JP2017048140A - Antiperspirant composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an antiperspirant composition which is excellent in an antiperspirant effect even when the perspiration amount and the perspiration time are increased and persistence of the antiperspirant effect and has easy application to the skin, no tight feeling of the skin, no stickiness of the skin and little irritation to skin.SOLUTION: An antiperspirant composition comprises (A) at least one kind of antiperspirant selected from an aluminium compound, a zirconium compound and a complex thereof, (B) a vinyl-based anionic polymer, (C) ethanol, (D) a hydrophobically modified alkyl cellulose and (E) a neutralizer, wherein the content of the (C) ethanol is 50 mass% to 85 mass% and the mass ratio (B/D) of the content (mass%) of the (B) vinyl-based anionic polymer to the content (mass%) of the (D) hydrophobically modified alkyl cellulose is 0.6 to 28.SELECTED DRAWING: None

Description

  The present invention relates to an antiperspirant composition.

  Conventionally, a deodorant composition containing chlorohydroxyaluminum and a specific anionic polymer and forming a film on the skin and having excellent antiperspirant effect and durability of the antiperspirant effect has been proposed (for example, patents). Reference 1 and 2). However, the proposal has a problem that the antiperspirant effect and the sustainability of the antiperspirant effect decrease as the perspiration amount and the perspiration time increase. In addition, the above proposal has not been sufficiently studied for ease of application to the skin, lack of skin tension, lack of skin stickiness, and lack of skin irritation.

  Therefore, even when the amount of sweating and the sweating time are increased, the antiperspirant effect and the durability of the antiperspirant effect are excellent, and the ease of application to the skin, the feeling of firmness of the skin and the non-stickiness of the skin are good. Therefore, it is desired to provide an antiperspirant composition with less skin irritation.

JP 2014-015421 A International Publication No. 2013/081055 Pamphlet

  An object of the present invention is to solve the above-described problems and achieve the following objects. That is, the present invention is excellent in antiperspirant effect and persistence of the antiperspirant effect even when the perspiration amount and perspiration time are increased, ease of application to the skin, lack of skin tightness, and non-stickiness of the skin. An object of the present invention is to provide an antiperspirant composition that has good skin irritation and little irritation to the skin.

  As a result of intensive studies by the inventor in order to solve the above problems, (A) at least one antiperspirant selected from an aluminum compound, a zirconium compound, and a complex thereof; and (B) a vinyl type anionic property. A polymer, (C) ethanol, (D) a hydrophobized modified alkyl cellulose, and (E) a neutralizing agent, wherein the content of (C) ethanol is 50% by mass to 85% by mass, The mass ratio (B / D) of the content (% by mass) of the (B) vinyl type anionic polymer and the content (% by mass) of the (D) hydrophobized modified alkyl cellulose is 0.6 to 28. The antiperspirant composition is excellent in antiperspirant effect and antiperspirant effect even when the sweating amount and sweating time increase due to the synergistic effect of each component, ease of application to the skin, and firmness of the skin No feeling and sticky skin Is is good, and found that skin irritation is less.

This invention is based on the said knowledge by this inventor, and as a means for solving the said subject, it is as follows.
<1> (A) at least one antiperspirant selected from aluminum compounds, zirconium compounds, and complexes thereof;
(B) a vinyl type anionic polymer;
(C) ethanol,
(D) a hydrophobically modified alkyl cellulose;
(E) a neutralizing agent,
The content of the (C) ethanol is 50% by mass to 85% by mass,
The mass ratio (B / D) of the content (% by mass) of the (B) vinyl type anionic polymer and the content (% by mass) of the (D) hydrophobized modified alkyl cellulose is 0.6 to 28. It is an antiperspirant composition characterized by being.
<2> (A) The antiperspirant composition according to <1>, wherein the antiperspirant is chlorohydroxyaluminum.
<3> (B) Vinyl type anionic polymer is selected from (vinyl acetate / crotonic acid / vinyl neodecanoate) copolymer, (vinyl methyl ether / ethyl maleate) copolymer, and (vinyl methyl ether / butyl maleate) copolymer The antiperspirant composition according to any one of <1> to <2>, wherein the antiperspirant composition is at least one kind.
<4> (D) The antiperspirant composition according to any one of <1> to <3>, wherein the hydrophobized modified alkylcellulose is stearoxyhydroxypropylmethylcellulose.
<5> (E) The antiperspirant composition according to any one of <1> to <4>, wherein the neutralizing agent is 2-amino-2-methyl-1-propanol.
<6> (A) The content of the antiperspirant is 6% by mass to 15% by mass,
(B) The content of the vinyl type anionic polymer is 1% by mass to 2.5% by mass,
(C) The content of ethanol is 60% by mass to 75% by mass,
(D) The content of the hydrophobically modified alkyl cellulose is 0.2% by mass to 0.6% by mass,
(E) The antiperspirant composition according to any one of <1> to <5>, wherein the content of the neutralizing agent is 0.1% by mass to 0.3% by mass.
<7> The mass ratio (B / D) of the content (% by mass) of (B) the vinyl type anionic polymer and the content (% by mass) of (D) the hydrophobized modified alkyl cellulose is 1.25 to 1.25. The antiperspirant composition according to any one of <1> to <6>, which is 12.5.
<8> The antiperspirant composition according to any one of <1> to <7>, wherein the composition is any one selected from a roll-on type, a gel type, a lotion type, and a mist type.

  According to the present invention, it is possible to solve the above-described problems and achieve the above-described object, and even when the sweating amount and the sweating time are increased, the antiperspirant effect and the persistence of the antiperspirant effect are excellent, and the skin. It is possible to provide an antiperspirant composition having good ease of application, no feeling of skin firmness, and non-sticky skin, and less irritation to the skin.

(Antiperspirant composition)
The antiperspirant composition of the present invention contains (A) an antiperspirant, (B) a vinyl type anionic polymer, (C) ethanol, (D) a hydrophobized modified alkyl cellulose, and (E) a neutralizer. And further contains other components as necessary.

<(A) Antiperspirant>
The antiperspirant as the component (A) is contained to improve the antiperspirant effect.

  Examples of the antiperspirant of the component (A) include aluminum compounds, zirconium compounds, and complexes thereof. These may be used alone or in combination of two or more.

Examples of the aluminum compound include an aluminum salt.
Examples of the aluminum salt include aluminum chloride, aluminum sulfate, potassium aluminum sulfate, aluminum acetate, chlorohydroxyaluminum, bromohydroxyaluminum, and allantochlorohydroxyaluminum. These may be used alone or in combination of two or more.

Examples of the zirconium compound include zirconium salts.
Examples of the zirconium salt include zirconium chloride, hydroxy zirconium chloride, zirconium hydroxide, ammonium zirconium carbonate, potassium zirconium carbonate, and zirconium sulfate. These may be used alone or in combination of two or more.

  Examples of these complexes include a complex of an aluminum compound and glycine, a complex of an aluminum compound and propylene glycol, a complex of a mixture of an aluminum compound and a zirconium compound and glycine, and the like. These may be used alone or in combination of two or more.

  Examples of the complex of the aluminum compound and glycine include aluminum chloride / glycine complex, aluminum sulfate / glycine complex, aluminum sulfate / glycine complex, aluminum acetate / glycine complex, chlorohydroxyaluminum / glycine complex, bromohydroxyaluminum / glycine. And a complex, an allantochlorohydroxyaluminum / glycine complex, and the like. These may be used alone or in combination of two or more.

  Examples of the complex of the aluminum compound and propylene glycol include an aluminum chloride / propylene glycol complex, an aluminum sulfate / propylene glycol complex, an aluminum sulfate / propylene glycol complex, an aluminum acetate / propylene glycol complex, and a chlorohydroxyaluminum / propylene glycol complex. Bromohydroxyaluminum / propylene glycol complex, allantoinchlorohydroxyaluminum / propylene glycol complex, and the like. These may be used alone or in combination of two or more.

Examples of the complex of a mixture of the aluminum compound and the zirconium compound with glycine include, for example, an aluminum chloride / zirconium compound / glycine complex, an aluminum sulfate / zirconium compound / glycine complex, an aluminum sulfate potassium / zirconium compound / glycine complex, and an aluminum acetate / zirconium complex. Examples thereof include a compound / glycine complex, a chlorohydroxyaluminum / zirconium compound / glycine complex, a bromohydroxyaluminum / zirconium compound / glycine complex, and an allantochlorohydroxyaluminum / zirconium compound / glycine complex. These may be used alone or in combination of two or more.
Among these, aluminum chloride, aluminum sulfate, potassium aluminum sulfate, aluminum acetate, chlorohydroxyaluminum, allantochlorohydroxyaluminum, chlorohydroxyaluminum / propylene glycol complex, chlor from the viewpoint of antiperspirant effect and antiperspirant effect. A hydroxyaluminum / zirconium-glycine complex is preferred, chlorohydroxyaluminum, chlorohydroxyaluminum-propylene glycol complex, potassium aluminum sulfate, chlorohydroxyaluminum / zirconium-glycine complex is more preferred, and chlorohydroxyaluminum is particularly preferred.

  The content of the antiperspirant of the component (A) is the total amount of the antiperspirant composition in terms of antiperspirant effect, durability of the antiperspirant effect, lack of skin tension, and non-stickiness of the skin. On the other hand, 4 mass%-20 mass% are preferable, and 6 mass%-15 mass% are more preferable. When the content is less than 4% by mass, the antiperspirant effect and the persistence of the antiperspirant effect may be insufficient. When the content exceeds 20% by mass, the skin does not feel tight, The non-stickiness may be insufficient.

<(B) Vinyl type anionic polymer>
The vinyl type anionic polymer of the component (B) is contained in order to improve the sustainability of the antiperspirant effect by a film formed on the skin.

  Examples of the vinyl type anionic polymer of the component (B) include a copolymer obtained by copolymerizing an anionic monomer and at least one of a vinyl ether compound and a vinyl ester compound; vinyl ester unit in the copolymer And a copolymer in which a vinyl alcohol unit is formed in the copolymer by further hydrolysis. These may be used alone or in combination of two or more.

  Examples of the anionic monomer include crotonic acid, maleic acid, maleic acid monoester, and itaconic acid. These may be used alone or in combination of two or more.

  Examples of the vinyl ether compound include vinyl methyl ether, vinyl ethyl ether, vinyl hexyl ether, vinyl octyl ether, vinyl decyl ether, vinyl ethyl hexyl ether, vinyl methoxy ethyl ether, vinyl ethoxy ethyl ether, vinyl chloro ethyl ether, 1-methyl. -2,2-dimethylpropyl vinyl ether, 2-ethylbutyl vinyl ether, hydroxyethyl vinyl ether, diethylene glycol vinyl ether, dimethylaminoethyl vinyl ether, diethylaminoethyl vinyl ether, butylaminoethyl vinyl ether, benzyl vinyl ether, tetrahydrofurfuryl vinyl ether, vinyl phenyl ether, vinyl tolyl Ether, vinyl chlorophenyl ether , Vinyl 2,4-dichlorophenyl ether, vinyl naphthyl ether, and vinyl anthranyl ether. These may be used alone or in combination of two or more.

  Examples of the vinyl ester compound include vinyl butyrate, vinyl isobutyrate, vinyl trimethyl acetate, vinyl diethyl acetate, vinyl valate, vinyl caproate, vinyl chloroacetate, vinyl dichloroacetate, vinyl methoxyacetate, vinyl butoxyacetate. Vinyl phenyl acetate, vinyl acetoacetate, vinyl lactate, vinyl-β-phenyl butyrate, vinyl cyclohexyl carboxylate, and the like. These may be used alone or in combination of two or more.

  Examples of the vinyl type anionic polymer of the component (B) include (vinyl acetate / crotonic acid / vinyl neodecanoate) copolymer (trade name: RESYN 28-2930, manufactured by Akzo Nobel Co., Ltd.), (vinyl methyl ether / maleic acid). Alkyl) copolymer (trade name: GANTREZ ES-225, trade name: ES-425, trade name: SP-215, and above, manufactured by IPS Japan Ltd.), vinyl acetate / crotonic acid copolymer (trade name: Resin 28- 1310, manufactured by National Starch Co., Ltd.), vinyl acetate / crotonic acid / vinyl propionate copolymer (trade name: Ruby Set CAP, manufactured by BASF), vinyl alcohol / itaconic acid copolymer (trade name: KM-118, manufactured by Kuraray Co., Ltd.) Etc. These may be used alone or in combination of two or more. Among these, (vinyl acetate / crotonic acid / vinyl neodecanoate) copolymers and (vinyl methyl ether / alkyl maleate) copolymers are preferable from the viewpoint of the persistence of the antiperspirant effect, and (vinyl acetate / crotonic acid / vinyl neodecanoate) are preferable. ))) Is more preferred. The (vinyl acetate / crotonic acid / vinyl neodecanoate) copolymer means a copolymer obtained by copolymerizing vinyl acetate, crotonic acid, and vinyl neodecanoate.

  Examples of the (vinyl methyl ether / alkyl maleate) copolymer include, for example, a (vinyl methyl ether / maleic acid) copolymer (trade name: GANTREZ AN, manufactured by IPS Japan Ltd.), (vinyl methyl ether / ethyl maleate). Copolymers (trade name: GANTREZ ES-225, manufactured by ISP Japan), (vinyl methyl ether / butyl maleate) copolymer (trade name: GANTREZ ES-425, manufactured by ISP Japan), and the like. . These may be used alone or in combination of two or more. Among these, (vinyl methyl ether / ethyl maleate) copolymer and (vinyl methyl ether / butyl maleate) copolymer are preferable from the viewpoint of the persistence of the antiperspirant effect. The (vinyl methyl ether / ethyl maleate) copolymer means a copolymer obtained by copolymerizing vinyl methyl ether and ethyl maleate, and the (vinyl methyl ether / butyl maleate) copolymer means vinyl methyl. It means a copolymer obtained by copolymerizing ether and butyl maleate.

  The content of the vinyl type anionic polymer of the component (B) is based on the total amount of the antiperspirant composition from the viewpoint of the persistence of the antiperspirant effect, the lack of skin firmness, and the non-stickiness of the skin. 0.5 mass% to 3 mass% is preferable, and 1 mass% to 2.5 mass% is more preferable. When the content is less than 0.5% by mass, the sustainability of the antiperspirant effect may be insufficient. When the content exceeds 3% by mass, the skin does not feel tight and the skin is not sticky. May be insufficient.

<(C) Ethanol>
The ethanol component (C) is contained to improve the non-stickiness of the skin.

  Examples of the component (C) ethanol include absolute ethanol, 95% by volume ethanol (standard value 95% by volume to 95.5% by volume), and the like. These may be used individually by 1 type and may use 2 or more types together.

  The content of ethanol as the component (C) is based on the antiperspirant composition in terms of antiperspirant effect, durability of the antiperspirant effect, non-stickiness of the skin, and no irritation to the skin. In terms of absolute ethanol, it is 50% by mass to 85% by mass, and preferably 60% by mass to 75% by mass. When the ethanol content is less than 50% by mass, the non-stickiness of the skin becomes insufficient, and when it exceeds 85% by mass, the antiperspirant effect and the sustainability of the antiperspirant effect become insufficient, and sensitive skin. Causes skin irritation.

The ethanol content of the component (C) is the total content of absolute ethanol including ethanol brought in from these components when a plant extract or the like is contained as another component.
The content (mass%) in terms of absolute ethanol when 95% by volume ethanol is used should be obtained from the following formula 1 (Independent Administrative Institution Pharmaceuticals and Medical Devices Agency Document 038-1309.pdf) and formula 2. Can do.
Ethanol mass% = volume% × 0.79422 (specific gravity of 100% by volume at 15 ° C.) / D (specific gravity at 15 ° C.) Formula 1
= (95 x 0.79422) /0.81639
= 92.42
-Absolute ethanol content (mass%) = 95 vol% ethanol content (mass%) x 92.42 / 100 Formula 2

<(D) Hydrophobized modified alkyl cellulose>
The hydrophobized modified alkylcellulose as the component (D) is contained in order to improve the sustainability of the antiperspirant effect even when the sweating amount and the sweating time are increased.

ただし、前記一般式（Ｄ１）中、Ｒ^１、Ｒ^２、及びＲ^３は、それぞれ独立に、水素原子、アルキル基、及びアルコキシ基のいずれかを示し、前記Ｒ^１、前記Ｒ^２、及び前記Ｒ^３から選択される少なくとも一つはアルコキシ基を示し、ｎは１００〜１０,０００の整数を示す。 The hydrophobized modified alkylcellulose of the component (D) is a hydrophobized product of modified alkylcellulose, and a compound represented by the following general formula (D1) is preferable.

However, in said general formula (D1), R < ¹ >, R < ² > and R < ³ > respectively independently show either a hydrogen atom, an alkyl group, and an alkoxy group, and said R < ¹ >, said R < ² >, and said At least one selected from R ³ represents an alkoxy group, and n represents an integer of 100 to 10,000.

  The alkoxy group may be linear or branched. Among these, from the viewpoint of high hydrophobicity, a long-chain alkoxy group is preferable, a long-chain alkoxy group having 12 or more carbon atoms is more preferable, and a long-chain alkoxy group having 12 to 22 carbon atoms is particularly preferable.

  Examples of the alkoxy group include dodecyloxy group (lauroxy group), tridecyloxy group, tetradecyloxy group (myristyloxy group), pentadecyloxy group, hexadecyloxy group (cetyloxy group), heptadecyloxy group, octadecyloxy group (stearoxy group). Group), nonadecyloxy group, eicosyloxy group, henecosyloxy group, docosyloxy group and the like. Among these, an octadecyloxy group (stearoxy group) is preferable from the viewpoint of sustaining the antiperspirant effect.

  Examples of the alkyl group include a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, a t-butyl group, and a cyclohexyl group.

As the kinematic viscosity of the hydrophobically-modified alkyl cellulose component (D), at 25 ° ^C., preferably from 20mm ² / s~300mm 2 / s, in terms of ^usability, 70mm ² / ^s~110mm 2 / s Gayori preferable. The kinematic viscosity can be measured using an Ubbelohde viscometer.

Examples of the hydrophobized modified alkyl cellulose as the component (D) include hydrophobized hydroxyalkyl cellulose.
Examples of the hydrophobized hydroxyalkyl cellulose include dodecyloxy hydroxyalkyl cellulose (lauroxy hydroxyalkyl cellulose), tridecyloxy hydroxyalkyl cellulose, tetradecyloxy hydroxyalkyl cellulose (myristyloxy hydroxyalkyl cellulose), and pentadecyloxy hydroxy. Alkylcellulose, hexadecyloxyhydroxyalkylcellulose (cetyloxyhydroxyalkylcellulose), heptadecyloxyhydroxyalkylcellulose, octadecyloxyhydroxyalkylcellulose (stearoxyhydroxyalkylcellulose), nonadecyloxyhydroxyalkylcellulose, eicosiloxyhydroxyalkylcellulose Henecosyloxyhydroxyal Le cellulose, docosyl siloxy hydroxyalkyl cellulose. These may be used alone or in combination of two or more. Among these, octadecyloxyhydroxyalkylcellulose (stearoxyhydroxyalkylcellulose) is preferable and octadecyloxyhydroxypropylmethylcellulose (stearoxyhydroxypropylmethylcellulose) is more preferable from the viewpoint of durability of the antiperspirant effect.

  A commercially available product may be used as the hydrophobized modified alkylcellulose of the component (D). Examples of the commercially available product include trade name: Sangelose 60L, trade name: Sangerose 60M, trade name: Sangerose 90L. , Trade name: Stangerose 90M (component name: stearoxyhydroxypropylmethylcellulose, above, manufactured by Daido Kasei Kogyo Co., Ltd.). These may be used alone or in combination of two or more.

  The content of the hydrophobized modified alkylcellulose of the component (D) is based on the total amount of the antiperspirant composition from the viewpoint of durability of the antiperspirant effect, ease of application to the skin, and lack of skin feeling. 0.1 mass% to 1 mass% is preferable, and 0.2 mass% to 0.6 mass% is more preferable. When the content is less than 0.1% by mass, durability of the antiperspirant effect and ease of application to the skin may be insufficient. When the content exceeds 1% by mass, it is easy to apply to the skin. In addition, there may be insufficient skin feeling.

<(E) Neutralizing agent>
The neutralizing agent of the component (E) is contained in order to improve the sustainability of the antiperspirant effect.

  Examples of the neutralizing agent for the component (E) include monoethanolamine, diethanolamine, triethanolamine, and 2-amino-2-methyl-1-propanol. These may be used individually by 1 type and may use 2 or more types together. Among these, 2-amino-2-methyl-1-propanol is preferable from the viewpoint of durability of the antiperspirant effect.

  The content of the neutralizing agent of the component (E) is 0.05% by mass to 0.3% by mass with respect to the total amount of the antiperspirant composition from the viewpoint of durability of the antiperspirant effect and skin irritation. % Is preferable, and 0.1% by mass to 0.3% by mass is more preferable. When the content is less than 0.05% by mass, the sustainability of the antiperspirant effect may be insufficient, and when it exceeds 0.3% by mass, skin irritation may occur in sensitive skin.

  Examples of the apparatus used for neutralization of the component (E) with a neutralizing agent include a Metrohm potentiometric automatic titration apparatus (manufactured by Metrohm Japan).

[Mass ratio (B / D)]
The mass ratio (B / D) between the content (% by mass) of the (B) vinyl type anionic polymer and the content (% by mass) of the (D) hydrophobized modified alkyl cellulose is an antiperspirant effect. From the standpoint of sustainability, ease of application to the skin, lack of skin tension, and non-stickiness of the skin, it is 0.6 to 28, and preferably 1.25 to 12.5. If the mass ratio (B / D) is less than 0.6, the ease of application to the skin and the lack of skin tension will be insufficient, and if it exceeds 28, the ease of application to the skin, skin The lack of feeling of stickiness and the non-stickiness of the skin become insufficient.

<Other ingredients>
There is no restriction | limiting in particular as said other component, According to the objective, it can select suitably, In the range which does not impair the effect of this invention other than each component of said (A)-(D) component, Other components can be contained. Examples of the other components include oil and fat compounds, wax compounds, silicone compounds, hydrocarbon oils, higher fatty acids, higher alcohols, surfactants, polymer compounds other than the component (B), antioxidants, dyes, and emulsifications. Stabilizers, pH adjusters, preservatives, ultraviolet absorbers, chelating agents, moisturizers, thickeners such as hydroxypropylcellulose other than the above component (D), cooling agents, anti-inflammatory agents, bactericides such as isopropylcellulose, Examples include amino acids, vitamins, fragrances, and various plant extracts.

-PH-
The pH at 25 ° C. of the antiperspirant composition is preferably 3 to 4.5 from the viewpoints of the antiperspirant effect, the persistence of the antiperspirant effect, and the non-stickiness of the skin. When the pH is less than 3, the antiperspirant effect and the persistence of the antiperspirant effect may be insufficient, and when it exceeds 4.5, the non-stickiness of the skin may be insufficient. .

-Viscosity-
The viscosity of the antiperspirant composition is not particularly limited and may be appropriately selected depending on the intended purpose. However, in the case of a liquid, the viscosity of the antiperspirant composition and the non-stickiness of the skin are 25. At m ° C., 1 mPa · s to 3,000 mPa · s is preferable, and 5 mPa · s to 1,600 mPa · s is more preferable. If the viscosity is less than 1 mPa · s, the sustainability of the antiperspirant effect may be insufficient, and if it exceeds 3,000 mPa · s, the non-stickiness of the skin may be insufficient.
The viscosity is, for example, No. 1 at 25 ° C. using a BL type viscometer. 1-3 rotors can be used and measured at 60 rpm for 1 minute.

-Dosage form-
There is no restriction | limiting in particular as a dosage form of the said antiperspirant composition, According to the objective, it can select suitably, For example, a solid type, a semi-solid type, a gel type, a liquid type etc. are mentioned. Among these, gel-type and liquid-type are preferable because it is effective for expression of the effect of being applied to the skin in a state dissolved in moisture, can be applied with high adhesion, and can exhibit a high antiperspirant effect. A type is more preferable.
Examples of the solid type include a stick type and a sheet type.
Examples of the semi-solid type include a cream type.
Examples of the gel type include a gel type.
Examples of the liquid type include a roll-on type, a lotion type, and a mist type. Among these, the roll-on type is preferable from the viewpoint of the antiperspirant effect.

When the antiperspirant composition is made into a roll-on type, it is preferable to make an antiperspirant product comprising the antiperspirant composition and a roll-on container having an application ball filled with the composition. The roll-on type preparation is housed in a known roll-on container, and a part of the roll-on container is exposed, and the antiperspirant composition is attached to a ball that is rotatably held by a holder. Such a ball can be applied to the skin.
Moreover, the gel formulation which fills the said antiperspirant composition in a bottle container, and apply | coats as it is using a container, the gel formulation applied using a fingertip and a hand, and a lotion formulation can also be used suitably.

-Manufacturing method-
There is no restriction | limiting in particular as a manufacturing method of the said antiperspirant composition, According to the objective, it can select suitably, For example, said (A)-said (E) component, and said other component (antiperspirant) It can be adjusted by mixing the remaining amount so that the whole composition becomes 100% by mass. Specifically, the component (B) is charged into the component (C) and dissolved uniformly, and then the component (A) is charged. Thereafter, the component (D), water and the other components are added, and uniformly dissolved and mixed. Thereafter, the antiperspirant composition can be obtained by neutralization with the component (E).
There is no restriction | limiting in particular as an apparatus which prepares the said antiperspirant composition, According to the objective, it can select suitably, For example, it equips with the several stirring blade (propeller, turbine, disper, etc.) which can be mixed with shearing. And a stirrer. In addition, as said (A)-(E) component and said other component, in preparing an antiperspirant composition, each may be used independently, and the mixture containing 2 or more types of components You may use in the state.

-Container-
Examples of the container include a roll-on container, a gel bottle container, a lotion bottle container, and a mist trigger spray container. Among these, a roll-on container is preferable from the viewpoint of easy application to the skin. The roll-on container can be suitably used in that the antiperspirant composition can be applied to the skin with high adhesion, and an antiperspirant effect can be exhibited. The roll-on container is not particularly limited as long as it can be filled with the antiperspirant composition, and can be appropriately selected according to the purpose. For example, those described in JP-A-2005-186997 Is mentioned.

  Examples of the roll-on container include a bottle (material: HDPE natural, full-fill volume: about 56 mL, trunk diameter: diameter about 33 mm, height: about 87 mm, manufactured by Yoshino Kogyo Co., Ltd.), ring (material: LLDPE natural) , Outer diameter: about 26 mm, height: about 18 mm, manufactured by Yoshino Kogyo Co., Ltd.), balls (material: PP white, diameter: about 20 mm, manufactured by Yoshino Kogyo Co., Ltd.), and the like.

  Examples of the bottle container for the gel include, for example, a bottle (trade name: TOMII, material: HDPE natural, full fill capacity: about 34 mL, trunk diameter: diameter of about 39 mm × 24 mm (oval), height: about 76 mm, Takemoto container Co., Ltd.), inner plug (trade name: TO cap nozzle B, material: PE natural, outer diameter: about 12 mm, height: about 13 mm, manufactured by Takemoto Container Co., Ltd.), cap (trade name: TO cap, material) : AS / PP white, outer diameter: diameter of about 37 mm × 23 mm (oval), height: about 22 mm, manufactured by Takemoto Container Co., Ltd., etc. can be used.

  Examples of the bottle container for lotion include, for example, bottles (trade name: TOMIII-50, material: HDPE natural, full capacity: about 34 mL, trunk diameter: diameter of about 42 mm × 29 mm (oval), height: about 88 mm, Takemoto Container Co., Ltd.), Inner plug (Product name: TO Cap Nozzle A, Material: PE Natural, Outer Diameter: about 12mm, Height: About 13mm, Takemoto Container Co., Ltd.), Cap (Product Name: TOMIII Cap) , Material: PP white, outer diameter: diameter of about 37 mm × 25 mm (oval), height: about 24 mm, manufactured by Takemoto Container Co., Ltd., etc. can be used.

  Examples of the trigger container for mist include, for example, a bottle (trade name: PH-100, material: PE natural, full capacity: about 100 mL, body diameter: about 40 mm in diameter, height: about 120 mm, Kamimura Chemical Co., Ltd. Manufactured), a trigger (trade name: Z-305, average diameter of spray holes: 0.45 mm, manufactured by Mitani Valve Co., Ltd.), and the like.

-Use-
The antiperspirant composition of the present invention is excellent in antiperspirant effect and persistence of the antiperspirant effect even when the amount of perspiration and the perspiration time increase, ease of application to the skin, lack of skin tension, and skin Good non-stickiness and little irritation to the skin, so it can be applied to cosmetics, pharmaceuticals, quasi-drugs, etc., for example, antiperspirants, deodorants, antiperspirants, deodorants It is suitable for a deodorant spray and is particularly suitable for a roll-on type antiperspirant.

  Hereinafter, the present invention will be described more specifically based on examples and comparative examples, but the present invention is not limited to the following examples. In addition, all the content of each component of description of an Example and a comparative example is the value converted into a pure part.

(Examples 1-30 and Comparative Examples 1-10)
Antiperspirant compositions having the compositions and contents shown in Tables 1 to 8 below were prepared by the following method. That is, the component (B) was added to the component (C) and dissolved uniformly, and then the component (A) was added. Then, (D) component or (D ') component, purified water, and a common component were thrown in, and it melt | dissolved and mixed uniformly. Then, it neutralized with (E) component and obtained the composition of pH 3-4.5. Note that the antiperspirant composition of Comparative Example 3 could not be formulated because it did not contain the component (C) ethanol serving as a solvent. Moreover, neutralization by the (E) component was confirmed using a Metrohm potentiometric automatic titrator (manufactured by Metrohm Japan).
Next, 40 mL of the antiperspirant compositions of Examples 1 to 25, 29 to 30, and Comparative Examples 1, 2, and 4 to 10 were filled in a roll-on container (container A) having the following specifications. In addition, the antiperspirant composition of Example 26 was applied to a gel bottle container (container B) having the following specifications, and the antiperspirant composition of Example 27 was applied to a lotion bottle container (container C) having the following specifications. 20 ml of each of 28 antiperspirant compositions was filled into a mist bottle container (container D) having the following specifications.

-Roll-on container (container A)-
・ Bottle (Material: HDPE natural, full capacity: approx. 56 mL, body diameter: approx. 33 mm in diameter, height: approx. 87 mm, manufactured by Yoshino Kogyo Co., Ltd.)
・ Ring (Material: LLDPE natural, outer diameter: approx. 26 mm, height: approx. 18 mm, manufactured by Yoshino Kogyo Co., Ltd.)
・ Ball (Material: PP white, diameter: approx. 20 mm, manufactured by Yoshino Kogyo Co., Ltd.)

-Bottle container for gel (container B)-
・ Bottle (trade name: TOMII, material: HDPE natural, full-fill volume: approx. 34 mL, trunk diameter: diameter approx. 39 mm × 24 mm (oval), height: approx. 76 mm, manufactured by Takemoto Container Co., Ltd.)
・ Inner stopper (Product name: TO cap nozzle B, Material: PE natural, Outer diameter: approx. 12 mm, Height: approx. 13 mm, Takemoto Container Co., Ltd.)
・ Cap (trade name: TO cap, material: AS / PP white, outer diameter: diameter approximately 37 mm × 23 mm (oval), height: approximately 22 mm, manufactured by Takemoto Container Co., Ltd.)

-Bottle container for lotion (container C)-
・ Bottle (trade name: TOMIII-50, material: HDPE natural, full capacity: approx. 34 mL, body diameter: diameter approx. 42 mm × 29 mm (oval), height: approx. 88 mm, manufactured by Takemoto Container Co., Ltd.)
・ Inner stopper (Product name: TO cap nozzle A, Material: PE natural, Outer diameter: approx. 12 mm, Height: approx. 13 mm, Takemoto Container Co., Ltd.)
・ Cap (trade name: TOMIII cap, material: PP white, outer diameter: diameter approximately 37 mm x 25 mm (oval), height: approximately 24 mm, manufactured by Takemoto Container Co., Ltd.)

-Mist bottle container (container D)-
・ Bottle (trade name: PH-100, material: PE natural, full-fill volume: about 100 mL, trunk diameter: about 40 mm in diameter, height: about 120 mm, manufactured by Kamimura Chemical Co., Ltd.)
・ Trigger (trade name: Z-305, average diameter of spray hole: 0.45 mm, manufactured by Mitani Valve Co., Ltd.)

  About the prepared antiperspirant compositions of Examples 1 to 30 and Comparative Examples 1, 2, and 4 to 10, “antiperspirant effect”, “persistence of antiperspirant effect”, “skin” "Easy to apply to skin", "No skin tightness", "No skin stickiness", and "No skin irritation" were evaluated. The results are shown in Tables 1-8. In addition, since the antiperspirant composition of the comparative example 3 did not contain ethanol of (C) component used as a solvent, it could not be formulated and could not be evaluated.

−制汗効果、及び制汗効果の持続性の評価基準−
◎ ：制汗率が５６％以上１００％以下
◎〜○ ：制汗率が４６％以上５６％未満
○ ：制汗率が３６％以上４６％未満
△ ：制汗率が２６％以上３６％未満
× ：制汗率が０％以上２６％未満 <Antiperspirant effect and persistence of antiperspirant effect>
For 20 professional panelists, 0.5 g of antiperspirant composition was applied as a sample to one axilla, and exercise bike (trade name: FB-300HP, manufactured by Remark) in an environment of 38 ° C. and relative humidity of 40%. Exercise was performed for 15 minutes. Then, the axilla (sample application part) to which the sample was applied using a sweat meter (trade name: SKN-2000, manufactured by Nishizawa Denki Keiki Seisakusho Co., Ltd.) and the other axilla to which the sample was not applied (sample non-application part) The amount of sweating was measured, and the antiperspirant rate was determined from the following formula. A result shows the average value of 20 professional panelists. From the results of the antiperspirant rate, the “antiperspirant effect” was evaluated based on the following evaluation criteria. Thereafter, the exercise by the exercise bike was further performed for 30 minutes, and “sustainability of antiperspirant effect” was evaluated by the same evaluation method.

-Evaluation criteria for antiperspirant effect and persistence of antiperspirant effect-
◎: Antiperspiratory rate is 56% or more and 100% or less ◎ to ○: Antiperspirant rate is 46% or more and less than 56% ○: Antiperspirant rate is 36% or more and less than 46% △: Antiperspirant rate is 26% or more and less than 36% X: Antiperspirant rate is 0% or more and less than 26%

<Ease of application to skin>
For 20 professional panelists, 0.5 g of each antiperspirant composition was applied to the axilla, and “easy to apply to skin” was evaluated based on the following evaluation criteria.
-Evaluation criteria-
◎: Reply that 19 to 20 out of 20 professional panelists are easy to apply on the skin ◎ to ○: Reply that 16 to 18 out of 20 professional panelists are easy to apply on the skin ○: Eleven out of 20 professional panelists 15 or more respondents say that it is easy to apply to the skin. △: 6 or more of the 20 professional panelists respond that it is easy to apply to the skin. ×: 5 or less of the 20 professional panelists respond that it is easy to apply to the skin.

<No skin tightness>
For 20 professional panelists, 0.5 g of each antiperspirant composition was applied to the axilla and allowed to dry. Then, “no skin tightness” was evaluated based on the following evaluation criteria.
-Evaluation criteria-
◎: 19 to 20 out of 20 professional panelists responded that there was no feeling of skin tightness ◎ ~ ○: 16 to 18 or less of 20 professional panelists answered that there was no feeling of skin feeling ○: Professional panelist 11 to 15 out of 20 respondents said that there was no feeling of skin tightness △: 6 or more of 20 professional panelists answered that there was no feeling of skin ×: 5 or less of 20 expert panelists answered Responded that there was no feeling of skin tightness

<No sticky skin>
For 20 professional panelists, 0.5 g of each antiperspirant composition was applied to the axilla. From the time immediately after application to the drying of each antiperspirant composition, the following evaluation criteria were used: "Nasa" was evaluated.

-Evaluation criteria-
◎: 19 to 20 out of 20 professional panelists responded that there was no skin stickiness ◎ ~ ○: 16 to 18 or less of 20 professional panelists responded that there was no skin stickiness ○: 20 professional panelists 11 to 15 of them answered that there was no skin stickiness △: 6 to 10 or less of 20 professional panelists responded that there was no skin stickiness ×: 5 or less of 20 professional panelists responded to skin stickiness No answer

<No skin irritation>
For 20 professional panelists (sensitive skin panelists), 0.5 g of each antiperspirant composition was applied to the axilla, and then “no skin irritation” was evaluated based on the following evaluation criteria.
-Evaluation criteria-
◎: 16 to 20 out of 20 professional panelists responded that there was no skin irritation ○: 11 to 15 out of 20 professional panelists answered that there was no skin irritation △: 20 specialized panelists 6 to 10 of them answered that there was no irritation to the skin ×: 5 or less of 20 professional panelists answered that there was no irritation to the skin

The details of various components used in the examples and comparative examples are shown in Table 9 below.

  The antiperspirant composition of the present invention is excellent in antiperspirant effect and persistence of the antiperspirant effect even when the amount of perspiration and the perspiration time increase, ease of application to the skin, lack of skin tension, and skin Good non-stickiness and little irritation to the skin, so it can be applied to cosmetics, pharmaceuticals, quasi-drugs, etc., for example, antiperspirants, deodorants, antiperspirants, deodorants It is suitable for a deodorant spray and is particularly suitable for a roll-on type antiperspirant.

Claims (7)

(A) at least one antiperspirant selected from aluminum compounds, zirconium compounds, and complexes thereof;
(B) a vinyl type anionic polymer;
(C) ethanol,
(D) a hydrophobically modified alkyl cellulose;
(E) a neutralizing agent,
The content of the (C) ethanol is 50% by mass to 85% by mass,
The mass ratio (B / D) of the content (% by mass) of the (B) vinyl type anionic polymer and the content (% by mass) of the (D) hydrophobized modified alkyl cellulose is 0.6 to 28. An antiperspirant composition characterized by being:   The antiperspirant composition according to claim 1, wherein (A) the antiperspirant is chlorohydroxyaluminum.   (B) the vinyl type anionic polymer is at least selected from (vinyl acetate / crotonic acid / vinyl neodecanoate) copolymer, (vinyl methyl ether / ethyl maleate) copolymer, and (vinyl methyl ether / butyl maleate) copolymer The antiperspirant composition according to claim 1, wherein the antiperspirant composition is one.   The antiperspirant composition according to any one of claims 1 to 3, wherein (D) the hydrophobically modified alkylcellulose is stearoxyhydroxypropylmethylcellulose. (A) The content of the antiperspirant is 6% by mass to 15% by mass,
(B) The content of the vinyl type anionic polymer is 1% by mass to 2.5% by mass,
(C) The content of ethanol is 60% by mass to 75% by mass,
(D) The content of the hydrophobically modified alkyl cellulose is 0.2% by mass to 0.6% by mass,
(E) The content of a neutralizing agent is 0.1 mass%-0.3 mass%, The antiperspirant composition in any one of Claim 1 to 4.   (B) The mass ratio (B / D) of the content (% by mass) of the vinyl type anionic polymer and the content (% by mass) of (D) the hydrophobically modified alkyl cellulose is 1.25 to 12.5. The antiperspirant composition according to any one of claims 1 to 5.   The antiperspirant composition according to any one of claims 1 to 6, which is any one selected from a roll-on type, a gel type, a lotion type, and a mist type.