid region
- region
- acid molecule
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010096520 | 2010-04-19 | ||
| JP2010096520 | 2010-04-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015165287A Division JP6311092B2 (ja) | 2010-04-19 | 2015-08-24 | 機能性核酸の安定化法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017070307A JP2017070307A (ja) | 2017-04-13 |
| JP2017070307A5 true JP2017070307A5 (cg-RX-API-DMAC7.html) | 2017-07-13 |
Family
ID=44834191
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511666A Active JP5892608B2 (ja) | 2010-04-19 | 2011-04-19 | 機能性核酸の安定化法 |
| JP2015165287A Active JP6311092B2 (ja) | 2010-04-19 | 2015-08-24 | 機能性核酸の安定化法 |
| JP2017002170A Pending JP2017070307A (ja) | 2010-04-19 | 2017-01-10 | 機能性核酸の安定化法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511666A Active JP5892608B2 (ja) | 2010-04-19 | 2011-04-19 | 機能性核酸の安定化法 |
| JP2015165287A Active JP6311092B2 (ja) | 2010-04-19 | 2015-08-24 | 機能性核酸の安定化法 |
Country Status (3)
| Country | Link |
|---|---|
| EP (2) | EP2562257A4 (cg-RX-API-DMAC7.html) |
| JP (3) | JP5892608B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011132672A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5892608B2 (ja) * | 2010-04-19 | 2016-03-23 | 国立研究開発法人理化学研究所 | 機能性核酸の安定化法 |
| US8785121B2 (en) | 2010-07-08 | 2014-07-22 | Bonac Corporation | Single-stranded nucleic acid molecule for controlling gene expression |
| US8691782B2 (en) | 2010-08-03 | 2014-04-08 | Bonac Corporation | Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
| US20140256794A1 (en) * | 2011-10-19 | 2014-09-11 | Riken | Activation of functional nucleic acid by specific modification |
| JP6137484B2 (ja) * | 2011-11-02 | 2017-05-31 | 公立大学法人大阪市立大学 | 遺伝子発現抑制用二本鎖核酸分子 |
| WO2013077446A1 (ja) * | 2011-11-26 | 2013-05-30 | 株式会社ボナック | 遺伝子発現制御のための一本鎖核酸分子 |
| EP2857513A4 (en) | 2012-05-26 | 2016-05-25 | Bonac Corp | Single-stranded nucleic acid molecule controlling the expression of a gene transporter |
| WO2015099122A1 (ja) | 2013-12-26 | 2015-07-02 | 学校法人東京医科大学 | 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途 |
| RU2697094C2 (ru) | 2013-12-27 | 2019-08-12 | Бонак Корпорейшн | ИСКУССТВЕННАЯ мкРНК С СООТВЕТСТВИЕМ ДЛЯ КОНТРОЛЯ ЭКСПРЕССИИ ГЕНОВ И ЕЕ ПРИМЕНЕНИЕ |
| WO2016100401A1 (en) * | 2014-12-15 | 2016-06-23 | Dicerna Pharmaceuticals, Inc. | Ligand-modified double-stranded nucleic acids |
| CA2971827A1 (en) | 2014-12-27 | 2016-06-30 | Bonac Corporation | Naturally occuring mirna for controlling gene expression, and use of same |
| US10550393B2 (en) | 2015-03-06 | 2020-02-04 | Tagcyx Biotechnologies | Method for stabilizing DNA aptamers |
| CN108064289A (zh) | 2015-03-27 | 2018-05-22 | 株式会社博纳克 | 具有递送功能和基因表达调控能力的单链核酸分子 |
| CN108342386B (zh) * | 2017-01-22 | 2022-04-15 | 广州市锐博生物科技有限公司 | 一种多聚寡核酸分子及其在多靶标干扰中的应用 |
| WO2019161904A1 (en) | 2018-02-23 | 2019-08-29 | Kamel Wael Sayed Saleh Elsayed | Stable rna molecules |
| CN108646014B (zh) * | 2018-05-21 | 2020-07-17 | 青岛大学 | 基于适体构象变化的荧光检测血小板源性生长因子的方法 |
| BR112021011294A2 (pt) * | 2018-12-12 | 2021-08-31 | Dicerna Pharmaceuticals, Inc. | Moléculas inibidoras de ácido nucleico de fita dupla contendo um triloop |
| BR112021021686A2 (pt) * | 2019-05-03 | 2022-03-22 | Dicerna Pharmaceuticals Inc | Moléculas inibidoras de ácido nucleico de fita dupla com fitas senso curtas |
| US20230183694A1 (en) * | 2020-03-16 | 2023-06-15 | Argonaute RNA Limited | Antagonist of pcsk9 |
| CN115997019A (zh) * | 2020-04-30 | 2023-04-21 | Mpeg La有限责任公司 | 具有分链的多聚寡核苷酸 |
| JP7743246B2 (ja) * | 2021-09-29 | 2025-09-24 | 栄研化学株式会社 | 標的ｒｎａ検出方法及びプローブキット |
| GB2618915B (en) * | 2022-05-18 | 2024-08-14 | Argonaute Rna Ltd | Treatment of cardiovascular disease |
| JP2024000312A (ja) * | 2022-06-20 | 2024-01-05 | Ｔｏｐｐａｎホールディングス株式会社 | 蛍光物質及び消光物質で標識された一本鎖オリゴヌクレオチド |
| WO2024189348A1 (en) * | 2023-03-14 | 2024-09-19 | Argonaute RNA Limited | Conjugate comprising a double stranded rna molecule linked to a single stranded dna molecule |
| WO2025096807A2 (en) * | 2023-10-31 | 2025-05-08 | Flagship Pioneering Innovations Vii, Llc | Novel therapeutic dna forms |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2104698A1 (en) * | 1991-02-21 | 1992-08-22 | John J. Toole | Aptamers specific for biomolecules and methods of making |
| US20030040613A1 (en) | 2000-04-24 | 2003-02-27 | Bishop Karl Duncan | Structurally modified molecular decoys for the manipulation of cellular or viral replication and other uses relating thereto |
| EP1499721B1 (en) * | 2002-04-26 | 2013-05-29 | AnGes MG, Inc. | CIRCULAR DUMBBELL DECOY OLIGODEOXYNUCLEOTIDES (CDODN) CONTAINING DNA BINDINGS SITES FOR THE TRANSCRIPTION FACTOR NF-kappa B |
| KR20120029002A (ko) * | 2002-08-05 | 2012-03-23 | 사일런스 테라퓨틱스 아게 | 신규한 형태의 간섭 ｒｎａ 분자 |
| WO2005014810A1 (ja) | 2003-08-08 | 2005-02-17 | National Institute Of Advanced Industrial Science And Technology | ダンベル型ｄｎａの効率的な製造方法 |
| KR20070101226A (ko) * | 2004-09-07 | 2007-10-16 | 아케믹스 코포레이션 | 앱타머의 약화학 |
| US20090023672A1 (en) * | 2005-01-27 | 2009-01-22 | Kurume University | Age-2 aptamer |
| EP1891216B1 (en) * | 2005-05-25 | 2012-02-22 | The University Of York | Hybrid interfering rna |
| JP2010096520A (ja) | 2008-10-14 | 2010-04-30 | National Institute Of Advanced Industrial Science & Technology | スキャン画像取得装置およびシステム |
| JP5892608B2 (ja) * | 2010-04-19 | 2016-03-23 | 国立研究開発法人理化学研究所 | 機能性核酸の安定化法 |
-
2011
- 2011-04-19 JP JP2012511666A patent/JP5892608B2/ja active Active
- 2011-04-19 EP EP11772007.8A patent/EP2562257A4/en not_active Ceased
- 2011-04-19 EP EP18158543.1A patent/EP3358014B1/en active Active
- 2011-04-19 WO PCT/JP2011/059619 patent/WO2011132672A1/ja not_active Ceased
-
2015
- 2015-08-24 JP JP2015165287A patent/JP6311092B2/ja active Active
-
2017
- 2017-01-10 JP JP2017002170A patent/JP2017070307A/ja active Pending