JP2017066115A - Methods for producing compositions containing glucosylceramide - Google Patents
Methods for producing compositions containing glucosylceramide Download PDFInfo
- Publication number
- JP2017066115A JP2017066115A JP2015196546A JP2015196546A JP2017066115A JP 2017066115 A JP2017066115 A JP 2017066115A JP 2015196546 A JP2015196546 A JP 2015196546A JP 2015196546 A JP2015196546 A JP 2015196546A JP 2017066115 A JP2017066115 A JP 2017066115A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- acid
- glucosylceramide
- oil
- containing composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- Coloring Foods And Improving Nutritive Qualities (AREA)
- Non-Alcoholic Beverages (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
本発明はグルコシルセラミド含有組成物の製造方法関する。 The present invention relates to a method for producing a glucosylceramide-containing composition.
麹菌(Aspergillus)は日本において古くから日本酒や味噌、醤油の製造に用いられており、我々の生活に必要不可欠な菌である。これらの発酵物は単なる食品だけでなく、機能性を有する食品として注目されており、発酵に伴って様々な生理活性物質が新たに産生する可能性がある。 Aspergillus has long been used in the production of sake, miso, and soy sauce in Japan, and is an indispensable fungus for our lives. These fermented products are attracting attention as functional foods as well as mere foods, and various physiologically active substances may be newly produced with fermentation.
一方、スフィンゴ脂質は、皮膚の保湿効果、水分調節、弾力性保持、表面保護(バリヤー効果)、コラーゲン保護、酸化防止(ビタミンCやEの安定化)等の機能が知られており、化粧品の分野で広く用いられている。また、最近では、スフィンゴ脂質の作用として、外界から体内への抗原の侵入を阻止し、アトピー性皮膚炎を抑えることが明らかになり、医薬品としての開発も進められている。 On the other hand, sphingolipids are known to have functions such as skin moisturizing effect, moisture control, elasticity retention, surface protection (barrier effect), collagen protection, and antioxidant (stabilization of vitamins C and E). Widely used in the field. Recently, it has become clear that the action of sphingolipids prevents the entry of antigens from the outside world into the body and suppresses atopic dermatitis, and development as a pharmaceutical is being promoted.
米から、スフィンゴ脂質含有組成物の製造方法としては、例えば、米糠油の製造工程で得られるガム質を、有機溶剤により脱脂し、この脱脂物を水またはアルコール抽出する方法が知られている(特許文献1)。
このような背景の下、本発明者は、米糠及び米胚芽を発酵させることにより、高濃度のグルコシルセラミドを含有する組成物を得ることができることを見出し、本発明を完成させた。
即ち、簡単で、高濃度のグルコシルセラミドを含有するセラミド含有組成物の製造方法を提供することを目的とする。
Under such a background, the present inventors have found that a composition containing a high concentration of glucosylceramide can be obtained by fermenting rice bran and rice germ, and have completed the present invention.
That is, an object is to provide a simple method for producing a ceramide-containing composition containing a high concentration of glucosylceramide.
上記課題を解決するための本発明の技術的特徴は以下のとおりである。
(1)米糠及び/又は米胚芽を発酵させて発酵物を得て、
その後、前記発酵物を極性溶媒で抽出し発酵物抽出液を得て、
その後、前記発酵物抽出液を分配することを特徴とする、
グルコシルセラミド含有組成物の製造方法。
(2)上記米糠及び/又は米胚芽は、脱脂したものであるであることを特徴とする上記(1)のグルコシルセラミド含有組成物の製造方法。
(3)上記分配は液液分配であり、ヘキサンと水で分配を行い、更にこの水層を酢酸エチルと水で分配を行い、更にその水層をクロロホルムとメタノール分配し、クロロホルムとメタノールの混合層の分離を行うことを特徴とする上記(1)又は(2)のグルコシルセラミド含有組成物の製造方法。
(4)上記発酵物は麹菌で発酵させたものであることを特徴とする上記(1)〜(3)のいずれか1つに記載のグルコシルセラミド含有組成物の製造方法。
The technical features of the present invention for solving the above-described problems are as follows.
(1) Fermenting rice bran and / or rice germ to obtain a fermented product,
Thereafter, the fermented product is extracted with a polar solvent to obtain a fermented product extract,
Then, the fermented product extract is dispensed,
A method for producing a glucosylceramide-containing composition.
(2) The method for producing a glucosylceramide-containing composition according to (1) above, wherein the rice bran and / or rice germ is defatted.
(3) The above distribution is a liquid-liquid distribution. The distribution is performed with hexane and water, the aqueous layer is further partitioned with ethyl acetate and water, the aqueous layer is further partitioned with chloroform and methanol, and chloroform and methanol are mixed. The method for producing a glucosylceramide-containing composition as described in (1) or (2) above, wherein the layers are separated.
(4) The method for producing a glucosylceramide-containing composition according to any one of (1) to (3), wherein the fermented product is fermented with koji mold.
以下に本発明を詳細に説明する。
本発明のグルコシルセラミド含有組成物の製造方法は、米糠及び/又は米胚芽を発酵させて発酵物を得て、その後、前記発酵米物を極性溶媒で抽出し発酵物抽出液を得て、その後、前記発酵物抽出液を分液用極性溶媒で分液することを特徴とする。
The present invention is described in detail below.
The method for producing a glucosylceramide-containing composition of the present invention comprises fermenting rice bran and / or rice germ to obtain a fermented product, then extracting the fermented rice product with a polar solvent to obtain a fermented product extract, The fermented product extract is separated with a polar solvent for liquid separation.
「米糠及び/又は米胚芽」には、玄米の精米工程で生じる生糠を用いるとよい。玄米は、果皮,種皮,胚乳および胚芽からなり、胚乳組織の外層には糊粉層という薄い層がある。精米が進むに従って,果皮、種皮だけでなく、糊粉層までが米糠(生糠)として排除される。必要に応じて、果皮、種皮、米胚芽または糊粉の混合物を用いるか、果皮、種皮、米胚芽または糊粉のいずれかを分離したものを用いることができる。 For “rice bran and / or rice germ”, ginger produced in the rice milling process of brown rice may be used. Brown rice is composed of pericarp, seed coat, endosperm and germ, and there is a thin layer called a paste layer on the outer layer of the endosperm tissue. As the milling progresses, not only the pericarp and seed coat, but also the glue layer is eliminated as rice bran (ginger). If necessary, a mixture of pericarp, seed coat, rice germ or paste can be used, or a mixture of pericarp, seed coat, rice germ or paste can be used.
また、上記米糠及び/又は米胚芽は脱脂したものと使用することが好ましい。より高濃度のグルコシルセラミドを含有する組成物を得ることができるからである。この脱脂の方法は特に限定されず、
このとき、好ましい脱脂用溶媒としては、n−ヘキサン、アセトン等が挙げられる。特に、脱脂用溶媒としてn−ヘキサンを用いることが好ましい。抽出油分を食用油として使用し得るとともに、脱脂キウイ種子の抽出物を食品素材等に利用しやすくなるからである。尚、これらの脱脂用の溶媒は、1種のみを用いても良いし2種以上併用しても良い。
上記「発酵」の際に使用する微生物は特に限定されないが、麹菌、酵母、クエン酸菌、乳酸菌、および酢酸菌等を用いることができる。そして、これらのうち、麹菌が好ましい。
上記「麹菌」として、特に限定されないが、例えば、清酒用、焼酎用、泡盛用、味噌用もしくは醤油用の麹菌から選ばれる1以上のものを用いることができる。
例えば、 アスペルギルス・カワチ(Aspergillus kawachii)、アスペルギルス・アワモリ(Aspergillus awamori)、アスペルギルス・オリゼ(Aspergillus oryzae)、アスペルギルス・ソーヤ(Aspergillus sojae)、アスペルギルス・サイトイ(Aspergillus saitoi)、アスペルギルス・ウサミ(Aspergillus usamii)から選ばれる1以上のものである、
発酵の温度は特に限定されないが、10〜60℃、更には20〜40℃、特に25〜35℃が好ましい。これらの範囲とすることにより、麹菌による発酵が進むのに最適な温度だからである。
また、発酵時間は、特に限定されず、1〜7日、更には、2〜4日行うことが好ましい。
The rice bran and / or rice germ is preferably used with a defatted one. This is because a composition containing a higher concentration of glucosylceramide can be obtained. This degreasing method is not particularly limited,
At this time, preferable degreasing solvents include n-hexane, acetone and the like. In particular, n-hexane is preferably used as a degreasing solvent. This is because the extracted oil can be used as an edible oil and the extract of defatted kiwi seeds can be easily used as a food material. These degreasing solvents may be used alone or in combination of two or more.
Microorganisms used in the above “fermentation” are not particularly limited, and koji molds, yeasts, citric acid bacteria, lactic acid bacteria, acetic acid bacteria, and the like can be used. Of these, Neisseria gonorrhoeae is preferred.
Although it does not specifically limit as said "gonococcus", For example, the 1 or more thing chosen from sake for sake, shochu, awamori, miso, or soy sauce can be used.
For example, Aspergillus kawachii, Aspergillus awamori, Aspergillus oryzae, Aspergillus sojae, Aspergillus sasperi (Aspergillus saitoi), Aspergillus sasperi (Aspergillus sasperi) One or more selected,
Although the temperature of fermentation is not specifically limited, 10-60 degreeC, Furthermore, 20-40 degreeC, Especially 25-35 degreeC is preferable. It is because it is the optimal temperature for the fermentation by Aspergillus to progress by setting it as these ranges.
Moreover, fermentation time is not specifically limited, It is preferable to carry out for 1 to 7 days, and also for 2 to 4 days.
「極性溶媒」として、水、メタノール、エタノール、イソプロピルアルコール、1,3−ブチレングリコール、エチレングリコール、プロピレングリコール、グリセリン、酢酸エチル等の極性溶媒を使用することができる。これらの溶媒を2種以上混合してもよい。
望ましくは、水エタノールまたはこれらの混合物である含水エタノールを抽出溶媒として用いると、有効成分が効率よく抽出される。
As the “polar solvent”, polar solvents such as water, methanol, ethanol, isopropyl alcohol, 1,3-butylene glycol, ethylene glycol, propylene glycol, glycerin, and ethyl acetate can be used. Two or more of these solvents may be mixed.
Desirably, when water ethanol or water-containing ethanol, which is a mixture thereof, is used as an extraction solvent, the active ingredient is efficiently extracted.
抽出溶媒としての含水エタノールを用いる場合、エタノールの濃度が特に限定されないが、特にエタノール濃度10〜90%(wt/wt)、望ましくはエタノール濃度20〜80%(wt/wt)であるとよい。エタノール濃度90%(wt/wt)以下としたのは、エタノール濃度が高すぎると、マキベリー中の油分が含水エタノール中に溶け出しやすくなるからである。 When hydrous ethanol is used as the extraction solvent, the ethanol concentration is not particularly limited, but in particular, the ethanol concentration is 10 to 90% (wt / wt), and desirably the ethanol concentration is 20 to 80% (wt / wt). The reason for setting the ethanol concentration to 90% (wt / wt) or less is that if the ethanol concentration is too high, the oil content in the maqui berry is likely to dissolve in the water-containing ethanol.
抽出温度としては、20〜80℃、望ましくは40〜50℃程度で行うとよい。抽出温度が低すぎると、有効成分が抽出されにくくなり、抽出温度が高すぎると、有効成分が分解し、生理活性(健康機能性)が低下するためである。 The extraction temperature is 20 to 80 ° C, preferably about 40 to 50 ° C. This is because if the extraction temperature is too low, it becomes difficult to extract the active ingredient, and if the extraction temperature is too high, the active ingredient is decomposed and the physiological activity (health functionality) is reduced.
抽出方法としては、撹拌抽出、連続抽出、浸漬抽出、向流抽出、超臨界抽出など任意の方法を採用することができ、室温ないし還流加熱下において任意の装置を使用することができる。 As the extraction method, any method such as stirring extraction, continuous extraction, immersion extraction, countercurrent extraction, and supercritical extraction can be employed, and any apparatus can be used at room temperature or under reflux heating.
上記「分配」の方法は特に限定されないが、液液分配を行うことが好ましい。
液液分配で用いる溶媒は特に限定されず、例えば、水、メタノール、エタノール、イソプロピルアルコール、1,3−ブチレングリコール、エチレングリコール、プロピレングリコール、グリセリン、ヘキサン、酢酸エチル、クロロホルム等を用いることができ、これらのうち、ヘキサン、メタノール、クロロホルムを用いること好ましい。
The method of “distribution” is not particularly limited, but liquid-liquid distribution is preferably performed.
The solvent used in the liquid-liquid distribution is not particularly limited, and for example, water, methanol, ethanol, isopropyl alcohol, 1,3-butylene glycol, ethylene glycol, propylene glycol, glycerin, hexane, ethyl acetate, chloroform and the like can be used. Of these, hexane, methanol, and chloroform are preferably used.
具体的には、発酵物抽出液をヘキサンと水で分配を行い、更にこの水層を酢酸エチルと水で分配を行い、更にその水層をクロロホルム:メタノール=6:1のクロロホルムメタノール混合溶液で分配し、クロロホルムメタノール層の分離を行うことによって得ることができる。 Specifically, the fermented extract is distributed with hexane and water, the aqueous layer is further partitioned with ethyl acetate and water, and the aqueous layer is further mixed with chloroform / methanol = 6: 1 chloroform / methanol mixed solution. It can be obtained by partitioning and separating the chloroform methanol layer.
上記方法により製造されたグルコシルセラミド含有組成物は、様々な用途に適用することができる。用途として、医薬品、試薬、経口摂取用組成物(たとえば、健康食品、機能性表示食品、サプリメント、特定用途食品、及びペット用サプリメント等)が挙げられる。 The glucosylceramide-containing composition produced by the above method can be applied to various uses. Applications include pharmaceuticals, reagents, and compositions for ingestion (eg, health foods, functional foods, supplements, foods for specific uses, and supplements for pets).
上記グルコシルセラミド含有組成物を含む医薬組成物は、賦形剤、担体又は添加剤を含んでいてもよい。賦形剤、担体及び添加剤としては、通常使用され、かつ薬学的に許容されるものであれば特に限定されず、その種類及び組成は、適宜変更が可能である。 The pharmaceutical composition containing the glucosylceramide-containing composition may contain an excipient, a carrier, or an additive. The excipient, carrier and additive are not particularly limited as long as they are usually used and pharmaceutically acceptable, and the type and composition thereof can be appropriately changed.
賦形剤としては、塩化ナトリウム、クエン酸ナトリウム等が挙げられ、担体としては、滅菌水、生理食塩水、及び各種緩衝液等が挙げられる。添加剤としては、粘ちょう剤、緩衝材、保存剤、防腐剤等が挙げられる。 Examples of the excipient include sodium chloride and sodium citrate, and examples of the carrier include sterilized water, physiological saline, and various buffers. Examples of additives include thickeners, buffer materials, preservatives, preservatives, and the like.
医薬用組成物の剤型としては特に制限されるものではなく、必要に応じて適宜選択すればよいが、例えば、錠剤、カプセル剤、顆粒剤、細粒剤、散剤等の経口剤;注射剤、坐剤、塗布剤等の非経口剤が挙げられる。 The dosage form of the pharmaceutical composition is not particularly limited and may be appropriately selected as necessary. For example, oral preparations such as tablets, capsules, granules, fine granules, powders; injections And parenterals such as suppositories and coating agents.
錠剤、カプセル剤、顆粒剤、細粒剤、散剤等の経口剤は、例えば、デンプン、乳糖、白糖、トレハロース、マンニット、カルボキシメチルセルロース、コーンスターチ、無機塩類等を用いて常法に従って製造される、これらの製剤中の本発明の化合物の配合量は特に限定されるものではなく、適宜設定することができる。この種の製剤には、結合剤、崩壊剤、界面活性剤、滑沢剤、流動性促進剤、矯味剤、着色剤、香料等を適宜使用することができる。 Oral preparations such as tablets, capsules, granules, fine granules, powders and the like are produced according to a conventional method using, for example, starch, lactose, sucrose, trehalose, mannitol, carboxymethylcellulose, corn starch, inorganic salts, The compounding quantity of the compound of this invention in these formulations is not specifically limited, It can set suitably. In this type of preparation, binders, disintegrants, surfactants, lubricants, fluidity promoters, corrigents, colorants, fragrances and the like can be used as appropriate.
非経口剤の場合、患者の年齢、体重、疾患の程度等に応じて用量を調節し、例えば、静注、点滴静注、皮下注射、筋肉注射等によって投与する。この非経口剤は常法に従って製造され、希釈剤として一般に注射用蒸留水、生理食塩水等を用いることができる。さらに必要に応じて、殺菌剤、防腐剤、安定剤等を加えてもよい。また、この非経口剤は安定性の点から、バイアル等に充填後冷凍し、通常の凍結乾燥処理により水分を除き、使用直前に凍結乾燥物から液剤を再調製することもできる。さらに必要に応じて、等張化剤、安定剤、防腐剤、無痛化剤等を加えてもよい。その他の非経口剤の例として、外用液剤、軟膏等の塗布剤、直腸内投与のための坐剤等が挙げられ、これらも常法に従って製造される。 In the case of a parenteral preparation, the dose is adjusted according to the age, weight, disease level, etc. of the patient, and for example, intravenous administration, intravenous infusion, subcutaneous injection, intramuscular injection or the like is used. This parenteral preparation is produced according to a conventional method, and distilled water for injection, physiological saline and the like can be generally used as a diluent. Furthermore, you may add a bactericidal agent, antiseptic | preservative, a stabilizer, etc. as needed. In addition, from the viewpoint of stability, this parenteral preparation can be frozen after filling into a vial or the like, the water can be removed by ordinary freeze-drying treatment, and the liquid preparation can be re-prepared from the freeze-dried product immediately before use. Further, if necessary, an isotonic agent, a stabilizer, an antiseptic, a soothing agent and the like may be added. Examples of other parenteral agents include liquid preparations for external use, coating agents such as ointments, suppositories for rectal administration, etc., and these are also produced according to conventional methods.
本発明を健康食品(機能性表示食品、特定保健用食品、健康飲料及びサプリメントを含む)に用いる場合、各種健康食品の原材料として本発明の化合物を健康食品に添加したり、必要に応じてデキストリン、乳糖、デンプン等の賦形剤や香料、色素等とともにペレット、錠剤、顆粒等に加工したり、またゼラチン等で被覆してカプセルに成形加工して健康食品を製造することができる。 When the present invention is used for health foods (including functional indication foods, foods for specified health use, health drinks and supplements), the compound of the present invention is added to the health foods as raw materials for various health foods, or dextrin as necessary It can be processed into pellets, tablets, granules, etc. together with excipients such as lactose and starch, fragrances, pigments, etc., or coated with gelatin and formed into capsules to produce health foods.
健康食品に配合されるグルコシルセラミド含有組成物の配合割合は、該グルコシルセラミド含有組成物から期待される効果が得られるのであれば特に制限されないが、通常、1回あたりの摂取量が0.0001〜2000mg程度である。 The blending ratio of the glucosylceramide-containing composition to be blended with the health food is not particularly limited as long as the effect expected from the glucosylceramide-containing composition can be obtained. About 2,000 mg.
これらの健康食品には、その種類に応じて種々の成分を配合することができ、例えば、ブドウ糖、果糖、ショ糖、マルトース、ソルビトール、ステビオサイド、コーンシロップ、乳糖、クエン酸、酒石酸、リンゴ酸、コハク酸、乳酸、L−アスコルビン酸、dl−α−トコフェロール、エリソルビン酸ナトリウム、グリセリン、プロピレングリコール、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル、ソルビタン脂肪酸エステル、プロピレングリコール脂肪酸エステル、アラビアガム、カラギーナン、カゼイン、ゼラチン、ペクチン、寒天、ビタミンB類、ニコチン酸アミド、パントテン酸カルシウム、アミノ酸類、カルシウム塩類、色素、香料、保存剤等の食品素材を使用することができる。さらに、健康維持機能をもったグルコシルセラミド含有組成物には、他の抗酸化物質や健康食品素材などの配剤、例えば、抗酸化物質(還元型アスコルビン酸(ビタミンC)、ビタミンE、還元型グルタチン、トコトリエノール、ビタミンA誘導体、リコピン、ルテイン、アスタキサンチン、ゼアキサンチン、フコキサンチン、尿酸、ユビキノン、コエンザイムQ10、葉酸、ニンニクエキス、アリシン、セサミン、リグナン類、カテキン、イソフラボン、カルコン、タンニン類、フラボノイド類、クマリン、イソクマリン類、ブルーベリーエキス)、健康食品素材(V.(ビタミン)A、V.B1、V.B2、V.B6、V.B12、V.C、V.D、V.E、V.P、コリン、ナイアシン、パントテン酸、葉酸カルシウム、EPA、オリゴ糖、食物繊維、スクアレン、大豆レシチン、タウリン、ドナリエラ、プロテイン、オクタコサノール、DHA、卵黄レシチン、リノール酸、ラクトフェリン、マグネシウム、亜鉛、クロム、セレン 、カリウム、ヘム鉄、カキ肉エキス、キトサン、キチンオリゴ糖、コラーゲン、コンドロイチン、ウコン、カンゾウ、クコシ、ケイヒ、サンザシ、生姜、霊芝、シジミエキス、スッポン、カミツレ、カモミール、セイヨウタンポポ、ハイビスカス、ハチミツ、ボーレン、ローヤルゼリー、ライム、ラベンダー、ローズヒップ 、ローズマリー、ビフィズス菌、フェーカリス菌、ラクリス、小麦胚芽油、ゴマ油、シソ油、大豆油、中鎖脂肪酸、アガリクス、イチョウ葉エキス、ウコン、コンドロイチン、玄米胚芽エキス、レイシ、タマネギ、DPA、 甜茶、冬虫夏草、ニンニク、蜂の子、パパイヤ、プーアル、プロポリス、メグスリの木、ヤブシタケ、ノコギリヤシ、ヒアルロン酸、コラーゲン、ギャバ、ハープシールオイル、サメ軟骨、グルコサミン、レシチン、ホスファチジルセリン、田七ニンジン、桑葉、大豆抽出物、エキナセア、エゾウコギ、大麦抽出物、オリーブ葉、オリーブ実、ギムネマ、バナバ、サラシア、ガルシニア、キトサン、セントジョーンズワート、ナツメ、ニンジン、パッションフラワー、ブロッコリー、プラセンタ、ハトムギ、ブドウ種子、ピーナッツ種皮、ビルベリー、ブラックコホシュ、マリアアザミ、月桂樹、セージ、ラフマ、黒酢、ゴーヤー、マカ、紅花、亜麻、ウーロン茶、花棘、カフェイン、カプサイシン、キシロオリゴ糖、グルコサミン、ソバ、シトラス、食物繊維、プロテイン、プルーン、スピルリナ、大麦若葉、核酸、酵母、椎茸、梅肉、アミノ酸、深海鮫抽出物、ノニ、カキ肉、シャンピニオン、オオバコ、アセロラ、パイナップル、バナナ、モモ、アンズ、メロン、イチゴ、ラズベリー、オレンジ、フコイダン、メシマコブ、クランベリー、コンドロイチン硫酸、亜鉛、鉄、セラミド、シルクペプチド、グリシン、ナイアシン、チェストツリー、L-システイン、赤ワイン葉、ミレット、ホーステール、ビオチン、センテラアジアティカ、ハスカップ、ピクノジェノール、フキ、ルバーブ、クローブ、カテキン、プーアル、クエン酸、ビール酵母、メリロート、ブラックジンガー、ショウガ、ガジュツ、ナットウキナーゼ、ベニコウジ、トコトリエノール、ラクトフェリン、シナモン、韃靼ソバ、ココア、ユズ種子エキス、シソの実エキス、ライチ種子エキス、月見草エキス、黒米エキス、α−リポ酸、生コーヒー豆エキス、温州みかんエキス、トリテルペノイド、キウイ種子エキス、赤ショウガエキス、アスタキサンチン、クルミエキス、レスベラトロール、赤米エキス、白キクラゲ多糖体、イチゴ種子エキス、イチゴ種子エキス、ニラ種子エキス、リンゴンベリーエキス、桜の花エキス、ササクレヒトヨダケエキス、マキベリーエキス、米ポリアミン、小麦ポリアミン)なども配合することができる。 These health foods can be blended with various components depending on the type, for example, glucose, fructose, sucrose, maltose, sorbitol, stevioside, corn syrup, lactose, citric acid, tartaric acid, malic acid, Succinic acid, lactic acid, L-ascorbic acid, dl-α-tocopherol, sodium erythorbate, glycerin, propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, gum arabic Food materials such as carrageenan, casein, gelatin, pectin, agar, vitamin Bs, nicotinic acid amide, calcium pantothenate, amino acids, calcium salts, pigments, fragrances and preservatives can be used. In addition, glucosylceramide-containing compositions with health maintenance functions include other antioxidants and health food ingredients such as antioxidants (reduced ascorbic acid (vitamin C), vitamin E, reduced glutatin). , Tocotrienol, vitamin A derivatives, lycopene, lutein, astaxanthin, zeaxanthin, fucoxanthin, uric acid, ubiquinone, coenzyme Q10, folic acid, garlic extract, allicin, sesamin, lignans, catechin, isoflavone, chalcone, tannins, flavonoids, coumarin , Isocoumarins, blueberry extract), health food ingredients (V. (vitamin) A, V.B1, V.B2, V.B6, V.B12, VC, VD, VE, VP, choline, niacin, pantothenic acid, Calcium folate, EPA, oligosaccharide, dietary fiber, squalene, soybean lecithin, taurine Donariella, protein, octacosanol, DHA, egg yolk lecithin, linoleic acid, lactoferrin, magnesium, zinc, chromium, selenium, potassium, heme iron, oyster meat extract, chitosan, chitin oligosaccharide, collagen, chondroitin, turmeric, licorice, kokushi, kehi , Hawthorn, ginger, ganoderma, swordfish extract, turtle, chamomile, chamomile, dandelion, hibiscus, honey, boren, royal jelly, lime, lavender, rosehip, rosemary, bifidobacteria, faecalis, lacris, wheat germ oil, sesame oil , Perilla oil, soybean oil, medium chain fatty acid, agaricus, ginkgo biloba extract, turmeric, chondroitin, brown rice germ extract, litchi, onion, DPA, green tea, cordyceps, garlic, bee, papaya, puer, pu Ropolis, Meguri Tree, Yabushitake, Saw Palmetto, Hyaluronic Acid, Collagen, Gabba, Harp Seal Oil, Shark Cartilage, Glucosamine, Lecithin, Phosphatidylserine, Padlock Carrot, Mulberry Leaf, Soybean Extract, Echinacea, Ezoukogi, Barley Extract, Olive leaf, olive fruit, Gymnema, banaba, Salacia, Garcinia, chitosan, St. John's wort, jujube, carrot, passionflower, broccoli, placenta, pearl barley, grape seeds, peanut seed coat, bilberry, black cohosh, maria thistle, laurel, sage, raffma , Black vinegar, bitter gourd, maca, safflower, flax, oolong tea, flower spine, caffeine, capsaicin, xylooligosaccharide, glucosamine, buckwheat, citrus, dietary fiber, protein, prunes, spirulina, large Young leaves, nucleic acids, yeast, shiitake mushrooms, plum meat, amino acids, deep-sea shark extract, noni, oyster meat, champignon, plantain, acerola, pineapple, banana, peach, apricot, melon, strawberry, raspberry, orange, fucoidan, mesimacob, cranberry , Chondroitin sulfate, zinc, iron, ceramide, silk peptide, glycine, niacin, chestnut tree, L-cysteine, red wine leaf, millet, horsetail, biotin, Centella Asiatica, Haskup, Pycnogenol, Fuki, Rhubarb, clove, catechin , Puer, citric acid, brewer's yeast, merirot, black zinger, ginger, gadget, nattokinase, benichouji, tocotrienol, lactoferrin, cinnamon, persimmon buckwheat, cocoa, yuzu seed extract, perilla seed extract, la Ichise seed extract, evening primrose extract, black rice extract, α-lipoic acid, fresh coffee bean extract, Unshu mandarin orange extract, triterpenoid, kiwi seed extract, red ginger extract, astaxanthin, walnut extract, resveratrol, red rice extract, white fungus polysaccharide Strawberry seed extract, strawberry seed extract, leek seed extract, lingon berry extract, cherry blossom extract, Sasa Kurihito yotake extract, maqui berry extract, rice polyamine, wheat polyamine) and the like.
上記グルコシルセラミド含有組成物は、本発明を健康食品として使用する場合、その形態としては、各種一般飲食品の剤型として使用することができる。
ここで「各種一般飲食品の剤型として使用することができる。」とは、上記グルコシルセラミド含有組成物としての効果を発揮することを目的として剤型とて一般飲食品を選択することができるという意味であり、グルコシルセラミド含有組成物から期待される効果を希望する人のみが食することを目的としており、上記グルコシルセラミド含有組成物としての効果を期待しない人をも含む広く万人に食することができるという意味ではない。
また、上記グルコシルセラミド含有組成物として効果を発揮するための配合量は特に限定されないが、飲食品に対して有効成分の含量が合計1〜20wt%であるのが好ましい。
また、配合する一般飲食品として特に限定さないが、例えば、食用油(サラダ油)、菓子類(ガム、キャンディー、キャラメル、チョコレート、クッキー、スナック、ゼリー、グミ、錠菓等)、麺類(そば、うどん、ラーメン等)、乳製品(ミルク、アイスクリーム、ヨーグルト等)、調味料(味噌、醤油等)、スープ類、飲料(ジュース、コーヒー、紅茶、茶、炭酸飲料、スポーツ飲料等)等が挙げられる。
When the present invention is used as a health food, the glucosylceramide-containing composition can be used as a dosage form for various general foods and drinks.
Here, “can be used as a dosage form of various general foods and drinks” means that the general food and drink can be selected as the dosage form for the purpose of exhibiting the effect as the glucosylceramide-containing composition. It is meant to be eaten only by those who desire the effect expected from the glucosylceramide-containing composition, and is widely eaten by everyone including those who do not expect the effect as the glucosylceramide-containing composition. It doesn't mean you can.
Moreover, although the compounding quantity for exhibiting an effect as said glucosylceramide containing composition is not specifically limited, It is preferable that the content of an active ingredient is 1-20 wt% in total with respect to food-drinks.
Moreover, although it does not specifically limit as general food / beverage products to mix | blend, For example, edible oil (salad oil), confectionery (gum, candy, caramel, chocolate, cookie, snack, jelly, gummi, tablet confection etc.), noodles (soba, Udon, ramen, etc.), dairy products (milk, ice cream, yogurt, etc.), seasonings (miso, soy sauce, etc.), soups, beverages (juice, coffee, tea, tea, carbonated drinks, sports drinks, etc.) It is done.
これら一般飲食品には、その種類に応じて種々の成分を配合することができ、例えば、ブドウ糖、果糖、ショ糖、マルトース、ソルビトール、ステビオサイド、コーンシロップ、乳糖、クエン酸、酒石酸、リンゴ酸、コハク酸、乳酸、L−アスコルビン酸、dl−α−トコフェロール、エリソルビン酸ナトリウム、グリセリン、プロピレングリコール、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル、ソルビタン脂肪酸エステル、プロピレングリコール脂肪酸エステル、アラビアガム、カラギーナン、カゼイン、ゼラチン、ペクチン、寒天、ビタミンB類、ニコチン酸アミド、パントテン酸カルシウム、アミノ酸類、カルシウム塩類、色素、香料、保存剤等の食品素材を使用することができる。さらに、健康維持機能をもった上記グルコシルセラミド含有組成物には、他の抗酸化物質や健康食品素材などの配剤、例えば、抗酸化物質(還元型アスコルビン酸(ビタミンC)、ビタミンE、還元型グルタチン、トコトリエノール、ビタミンA誘導体、リコピン、ルテイン、アスタキサンチン、ゼアキサンチン、フコキサンチン、尿酸、ユビキノン、コエンザイムQ10、葉酸、ニンニクエキス、アリシン、セサミン、リグナン類、カテキン、イソフラボン、カルコン、タンニン類、フラボノイド類、クマリン、イソクマリン類、ブルーベリーエキス)、健康食品素材(V.(ビタミン)A、V.B1、V.B2、V.B6、V.B12、V.C、V.D、V.E、V.P、コリン、ナイアシン、パントテン酸、葉酸カルシウム、EPA、オリゴ糖、食物繊維、スクアレン、大豆レシチン、タウリン、ドナリエラ、プロテイン、オクタコサノール、卵黄レシチン、リノール酸、ラクトフェリン、マグネシウム、クロム、セレン、カリウム、ヘム鉄、カキ肉エキス、キトサン、キチンオリゴ糖、コラーゲン、コンドロイチン、ウコン、カンゾウ、クコシ、ケイヒ、サンザシ、生姜、霊芝、シジミエキス、カンゾウ、クコシ、ケイヒ、サンザシ、生姜、霊芝、オオバコ、カミツレ、カモミール、セイヨウタンポポ、ハイビスカス、ハチミツ、ボーレン、ローヤルゼリー、ライム、ラベンダー、ローズヒップ、ローズマリー、セージ、ビフィズス菌、フェーカリス菌、ラクリス、小麦胚芽油、ゴマ油、シソ油、大豆油、中鎖脂肪酸、アガリクス、イチョウ葉エキス、ウコン、コンドロイチン、玄米胚芽エキス、レイシ、タマネギ、DHA、 EPA、 DPA、甜茶、冬虫夏草、ニンニク、蜂の子、パパイヤ、プーアル、プロポリス、メグスリの木、ヤブシタケ、ロイヤルゼリー、ノコギリヤシ、ヒアルロン酸、コラーゲン、ギャバ、ハープシールオイル、サメ軟骨、グルコサミン、レシチン、ホスファチジルセリン、田七ニンジン、桑葉、大豆抽出物、エキナセア、エゾウコギ、大麦抽出物、オリーブ葉、オリーブ実、ギムネマ、バナバ、サラシア、ガルシニア、キトサン、セントジョーンズワート、ナツメ、ニンジン、パッションフラワー、ブロッコリー、プラセンタ、ハトムギ、ブドウ種子、ピーナッツ種皮、ビルベリー、ブラックコホシュ、マリアアザミ、月桂樹、セージ、ローズマリー、ラフマ、黒酢、ゴーヤー、マカ、紅花、亜麻、ウーロン茶、花棘、カフェイン、カプサイシン、キシロオリゴ糖、グルコサミン、ソバ、シトラス、食物繊維、プロテイン、プルーン、スピルリナ、大麦若葉、核酸、酵母、椎茸、梅肉、アミノ酸、深海鮫抽出物、ノニ、カキ肉、スッポン、シャンピニオン、オオバコ、アセロラ、パイナップル、バナナ、モモ、アンズ、メロン、イチゴ、ラズベリー、オレンジ、フコイダン、メシマコブ、クランベリー、コンドロイチン硫酸、亜鉛、鉄、セラミド、シルクペプチド、グリシン、ナイアシン、チェストツリー、L-システイン、赤ワイン葉、ミレット、ホーステール、ビオチン、センテラアジアティカ、ハスカップ、ピクノジェノール、フキ、ルバーブ、クローブ、ローズマリー、カテキン、プーアル、クエン酸、ビール酵母、メリロート、ブラックジンガー、ショウガ、ガジュツ、ナットウキナーゼ、ベニコウジ、トコトリエノール、ラクトフェリン、シナモン、韃靼ソバ、ココア、ユズ種子エキス、シソの実エキス、ライチ種子エキス、月見草エキス、黒米エキス、α−リポ酸、ギャバ、生コーヒー豆エキス、フキエキス、キウイ種子エキス、温州みかんエキス、アカショウガエキス、アスタキサンチン、クルミエキス、ニラ種子エキス、赤米エキス、カンカエキス、白キクラゲ多糖体、フコキサンチン、リンゴンベリーエキス、桜の花エキス、マキベリーエキス、ササクレヒトヨタケエキス、米ポリアミン、小麦ポリアミン)なども配合することができる。 In these general foods and drinks, various components can be blended depending on the type, for example, glucose, fructose, sucrose, maltose, sorbitol, stevioside, corn syrup, lactose, citric acid, tartaric acid, malic acid, Succinic acid, lactic acid, L-ascorbic acid, dl-α-tocopherol, sodium erythorbate, glycerin, propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, gum arabic Food materials such as carrageenan, casein, gelatin, pectin, agar, vitamin Bs, nicotinic acid amide, calcium pantothenate, amino acids, calcium salts, pigments, fragrances and preservatives can be used. Furthermore, the glucosylceramide-containing composition having a health maintenance function includes other antioxidants and health food ingredients such as antioxidants (reduced ascorbic acid (vitamin C), vitamin E, reduced form). Glutatin, tocotrienol, vitamin A derivative, lycopene, lutein, astaxanthin, zeaxanthin, fucoxanthin, uric acid, ubiquinone, coenzyme Q10, folic acid, garlic extract, allicin, sesamin, lignans, catechin, isoflavone, chalcone, tannins, flavonoids, Coumarin, isocoumarins, blueberry extract), health food ingredients (V. (vitamin) A, V.B1, V.B2, V.B6, V.B12, VC, VD, VE, VP, choline, niacin, pantothenic acid , Calcium folate, EPA, oligosaccharide, dietary fiber, squalene, soy lecithin, tau , Donariella, protein, octacosanol, egg yolk lecithin, linoleic acid, lactoferrin, magnesium, chromium, selenium, potassium, heme iron, oyster meat extract, chitosan, chitin oligosaccharide, collagen, chondroitin, turmeric, licorice, kokushi, kehi, hawthorn , Ginger, ganoderma, rainbow trout extract, licorice, kokushi, keihi, hawthorn, ginger, ganoderma, plantain, chamomile, chamomile, dandelion, hibiscus, honey, bohlen, royal jelly, lime, lavender, rosehip, rosemary, sage, Bifidobacterium, faecalis, lacris, wheat germ oil, sesame oil, perilla oil, soybean oil, medium chain fatty acid, agaricus, ginkgo biloba extract, turmeric, chondroitin, brown rice germ extract, litchi, onion, DHA, EPA, DPA甜 Tea, Cordyceps, Garlic, Bee, Papaya, Puaru, Propolis, Meguri Tree, Yabushitake, Royal Jelly, Saw Palmetto, Hyaluronic Acid, Collagen, Gabba, Harpseal Oil, Shark Cartilage, Glucosamine, Lecithin, Phosphatidylserine, Tabashi Carrot, mulberry leaf, soy extract, echinacea, sorghum, barley extract, olive leaf, olive fruit, gymnema, banaba, salacia, garcinia, chitosan, st jones wort, jujube, carrot, passion flower, broccoli, placenta, pearl barley, grape Seeds, peanut seed coat, bilberry, black cohosh, maria thistle, laurel, sage, rosemary, raffma, black vinegar, bitter gourd, maca, safflower, flax, oolong tea, flower spine, caffeine, capsaicin, xy Oligosaccharide, Glucosamine, Buckwheat, Citrus, Dietary fiber, Protein, Prunes, Spirulina, Barley young leaves, Nucleic acid, Yeast, Shiitake, Plum meat, Amino acid, Deep sea potato extract, Noni, Oyster meat, Suppon, Champignon, Psyllium, Acerola, Pineapple, banana, peach, apricot, melon, strawberry, raspberry, orange, fucoidan, mesimacob, cranberry, chondroitin sulfate, zinc, iron, ceramide, silk peptide, glycine, niacin, chesttree, L-cysteine, red wine leaf, millet, Horsetail, Biotin, Centella Asiatica, Lotus Cup, Pycnogenol, Japanese cypress, Rhubarb, Clove, Rosemary, Catechin, Pual, Citric Acid, Beer Yeast, Merirot, Black Zinger, Ginger, Gajutsu, Nattokina , Benikouji, Tocotrienol, Lactoferrin, Cinnamon, Persimmon Buckwheat, Cocoa, Yuzu Seed Extract, Perilla Seed Extract, Lychee Seed Extract, Evening Primrose Extract, Black Rice Extract, α-Lipoic Acid, Gabba, Fresh Coffee Bean Extract, Fuquisa Extract, Kiwi Seed Extract , Wenzhou mandarin orange extract, red ginger extract, astaxanthin, walnut extract, leek seed extract, red rice extract, kanka extract, white jellyfish polysaccharide, fucoxanthin, lingonberry extract, cherry blossom extract, maquiberry extract, Japanese cherry extract, rice polyamine, Wheat polyamine) can also be blended.
上記グルコシルセラミド含有組成物は、皮膚外用剤(化粧品、医薬品および医薬部外品を含む)として用いることができる。
上記グルコシルセラミド含有組成物を配合しうる皮膚外用剤の形態としては、例えば、乳液、石鹸、洗顔料、入浴剤、クリーム、乳液、化粧水、オーデコロン、ひげ剃り用クリーム、ひげ剃り用ローション、化粧油、日焼け・日焼け止めローション、おしろいパウダー、ファンデーション、香水、パック、爪クリーム、エナメル、エナメル除去液、眉墨、ほお紅、アイクリーム、アイシャドー、マスカラ、アイライナー、口紅、リップクリーム、シャンプー、リンス、染毛料、分散液、洗浄料等が挙げられる。また、上記グルコシルセラミド含有組成物を配合しうる医薬品または医薬部外品の形態としては、軟膏剤、クリーム剤、外用液剤等が挙げられる。
The glucosylceramide-containing composition can be used as a skin external preparation (including cosmetics, pharmaceuticals, and quasi drugs).
Examples of the external preparation for skin to which the glucosylceramide-containing composition can be formulated include, for example, emulsion, soap, facial cleanser, bath preparation, cream, emulsion, lotion, eau de cologne, shaving cream, shaving lotion, makeup Oil, sunscreen / sunscreen lotion, funny powder, foundation, perfume, pack, nail cream, enamel, enamel remover, eyebrow, blusher, eye cream, eye shadow, mascara, eyeliner, lipstick, lip balm, shampoo, rinse, Examples include hair dyes, dispersions, and cleaning materials. Examples of the form of a pharmaceutical or quasi-drug that can contain the glucosylceramide-containing composition include ointments, creams, and liquids for external use.
上記形態の皮膚外用剤には、上記グルコシルセラミド含有組成物の他に、その上記グルコシルセラミド含有組成物が有する作用を損なわない範囲で化粧品、医薬部外品などの皮膚外用剤に配合される成分、油分、高級アルコール、脂肪酸、紫外線吸収剤、粉体、顔料、界面活性剤、多価アルコール・糖、高分子、生理活性成分、溶媒、酸化防止剤、香料、防腐剤等を配合することができる。
例を以下に羅列するが、本発明はこれらの例に限定されるものではない。
In addition to the glucosylceramide-containing composition, the external preparation for skin of the above-described form is a component blended in an external preparation for skin such as cosmetics and quasi-drugs as long as the action of the glucosylceramide-containing composition is not impaired. , Oils, higher alcohols, fatty acids, UV absorbers, powders, pigments, surfactants, polyhydric alcohols / sugars, polymers, physiologically active ingredients, solvents, antioxidants, fragrances, preservatives, etc. it can.
Examples are listed below, but the present invention is not limited to these examples.
(1)油分の例
エステル系の油相成分:トリ2-エチルヘキサン酸グリセリル、2-エチルヘキサン酸セチル、ミリスチン酸イソプロピル、ミリスチン酸ブチル、パルミチン酸イソプロピル、ステアリン酸エチル、パルミチン酸オクチル、イソステアリン酸イソセチル、ステアリン酸ブチル、ミリスチン酸ブチル、リノール酸エチル、リノール酸イソプロピル、オレイン酸エチル、ミリスチン酸イソセチル、ミリスチン酸イソステアリル、パルミチン酸イソステアリル、ミリスチン酸オクチルドデシル、イソステアリン酸イソセチル、セバシン酸ジエチル、アジピン酸ジイソプロピル、ネオペンタン酸イソアラキル、トリ(カプリル・カプリン酸)グリセリル、トリ2-エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ2-エチルヘキサン酸ペンタエリスリトール、カプリル酸セチル、ラウリン酸デシル、ラウリン酸ヘキシル、ミリスチン酸デシル、ミリスチン酸ミリスチル、ミリスチン酸セチル、ステアリン酸ステアリル、オレイン酸デシル、リシノレイン酸セチル、ラウリン酸イソステアリル、ミリスチン酸イソトリデシル、ミリスチン酸イソセチル、ミリスチン酸イソステアリル、パルミチン酸イソセチル、パルミチン酸イソステアリル、ステアリン酸オクチル、ステアリン酸イソセチル、オレイン酸イソデシル、オレイン酸オクチルドデシル、リノール酸オクチルドデシル、イソステアリン酸イソプロピル、2-エチルヘキサン酸セトステアリル、2-エチルヘキサン酸ステアリル、イソステアリン酸ヘキシル、ジオクタン酸エチレングリコール、ジオレイン酸エチレングリコール、ジカプリン酸プロピレングリコール、ジ(カプリル・カプリン酸)プロピレングリコール、ジカプリル酸プロピレングリコール、ジカプリン酸ネオペンチルグリコール、ジオクタン酸ネオペンチルグリコール、トリカプリル酸グリセリル、トリウンデシル酸グリセリル、トリイソパルミチン酸グリセリル、トリイソステアリン酸グリセリル、ネオペンタン酸オクチルドデシル、オクタン酸イソステアリル、イソノナン酸オクチル、ネオデカン酸ヘキシルデシル、ネオデカン酸オクチルドデシル、イソステアリン酸イソセチル、イソステアリン酸イソステアリル、イソステアリン酸オクチルデシル、ポリグリセリンオレイン酸エステル、ポリグリセリンイソステアリン酸エステル、炭酸ジプロピル、炭酸ジアルキル(C12-18)、クエン酸トリイソセチル、クエン酸トリイソアラキル、クエン酸トリイソオクチル、乳酸ラウリル、乳酸ミリスチル、乳酸セチル、乳酸オクチルデシル、クエン酸トリエチル、クエン酸アセチルトリエチル、クエン酸アセチルトリブチル、クエン酸トリオクチル、リンゴ酸ジイソステアリル、ヒドロキシステアリン酸2-エチルヘキシル、コハク酸ジ2-エチルヘキシル、アジピン酸ジイソブチル、セバシン酸ジイソプロピル、セバシン酸ジオクチル、ステアリン酸コレステリル、イソステアリン酸コレステリル、ヒドロキシステアリン酸コレステリル、オレイン酸コレステリル、オレイン酸ジヒドロコレステリル、イソステアリン酸フィトステリル、オレイン酸フィトステリル、12-ステアロイルヒドロキシステアリン酸イソセチル、12-ステアロイルヒドロキシステアリン酸ステアリル、12-ステアロイルヒドロキシステアリン酸イソステアリル等が挙げられる。
炭化水素系の油相成分:スクワラン、流動パラフィン、α-オレフィンオリゴマー、イソパラフィン、セレシン、パラフィン、流動イソパラフィン、ポリブテン、マイクロクリスタリンワックス、ワセリン等が挙げられる。
動植物油とその硬化油、および天然由来のロウ:牛脂、硬化牛脂、豚脂、硬化豚脂、馬油、硬化馬油、ミンク油、オレンジラフィー油、魚油、硬化魚油、卵黄油等の動物油およびその硬化油、アボカド油、アルモンド油、オリーブ油、カカオ脂、キウイ種子油、杏仁油、ククイナッツ油、ゴマ油、小麦胚芽油、コメ胚芽油、コメヌカ油、サフラワー油、シアバター、大豆油、月見草油、シソ油、茶実油、ツバキ油、トウモロコシ油、ナタネ油、硬化ナタネ油、パーム核油、硬化パーム核油、パーム油、硬化パーム油、ピーナッツ油、硬化ピーナッツ油、ヒマシ油、硬化ヒマシ油、ヒマワリ油、ブドウ種子油、ホホバ油、硬化ホホバ油、マカデミアナッツ油、メドホーム油、綿実油、硬化綿実油、ヤシ油、硬化ヤシ油等の植物油およびその硬化油、ミツロウ、高酸価ミツロウ、ラノリン、還元ラノリン、硬化ラノリン、液状ラノリン、カルナバロウ、モンタンロウ等のロウ等が挙げられる。
シリコーン系の油相成分:ジメチルポリシロキサン、メチルフェニルポリシロキサン、メチルシクロポリシロキサン、オクタメチルポリシロキサン、デカメチルポリシロキサン、ドデカメチルシクロシロキサン、メチルハイドロジェンポリシロキサン、ポリエーテル変性オルガノポリシロキサン、ジメチルシロキサン・メチルセチルオキシシロキサン共重合体、ジメチルシロキサン・メチルステアロキシシロキサン共重合体、アルキル変性オルガノポリシロキサン、末端変性オルガノポリシロキサン、アミノ変性シリコーン油、アミノ変性オルガノポリシロキサン、ジメチコノール、シリコーンゲル、アクリルシリコーン、トリメチルシロキシケイ酸、シリコーンRTVゴム等が挙げられる。
フッ素系の油相成分:パーフルオロポリエーテル、フッ素変性オルガノポリシロキサン、フッ化ピッチ、フルオロカーボン、フルオロアルコール、フルオロアルキル・ポリオキシアルキレン共変性オルガノポリシロキサン等が挙げられる。
(1) Examples of oil components Ester-based oil phase components: glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isostearic acid Isocetyl, butyl stearate, butyl myristate, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, adipine Diisopropyl acid, isoaralkyl neopentanoate, glyceryl tri (capryl / caprate), trimethylolpropane tri-2-ethylhexanoate, trimethylol triisostearate Propane, pentaerythritol tetra-2-ethylhexanoate, cetyl caprylate, decyl laurate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinoleate, isolaurate Stearyl, isotridecyl myristate, isocetyl myristate, isostearyl myristate, isocetyl palmitate, isostearyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl linoleate, octyldodecyl isoleate, isopropyl isostearate Cetostearyl 2-ethylhexanoate, stearyl 2-ethylhexanoate, hexyl isostearate, ethyleneglycol dioctanoate , Ethylene glycol dioleate, propylene glycol dicaprate, propylene glycol di (capryl / capric acid), propylene glycol dicaprylate, neopentyl glycol dicaprate, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl triundecylate, triisopalmitine Glyceryl acid, glyceryl triisostearate, octyldodecyl neopentanoate, isostearyl octanoate, octyl isononanoate, hexyl decyl neodecanoate, octyldodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, octyldecyl isostearate, polyglycerin oleic acid Ester, polyglycerol isostearate, dipropyl carbonate, charcoal Dialkyl (C12-18), triisocetyl citrate, triisoaralkyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyl decyl lactate, triethyl citrate, acetyl triethyl citrate, acetyl tributyl citrate, Trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di-2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, olein Cholesteryl acid, dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, 12-stearoyl hydroxystearate Cetyl, 12-stearoyl-hydroxystearic acid stearyl 12-stearoyl-hydroxystearic acid isostearate, and the like.
Hydrocarbon oil phase components: squalane, liquid paraffin, α-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybutene, microcrystalline wax, petrolatum and the like.
Animal and vegetable oils and their hydrogenated oils, and naturally occurring waxes: beef tallow, hydrogenated beef tallow, lard, hydrogenated tallow, horse oil, hydrogenated horse oil, mink oil, orange luffy oil, fish oil, hydrogenated fish oil, egg yolk oil and other animal oils and Its hardened oil, avocado oil, almond oil, olive oil, cacao butter, kiwi seed oil, apricot oil, kukui nut oil, sesame oil, wheat germ oil, rice germ oil, rice bran oil, safflower oil, shea butter, soybean oil, evening primrose oil , Perilla oil, tea seed oil, camellia oil, corn oil, rapeseed oil, hydrogenated rapeseed oil, palm kernel oil, hydrogenated palm kernel oil, palm oil, hydrogenated palm oil, peanut oil, hydrogenated peanut oil, castor oil, hydrogenated castor oil , Vegetable oils such as sunflower oil, grape seed oil, jojoba oil, hardened jojoba oil, macadamia nut oil, medhome oil, cottonseed oil, hardened cottonseed oil, coconut oil, hardened coconut oil and its hardened , Beeswax, high acid value beeswax, lanolin, reduced lanolin, hydrogenated lanolin, liquid lanolin, carnauba wax and montan wax.
Silicone oil phase components: dimethylpolysiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, methylhydrogenpolysiloxane, polyether-modified organopolysiloxane, dimethyl Siloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / methylstearoxysiloxane copolymer, alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, amino-modified silicone oil, amino-modified organopolysiloxane, dimethiconol, silicone gel, acrylic Examples include silicone, trimethylsiloxysilicic acid, and silicone RTV rubber.
Fluorine oil phase components: perfluoropolyether, fluorine-modified organopolysiloxane, fluorinated pitch, fluorocarbon, fluoroalcohol, fluoroalkyl / polyoxyalkylene co-modified organopolysiloxane, and the like.
(2)高級アルコールの例
ラウリルアルコール、ミリスチルアルコール、セチルアルコール、ステアリルアルコール、イソステアリルアルコール、オレイルアルコール、ベヘニルアルコール、2-エチルヘキサノール、ヘキサデシルアルコール、オクチルドデカノール等が挙げられる。
(2) Examples of higher alcohols include lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, behenyl alcohol, 2-ethylhexanol, hexadecyl alcohol, octyldodecanol and the like.
(3)脂肪酸の例
カプリル酸、カプリン酸、ウンデシレン酸、ラウリン酸、ミリスチン酸、パルミチン酸、パルミトレイン酸、ステアリン酸、イソステアリン酸、オレイン酸、リノール酸、リノレン酸、アラキン酸、アラキドン酸、ベヘン酸、エルカ酸、2-エチルヘキサン酸等が挙げられる。
(3) Examples of fatty acids Caprylic acid, capric acid, undecylenic acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid, arachidonic acid, behenic acid , Erucic acid, 2-ethylhexanoic acid and the like.
(4)紫外線吸収剤の例
パラアミノ安息香酸、パラアミノ安息香酸アミル、パラアミノ安息香酸エチルジヒドロキシプロピル、パラアミノ安息香酸グリセリル、パラアミノ安息香酸エチル、パラアミノ安息香酸オクチル、パラアミノ安息香酸オクチルジメチル、サリチル酸エチレングリコール、サリチル酸オクチル、サリチル酸トリエタノールアミン、サリチル酸フェニル、サリチル酸ブチルフェニル、サリチル酸ベンジル、サリチル酸ホモメンチル、ケイ皮酸ベンジル、パラメトキシケイ皮酸オクチル、パラメトキシケイ皮酸2-エチルヘキシル、ジパラメトキシケイ皮酸モノ2-エチルヘキサン酸グリセリル、パラメトキシケイ皮酸イソプロピル、パラメトキシヒドロケイ皮酸ジエタノールアミン塩、ジイソプロピル・ジイソプロピルケイ皮酸エステル混合物、ウロカニン酸、ウロカニン酸エチル、ヒドロキシメトキシベンゾフェノン、ヒドロキシメトキシベンゾフェノンスルホン酸及びその塩、ジヒドロキシメトキシベンゾフェノン、ジヒドロキシメトキシベンゾフェノンジスルホン酸ナトリウム、ジヒドロキシベンゾフェノン、ジヒドロキシジメトキシベンゾフェノン、ヒドロキシオクトキシベンゾフェノン、テトラヒドロキシベンゾフェノン、ブチルメトキシジベンゾイルメタン、2、4、6-トリアニリノ-p-(カルボ-2-エチルヘキシル-1-オキシ)-1、3、5-トリアジン、2-(2-ヒドロキシ-5-メチルフェニル)ベンゾトリアゾール、メチル-O-アミノベンゾエート、2-エチルヘキシル-2-シアノ-3、3-ジフェニルアクリレート、フェニルベンゾイミダゾール硫酸、3-(4-メチルベンジリデン)カンフル、イソプロピルジベンゾイルメタン、4-(3、4-ジメトキシフェニルメチレン)-2、5-ジオキソ-1-イミダゾリジンプロピオン酸2-エチルヘキシル等、およびこれらの高分子誘導体やシラン誘導体等が挙げられる。
(4) Examples of UV absorbers Paraaminobenzoic acid, amyl paraaminobenzoate, ethyldihydroxypropyl paraaminobenzoate, glyceryl paraaminobenzoate, ethyl paraaminobenzoate, octyl paraaminobenzoate, octyldimethyl paraaminobenzoate, ethylene glycol salicylate, salicylic acid Octyl, triethanolamine salicylate, phenyl salicylate, butylphenyl salicylate, benzyl salicylate, homomenthyl salicylate, benzyl cinnamate, octyl paramethoxycinnamate, 2-ethylhexyl paramethoxycinnamate, mono-2-diparamethoxycinnamate Glyceryl ethylhexanoate, isopropyl paramethoxycinnamate, diethanolamine salt of paramethoxyhydrocinnamic acid, diisopropyl diisopropylcinnamic acid Stealth mixture, urocanic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its salts, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium disulfonate, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, hydroxyoctoxybenzophenone, tetrahydroxybenzophenone, Butylmethoxydibenzoylmethane, 2,4,6-trianilino-p- (carbo-2-ethylhexyl-1-oxy) -1,3,5-triazine, 2- (2-hydroxy-5-methylphenyl) benzotriazole , Methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano-3, 3-diphenyl acrylate, phenylbenzimidazole sulfate, 3- (4-methylbenzylidene) can Le, isopropyl dibenzoylmethane, 4- (3,4-dimethoxyphenyl methylene) 2-ethylhexyl-2,5-dioxo-1-imidazolidin propionate,, and polymer derivatives and silane derivatives thereof.
(5)粉体・顔料の例
赤色104号、赤色201号、黄色4号、青色1号、黒色401号等の色素、黄色4号ALレーキ、黄色203号BAレーキ等のレーキ色素、ナイロンパウダー、シルクパウダー、ウレタンパウダー、テフロン(登録商標)パウダー、シリコーンパウダー、ポリメタクリル酸メチルパウダー、セルロースパウダー、デンプン、シリコーンエラストマー球状粉体、ポリエチレン末等の高分子、黄酸化鉄、赤色酸化鉄、黒酸化鉄、酸化クロム、カーボンブラック、群青、紺青等の有色顔料、酸化亜鉛、酸化チタン、酸化セリウム等の白色顔料、タルク、マイカ、セリサイト、カオリン、板状硫酸バリウム等の体質顔料、雲母チタン等のパール顔料、硫酸バリウム、炭酸カルシウム、炭酸マグネシウム、珪酸アルミニウム、珪酸マグネシウム等の金属塩、シリカ、アルミナ等の無機粉体、ステアリン酸アルミニウム、ステアリン酸マグネシウム、パルミチン酸亜鉛、ミリスチン酸亜鉛、ミリスチン酸マグネシウム、ラウリン酸亜鉛、ウンデシレン酸亜鉛等の金属セッケン、ベントナイト、スメクタイト、窒化ホウ素等が挙げられる。これらの粉体の形状(球状、棒状、針状、板状、不定形状、燐片状、紡錘状等)および粒子径に特に制限はない。なおこれらの粉体は、従来公知の表面処理、例えばフッ素化合物処理、シリコーン処理、シリコーン樹脂処理、ペンダント処理、シランカップリング剤処理、チタンカップリング剤処理、油剤処理、N-アシル化リジン処理、ポリアクリル酸処理、金属セッケン処理、アミノ酸処理、レシチン処理、無機化合物処理、プラズマ処理、メカノケミカル処理等によって事前に表面処理されていてもいなくても構わない。
(5) Examples of powders and pigments Red 104, Red 201, Yellow 4, Blue 1, Black 401 and other dyes, Yellow 4 AL lake, Yellow 203 BA lake and other lake dyes, nylon powder , Silk powder, urethane powder, Teflon (registered trademark) powder, silicone powder, polymethyl methacrylate powder, cellulose powder, starch, silicone elastomer spherical powder, polyethylene powder, yellow iron oxide, red iron oxide, black Colored pigments such as iron oxide, chromium oxide, carbon black, ultramarine and bitumen, white pigments such as zinc oxide, titanium oxide and cerium oxide, extender pigments such as talc, mica, sericite, kaolin and barium sulfate plate, titanium mica Pearl pigments such as barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, metal salts such as magnesium silicate, Inorganic powders such as Rica and alumina, metal soaps such as aluminum stearate, magnesium stearate, zinc palmitate, zinc myristate, magnesium myristate, zinc laurate, zinc undecylenate, bentonite, smectite, boron nitride, etc. It is done. There are no particular restrictions on the shape of these powders (spherical, rod-like, needle-like, plate-like, irregular shape, flake-like, spindle-like, etc.) and particle diameter. These powders are conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, The surface treatment may or may not be performed in advance by polyacrylic acid treatment, metal soap treatment, amino acid treatment, lecithin treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment or the like.
(6)界面活性剤の例
アニオン性界面活性剤:脂肪酸セッケン、α-アシルスルホン酸塩、アルキルスルホン酸塩、アルキルアリルスルホン酸塩、アルキルナフタレンスルホン酸塩、アルキル硫酸塩、POEアルキルエーテル硫酸塩、アルキルアミド硫酸塩、アルキルリン酸塩、POEアルキルリン酸塩、アルキルアミドリン酸塩、アルキロイルアルキルタウリン塩、N-アシルアミノ酸塩、POEアルキルエーテルカルボン酸塩、アルキルスルホコハク酸塩、アルキルスルホ酢酸ナトリウム、アシル化加水分解コラーゲンペプチド塩、パーフルオロアルキルリン酸エステル等が挙げられる。
カチオン性界面活性剤:塩化アルキルトリメチルアンモニウム、塩化ステアリルトリメチルアンモニウム、臭化ステアリルトリメチルアンモニウム、塩化セトステアリルトリメチルアンモニウム、塩化ジステアリルジメチルアンモニウム、塩化ステアリルジメチルベンジルアンモニウム、臭化ベヘニルトリメチルアンモニウム、塩化ベンザルコニウム、塩化ベヘニン酸アミドプロピルジメチルヒドロキシプロピルアンモニウム、ステアリン酸ジエチルアミノエチルアミド、ステアリン酸ジメチルアミノプロピルアミド、ラノリン誘導体第四級アンモニウム塩等が挙げられる。
両性界面活性剤:カルボキシベタイン型、アミドベタイン型、スルホベタイン型、ヒドロキシスルホベタイン型、アミドスルホベタイン型、ホスホベタイン型、アミノカルボン酸塩型、イミダゾリン誘導体型、アミドアミン型等が挙げられる。
ノニオン性界面活性剤:プロピレングリコール脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、POEソルビタン脂肪酸エステル、POEソルビット脂肪酸エステル、POEグリセリン脂肪酸エステル、POEアキルエーテル、POE脂肪酸エステル、POE硬化ヒマシ油、POEヒマシ油、POE・POP共重合体、POE・POPアルキルエーテル、ポリエーテル変性シリコーンラウリン酸アルカノールアミド、アルキルアミンオキシド、水素添加大豆リン脂質等が挙げられる。
天然系界面活性剤:レシチン、サポニン、糖系界面活性剤等が挙げられる。
(6) Examples of surfactants Anionic surfactants: fatty acid soap, α-acyl sulfonate, alkyl sulfonate, alkyl allyl sulfonate, alkyl naphthalene sulfonate, alkyl sulfate, POE alkyl ether sulfate , Alkylamide sulfate, alkyl phosphate, POE alkyl phosphate, alkylamide phosphate, alkyloylalkyl taurine salt, N-acyl amino acid salt, POE alkyl ether carboxylate, alkyl sulfosuccinate, alkyl sulfoacetic acid Sodium, acylated hydrolyzed collagen peptide salt, perfluoroalkyl phosphate, etc. are mentioned.
Cationic surfactant: alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, benzalkonium chloride , Behenic acid amidopropyldimethylhydroxypropylammonium chloride, stearic acid diethylaminoethylamide, stearic acid dimethylaminopropylamide, lanolin derivative quaternary ammonium salts, and the like.
Amphoteric surfactants: carboxybetaine type, amide betaine type, sulfobetaine type, hydroxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amidoamine type and the like.
Nonionic surfactant: Propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE sorbitol fatty acid ester, POE glycerin fatty acid ester, POE akyle ether, POE fatty acid ester, POE cured castor Oil, POE castor oil, POE / POP copolymer, POE / POP alkyl ether, polyether-modified silicone lauric acid alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid, and the like.
Natural surfactant: lecithin, saponin, sugar surfactant and the like.
(7)多価アルコール、糖の例
エチレングリコール、ジエチレングリコール、ポリエチレングリコール、プロピレングリコール、ジプロピレングリコール、ポリプロピレングリコール、グリセリン、ジグリセリン、ポリグリセリン、3-メチル-1、3-ブタンジオール、1、3-ブチレングリコール、ソルビトール、マンニトール、ラフィノース、エリスリトール、グルコース、ショ糖、果糖、キシリトール、ラクトース、マルトース、マルチトール、トレハロース、アルキル化トレハロース、混合異性化糖、硫酸化トレハロース、プルラン等が挙げられる。またこれらの化学修飾体等も使用可能である。
(7) Examples of polyhydric alcohols and sugars Ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1, 3 -Butylene glycol, sorbitol, mannitol, raffinose, erythritol, glucose, sucrose, fructose, xylitol, lactose, maltose, maltitol, trehalose, alkylated trehalose, mixed isomerized sugar, sulfated trehalose, pullulan and the like. These chemically modified compounds can also be used.
(8)高分子の例
アクリル酸エステル/メタクリル酸エステル共重合体(プラスサイズ、互応化学社製)、酢酸ビニル/クロトン酸共重合体(レジン28-1310、NSC社製)、酢酸ビニル/クロトン酸/ビニルネオデカネート共重合体(28-2930、NSC社製)、メチルビニルエーテルマレイン酸ハーフエステル(ガントレッツES、ISP社製)、T-ブチルアクリレート/アクリル酸エチル/メタクリル酸共重合体(ルビマー、BASF社製)、ビニルピロリドン/ビニルアセテート/ビニルプロピオネート共重合体(ルビスコールVAP、BASF社製)、ビニルアセテート/クロトン酸共重合体(ルビセットCA、BASF社製)、ビニルアセテート/クロトン酸/ビニルピロリドン共重合体(ルビセットCAP、BASF社製)、ビニルピロリドン/アクリレート共重合体(ルビフレックス、BASF社製)、アクリレート/アクリルアミド共重合体(ウルトラホールド、BASF社製)、ビニルアセテート/ブチルマレエート/イソボルニルアクリラート共重合体(アドバンテージ、ISP社製)、カルボキシビニルポリマー(カーボポール、BFGoodrich社製)、アクリル酸・メタクリル酸アルキル共重合体(ペミュレン、BF Goodrich社製)等のアニオン性高分子化合物や、ジアルキルアミノエチルメタクリレート重合体の酢酸両性化物(ユカフォーマー、三菱化学社製)、アクリル酸オクチルアクリルアミド/アクリル酸ヒドロキシプロピル/メタクリル酸ブチルアミノエチル共重合体(AMPHOMER、NSC社製)等の両性高分子化合物、ビニルピロリドン/ジメチルアミノエチルメタクリレートの4級化物(GAFQUAT、ISP社製)、メチルビニルイミダゾリウムクロリド/ビニルピロリドン共重合体(ルビコート、BASF社製)等のカチオン性高分子化合物、ポリビニルピロリドン(ルビスコールK、BASF社製)、ビニルピロリドン/酢酸ビニル共重合体(ルビスコールVA、BASF社製)、ビニルピロリドン/ジメチルアミノエチルメタクリレート共重合体(コポリマー937、ISP社製)、ビニルカプロラクタム/ビニルピロリドン/ジメチルアミノエチルメタクリレート共重合体(コポリマーVC713、ISP社製)等のノニオン性高分子化合物等がある。また、セルロースまたはその誘導体、ケラチン及びコラーゲンまたはその誘導体、アルギン酸カルシウム、プルラン、寒天、ゼラチン、タマリンド種子多糖類、キサンタンガム、カラギーナン、ハイメトキシルペクチン、ローメトキシルペクチン、グアーガム、アラビアゴム、結晶セルロース、アラビノガラクタン、カラヤガム、トラガカントガム、アルギン酸、アルブミン、カゼイン、カードラン、ジェランガム、デキストラン等の天然由来高分子化合物も好適に用いることができる。
(8) Examples of polymers Acrylic ester / methacrylic acid ester copolymer (plus size, manufactured by Kyoyo Chemical), vinyl acetate / crotonic acid copolymer (resin 28-1310, manufactured by NSC), vinyl acetate / croton Acid / vinyl neodecanate copolymer (28-2930, manufactured by NSC), methyl vinyl ether maleic acid half ester (Gantrez ES, manufactured by ISP), T-butyl acrylate / ethyl acrylate / methacrylic acid copolymer (rubymer) , BASF), vinyl pyrrolidone / vinyl acetate / vinyl propionate copolymer (Rubicol VAP, BASF), vinyl acetate / crotonic acid copolymer (Rubiset CA, BASF), vinyl acetate / croton Acid / vinyl pyrrolidone copolymer (Rubiset CAP, manufactured by BASF), vinyl pyrrolidone / acrylate copolymer (Rubiflex, BAS) F), acrylate / acrylamide copolymer (Ultrahold, BASF), vinyl acetate / butyl maleate / isobornyl acrylate copolymer (Advantage, ISP), carboxyvinyl polymer (Carbopol, BF Goodrich), anionic polymer compounds such as acrylic acid / alkyl methacrylate copolymer (Pemulene, BF Goodrich), and acetic acid amphoteric products of dialkylaminoethyl methacrylate polymers (Yukaformer, Mitsubishi Chemical) Amphoteric polymer compounds such as octyl acrylate acrylate / hydroxypropyl acrylate / butylaminoethyl methacrylate copolymer (AMPHOMER, NSC), quaternized vinylpyrrolidone / dimethylaminoethyl methacrylate (GAFQUAT, ISP) , Methyl vinyl imidazolium chloride / Cationic polymer compounds such as vinylpyrrolidone copolymer (rubicoat, manufactured by BASF), polyvinylpyrrolidone (rubiscol K, manufactured by BASF), vinylpyrrolidone / vinyl acetate copolymer (rubiscol VA, manufactured by BASF) Nonionic polymer compounds such as vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer 937, manufactured by ISP), vinylcaprolactam / vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer VC713, manufactured by ISP), etc. is there. Cellulose or derivatives thereof, keratin and collagen or derivatives thereof, calcium alginate, pullulan, agar, gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabino Naturally derived polymer compounds such as galactan, gum karaya, gum tragacanth, alginic acid, albumin, casein, curdlan, gellan gum and dextran can also be suitably used.
(9)生理活性成分の例
生理活性成分としては、皮膚に塗布した場合に皮膚に何らかの生理活性を与える物質が挙げられる。例えば、美白成分、免疫賦活剤、老化防止剤、紫外線防御剤、スリミング剤、ひきしめ剤、抗酸化剤、発毛剤、育毛剤、保湿剤、血行促進剤、抗菌剤、殺菌剤、乾燥剤、冷感剤、温感剤、ビタミン類、アミノ酸、創傷治癒促進剤、刺激緩和剤、鎮痛剤、細胞賦活剤、酵素成分等が挙げられる。これらの好適な配合成分の例としては、例えばアシタバエキス、アボカドエキス、アマチャエキス、アルテアエキス、アルニカエキス、アロエエキス、アンズエキス、アンズ核エキス、イチョウエキス、ウイキョウエキス、ウコンエキス、ウーロン茶エキス、エイジツエキス、エチナシ葉エキス、オウゴンエキス、オウバクエキス、オウレンエキス、オオムギエキス、オトギリソウエキス、オドリコソウエキス、オランダカラシエキス、オレンジエキス、海水乾燥物、海藻エキス、加水分解エラスチン、加水分解コムギ末、加水分解シルク、カモミラエキス、カロットエキス、カワラヨモギエキス、甘草エキス、カルカデエキス、カキョクエキス、キナエキス、キューカンバ-エキス、グアノシン、クチナシエキス、クマザサエキス、クララエキス、クルミエキス、グレープフルーツエキス、クレマティスエキス、クロレラエキス、クワエキス、ゲンチアナエキス、紅茶エキス、酵母エキス、ゴボウエキス、コメヌカ発酵エキス、コメ胚芽油、コンフリーエキス、コラーゲン、コケモモエキス、サイシンエキス、サイコエキス、サイタイ抽出液、サルビアエキス、サボンソウエキス、ササエキス、サンザシエキス、サンショウエキス、シイタケエキス、ジオウエキス、シコンエキス、シソエキス、シナノキエキス、シモツケソウエキス、シャクヤクエキス、ショウブ根エキス、シラカバエキス、スギナエキス、セイヨウキズタエキス、セイヨウサンザシエキス、セイヨウニワトコエキス、セイヨウノコギリソウエキス、セイヨウハッカエキス、セ-ジエキス、ゼニアオイエキス、センキュウエキス、センブリエキス、ダイズエキス、タイソウエキス、タイムエキス、茶エキス、チョウジエキス、チガヤエキス、チンピエキス、トウキエキス、トウキンセンカエキス、トウニンエキス、トウヒエキス、ドクダミエキス、トマトエキス、納豆エキス、ニンジンエキス、ニンニクエキス、ノバラエキス、ハイビスカスエキス、バクモンドウエキス、パセリエキス、蜂蜜、ハマメリスエキス、パリエタリアエキス、ヒキオコシエキス、ビサボロール、ビワエキス、フキタンポポエキス、フキノトウエキス、ブクリョウエキス、ブッチャーブルームエキス、ブドウエキス、プロポリス、ヘチマエキス、ベニバナエキス、ペパーミントエキス、ボダイジュエキス、ボタンエキス、ホップエキス、マツエキス、マロニエエキス、ミズバショウエキス、ムクロジエキス、メリッサエキス、モモエキス、ヤグルマギクエキス、ユーカリエキス、ユキノシタエキス、ヨクイニンエキス、ヨモギエキス、ラベンダーエキス、リンゴエキス、レタスエキス、レモンエキス、レンゲソウエキス、ローズエキス、ローズマリーエキス、ローマカミツレエキス、ローヤルゼリーエキス等を挙げることができる。
また、デオキシリボ核酸、ムコ多糖類、ヒアルロン酸ナトリウム、コンドロイチン硫酸ナトリウム、コラーゲン、エラスチン、キチン、キトサン、加水分解卵殻膜などの生体高分子、アミノ酸、加水分解ペプチド、乳酸ナトリウム、尿素、ピロリドンカルボン酸ナトリウム、ベタイン、ホエイ、トリメチルグリシンなどの保湿成分、スフィンゴ脂質、セラミド、フィトスフィンゴシン、コレステロール、コレステロール誘導体、リン脂質などの油性成分、ε-アミノカプロン酸、グリチルリチン酸、β-グリチルレチン酸、塩化リゾチーム、グアイアズレン、ヒドロコールチゾン等の免疫賦活剤、ビタミンA、ビタミンB2、ビタミンB6、ビタミンC、ビタミンD、ビタミンE、パントテン酸カルシウム、ビオチン、ニコチン酸アミド、ビタミンCエステル等のビタミン類、アラントイン、ジイソプロピルアミンジクロロアセテート、4-アミノメチルシクロヘキサンカルボン酸等の活性成分、トコフェロール、カロテノイド、フラボノイド、タンニン、リグナン、サポニン等の抗酸化剤、α-ヒドロキシ酸、β-ヒドロキシ酸などの細胞賦活剤、γ-オリザノール、ビタミンE誘導体などの血行促進剤、レチノール、レチノール誘導体等の創傷治癒剤、アルブチン、コウジ酸、プラセンタエキス、イオウ、エラグ酸、リノール酸、トラネキサム酸、グルタチオン等の美白剤、セファランチン、カンゾウ抽出物、トウガラシチンキ、ヒノキチオール、ヨウ化ニンニクエキス、塩酸ピリドキシン、DL-α-トコフェロール、酢酸DL-α-トコフェロール、ニコチン酸、ニコチン酸誘導体、パントテン酸カルシウム、D-パントテニルアルコール、アセチルパントテニルエチルエーテル、ビオチン、アラントイン、イソプロピルメチルフェノール、エストラジオール、エチニルエストラジオール、塩化カプロニウム、塩化ベンザルコニウム、塩酸ジフェンヒドラミン、タカナール、カンフル、サリチル酸、ノニル酸バニリルアミド、ノナン酸バニリルアミド、ピロクトンオラミン、ペンタデカン酸グリセリル、L-メントール、モノニトログアヤコール、レゾルシン、γ-アミノ酪酸、塩化ベンゼトニウム、塩酸メキシレチン、オーキシン、女性ホルモン、カンタリスチンキ、シクロスポリン、ジンクピリチオン、ヒドロコールチゾン、ミノキシジル、モノステアリン酸ポリオキシエチレンソルビタン、ハッカ油、ササニシキエキス等の育毛剤などが挙げられる。
(9) Examples of physiologically active ingredients Examples of physiologically active ingredients include substances that impart some physiological activity to the skin when applied to the skin. For example, whitening ingredients, immunostimulants, anti-aging agents, UV protection agents, slimming agents, tanning agents, antioxidants, hair growth agents, hair restorers, moisturizers, blood circulation promoters, antibacterial agents, bactericides, desiccants, A cooling sensation agent, a warming sensation agent, vitamins, an amino acid, a wound healing promoter, an irritation relaxation agent, an analgesic agent, a cell activator, an enzyme component, etc. are mentioned. Examples of these suitable ingredients include, for example, ashitaba extract, avocado extract, amateur extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract, fennel extract, turmeric extract, oolong tea extract, ages Extract, Echinacea leaf extract, Ogon extract, Oat extract, Oen extract, Barley extract, Hypericum extract, Oyster extract, Dutch mustard extract, Orange extract, Seawater dried product, Seaweed extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk , Chamomile extract, Carrot extract, Kawara mugwort extract, Licorice extract, Calcade extract, Oyster extract, Kina extract, Cucumber extract, Guanosine, Gardenia extract, Kumazasa extract, Clarae Kiss, walnut extract, grapefruit extract, clematis extract, chlorella extract, mulberry extract, gentian extract, tea extract, yeast extract, burdock extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, bilberry extract, saicin extract, psycho extract Extract Kizuta extract, hawthorn extract, elderberry extract, yarrow extract, mint extract, sage extract, mallow extract, senki Sue extract, assembly extract, soybean extract, tiso extract, thyme extract, tea extract, clove extract, chigaya extract, chimpi extract, touki extract, toshinsen extract, tonin extract, spruce extract, dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, Novara extract, hibiscus extract, bacmond extract, parsley extract, honey, hamamelis extract, parietalia extract, toad extract, bisabolol, loquat extract, dandelion extract, burdock extract, bukuro extract, butcher bloom extract, grape extract, propolis, loofah extract, Safflower extract, peppermint extract, bodaige extract, button extract, hop extract, pine extract, marronnier extract, mizubasho Kiss, Mukuroji extract, Melissa extract, Peach extract, Cornflower extract, Eucalyptus extract, Yukinoshita extract, Yokuinin extract, Artemisia extract, Lavender extract, Apple extract, Lettuce extract, Lemon extract, Lotus root extract, Rose extract, Rosemary extract, Roman chamomile extract And royal jelly extract.
Biopolymers such as deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membranes, amino acids, hydrolyzed peptides, sodium lactate, urea, sodium pyrrolidonecarboxylate , Moisturizing ingredients such as betaine, whey, trimethylglycine, oily ingredients such as sphingolipid, ceramide, phytosphingosine, cholesterol, cholesterol derivatives, phospholipids, ε-aminocaproic acid, glycyrrhizic acid, β-glycyrrhetinic acid, lysozyme chloride, guaiazulene, Immunostimulants such as hydrocortisone, vitamin A, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, calcium pantothenate, biotin, nicotinamide, vitamin C ester Vitamins, active ingredients such as allantoin, diisopropylamine dichloroacetate, 4-aminomethylcyclohexanecarboxylic acid, antioxidants such as tocopherols, carotenoids, flavonoids, tannins, lignans, saponins, α-hydroxy acids, β-hydroxy acids, etc. Cell activators, blood circulation promoters such as γ-oryzanol and vitamin E derivatives, wound healing agents such as retinol and retinol derivatives, arbutin, kojic acid, placenta extract, sulfur, ellagic acid, linoleic acid, tranexamic acid, glutathione, etc. Whitening agent, cephalanthin, licorice extract, red pepper tincture, hinokitiol, garlic iodide extract, pyridoxine hydrochloride, DL-α-tocopherol, DL-α-tocopherol acetate, nicotinic acid, nicotinic acid derivative, calcium pantothenate, D-pan Tothenyl alcohol, acetyl pantothenyl ethyl ether, biotin, allantoin, isopropylmethylphenol, estradiol, ethinyl estradiol, capronium chloride, benzalkonium chloride, diphenhydramine hydrochloride, takanal, camphor, salicylic acid, nonyl acid vanillylamide, nonanoic acid vanillylamide, pyroctone Olamine, glyceryl pentadecanoate, L-menthol, mononitroguaiacol, resorcin, γ-aminobutyric acid, benzethonium chloride, mexiletine hydrochloride, auxin, female hormone, cantalis tincture, cyclosporine, zinc pyrithione, hydrocortisone, minoxidil, monostearic acid Examples include hair growth agents such as polyoxyethylene sorbitan, mint oil, and Sasanishiki extract.
(10)酸化防止剤の例
亜硫酸水素ナトリウム、亜硫酸ナトリウム、エリソルビン酸、エリソルビン酸ナトリウム、チオジプロピオン酸ジラウリル、トコフェロール、トリルビグアナイド、ノルジヒドログアヤレチン酸、パラヒドロキシアニソール、ブチルヒドロキシアニソール、ジブチルヒドロキシトルエン、ステアリン酸アスコルビル、パルミチン酸アスコルビル、没食子酸オクチル、没食子酸プロピル、カロテノイド、フラボノイド、タンニン、リグナン、サポニン、リンゴエキスやチョウジエキスなどの酸化防止効果の認められる植物エキス等が挙げられる。
(10) Examples of antioxidants: sodium bisulfite, sodium sulfite, erythorbic acid, sodium erythorbate, dilauryl thiodipropionate, tocopherol, tolylbiguanide, nordihydroguaiaretic acid, parahydroxyanisole, butylhydroxyanisole, dibutylhydroxy Examples include plant extracts having an antioxidant effect such as toluene, ascorbyl stearate, ascorbyl palmitate, octyl gallate, propyl gallate, carotenoid, flavonoid, tannin, lignan, saponin, apple extract and clove extract.
具体的な製法としては、上記グルコシルセラミド含有組成物を粉末セルロースとともにスプレードライまたは凍結乾燥し、これを粉末、顆粒、打錠または溶液にすることで容易に一般飲食品(インスタント食品等)に含有させることができる。また、上記グルコシルセラミド含有組成物を、例えば、油脂、エタノール、グリセリンあるいはこれらの混合物に溶解して液状にし、飲料に添加するか、固形食品に添加することが可能である。必要に応じてアラビアガム、デキストリン等のバインダーと混合して粉末状あるいは顆粒状にし、飲料に添加するか固形食品に添加することも可能である。 As a specific production method, the above glucosylceramide-containing composition is spray-dried or freeze-dried together with powdered cellulose, and it is easily contained in general foods and drinks (instant foods, etc.) by making it into powder, granules, tablets or solutions. Can be made. In addition, the glucosylceramide-containing composition can be dissolved in, for example, fats and oils, ethanol, glycerin or a mixture thereof to form a liquid and added to a beverage or added to a solid food. If necessary, it can be mixed with a binder such as gum arabic or dextrin to form a powder or granules and added to a beverage or a solid food.
以下、本発明を実施例に基づいて説明する。
脱脂米胚芽1.4 kgと等量の蒸留水を混合し、オートクレーブ滅菌したものに560 mgの麹菌および香煎42 gを加えて混合したものを35℃の条件下で3日間発酵させ、麹菌発酵米胚芽を得た。この発酵米胚芽を3 kgのメタノールでの加温抽出を3回行い、抽出液を減圧濃縮することにより156.06 gのメタノール抽出液を得た。
このメタノール抽出物 83 gを図1のスキームに従って、をヘキサンと水で分配を行い、更にこの水層を酢酸エチルと水で分配を行い、更にその水層をクロロホルム:メタノール=6:1の混合溶液で分配し、クロロホルムメタノール層(クロメタ層)の分離を行うことによって、ヘキサン可溶部17.67 g、酢酸エチル可溶部5.73 g、クロメタ可溶部(本実施例)3.73 gを得た。
その後、図1の分画スキームに従って分画を行い、Compound Eの成分を4.1mg単離した。単離した成分についてNMRによる構造解析を行った。そのCompound Eスペクトルを図2に示す。図2及び文献Jung JH et al., J. Nat. Prod., 1996, 59, 319-322により、Compound Eは下記化学式(1)に示されるグルコシルセラミドであることが確認された。また、クロメタ可溶部におけるCompound Eの含有量は0.12%であった。即ち、実施例はグルコシルセラミドを含有することが確認された。
Hereinafter, the present invention will be described based on examples.
A mixture of 1.4 kg of defatted rice germ and an equal amount of distilled water, sterilized by autoclaving, mixed with 560 mg of koji mold and 42 g of decoction, fermented at 35 ° C for 3 days, and then koji mold fermented rice germ Got. The fermented rice germ was subjected to warm extraction with 3 kg of methanol three times, and the extract was concentrated under reduced pressure to obtain 156.06 g of methanol extract.
According to the scheme of FIG. 1, 83 g of this methanol extract was partitioned with hexane and water, this aqueous layer was further partitioned with ethyl acetate and water, and the aqueous layer was further mixed with chloroform: methanol = 6: 1. By partitioning with the solution and separating the chloroform methanol layer (chromate layer), 17.67 g of a hexane soluble part, 5.73 g of an ethyl acetate soluble part and 3.73 g of a chromate soluble part (this example) were obtained.
Thereafter, fractionation was performed according to the fractionation scheme of FIG. 1, and 4.1 mg of Compound E component was isolated. The isolated component was subjected to NMR structural analysis. The Compound E spectrum is shown in FIG. FIG. 2 and the document Jung JH et al., J. Nat. Prod., 1996, 59, 319-322 confirmed that Compound E is a glucosylceramide represented by the following chemical formula (1). Further, the content of Compound E in the chromometa-soluble part was 0.12%. That is, it was confirmed that the examples contain glucosylceramide.
以下に本発明に本発明の方法にて製造されたグルコシルセラミド含有組成物の配合例を挙げるが、下記配合例は本発明を限定するものではない。
配合例1:チューインガム(機能性表示食品又は特定保健用食品)
砂糖 53.0wt%
ガムベース 20.0
グルコース 10.0
水飴 16.0
香料 0.5
グルコシルセラミド含有組成物 0.5
100.0wt%
Although the compounding example of the glucosylceramide containing composition manufactured by the method of this invention is given to this invention below, the following compounding example does not limit this invention.
Formulation Example 1: Chewing gum (functional indication food or food for specified health use)
53.0wt% sugar
Gum base 20.0
Glucose 10.0
Minamata 16.0
Fragrance 0.5
Glucosylceramide-containing composition 0.5
100.0wt%
配合例2:グミ(機能性表示食品又は特定保健用食品)
還元水飴 40.0wt%
グラニュー糖 20.0
ブドウ糖 20.0
ゼラチン 4.7
水 9.68
キウイ果汁 4.0
キウイフレーバー 0.6
色素 0.02
グルコシルセラミド含有組成物 1.0
100.0wt%
Formulation Example 2: Gummy (Functional indication food or food for specified health use)
Reduced water tank 40.0wt%
Granulated sugar 20.0
Glucose 20.0
Gelatin 4.7
Water 9.68
Kiwi juice 4.0
Kiwi flavor 0.6
Dye 0.02
Glucosylceramide-containing composition 1.0
100.0wt%
配合例3:キャンディー(機能性表示食品又は特定保健用食品)
砂糖 50.0wt%
水飴 33.0
水 14.4
有機酸 2.0
香料 0.2
グルコシルセラミド含有組成物 0.4
100.0wt%
Formulation example 3: Candy (functional indication food or food for specified health use)
50.0 wt% sugar
Minamata 33.0
Water 14.4
Organic acid 2.0
Fragrance 0.2
Glucosylceramide-containing composition 0.4
100.0wt%
配合例4:ヨーグルト(ハード・ソフト)(機能性表示食品又は特定保健用食品)
牛乳 41.5wt%
脱脂粉乳 5.8
砂糖 8.0
寒天 0.15
ゼラチン 0.1
乳酸菌 0.005
グルコシルセラミド含有組成物 0.4
香料 微量
水 残余
100.0wt%
Formulation Example 4: Yogurt (hardware / soft) (functional food or food for specified health use)
Milk 41.5wt%
Nonfat dry milk 5.8
Sugar 8.0
Agar 0.15
Gelatin 0.1
Lactic acid bacteria 0.005
Glucosylceramide-containing composition 0.4
Perfume
Water residue
100.0wt%
配合例5:清涼飲料(機能性表示食品又は特定保健用食品)
果糖ブドウ糖液糖 30.0wt%
乳化剤 0.5
グルコシルセラミド含有組成物 0.05
香料 適量
精製水 残余
100.0wt%
Formulation Example 5: Soft drink (functional display food or food for specified health use)
Fructose glucose liquid sugar 30.0wt%
Emulsifier 0.5
Glucosylceramide-containing composition 0.05
Perfume
Purified water residue
100.0wt%
配合例6:ソフトカプセル(機能性表示食品又は特定保健用食品)
米胚芽油 87.0wt%
乳化剤 12.0
グルコシルセラミド含有組成物 1.0
100.0wt%
Formulation Example 6: Soft capsule (functional indication food or food for specified health use)
Rice germ oil 87.0wt%
Emulsifier 12.0
Glucosylceramide-containing composition 1.0
100.0wt%
配合例7:錠剤(機能性表示食品又は特定保健用食品)
乳糖 54.0wt%
結晶セルロース 30.0
澱粉分解物 10.0
グリセリン脂肪酸エステル 5.0
グルコシルセラミド含有組成物 1.0
100.0wt%
Formulation Example 7: Tablet (Functional indication food or specified health food)
Lactose 54.0wt%
Crystalline cellulose 30.0
Starch degradation product 10.0
Glycerin fatty acid ester 5.0
Glucosylceramide-containing composition 1.0
100.0wt%
配合例8:顆粒内服剤(医薬品)
グルコシルセラミド含有組成物 1.0wt%
乳糖 30.0
コーンスターチ 60.0
結晶セルロース 8.0
ポリビニールピロリドン 1.0
100.0wt%
Formulation Example 8: Oral granules (pharmaceuticals)
Glucosylceramide-containing composition 1.0 wt%
Lactose 30.0
Cornstarch 60.0
Crystalline cellulose 8.0
Polyvinylpyrrolidone 1.0
100.0wt%
配合例9:錠菓
砂糖 76.4wt%
グルコース 19.0
ショ糖脂肪酸エステル 0.2
グルコシルセラミド含有組成物 0.5
精製水 3.9
100.0wt%
Formulation Example 9: Tablet
76.4 wt% sugar
Glucose 19.0
Sucrose fatty acid ester 0.2
Glucosylceramide-containing composition 0.5
Purified water 3.9
100.0wt%
配合例15:キャットフード
とうもろこし 34.0wt%
小麦粉 35.0
ミートミール 15.0
牛脂 8.9
食塩 1.0
かつおエキス 4.0
グルコシルセラミド含有組成物 1.0
タウリン 0.1
ビタミン類 0.5
ミネラル類 0.5
100.0wt%
Formulation Example 15: Cat food
Corn 34.0wt%
Flour 35.0
Meat meal 15.0
Beef tallow 8.9
Salt 1.0
Skipjack extract 4.0
Glucosylceramide-containing composition 1.0
Taurine 0.1
Vitamins 0.5
Minerals 0.5
100.0wt%
配合例16:ドッグフード
とうもろこし 30.0wt%
肉類(チキン) 15.0
脱脂大豆 10.0
小麦粉 25.0
糟糠類 5.0
グルコシルセラミド含有組成物 5.0
動物性油脂 8.9
オリゴ糖 0.1
ビタミン 0.5
ミネラル 0.5
100.0wt%
Formulation Example 16: Dog food
Corn 30.0wt%
Meat (chicken) 15.0
Defatted soybean 10.0
Flour 25.0
Mosses 5.0
Glucosylceramide-containing composition 5.0
Animal fats and oils 8.9
Oligosaccharide 0.1
Vitamin 0.5
Mineral 0.5
100.0wt%
配合例10:化粧クリーム
スクワラン 20.0wt%
ミツロウ 5.0
精製ホホバ油 5.0
グリセリン 5.0
グリセリンモノステアレート 2.0
ポリオキシエチレン(20)ソルビタン-
モノステアレート 2.0
グルコシルセラミド含有組成物 2.0
防腐剤 適量
香料 適量
精製水 残余
100.0wt%
Formulation Example 10: Cosmetic cream squalane 20.0 wt%
Beeswax 5.0
Refined jojoba oil 5.0
Glycerin 5.0
Glycerol monostearate 2.0
Polyoxyethylene (20) sorbitan-
Monostearate 2.0
Glucosylceramide-containing composition 2.0
Antiseptic agent
Purified water residue
100.0wt%
配合例11:化粧水
エタノール 5.0wt%
グリセリン 2.0
1,3−ブチレングリコール 2.0
ポリエチレンオレイルエーテル 0.5
クエン酸ナトリウム 0.1
クエン酸 0.1
グルコシルセラミド含有組成物 5.0
精製水 残余
100.0wt%
Formulation Example 11: Lotion ethanol 5.0 wt%
Glycerin 2.0
1,3-butylene glycol 2.0
Polyethylene oleyl ether 0.5
Sodium citrate 0.1
Citric acid 0.1
Glucosylceramide-containing composition 5.0
Purified water residue
100.0wt%
配合例12:ボディージェル
マカデミアナッツ油 2.0wt%
ミリスチン酸オクチルドデシル 10.0
メチルフェニルポリシロキサン 5.0
ベヘニルアルコール 3.0
ステアリン酸 3.0
バチルアルコール 1.0
モノステアリン酸グリセリル 1.0
テトラオレイン酸ポリオキシエチレンソルビット
2.0
水素添加大豆リン脂質 1.0
セラミド 0.1
パルミチン酸レチノール 0.1
防腐剤 適量
ツボクサ抽出物 1.0
グルコシルセラミド含有組成物 1.0
1、3−ブチレングリコール 5.0
精製水 残余
100.0wt%
Formulation Example 12: Body gel macadamia nut oil 2.0 wt%
Octyldodecyl myristate 10.0
Methylphenylpolysiloxane 5.0
Behenyl alcohol 3.0
Stearic acid 3.0
Batyl alcohol 1.0
Glyceryl monostearate 1.0
Tetraoleic acid polyoxyethylene sorbit 2.0
Hydrogenated soybean phospholipid 1.0
Ceramide 0.1
Retinol palmitate 0.1
Preservative Appropriate amount Clover extract 1.0
Glucosylceramide-containing composition 1.0
1,3-butylene glycol 5.0
Purified water residue
100.0wt%
配合例13:乳液
スクワラン 4.0wt%
ワセリン 2.5
セタノール 2.0
グリセリン 2.0
親油型モノステアリン酸グリセリン 1.0
ステアリン酸 1.0
L−アルギニン 1.0
グルコシルセラミド含有組成物 0.5
水酸化カリウム 0.1
香料 微量
精製水 残余
100.0wt%
Formulation Example 13: Latex Squalane 4.0 wt%
Vaseline 2.5
Cetanol 2.0
Glycerin 2.0
Lipophilic glyceryl monostearate 1.0
Stearic acid 1.0
L-Arginine 1.0
Glucosylceramide-containing composition 0.5
Potassium hydroxide 0.1
Perfume
Purified water residue
100.0wt%
以上、説明したように、本発明は、簡単で、高濃度のグルコシルセラミドを含有するセラミド含有組成物の製造方法を提供することができる。 As described above, the present invention can provide a simple method for producing a ceramide-containing composition containing a high concentration of glucosylceramide.
Claims (4)
その後、前記発酵物を極性溶媒で抽出し発酵物抽出液を得て、
その後、前記発酵物抽出液を分配することを特徴とする、
グルコシルセラミド含有組成物の製造方法。 Fermenting rice bran and / or rice germ to obtain a fermented product,
Thereafter, the fermented product is extracted with a polar solvent to obtain a fermented product extract,
Then, the fermented product extract is dispensed,
A method for producing a glucosylceramide-containing composition.
The method for producing a glucosylceramide-containing composition according to any one of claims 1 to 3, wherein the fermented product is fermented with koji mold.
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JP2020186185A (en) * | 2019-05-13 | 2020-11-19 | 株式会社東洋新薬 | Composition |
WO2022234758A1 (en) * | 2021-05-06 | 2022-11-10 | 学校法人帝京大学 | Plant variant having improved glucosylceramide percentage content |
CN115369045A (en) * | 2022-07-19 | 2022-11-22 | 厦门医学院 | Marine aspergillus fungi and application and analysis method thereof |
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JP2020186185A (en) * | 2019-05-13 | 2020-11-19 | 株式会社東洋新薬 | Composition |
JP7382622B2 (en) | 2019-05-13 | 2023-11-17 | 株式会社東洋新薬 | Composition |
WO2022234758A1 (en) * | 2021-05-06 | 2022-11-10 | 学校法人帝京大学 | Plant variant having improved glucosylceramide percentage content |
CN115369045A (en) * | 2022-07-19 | 2022-11-22 | 厦门医学院 | Marine aspergillus fungi and application and analysis method thereof |
CN115369045B (en) * | 2022-07-19 | 2023-06-27 | 厦门医学院 | Marine aspergillus fungus and application and analysis method thereof |
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