JP2017065717A - NSAIDs-CONTAINING SPRAY AGENT - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an NSAIDs-containing spray agent where a liquefied gas and a compressed gas are not used, the corrosion of a container can be prevented, the container is hardly rotatable and a content liquid can be administered in a misty state.SOLUTION: An NSAIDs-containing content liquid is filled in a spray container constituted by a bottle body where the horizontal cross section of a trunk when being cut in parallel with a bottom surface is oval or approximately rectangular and which is made of a synthetic resin and a dispenser which can spray the content liquid in a misty state without using a liquefied gas and a compressed gas. Then, an NSAIDs-containing spray agent where a liquefied gas and a compressed gas are not used, the corrosion of a container can be prevented, the container is hardly rotatable and the content liquid can be administered in a misty state is provided.SELECTED DRAWING: Figure 1

Description

  The present invention is a content liquid containing non-steroidal anti-inflammatory drugs (NSAIDs), which does not use liquefied gas or compressed gas, can prevent corrosion of the container, and the container is difficult to roll. The present invention relates to an NSAIDs-containing spray for external use, which can administer the liquid in a mist form. More specifically, the present invention fills a liquid container containing NSAIDs into a spray container composed of a synthetic resin bottle body and a dispenser that can be sprayed in a mist form without using liquefied gas or compressed gas. The present invention relates to an NSAIDs-containing spray agent that does not use liquefied gas or compressed gas, can prevent corrosion of the container, is difficult to roll, and can administer the content liquid in a mist form.

  Conventionally, non-steroidal anti-inflammatory analgesics (Non−) have been used to relieve local inflammatory symptoms such as bruises and sprains during sports, muscle pain, shoulder pain associated with stiff shoulders, back pain, joint pain, and elbow pain. There are many products on the market that absorb Steroidal Anti-Inflammatory Drugs (NSAIDs) from the skin. These products include patches such as poultices and tapes, and coating agents such as ointments, creams, and liquids, and are used properly according to the purpose of the dosage form.

  Since patches can be applied to affected areas for a long time, they are often used as preparations having excellent drug efficacy. The coating agent is excellent in spreadability and has an advantage that it can be administered regardless of the shape of the administration site. Among them, the liquid is a dosage form in which the stickiness is suppressed because the viscosity is lower than that of an ointment or cream. In addition, since the liquid agent is mainly composed of alcohol or water, the liquid agent is preferred in summer because it can provide a refreshing feeling due to the heat of vaporization, and an effect of cooling the inflamed site can be expected. Furthermore, a liquid agent has the advantage that it can administer without making a hand dirty by devising a product form so that a content liquid can be administered to an affected part via a discharge part, without taking a hand. However, since the discharge part has a unique shape such as a circle, there is a problem that it is difficult to spread the content liquid when the liquid agent is administered to an uneven part such as a joint. Moreover, since such a liquid agent contacts the discharge part and the skin, not only the discharge part is contaminated by resident bacteria of the skin, but also there is a problem accompanied by tenderness when administered to the inflamed site.

  On the other hand, NSAIDs-containing sprays are available as dosage forms that can administer the content liquid to the inflamed site from a remote location without going through the hand or discharge part, and many aerosols using liquefied gas or compressed gas are sold. ing. Aerosols use liquefied gas or compressed gas, and together with these, the liquid contents can be sprayed from a remote location toward the desired affected area, so that the hands and discharge parts are not contaminated and are easy to administer regardless of the shape of the affected area. And there is an advantage without tenderness. In addition, when using an aerosol agent, the content liquid can be ejected in a mist form together with the gas, so that the content liquid does not concentrate on the affected area and the dripping is less likely to occur than when it is ejected in liquid form. Further, the droplets generated when the content liquid is sprayed are easy to vaporize because of the large surface area. Therefore, the aerosol is a dosage form that is widely used in summer because it can be expected to cool the inflammatory site against symptoms such as bruises, sprains, and muscle pain during sports. Thus, the usefulness of the aerosol which can be sprayed in mist form attracts attention from the viewpoint of use and treatment.

However, since aerosols use liquefied gas or compressed gas, there have been traditionally pointed out dangers during storage or use, such as rupture of containers due to storage in high temperature environments and frostbite of affected areas. Especially in summer, these risks increase. Moreover, although the container used with an aerosol agent is generally made of metal and has a cylindrical shape, the metal is easily corroded by moisture in the atmosphere, and the shape is easy to roll because of the cylindrical shape. Therefore, when the metal is corroded, the container becomes brittle and the content liquid oozes out. There is a fear.
As a technique that can prevent corrosion without using a metal with an aerosol agent, as shown in Patent Document 1, a plastic container using polyethylene terephthalate or the like has been developed. It has not been solved.

  Therefore, there has been a demand for an NSAIDs-containing spray agent that does not use liquefied gas or compressed gas, can prevent corrosion of the container, is difficult to roll, and can administer the content liquid in a mist form.

JP 2002-29581 A

  An object of the present invention has been made in view of the above-described circumstances, and does not use liquefied gas or compressed gas, can prevent corrosion of the container, the container is difficult to roll, and can contain the NSAIDs containing the liquid in a mist form. Is to provide an agent.

As a result of intensive studies to solve the above-mentioned problems, the inventors of the present invention have a horizontal cross section of the trunk when the content liquid containing NSAIDs is cut in parallel with the bottom surface, or an oval shape or a substantially rectangular shape. And by filling the spray container composed of a dispenser that can spray the liquid contents in a mist form without using a synthetic resin bottle body and liquefied gas or compressed gas, liquefied gas or compressed gas is not used, It has been found that the corrosion of the container can be prevented, the container is difficult to roll, and the content liquid can be administered in the form of a mist, and the present invention has been completed.
That is, this invention is shown to the following (1)-(4).
(1) NSAIDs-containing spray agent that does not use liquefied gas or compressed gas, can prevent corrosion of the container, the container is difficult to roll, and can administer the content liquid in mist form,
The spray agent consists of a bottle body made of synthetic resin and a dispenser capable of spraying the liquid contents in a mist form without using liquefied gas or compressed gas,
The bottle body has a content liquid filling space inside, a neck formed at the top and having an opening, and a long diameter passing through the center of gravity of the horizontal section when the body of the bottle body is cut parallel to the bottom surface. NSAIDs-containing spray, characterized in that it has an oval shape with a maximum minor axis ratio of 1.3 to 10.0 or a substantially rectangular shape with a maximum ratio of long side to short side of 1.3 to 10.0 Agent.
(2) The NSAIDs-containing spray agent according to (1), wherein the synthetic resin is one or more of polyethylene, polypropylene, polyester, or polystyrene.
(3) Any of the above (1) to (2), wherein the outer circumference of the body of the bottle body is 100 to 150 mm at the maximum, and the height from the bottom surface to the neck of the bottle body is 50 to 200 mm. NSAIDs-containing sprays described in 1.
(4) The NSAIDs-containing spray according to any one of (1) to (3), wherein the dispenser is an air pump type.

  As described above, the present invention can provide an NSAIDs-containing spray that does not use liquefied gas or compressed gas, can prevent corrosion of the container, is difficult to roll, and can administer the liquid in a mist form. .

It is the figure which showed the schematic diagram of the NSAIDs containing spray agent of this invention. It is a front view of a bottle main body. It is a front view of a bottle main body. It is a horizontal sectional view of an oval bottle body. It is a horizontal sectional view of a substantially rectangular bottle body. It is a top view of an oval-shaped bottle main body. It is a top view of a substantially rectangular bottle body.

  Hereinafter, the NSAIDs-containing spray of the present invention will be described in detail. Note that the examples described in the present specification do not particularly limit the present invention.

  The term “difficult to roll” in the present invention refers to the rolling after landing on a flat surface when the NSAIDs-containing spray agent is installed on a slope with an inclination angle of 7 ° and a height of 3 cm from the flat surface. Say it. That is, when the rolled distance was 10 cm or more, it was “rolled”, and when it was less than 10 cm, it was “not rolled”.

  As shown in FIG. 1, the NSAIDs-containing spray of the present invention comprises a bottle body A and a dispenser B. The dispenser B can spray the content liquid in a mist form without using liquefied gas or compressed gas. The cap C can be attached to the upper part.

  The capacity of the bottle main body A in the present invention is not particularly limited, but if the bottle main body A is less than 50 mL, the fit when the bottle main body A is small and held in hand is poor, and if it exceeds 200 mL, the container is bulky and lacks portability. It is preferable that it is 50-200 mL.

  As shown in FIGS. 2 to 3, the bottle main body A includes a bottom portion 1, a trunk portion 2, a shoulder portion 3, and a neck portion 4. The bottle body A is molded as a single layer or a laminate using a synthetic resin as a base resin, and from the bottom surface 5 to the neck portion 4. Although the height in particular is not restrict | limited, 50-200 mm is preferable. Examples of the synthetic resin include polyethylene such as high-density polyethylene and low-density polyethylene, polypropylene, polyester, polystyrene, and the like, and they can be used alone or in combination of two or more.

  As shown in FIGS. 2 to 3, the bottom 1 constitutes a bottom surface 5 that is a landing surface of the bottle body A.

  2-3, the trunk | drum 2 exists between the bottom part 1 and the shoulder part 3, and as shown in FIGS. 4-5, the horizontal cross section cut | disconnected in parallel with the bottom face 5 is an ellipse shape or substantially rectangular shape. Is forming. More specifically, as shown in FIG. 4, the major axis 6 and the minor axis 7 passing through the elliptical center of gravity are 10 to 100 mm, respectively, and the ratio of the major axis 6 to the minor axis 7 is 1.1 to 15.0 at the maximum. More preferably, the major axis 6 and the minor axis 7 passing through the elliptical center of gravity are each 20 to 50 mm, and the ratio of the major axis 6 to the minor axis 7 is 1.3 to 10.0 at the maximum. . As shown in FIG. 5, the long side 8 and the short side 9 passing through the substantially rectangular center of gravity are 10 to 100 mm each, and the ratio of the long side 8 to the short side 9 is 1.1 to 15.0 at the maximum. More preferably, the long side 8 and the short side 9 passing through the substantially rectangular center of gravity are each 20 to 50 mm, and the ratio of the long side 8 to the short side 9 is 1.3 to 10.0 at the maximum. . As shown in FIGS. 6-7, the corner part 10 of the trunk | drum 2 is chamfered and the outer periphery is made 100-150 mm in size, so that the fit with the bottle body A when held in the hand can be improved. The user can make the bottle main body A easier to hold.

  The shoulder 3 is located at the upper part of the body 2 and is formed to have the same shape and size as the body 2 as shown in FIG. 2, or from the body 2 as shown in FIG. The diameter gradually decreases over the neck 4 and is formed like a shoulder. The shoulder portion 3 is formed in an oval shape or a substantially rectangular shape as a whole, like the bottom portion 1 and the trunk portion 2, and its outer periphery is smaller than the trunk portion 2 and larger than the neck portion 4.

  As shown in FIGS. 2 to 3, the neck 4 is positioned at the upper end of the bottle main body A, and a screw 11 configured to be detachable from the dispenser may be screwed around the outer periphery of the neck 4. Moreover, as shown in FIGS. 6-7, the neck part 4 has opened the upper end, and functions as a supply port of a content liquid.

  As a molding method of the bottle body used for the NSAIDs-containing spray of the present invention, a blow molding method can be mentioned. By adopting blow molding, bottle bodies of various shapes can be easily produced freely. it can. Here, either direct blow molding or injection blow molding may be used as the blow molding method. Further, either the cold parison method or the hot parison method may be used.

  The dispenser B in the present invention is not particularly limited in shape, structure, material and the like as long as the liquid content can be sprayed in a mist form without using liquefied gas or compressed gas, but examples include an air pump type and a trigger type. Preferably, the dispenser main body is not large and is an air pump type excellent in portability.

When the dispenser B in the present invention is operated once, the amount of the content liquid sprayed is less than 0.05 mL, and a sufficient anti-inflammatory analgesic effect cannot be obtained. Since the risk of developing side effects increases, it is preferably 0.05 to 0.5 mL. Furthermore, since the NSAIDs-containing spray of the present invention is used for an inflammatory site or the like, it is preferable that the content liquid is sprayed on the entire inflammatory site when the dispenser B is operated once. Therefore, when the content liquid is sprayed toward a vertical plate surface 10 cm away, the maximum diameter of the wet portion on the plate surface is 5 to 30 cm, and the area of the wet portion is 10 to 700 cm ² . It is preferable. When the area of the wet portion is less than 10 cm ² , spraying cannot be performed in a desired range, and when the area exceeds 700 cm ² , spraying is performed outside the desired range, resulting in waste. Further, since the NSAIDs-containing spray of the present invention may be used upside down, the dispenser B is preferably sprayed not only in an upright state but also in an inverted state.

  The method of molding the dispenser used for the NSAIDs-containing spray of the present invention is not particularly limited as long as it is a commonly used method, but known molding methods such as injection molding and compression molding can be applied.

  Examples of NSAIDs used in the present invention include indomethacin, ibuprofen, ketoprofen, ibuprofen piconol, piroxicam, acetylsalicylic acid, aspirin, felbinac, alclofenac, clidanac, salsalate, naproxen, fenbufen, flufenamic acid, flurbiprofen, methiazine. Acid, mefenamic acid, bendazac, bufexamac, ufenamate, loxoprofen and its salt, glycyrrhetinic acid and its salt, methyl salicylate, glycolic salicylate and the like can be mentioned, and these can be used alone or in combination of two or more. If the content of NSAIDs is less than 0.01% by mass relative to the entire content liquid, a sufficient anti-inflammatory analgesic effect cannot be obtained, and if it exceeds 10% by mass, the risk of developing side effects increases. Although it is preferable that it is 0.01-10 mass%, More preferably, it is 0.5-5 mass%.

  Examples of the water used in the present invention include purified water, sterilized water, natural water, normal water, and water for injection. These can be used alone or in combination of two or more, but purified water is preferred.

  The NSAIDs-containing spray of the present invention has various components that are acceptable for producing pharmaceuticals within the range that does not impair the effects of the present invention, that is, alcohol, surfactant, thickener, moisturizer, oily component, pH adjustment An agent, a chelating agent, a fragrance / cooling agent, an antioxidant, an antiseptic, an absorption accelerator, and the like can be appropriately blended.

  Examples of the alcohol used in the present invention include ethanol, absolute ethanol, various denatured ethanol, n-propanol, isopropanol, n-butanol, and isobutanol, and these can be used alone or in combination of two or more. If the alcohol content is less than 5% by mass with respect to the entire content liquid, it is difficult to sufficiently dissolve or disperse NSAIDs, and if it exceeds 60% by mass, skin irritation becomes high. Although it is preferable that it is 5-60 mass%, More preferably, it is 15-40 mass%.

  Examples of the surfactant include ether compounds such as polyoxyethylene alkyl ether and polyoxyethylene polypropylene alkyl ether, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin. Fatty acid esters, polyethylene glycol fatty acid esters, ester compounds such as sucrose fatty acid esters, nonionic surfactants such as polyoxyethylene castor oil / hardened castor oil, polyoxyethylene polyoxypropylene polymer, and alkylbetaines such as lauryl dimethyl betaine , Amphoteric surfactants such as alkylamide betaines such as coconut oil fatty acid amidopropylbetaine, alkylsulfobetaines and imidazolines Agents, saturated higher fatty acid salts, alkyl sulfonates, alkyl ether sulfonates, anionic surfactants such as polyoxyethylene alkyl ether phosphate and the like, may be used alone or in combination of two or more.

  Examples of the thickener include cellulose derivatives such as hydroxypropylcellulose, hydroxypropylmethylcellulose, carmellose, croscarmellose and methylcellulose, modified starches such as partially pregelatinized starch, polyvinyl alcohol, polyvinylpyrrolidone, crospovidone, polyethylene glycol, carboxy Vinyl polymers, acrylic acid / alkyl methacrylate copolymers, xanthan gum, carrageenan, sodium alginate, gum arabic, guar gum, locust bean gum, pullulan, gelatin, sodium polyacrylate, etc. are used alone or in combination of two or more. be able to.

  Examples of the humectant include ethylene glycol, diethylene glycol, propylene glycol, butylene glycol, dibutylene glycol, glycerin, diglycerin, polyglycerin and sucrose, lactose, malose, mannitol, erythritol, xylitol and other sugars and sugar alcohols. Can be used alone or in combination of two or more.

  Examples of the oil component include unsaturated fatty alcohols such as palmitooleic alcohol, oleic alcohol, eicosonyl alcohol, elaidyl alcohol, linoleyl alcohol, oleic acid, elaidic acid, linoleic acid, undecylenic acid, myristoleic acid, Unsaturated fatty acids such as palmitoleic acid, lindelic acid, lauroleic acid, tuzuic acid, peteroselic acid, bassenic acid, gondonic acid, glyceryl monooleate glycerin, dioleate, octyldodecyl oleate, oleyl oleate Fatty acid esters, oleyl alcohol, elidyl alcohol liquid paraffin, petrolatum, hydrocarbons such as microcrystalline wax, methylpolysiloxane, methylphenylpolysiloxane, dimethyl Silicon oils such as lucyclopolysiloxane, waxes such as beeswax, higher alcohols such as cetyl alcohol and stearyl alcohol, sterols such as cholesterol, octyldodecyl oleate, oleyl oleate, cetyl octanoate, isopropyl myristate, Examples include fatty acid esters such as myristyl myristate, and metal soaps such as aluminum stearate and magnesium stearate, which can be used alone or in combination of two or more.

  Examples of pH adjusters include acetic acid, formic acid, lactic acid, tartaric acid, oxalic acid, glycolic acid, malic acid, citric acid, succinic acid, fumaric acid, phosphoric acid, hydrochloric acid, nitric acid, sulfuric acid and their salts, sodium hydroxide , Potassium hydroxide, calcium hydroxide, arginine, methylamine, ethylamine, propylamine, dimethylamine, diethylamine, dipropylamine, trimethylamine, triethylamine, tripropylamine, monomethanolamine, monoethanolamine, monopropanolamine, dimethanol Amine, diethanolamine, dipropanolamine, trimethanolamine, triethanolamine, isopropanolamine, diisopropanolamine, tripropanolamine, ammonia water, guanidine carbonate, bicarbonate Potassium, and ammonium carbonate and the like, may be used alone or in combination of two or more.

  Examples of the chelating agent include pyrophosphoric acid, hexametaphosphoric acid, gluconic acid and the like, and can be used alone or in combination of two or more.

  Examples of fragrances and refreshing agents include mint oil, mint oil, cinnamon oil, clove oil, fennel oil, castor oil, turpentine oil, eucalyptus oil, orange oil, lavender oil, lemon oil, rose oil, lemongrass oil, Fragrances such as daikyo oil, thiamine oil, henoposi oil, yamadine oil, touka oil, bergamot oil, citronella oil, camphor oil, cerium oil and plant extracts such as rosemary and sage, l-menthol, camphor, Cooling agents such as thymol, N-ethyl-p-menthane-carboxamide, p-menthane-3,8-diol, l-isopulegol, l-menthyl glyceryl ether, and the like may be used alone or in combination of two or more. Can do.

  Examples of the antioxidant include ascorbic acid, propyl gallate, butylhydroxyanisole, dibutylhydroxytoluene, nordihydroguaiaretic acid, tocopherol, and tocopherol acetate, which can be used alone or in combination of two or more. .

  Examples of preservatives include thymol, isopropylmethylphenol, benzoic acid, methyl benzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, benzyl alcohol, benzalkonium chloride, benzethonium chloride, and the like. It can be used alone or in combination of two or more.

  Examples of the absorption promoter include diisopropyl adipate, lecithin, squalane, squalene, azone, l-menthol, polyethylene glycol, isopropyl myristate, dimethyl sulfoxide, peppermint oil, eucalyptus oil, d-limonene, dl-limonene and the like. These can be used alone or in combination of two or more.

  The NSAIDs-containing spray of the present invention can be produced by a conventionally known conventional method or a method newly provided in the future. As typical methods, NSAIDs and alcohol are sufficiently dissolved or dispersed in purified water, and further surfactants, thickeners, moisturizers, oil components, pH adjusters, chelating agents, fragrances / cooling agents, Antioxidants, preservatives, absorption promoters, etc. are added and sufficiently dissolved or dispersed to prepare the content liquid. The prepared content liquid can be filled in a spray container consisting of a synthetic resin bottle body and a dispenser that can be sprayed in a mist form without using liquefied gas or compressed gas to produce the NSAIDs-containing spray of the present invention. it can.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.
Example 1
Based on the formulation shown in Table 1, it was prepared by the method of Preparation Method 1 described later to obtain the NSAIDs-containing spray agent 1 of the present invention. Using the obtained NSAIDs-containing spray 1, a rolling test was carried out according to Test Example 1 and the result was 4 cm. The results are shown in Table 2.

(Preparation method 1)
The horizontal cross section of the body when the content liquid obtained by adding diisopropanolamine, felbinac, ethanol, and glycerin to purified water in order, stirring and dissolving, with polypropylene as the main component and parallel to the bottom surface is an ellipse. The main body of the bottle with a major axis of 48 mm, a minor axis of 31 mm (ratio of major axis to minor axis is 1.5), an outer circumference of 120 mm, and a height from the bottom to the neck of 146 mm. Filled with 100 mL of NOC-120 made by Plus Co., Ltd. and equipped with an air pump dispenser (Z-155, manufactured by Mitani Valve Co., Ltd.) that can be sprayed in a mist form without using liquefied gas or compressed gas, The NSAIDs-containing spray 1 of the present invention was obtained.

(Test Example 1)
Rolling test A rolling test was carried out using the NSAIDs-containing spray 1 of Example 1 described above, the NSAIDs-containing spray 2 of Example 2 described later and the spray 1 of Comparative Example 1.
Each spray was placed on a slope with an inclination angle of 7 ° and a height from a plane of 3 cm. The rolling distance after each spray agent landed on a flat surface was measured. When this distance was 10 cm or more, it was “rolled”, and when it was less than 10 cm, it was “not rolled”.

(Example 2)
When the bottle body used in Example 1 is cut in parallel with the bottom surface, the horizontal cross section of the body portion is substantially rectangular (R rectangular shape with curved corners), and the length of the long side passing through the center of gravity of the horizontal cross section is 44mm, the length of the short side is 34mm (the ratio of the long side to the short side is 1.3), the outer periphery is 130mm, and the height from the bottom to the neck is 134mm (manufactured by Honda Plus Co., Ltd., MRC -The same preparation method as Example 1 was repeated except that it was set to -120), and the NSAIDs containing spray agent 2 was obtained. Using the obtained NSAIDs-containing spray 2, a rolling test was carried out according to Test Example 1, and the result was 5 cm, which did not roll. The results are shown in Table 2.

(Comparative Example 1)
When the bottle body used in Example 1 is cut in parallel with the bottom surface, the horizontal section of the trunk portion is a true circle with a diameter of 39 mm and the outer periphery is 120 mm, and the height from the bottom surface to the neck portion is 121 mm. Except for using NCC-100 (manufactured by Multiplus Co., Ltd.), the same preparation method as in Example 1 was repeated to obtain a spray agent 1. As a result of carrying out a rolling test according to Test Example 1 using the obtained spray agent 1, it became 80 cm and rolled. The results are shown in Table 2.

  The present invention uses a liquid body containing liquefied gas or compressed gas, and the horizontal section of the body when the content liquid containing NSAIDs is cut parallel to the bottom surface is an oval shape or a substantially rectangular shape. By filling the spray container with a dispenser that can spray the contents liquid in a mist form without using liquefied gas or compressed gas, corrosion of the container can be prevented, the container is difficult to roll, and the contents liquid is not The present invention relates to a spray containing NSAIDs that can be administered in the form of a mist, and can be used industrially.

A Bottle body B Dispenser C Cap 1 Bottom part 2 Body part 3 Shoulder part 4 Neck part 5 Bottom face 6 Long diameter 7 Short diameter 8 Long side 9 Short side 10 Corner part 11 Screw

Claims (4)

NSAIDs-containing spray agent that does not use liquefied gas or compressed gas, can prevent corrosion of the container, is difficult to roll, and can administer the content liquid in mist form,
The spray agent consists of a bottle body made of synthetic resin and a dispenser capable of spraying the liquid contents in a mist form without using liquefied gas or compressed gas,
The bottle body has a content liquid filling space inside, a neck formed at the top and having an opening, and a long diameter passing through the center of gravity of the horizontal section when the body of the bottle body is cut parallel to the bottom surface. NSAIDs-containing, characterized in that it has an elliptical shape with a short diameter ratio of 1.3 to 10.0 at the maximum, or a substantially rectangular shape with a long to short side ratio of 1.3 to 10.0 at the maximum Spray agent.   The NSAIDs-containing spray agent according to claim 1, wherein the synthetic resin is at least one of polyethylene, polypropylene, polyester, and polystyrene.   3. The NSAIDs-containing spray according to claim 1, wherein the outer circumference of the body of the bottle body is 100 to 150 mm at a maximum, and the height from the bottom surface to the neck of the bottle body is 50 to 200 mm. Agent. The NSAIDs-containing spray according to any one of claims 1 to 3, wherein the dispenser is an air pump type.

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