JP2002212105A - Aqueous skin care composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a homogeneous aqueous skin care composition which contains an anti-inflammatory agent, is stable, does not irritate skins, and has an excellent antiseptic force. SOLUTION: This homogeneous aqueous skin care composition comprising (A) an anti-inflammatory agent, (B) one or more compounds selected from an aliphatic alcohol having a 12 to 20C unsaturated hydrocarbon group, a fatty acid having a 12 to 20C unsaturated hydrocarbon group and/or its salt, ester, and (C) a preservative is characterized in that the content of the 1 to 6C monohydric lower alcohol is <=70 wt.%.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a homogeneous aqueous external preparation composition containing an anti-inflammatory agent.

[0002]

2. Description of the Related Art Many of anti-inflammatory agents used for external skin preparations such as antiphlogistic analgesics and eczema drugs are poorly water-soluble, so that when they are used as aqueous preparations, the stability of the solution is a major problem.
In addition, performance improvers such as lipophilic absorption enhancers incorporated to improve the effect of the anti-inflammatory agent also inhibit the stabilization of the aqueous preparation. In order to stabilize these in an aqueous composition, there is a method in which a uniform preparation is dissolved with a large amount of lower alcohol, but this tends to cause troubles due to skin irritation such as defatting of the skin and soaking in wounds. Therefore, in order to suppress skin irritation, there has been a demand for a stable external preparation containing an anti-inflammatory agent while suppressing the blending of lower alcohol. On the other hand, in the case of an aqueous preparation having a lower blending amount of lower alcohol, the preservative power of the preparation is not sufficient, and when used, dirt adheres to the mouth, inner plug, cap, and the like of the container, thereby causing secondary contamination. There's a problem.

[0003]

SUMMARY OF THE INVENTION The present invention provides a homogeneous aqueous skin external preparation composition containing an anti-inflammatory agent which is stable, does not irritate the skin, and has excellent antiseptic properties. The “homogeneous system” in the present invention means a system in which a liquid component is not separated or emulsified and dispersed in an oil phase and an aqueous phase, that is, a liquid system in a dissolved or solubilized state.

[0004]

As a result of the study, the present inventors have found that the above problems can be solved by selecting a specific performance improver and blending a preservative, and have completed the present invention. Was. That is, the present invention provides (A) an anti-inflammatory agent, (B) an aliphatic alcohol having an unsaturated hydrocarbon group having 12 to 20 carbon atoms, a fatty acid having an unsaturated hydrocarbon group having 12 to 20 carbon atoms and / or A uniform aqueous external skin composition comprising at least one preservative selected from salts and esters and having a monohydric lower alcohol content of 1 to 6 carbon atoms of 70% by mass or less. Offer things.

In the present invention, the aqueous solvent of the above composition is (D) a monohydric lower alcohol having 1 to 6 carbon atoms / water = 0.7.
The present invention provides an aqueous dermatological composition for external use as an aqueous solvent having an aqueous solvent content of from 1.4 to 1.4.

Further, according to the present invention, the aqueous skin external preparation composition of the present invention having a viscosity at 25 ° C. of 1 to 1000 cp is contained in a container having an outlet or outlet having a diameter of 0.1 to 5 mm. The present invention also provides a skin external preparation, wherein the aqueous skin external preparation composition of the present invention having a viscosity at 25 ° C of 500 to 100000 cp is housed in a tube made of a flexible material.
Hereinafter, the present invention will be described in detail.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION (A) Examples of the anti-inflammatory agent used in the aqueous skin external preparation composition of the present invention include the following. Nonsteroidal anti-steroids such as ketoprofen, indomethacin, bufexamac, ibuprofen, piroxicam, suprofen, flurbiprofen, naproxen, loxoprofen, glycyrrhetinic acid and its salts, mefenamic acid, allantoin, methyl salicylate, glycol salicylate, dipotassium glycyrrhizinate, etc. Inflammatory agents, steroidal anti-inflammatory agents such as hydrocortisone, prednisolone, dexamethasone, etc., and crude drug extracts such as oak, cinnamon flour, arnica, chamomile and the like.

Preferred are non-steroidal anti-inflammatory drugs and herbal anti-inflammatory drugs. Particularly preferred anti-inflammatory agents are ketoprofen, indomethacin, bufexamac, suprofen. The compounding amount of the nonsteroidal anti-inflammatory agent is preferably 0.01 to 20% by mass, more preferably 0.1 to 10% by mass in the composition.

(B) An aliphatic alcohol having an unsaturated hydrocarbon group having 12 to 20 carbon atoms and a fatty acid having an unsaturated hydrocarbon group having 12 to 20 carbon atoms used in the aqueous external preparation for skin of the present invention. And / or salts and esters thereof are used for the purpose of improving the efficacy of non-steroidal anti-inflammatory drugs. Specifically, the following are mentioned.

Examples of the unsaturated aliphatic alcohol having 12 to 20 carbon atoms include palmitooleyl alcohol, oleyl alcohol, eicosonyl alcohol, elaidyl alcohol, linoleyl alcohol and the like. Preferably, it is oleyl alcohol, elaidyl alcohol or a mixture thereof.

The unsaturated fatty acids having 12 to 20 carbon atoms and / or salts thereof include oleic acid, elaidic acid, linoleic acid, undecylenic acid, myristoleic acid, palmitoleic acid, lindelic acid, lauroleic acid, tuzunic acid, petroselin Acids, basenic acid, gondic acid and the like. Preferably, it is oleic acid, elaidic acid or a mixture thereof.

Examples of unsaturated fatty acid esters include esters of the above unsaturated fatty acids with monohydric alcohols having 1 to 18 carbon atoms, glycerin and diglycerin. For example,
Isopropyl oleate, glycerin monooleate glycerin, dioleate, octyldodecyl oleate, oleyl oleate and the like can be mentioned.

The content of the component (B) in the composition is preferably 0.005 to 20% by mass, more preferably 0.1 to 20% by mass.
It is 10% by mass, particularly preferably 0.0 to 5% by mass.
Within this range, particularly good solution stability and drug efficacy are obtained.

The preservative which is the component (C) of the present invention includes:
Refers to a compound described as a preservative in the "Pharmaceutical Excipients Dictionary 2000" (edited by Japan Pharmaceutical Excipients Association, Yakuji Nippo) Specifically, benzoic acid, sodium benzoate, anthracite, phenol, sodium edetate,
Tetrasodium edetate, cetylpyridinium chloride, benzalkonium chloride, benzalkonium chloride solution, benzethonium chloride, chlorhexidine hydrochloride, caatresin, captan, dried sodium sulfite, citric acid, chlorhexidine gluconate solution, potassium L-glutamate, cresol, m Cresol, chlorocresol, chlorobutanol, salicylic acid, sodium salicylate, dibutylhydroxytoluene, D-sorbitol, sorbic acid, potassium sorbate, thimerosal, thymol, sodium dehydroacetate, concentrated benzalkonium chloride solution 5
0, normal butyl glycidyl ether, isobutyl parahydroxybenzoate, isopropyl paraoxybenzoate,
Ethyl paraoxybenzoate, butyl paraoxybenzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, human serum albumin, phenylethyl alcohol, phenol, propylene glycol, benzyl alcohol, boric acid, borax, formalin, 2-mercaptobenzimidazole, Examples include copper sulfate and phosphoric acid.

Preferably, dibutylhydroxytoluene, sodium edetate, benzalkonium chloride, citric acid, salicylic acid, isobutyl parahydroxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, propyl paraoxybenzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, D -Sorbitol, particularly preferably dibutylhydroxytoluene, sodium edetate, butyl paraoxybenzoate, propyl paraoxybenzoate,
Methyl paraoxybenzoate. The most preferred preservative is dibutylhydroxytoluene.

The content of the preservative in the composition is preferably 0.01 to 50% by mass, more preferably 0.02 to 3% by mass.
0 mass%, particularly preferably 0.05 to 10 mass%.

(D) The aqueous skin external preparation composition of the present invention comprises:
It contains a monohydric lower alcohol having 1 to 6 carbon atoms, and its content is 70% by mass or less, preferably 5 to 70% by mass, more preferably 10 to 60% by mass, particularly preferably 20 to 50% by mass in the composition. It has an aqueous solvent which is% by weight. Within this range, the stability of the solution and the suppression of skin irritation are good. Preferably, an aqueous solvent having a monohydric lower alcohol having 1 to 6 carbon atoms / water = 0.7 to 1.4 is used as the solvent. Monohydric lower alcohols include ethanol, isopropanol, n
-Propanol, butanol, isobutanol and the like. Preferably ethanol, isopropanol,
n-propanol. The lower alcohol is preferably a mixed alcohol of two or more, and a mixed alcohol of ethanol and isopropyl alcohol provides particularly good stability of the composition. A mixture of ethanol / isopropanol (mass ratio) = 0.7 to 10, particularly 1 to 8, has particularly good stability and is preferred.

As the ethanol, various denatured alcohols (methanol denatured, geraniol denatured, octaacetylated sucrose denatured, denatonium benzoate denatured, brucine denatured, etc.) can be used.

The aqueous skin external preparation composition of the present invention may contain the following components in addition to those described above, as long as the effects of the present invention are not impaired.

(E) Surfactant For the purpose of further improving the liquid properties of the aqueous liquid of the present invention, a surfactant can be used. As a surfactant,
Any of an anionic surfactant, a cationic surfactant, a nonionic surfactant and an amphoteric surfactant can be used, but a nonionic surfactant and an amphoteric surfactant are preferred.

Examples of the nonionic surfactant include ether compounds such as polyoxyethylene alkyl ether and polyoxyethylene polypropylene alkyl ether; sorbitan fatty acid ester; polyoxyethylene sorbitan fatty acid ester; glycerin fatty acid ester; polyglycerin fatty acid ester; Ester compounds such as ethylene glycerin fatty acid ester, polyethylene glycol fatty acid ester and sucrose fatty acid ester, polyoxyethylene castor oil / hardened castor oil, polyoxyethylene polyoxypropylene polymer and the like.

Examples of the amphoteric surfactant include alkyl betaines such as lauryl dimethyl betaine, alkyl amide betaines such as coconut fatty acid amide propyl betaine, alkyl sulfobetaines, imidazolines and the like.

Examples of the anionic surfactant include saturated higher fatty acid salts, alkyl sulfonates, alkyl ether sulfonates, and alkyl ether sulfonates. These can be used alone or in combination of two or more.

As the cationic surfactant, a quaternary ammonium salt such as trimethylalkylammonium chloride;
And alkylamine salts such as dimethylalkylamine hydrochloride.

The compounding amount is preferably 0.01% in the composition.
10 to 10% by mass, more preferably 0.05 to 5% by mass.

(F) Thickener The aqueous external preparation composition of the present invention may optionally contain a thickener. As the thickener, a water-soluble polymer or a crosslinked body thereof is preferably used. Specific examples include hydroxypropylcellulose, hydroxypropylmethylcellulose, carmellose, croscarmellose, cellulose derivatives such as methylcellulose, modified starches such as partially pregelatinized starch, polyvinyl alcohol, polyvinylpyrrolidone, crospopidone, polyethylene glycol, carboxyvinyl Polymers, acrylic acid / alkyl methacrylate copolymer, xanthan gum, carrageenan, sodium alginate, gum arabic, guar gum, locust bean gum, pullulan, gelatin, sodium polyacrylate and the like. These can be used alone or in combination of two or more.

The amount is appropriately selected depending on the set viscosity of the preparation, but particularly good viscosity characteristics are obtained in the range of 0.01 to 5% by mass, preferably 0.05 to 2% by mass in the composition. be able to.

(G) Drugs In addition to the anti-inflammatory agent of the present invention, drugs such as antipruritics, antihistamines, local anesthetics, and blood circulation promoters can be contained. Antipruritic: crotamiton, etc. Antihistamine: diphenhydramine and its salts,
Chlorpheniramine and its salts, etc. Local anesthetic: ethyl aminobenzoate, lidocaine and its salts, dibucaine and its salts, etc. Blood circulation promoters: capsaicin, capsicum, topherol acetate, etc. Fungicides: acrinol, isopropylmethylphenol, chlorhexidine hydrochloride, Chlorhexidine gluconate, phenol, resorcin, sulfur, etc. Antibacterial agents: sulfa agents such as sulfadiazine, sulfisomidine, homosulfamine, etc. Antifungal agents: miconazole nitrate, econazole nitrate, ciclopirox, olamine, clotrimazole, pyrrolnitrin, etc. Painkiller: methyl salicylate , Aspirin, aminopyrine, acetaminophen, etensamide, etc. Keratin softener: urea, etc. ▲ 10 ▼ Vitamins: ascorbic acid, pyridoxy hydrochloride Oil-soluble vitamins such as tocopherol, tocopherol acetate, palmitic acid, retinol, vitamin A oil, etc. ▲ 11 ▼ Mucopolysaccharides: Heparin-like substances and chondroitin sulfate sodium ▲ 12 ▼ Acidic amino acids: glycine, Neutral amino acids such as alanine, aromatic amino acids such as tryptophan and phenylalanine, basic amino acids such as histidine and arginine, aspartic acid, glutamic acid and the like The above-mentioned active ingredients are used alone or in combination of two or more as necessary. can do. The compounding amount is an appropriate compounding amount of each drug.

(H) Polyhydric Alcohol It is preferable to add a polyhydric alcohol for the purpose of improving the moisture retention of the skin when applied to the skin. Examples of polyhydric alcohols include saccharides such as ethylene glycol, diethylene glycol, propylene glycol, butylene glycol, dibutylene glycol, glycerin, diglycerin, polyglycerin, and sucrose, lactose, maltose, mannitol, erythritol, xylitol, and sugar alcohols. can give. The content of polyhydric alcohol is
It can be contained in the composition in an amount of preferably 0.1 to 30% by mass, more preferably 1 to 20% by mass.

(I) Oily Component As the oily component other than (B), for example, the following can be used. Hydrocarbons such as liquid paraffin, petrolatum, microcrystalline wax, etc., silicone oils such as methylpolysiloxane, methylphenylpolysiloxane, dimethylcyclopolysiloxane, waxes such as beeswax, and higher alcohols such as cetyl alcohol and stearyl alcohol Sterols such as cholesterol, octyldodecyl oleate, oleyl oleate, cetyl octoate, isopropyl myristate, myristyl myristate, and the like; metal soaps such as aluminum stearate and magnesium stearate. These can be used alone or in combination of two or more. The compounding amount can be compounded in the composition in the range of 0.05 to 50% by mass, preferably 0.1 to 30% by mass.

(J) Inorganic powder Layered silicate minerals such as talc, kaolin, bentonite and aluminum magnesium silicate, titanium oxide, zinc oxide, etc.

(K) Organic powder Spherical powder such as nylon, silica, polymethyl methacrylate, polyethylene beads, cellulose powder, starch, etc.

In the present invention, the term "uniform" means not being emulsified, but being uniformly dissolved or solubilized.
Solid organic or inorganic powders such as (J) and (K) may be dispersed therein.

(L) pH adjuster The aqueous skin external preparation composition of the present invention preferably has a pH of 3 to 3.
8, more preferably 4 to 7. Examples of the pH adjuster include hydrochloric acid, lactic acid, sodium hydroxide, potassium hydroxide, triethanolamine, diisopropanolamine, and potassium hydrogen phosphate. Diisopropanolamine, especially when acidic drugs are used
This is preferable because the stability is good. The amount of the pH adjuster can be appropriately selected depending on the set pH.

(M) Chelating agent (N) Dyes such as pyrophosphate, hexametaphosphate, and gluconate (N) Dyes Acidic dyes, basic dyes, oxidation dyes and the like can be optionally used.

(O) Flavors Plant flavors such as peppermint oil, spearmint oil, peppermint oil, eucalyptus oil, jasmine oil, lavender oil, lemon oil, orange oil, lime oil, mandarin oil, rose oil, rosemary oil, etc. Terpenes, diterpenes,
Synthetic fragrances such as sesquiterpenes are exemplified. Specifically, menthol, borneol, geraniol, linalool, citronellol, nerol, limonene, pinene,
Examples include camphene, citral, citronellal, cineol, curcumen, hinoki acid, hinokiol, and phytol.

The composition of the present invention has a relatively low viscosity (1 to 1).
In the case of a liquid lotion of 000 cp), the container has a diameter of 0.
Those having an outlet or outlet of 1 to 5 mm are preferred. The mouth may be integral with the container, or may be a removable cap or inner plug. For example, it can be stored in a container provided with a resin inner plug or cap having one or more holes. Inner stoppers and caps have a drip prevention mechanism such as a groove on the surface so that the liquid does not flow down to the outer wall, or a container with a convex structure around the hole or a check valve to install inside the container. It is preferable to provide a liquid return prevention mechanism. Further, a coating cap or inner plug in which a cloth or a porous body serving as a coating portion is further disposed above the hole, or a discharge hole having a diameter of 0.1 to
A spray container or a squeeze container provided with an inner stopper or a cap having a discharge mechanism of 0.5 mm is preferably used.

The material of the inner plug, the cap, and the nozzle of the discharge container include resins such as PET, polypropylene (PP), polyethylene (high-density polyethylene: HDPE, low-density polyethylene: LDPE), and polystyrene. The above materials can be used alone or in combination of two or more. When a porous coating portion is provided on the inner plug or the cap, the coating portion is preferably made of cloth or a porous material such as porous natural rubber and urethane foam, sponge, or ceramic sintered body.

The material of the container body is PET, polypropylene (PP), polyethylene (high-density polyethylene: HD
PE, low density polyethylene: LDPE), glass, polystyrene, metals such as aluminum and the like. The above materials can be used alone or in combination of two or more.

When the composition of the present invention has a relatively high viscosity (500
In the case of １００100,000 cp), the container can be preferably stored in a tube or a bottle. In the case of a bottle, it is preferable to use a resin having flexibility. The material is PE
T, polypropylene (PP), polyethylene (high density polyethylene: HDPE, low density polyethylene: LDP
E) and the like. Examples of the material of the tube include flexible polyethylene (high-density polyethylene: HDPE, low-density polyethylene: LDPE), aluminum, and the like. A single-layer or multi-layer tube made of the above-mentioned materials, a laminated tube obtained by combining one or two or more of the above-mentioned materials can be used.

[0041]

EXAMPLES The aqueous skin external preparation composition of the present invention will be described below with reference to specific examples. The compositions of the following Examples and Comparative Examples were prepared, and each test was performed and evaluated.

<Preparation Method> Each preparation having a pH of 4 to 9, which is a general pH of the external preparation for skin, was prepared according to a conventional method, and the applied portion was filled in a polypropylene container with a natural rubber sponge. <Irritation test> The sample was applied to the forearm in a constant temperature room at room temperature of 20 ° C and humidity of 65%, and the test was performed. Evaluation was made according to the following criteria. The evaluation was performed in the following three grades, and 以上 or more was judged to be a good level. (◎: None, ○: Almost none, × felt) <Storage stability> The sample was stored in a transparent PET container,
After storage at 5 ° C. for one month, the composition was examined for appearance and odor. (◎: Transparent ○: Almost transparent (slightly pale) △: Ultra-thin, cloudy ×: Cloudy) (◎: Odorless ○: Almost odorless △: Slightly odorous
X: Offensive odor) <Secondary contamination test> The sample was applied three times a day for one month, and then a microbe test was performed on the inner plug and the inner solution of the container. The evaluation items were performed based on the number of microorganisms (the total number of bacteria and fungi) in the inner stopper and the content liquid. The evaluation was performed in the following three grades, and 以上 or more was judged to be a good level. (A: The number of microorganisms is at or below the level of 10 ¹ , ○: The number of microorganisms is at the level of 10 ² to 10 ³ ×: The number of microorganisms is 10 ⁴ or more)

[0043]

[Table 1]

[0044]

[Table 2]

[0045]

[Table 3] Similar favorable evaluations were obtained for other drugs (Table 2).

[0046]

[Table 4]

[0047]

[Table 5] The composition was an aqueous skin external preparation having extremely good moisturizing properties.

Example 41 Antiphlogistic Analgesic Lotion An antiphlogistic analgesic lotion (viscosity 9 cp) having the following composition was stored in a polypropylene container having a urethane sponge coating portion (head space 10%). The coated part was also stored in a similar container made of foamed rubber. Ketoprofen 3.0 Oleic acid 0.8 Oleyl alcohol 0.2 1-Menthol 3.0 Glycerin 5.0 Octaacetyl sucrose denatured alcohol 40.0 Isopropyl alcohol 10.0 Hydroxypropyl cellulose 0.5 Dibutylhydroxytoluene 0.05 Di Isopropanolamine 0.5 eucalyptus oil 0.1 purified water balance

(Example 42) Antiphlogistic analgesic lotion An antiphlogistic analgesic lotion (viscosity 8 cp) having the following composition was stored in a polypropylene container having a polypropylene inner plug having a hole of 1 mm in the bottle mouth (headspace 10%). ). Ketoprofen 3.0 Oleic acid 0.8 Oleyl alcohol 0.2 1-Menthol 3.0 1,3-butylene glycol 5.0 Octaacetyl sucrose denatured alcohol 37.0 Isopropyl alcohol 10.0 Hydroxypropyl cellulose 0.5 Dibutylhydroxy Toluene 0.05 diisopropanolamine 0.5 purified water balance

Example 43 Antiphlogistic Analgesic Spray An antiphlogistic analgesic solution (viscosity 10 cp) having the following composition was added to a 0.1 mm caliber.
It was housed in a manual spray container having a 45 mm discharge port (headspace 10%). Ketoprofen 3.0 camphor 1.0 oleic acid 0.8 oleyl alcohol 0.2 1-menthol 3.0 1,3-butylene glycol 5.0 orange-denatured alcohol 35.0 isopropyl alcohol 10.0 hydroxypropylcellulose 0.5 Dibutylhydroxytoluene 0.05 Diisopropanolamine 0.5 Lemon oil 0.1 Rosemary oil 0.1 Purified water Balance

Example 44 Antiphlogistic Analgesic Aerosol The following antiphlogistic analgesic solution (viscosity 7 cp) was stored in an aluminum aerosol can with a polystyrene nozzle to form an aerosol. (Unit: g / 100 g) (stock solution) 80 parts indomethacin 0.75 1-menthol 1.0 oleic acid 0.5 oleyl alcohol 0.5 hydroxypropylcellulose 0.4 ethanol 48.0 propylene glycol 5.0 triethanolamine 0.8 Dibutylhydroxytoluene 0.05 1,3-butylene glycol 5.0 Polyoxyethylene hydrogenated castor oil 0.5 Isopropyl myristate 0.5 Mint oil 0.1 Purified water 39.0 (Propellant) 20 parts Dimethyl ether 100

Example 45 Insect Biting Gel An insect biting gel (viscosity of 10,000 cp) having the following composition was prepared.
It was stored in a polyethylene tube. Diphenhydramine 2.0 Methyl salicylate 2.0 Monoglycerin oleate 1.0 Brucine-denatured ethanol 25.0 Isopropanol 10.0 Sodium edetate 0.1 Citric acid 0.3 Hydroxyethyl cellulose 1.5 Propylene glycol 10.0 Diisopropanolamine 0.2 Rose oil 0.1 Purified water Remainder

(Example 46) Anti-itch lotion (viscosity 5 cp) (Container: polyethylene container with natural rubber sponge plug) Urea 10.0 Crotamiton 5.0 Diphenhydramine 1.0 Glycyrrhetinic acid 0.5 Lactic acid 2.0 Oleic acid 0 .1 Denatonium benzoate modified alcohol 20.0 Isopropyl alcohol 12.0 Sodium edetate 0.1 Potassium hydroxide 2.3 Triethanolamine 0.8 Eucalyptus oil 0.2 Mint oil 0.3 Purified water Remainder

Example 47 Muscle pain gel (viscosity 180)
00 cp) (Container: Polypropylene container with PET inner stopper, 3 m diameter)
m) Ketoprofen 3.0 1-menthol 3.0 Oleic acid 0.5 Oleyl alcohol 0.1 Acrylic acid / alkyl methacrylate copolymer 2.0 (Carbopol 138 manufactured by BF Goodrich)
2) ethanol 25.0 isopropyl alcohol 15.0 1,3-butylene glycol 5.0 triethanolamine 0.5 rosemary oil 0.2 purified water balance

Example 48 Back pain gel (viscosity 1400)
0 cp) (Container: Polypropylene container with a plug in polyethylene, diameter 5 mm) Indomethacin 0.75 1-Menthol 3.0 Oleic acid 0.5 Carboxyvinyl polymer 2.0 (Carbopol 98 manufactured by BF Goodrich)
1) Ethanol 40.0 Isopropyl alcohol 5.0 Diisopropampanolamine 0.5 Purified water Remainder

Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat II (Reference) A61K 47/08 A61K 47/08 47/12 47/12 47/14 47/14 47/18 47/18 47/26 47 / 26 A61P 29/00 A61P 29/00

Claims (9)

[Claims] (A) an anti-inflammatory agent (B) an aliphatic alcohol having an unsaturated hydrocarbon group having 12 to 20 carbon atoms, 1 carbon atom
It contains at least one (C) preservative selected from fatty acids having 2 to 20 unsaturated hydrocarbon groups and / or salts and esters thereof, and the content of monohydric lower alcohol having 1 to 6 carbon atoms is 70 mass%. % Or less, a homogeneous aqueous skin external preparation composition. 2. The aqueous external skin composition according to claim 1, wherein the aqueous solvent (D) contains a mixture of two or more monohydric lower alcohols and water. 3. The aqueous skin according to claim 1, further comprising (D) an aqueous solvent having a monohydric lower alcohol having 1 to 6 carbon atoms / water = 0.7 to 1.4. External preparation composition. 4. A method according to claim 1, wherein (C) is dibutylhydroxytoluene, sodium edetate, benzalkonium chloride, citric acid,
Salicylic acid, isobutyl parahydroxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate,
The aqueous external skin composition according to any one of claims 1 to 3, which is at least one or more preservatives selected from propyl paraoxybenzoate, methyl paraoxybenzoate, and D-sorbitol. 5. Further, peppermint oil, spearmint oil, peppermint oil, eucalyptus oil, jasmine oil, lavender oil, lemon oil, orange oil, lime oil, mandarin oil,
Rose oil, vegetable flavor selected from rosemary oil, menthol, borneol, geraniol, linalool,
Citronellol, nerol, limonene, pinene, camphene, citral, citronellal, cineol, curcumen, hinoki acid, hinokiol, characterized by containing one or more synthetic flavors selected from phytol, according to claim 1 to 4, characterized in that Aqueous skin external preparation composition. 6. The aqueous skin external preparation composition according to claim 1, which has a viscosity at 25 ° C. of 1 to 1000 cp, which is contained in a container having an outlet or an outlet having a diameter of 0.1 to 5 mm. An external preparation for skin, characterized in that: 7. The container main body is made of at least one single layer selected from polyethylene terephthalate (PET), polypropylene (PP), polyethylene (high-density polyethylene: HDPE, low-density polyethylene: LDPE), glass, polystyrene, and metal. 7. The external preparation for skin according to claim 6, wherein the external preparation comprises a multilayer material. 8. An outflow port or a discharge port is made of polyethylene terephthalate (PET), polypropylene (PP),
8. The external preparation for skin according to claim 6 or 7, comprising one or more single-layer or multilayer materials selected from polyethylene (high-density polyethylene: HDPE, low-density polyethylene: LDPE) and polystyrene. 9. A viscosity at 25 ° C. of 500 to 10,000.
An external preparation for skin, characterized in that the aqueous skin external preparation composition according to any one of claims 1 to 5 is contained in a tube made of a flexible material.