JP2014141424A - Composition for external preparations - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a petrolatum having a little stickiness in spite of a pasty form, and to provide a composition for external preparations containing the petrolatum, and to provide a formulation, such as an ointment prepared with the composition for external preparations.SOLUTION: Disclosed is the composition for external preparations containing a hydrophobically modified alkyl cellulose and a petrolatum.

Description

  The present invention relates to an external preparation composition with improved stickiness when applying petrolatum and a method for producing the same.

  Conventionally, in the pharmaceuticals, quasi-drugs, cosmetics industries, etc., petrolatum is used alone or as an external preparation composition base as a pharmaceutical base such as an analgesic / anti-inflammatory / antipruritic ointment, or as a cosmetic cream. It has been widely used as a base material for many years. Vaseline is used as a base for cosmetics and external preparations for the purpose of, for example, improving the occlusiveness of the skin. Vaseline is also used as a lubricant and skin moisturizing protective agent. Vaseline is non-ionic and neutral, has little irritation to the skin and is excellent in skin moisturizing properties, has good compounding with various active ingredients and additives, and other animal and vegetable oils. This is because there is less acid loss compared to the other. In particular, since it is excellent in safety and moisture retention, it is used for atopic dermatitis, cuts, abrasions, burns, cracks, dry skin and the like.

  However, after applying petrolatum to the skin, it has been a problem that stickiness remains on the skin. In particular, when petrolatum is used alone as a skin moisturizer, it is often applied in large quantities, and the stickiness of petrolatum has been a major problem in use. In addition, petrolatum was noticeable. In addition, in infants and atopic dermatitis patients, when applied to the face, around the mouth, limbs, etc., a sticky feeling and a sensation are generated, and an external preparation having high moisture retention for sensitive skin is desired. In addition, surfactants are generally used in emulsions and creams containing oily ingredients, but for sensitive skin in infants and patients with atopic dermatitis, skin irritation and skin should be reduced to reduce skin irritation. It was necessary to use a surfactant with low sensitization or to keep the amount of surfactant used low. However, if the amount of the surfactant used is kept low, the emulsifying power becomes weak and a stable emulsifying system cannot be obtained.

  An object of the present invention is to provide a vaseline that is paste-like and less sticky, a composition for an external preparation containing the petrolatum, and a preparation such as an ointment prepared from the composition for external preparation.

  The present inventor examines the above problems and provides a technique for providing a composition for external preparation containing petrolatum that is paste-like and less sticky by blending petrolatum (white petrolatum) with hydrophobized modified alkylcellulose. The headline and the present invention were completed.

  The present invention provides the following compositions for external preparations.

  Item 1. A composition for external use comprising hydrophobically modified alkyl cellulose and petrolatum.

Item 2. The hydrophobically modified alkyl cellulose is
The following structural formula (1):

[Wherein R ¹ , R ² and R ³ are the same or different and each represents a hydrogen atom, a lower alkyl group,
_{Groups: - [CH 2 CH 2-} k (CH 3) k O] m H,
Or the group: —CH ₂ CH (OH) CH ₂ OC _j H _{2j + 1} .
n is an integer of 100 to 10,000, k is an integer of 0 or 1, m is an integer of 1 to 10,
j represents an integer of 6 to 26. ]
Represented by
The hydrophobized modified alkyl cellulose necessarily contains the group: —CH ₂ CH (OH) CH ₂ OC _j H _{2j + 1} ,
Item 2. The composition for external use according to Item 1.

Item 3. Hydrophobized modified alkyl cellulose represented by the structural formula (1)
Lower alkyl group: 10.0 to 50.0% by mass,
_{Groups: - [CH 2 CH 2-} k (CH 3) k O] m H: 3.0~20.0 wt%, and _{groups: -CH 2 CH (OH) CH} 2 OC j H 2j + 1: 0.1 ~ 10.0 mass%
Item 3. The composition for external use according to Item 2, comprising

Item 4. Item 4. The composition for external preparation according to Item 2 or 3, wherein j in the group: —CH ₂ CH (OH) CH ₂ OC _j H _{2j + 1} included in the structural formula (1) is 18.

  Item 5. The manufacturing method of the composition for external preparations containing the hydrophobization modified | denatured alkyl cellulose and petrolatum characterized by adding powdery hydrophobization modified alkyl cellulose to petrolatum.

  By blending the hydrophobized modified alkyl cellulose with the composition for external preparation containing petrolatum, the composition for external preparation containing petrolatum that is pasty and has little stickiness is obtained. Furthermore, it becomes the composition for external preparations which contains the petrolatum which is excellent in dispersion | distribution with a water | moisture content and a water phase, has good elongation, and can be apply | coated to skin easily.

  In the present invention, the “composition for an external preparation” is a composition for use in an external preparation and means a composition containing at least petrolatum and a hydrophobically modified alkyl cellulose. The “external preparation” means a final form used by the user, and includes the external preparation composition. Therefore, if the external preparation is a cream or the like, the composition for external preparation may further contain an aqueous phase component. However, in the present invention, the external preparation composition may be distributed and used as a final product as it is, or the external preparation may be a use form containing 100% by mass of the external preparation composition. . Examples of such external preparations include preparations such as ointments.

1. Composition for external preparation The composition for external preparation of the present invention comprises a hydrophobically modified alkyl cellulose and petrolatum. By blending the hydrophobized modified alkyl cellulose with the composition for external preparation containing petrolatum, the composition for external preparation containing petrolatum can reduce the sticky feeling while being paste-like. Furthermore, the composition for external preparations containing petrolatum has good elongation and is easy to apply to the skin.

  Hereinafter, petrolatum, hydrophobized modified alkyl cellulose and the like will be described.

1-1. Vaseline As the petrolatum used in the composition for external use of the present invention, yellow petrolatum, white petrolatum and hydrophilic petrolatum defined in the 16th revised Japanese Pharmacopoeia manual can be used. Yellow petrolatum is a refined mixture of hydrocarbons obtained from petroleum. White petrolatum is obtained by decolorizing and purifying a mixture of hydrocarbons obtained from petroleum. Hydrophilic petrolatum is 80 g of white beeswax, 30 g of stearyl alcohol or cetal, 30 g of cholesterol, and white petrolatum with a total amount of 1000 g. In addition, it is possible to use petrolatum to which polyethylene resin (about 5% by mass) is added as petrolatum.

  Vaseline used in the composition for external use of the present invention is easy to mix with other components such as hydrophobized modified alkyl cellulose, has no stickiness when used as an external preparation, and can be applied to the skin. White petrolatum is preferred from the standpoints of ease and ease of use.

  The blending amount of petrolatum used in the composition for external preparation of the present invention is easy to mix with other components such as hydrophobized modified alkyl cellulose, there is no stickiness when used as an external preparation, From the viewpoint of ease of application, good feeling of use, etc., it is preferable to be a main component in the composition for external preparations, preferably about 80 to 99.8% by mass, based on the total amount of the composition for external preparations, More preferably, it is about 90-99.8 mass%, Most preferably, it is about 95-99.5 mass%.

  Hereinafter, components that are components other than petrolatum and are preferably included in the composition for external preparation of the present invention will be described. About each component, it represents with the compounding ratio (mass part) with respect to 100 mass parts of petrolatum, while expressing with the compounding ratio (mass%) with respect to the composition amount for external preparations (or each form).

1-2. Hydrophobized Modified Alkyl Cellulose Hydrophobized modified alkyl cellulose used in the composition for external use of the present invention is obtained by introducing a long-chain alkyl group, which is a hydrophobic group, into a cellulose ether derivative.

  The hydrophobically modified alkyl cellulose has the following structural formula (1):

[Wherein R ¹ , R ² and R ³ are the same or different and each represents a hydrogen atom, a lower alkyl group,
_{Groups: - [CH 2 CH 2-} k (CH 3) k O] m H,
Or the group: —CH ₂ CH (OH) CH ₂ OC _j H _{2j + 1} .
n is an integer of 100 to 10,000, k is an integer of 0 or 1, m is an integer of 1 to 10,
j represents an integer of 6 to 26. ]
Represented by
It is preferable that the hydrophobized modified alkyl cellulose necessarily contains the group: —CH ₂ CH (OH) CH ₂ OC _j H _{2j + 1} .

Of the cellulose ether derivatives that form the basis of the hydrophobically modified alkyl cellulose, it is particularly preferable to select hydroxypropylmethylcellulose from the standpoint of availability. Hydroxypropylmethylcellulose (HPMC) is the same as or different from R ¹ , R ² and R ³ in the structural formula (1), and —H, —CH ₃ or a group: — [CH ₂ CH (CH ₃ ) O] _m H, including the group:-[CH ₂ CH (CH ₃ ) O] _m H.

  Hydrophobized modified alkyl cellulose is a product in which a long chain alkyl group is introduced into HPMC. For example, in the presence of an alkali catalyst, stearyl glycidyl ether:

It can manufacture by making this react. In addition to stearyl glycidyl ether, cetyl glycidyl ether and decyl glycidyl ether may be used.

Is a hydrophobic group introduced to the hydrophobic modified alkylcellulose _{group: -CH 2 CH (OH) CH} 2 OC j H C j H 2j + 1 of _{2j + 1} is to be a stearyl group _(-C 18 _{H 37),} petrolatum It is suitable from the viewpoints of ease of application to the skin, good feeling of use, and the like (the group: —CH ₂ CH (OH)). CH ₂ OC _j H _{2j + 1} is a _group: a _{-CH 2 CH (OH) CH 2} OC 18 H 37).

Hydrophobized modified alkylcellulose represented by the structural formula (1) is well mixed with petrolatum, has no stickiness when used as an external preparation, easy to apply to the skin, good usability, etc. From the viewpoint, it is preferable to contain 0.1 to 10.0% by mass, more preferably 0.1 to 2.0% by mass, and more preferably 0.1 to 2.0% by mass of the group: —CH ₂ CH (OH) CH ₂ OC _j H _{2j + 1} . It is particularly preferable to contain 1 to 1.0% by mass.

  The lower alkyl group contained in the hydrophobically modified alkyl cellulose represented by the structural formula (1) is preferably a methyl group, an ethyl group, or the like, and more preferably a methyl group. Hydrophobized modified alkylcellulose represented by the structural formula (1) is well mixed with petrolatum, has no stickiness when used as an external preparation, easy to apply to the skin, good usability, etc. From the point, it is preferable that 10.0-50.0 mass% of lower alkyl groups, such as a methyl group, are included, and it is more preferable that 21.5-30.0 mass% is included.

Groups contained in the hydrophobic modified alkylcellulose represented by the structural formula _{(1): - [CH 2} CH 2-k (CH 3) k O] m H , if k is 0, groups: - [ CH ₂ CH ₂ O] _m H, and when k is 1, the group: — [CH ₂ CH (CH ₃ ) O] _m H. Particularly preferred is a group when k is 1: — [CH ₂ CH (CH ₃ ) O] _m H. Hydrophobized modified alkylcellulose represented by the structural formula (1) is well mixed with petrolatum, has no stickiness when used as an external preparation, easy to apply to the skin, good usability, etc. from the point, based _{on: - [CH 2 CH 2-} k (CH 3) k O] preferably contains 3.0 to 20.0 wt% of _m H, more may contain 7.0 to 11.0 wt% preferable.

The composition for external preparation of the present invention contains a hydrophobically modified alkylcellulose (stearoxyhydroxypropylmethylcellulose) in which a long-chain alkyl group such as a stearyl group (—C ₁₈ H ₃₇ ) is introduced into a cellulose ether derivative. Thus, the composition for external preparation has good slip and good elongation.

Incidentally, the lower alkyl group included in the hydrophobic modified alkylcellulose, _{groups: - [CH 2 CH 2-} k (CH 3) k O] m H, and _{groups: -CH 2 CH (OH) CH} 2 OC j H The content of _{2j + 1} is a value measured by a method according to the section of the 13th revised Japanese Pharmacopoeia “Hydroxypropylmethylcellulose 2208”.

As an example of a hydrophobically modified alkyl cellulose that satisfies these conditions, a trade name: Sangelose manufactured by Daido Kasei Kogyo Co., Ltd. can be preferably exemplified. Sangelose (hydrophobized HPMC) is a cellulose ether obtained by adding a C18 hydrophobic group to hydroxypropyl methylcellulose (HPMC). That is, in the structural formula _(1), a _{-CH 2 CH (OH) CH 2} OC j H 2j + 1 of _C j _{H 2j + 1} is stearyl group _(-C 18 _{H 37).}

  The following grades of products can be used as sangerose.

  The hydrophobized modified alkyl cellulose used in the composition for external use of the present invention is a powdery component, and the average particle size is preferably about 20 to 800 μm, more preferably about 50 to 600 μm, and still more preferably 80 to It is about 300 μm, particularly preferably about 100 to 200 μm. By making the average particle size of the hydrophobized modified alkyl cellulose within the above range, when the hydrophobized modified alkyl cellulose is uniformly dispersed in petrolatum and applied to the skin surface as an external preparation, the feeling of use such as roughness is used. Can be prevented from being damaged. Further, it is prevented from scattering during handling, and handling is easy.

  The blending amount of the hydrophobized modified alkyl cellulose used in the composition for external preparation of the present invention is well mixed with petrolatum, has no stickiness when used as an external preparation, ease of application to the skin, and feeling of use. From the point of goodness, it is preferably 20 to 0.1% by mass, more preferably about 10 to 0.1% by mass, and further preferably about 5 to 0.1% by mass with respect to the total amount of the composition for external preparation. is there. For the same reason, the blending amount of the hydrophobized modified alkylcellulose contained in the composition for external use (total amount) of the present invention is preferably about 0.1 to 5 parts by mass with respect to 100 parts by mass of petrolatum. About 5 to 2 parts by mass is more preferable, and about 0.5 to 1.5 parts by mass is even more preferable. By making the blending amount of the hydrophobized modified alkyl cellulose within the above range, the feeling of use when an external preparation is applied is excellent, the external preparation is not too soft, and there is not much stickiness peculiar to petrolatum, and there is no stickiness. . Moreover, by making the compounding quantity of hydrophobic modification | denaturation alkyl cellulose into the said range, an external preparation does not become hard too much, elongation is excellent, and it is excellent in a usability | use_condition.

1-3. Fatty acid and / or salt thereof In the composition for external use of the present invention, a fatty acid and / or a salt thereof (hereinafter also referred to as “fatty acid (salt)”) may be blended in addition to the hydrophobically modified alkyl cellulose and petrolatum. it can. The effects of hydrophobically modified alkyl cellulose by blending a fatty acid (salt) with the composition for external use (no stickiness when used as an external preparation, ease of application to the skin, good usability Etc.) can be supplemented or enhanced.

  The fatty acid (salt) used in the composition for external use of the present invention can be used without particular limitation as long as it can be used for external preparations (for example, cosmetics and the like). For example, using stearic acid, calcium stearate, magnesium stearate (hereinafter referred to as stearic acid and / or a salt thereof (hereinafter also referred to as “stearic acid (salt)”)) described in the 16th revised Japanese Pharmacopoeia Description can do. In addition, sodium stearate or the like can be used. Among these, stearic acid is particularly preferable from the viewpoint of easy mixing with petrolatum, no stickiness when used as an external preparation, ease of application to the skin, and good usability.

  The fatty acid (salt) used in the composition for external preparation of the present invention is a powdery component. Fatty acids are also components that dissolve when heated and mixed with petrolatum. Since the fatty acid (salt) is uniformly dispersed in petrolatum, it is possible to prevent impairing the feeling of use such as roughness when applied to the skin surface as an external preparation. Further, it is prevented from scattering during handling, and handling is easy.

  The amount of fatty acid (salt) used in the composition for external preparation of the present invention is easy to mix with petrolatum, has no stickiness when used as an external preparation, is easy to apply to the skin, and has a good feeling of use. From this point, it is preferably about 20 to 0.1% by mass, more preferably about 10 to 0.1% by mass, and still more preferably about 5 to 0.1% by mass with respect to the total amount of the composition for external preparation. . For the same reason, the blending amount of the fatty acid (salt) contained in the composition for external preparation (total amount) of the present invention is preferably about 0.1 to 5 parts by mass with respect to 100 parts by mass of petroleum jelly, 0.5 About 2 mass parts is preferable, and about 0.5-1.5 mass parts is still more preferable. When the blending amount of the fatty acid (salt) is within the above range, the feeling of use when the external preparation is applied is excellent, the external preparation is not too soft, the vaseline-specific light does not increase, and the sticky feeling does not occur. Moreover, by making the compounding quantity of a fatty acid (salt) into the said range, an external preparation does not become hard too much, elongation is excellent, and it is excellent in a usability | use_condition.

1-4. Other Components In the composition for external preparation of the present invention, a polyhydric alcohol may be further blended from the viewpoint of smoothing the physical properties when used as an external preparation and the stability of the product. The polyhydric alcohol is a polyhydric alcohol having 2 to 6 carbon atoms and 2 to 3 oxygen atoms. Polyhydric alcohols include ethylene glycol, diethylene glycol, propylene glycol, 1,3-propanediol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 3-methyl- 1,3-butanediol, glycerin and the like are preferable.

  Moreover, the composition for external preparations of this invention can contain the arbitrary components normally used with cosmetics other than the said essential component. As optional ingredients, hydrocarbons such as squalane, liquid paraffin, liquid oils such as olive oil, macadamia nut oil, castor oil, solid fats such as coconut oil, palm oil, shea fat, waxes such as beeswax, carnauba wax, lanolin, Higher alcohols such as stearyl alcohol, behenyl alcohol, isostearyl alcohol, synthetic ester oils such as cetyl octanoate, isopropyl palmitate, glyceryl tri-2-ethylhexanoate, dimethylpolysiloxane, decamethylcyclopentasiloxane, silicone resin, amino-modified Silicone oil such as polysiloxane, lipophilic nonionic surfactant such as glyceryl monostearate, propylene glycol monostearate, sorbitan monostearate, decaglyceryl monostearate, POE-glycol Hydrophilic nonionic surfactants such as phosphorus monoisostearate, POE-sorbitan tetraoleate, POE-behenyl ether, coconut oil fatty acid monoethanolamide, sodium stearate, N-stearoyl-L-sodium glutamate, POE-oleyl Anionic surfactants such as sodium ether phosphate, sodium lauroyl sarcosine, sodium lauroylmethylalanine, cationic surfactants such as stearyltrimethylammonium chloride, dimethylaminopropylamide stearate, benzalkonium chloride, palm oil fatty acid amidopropyl Amphoteric surfactants such as betaine, lauryldimethylaminoacetic acid betaine, lower alcohols such as ethanol and isopropanol, xanthan gum, hydroxyethyl cellulose, carbo Water-soluble polymers such as sivinyl polymer, sequestering agents such as disodium edetate, powder components, UV absorbers, antioxidants, pH adjusters, organic amines, preservatives (phenoxyethanol, glycerin ethylhexyl ether, Methylparaben, etc.), bactericides, anti-inflammatory agents, astringents, whitening agents, vitamins, amino acids, blood circulation promoters, activators, excipients (maltitol, lactose, dextrin, starch, etc.), refreshing agents, various extracts, A fragrance | flavor, water, etc. are mentioned. However, the present invention is of course not limited to these examples.

  The composition for external use of the present invention contains an appropriate amount of water, polyhydric alcohols such as ethanol, propylene glycol, butylene glycol, glycerin, etc., and thus can adjust the hardness, elongation, etc., and can be easily applied to the skin. Thus, the feeling of use is excellent. The amount of water used in the composition for external preparation of the present invention is preferably about 0.1 to 5% by mass, more preferably 0.3 to 4 based on the total amount of the composition for external preparation for the above reason. It is about mass%, More preferably, it is about 0.5-3 mass%. Moreover, about 0.1-5 mass parts is preferable with respect to 100 mass parts of petrolatum, and, as for the compounding quantity of the water contained in the composition for external preparations (total quantity) of this invention, about 0.2-4 mass parts is preferable. More preferably, about 0.3 to 3 parts by mass is more preferable. In addition, the amount of water contained in the composition for external use (total amount) of the present invention is preferably about 10 to 100 parts by mass and about 20 to 80 parts by mass with respect to 100 parts by mass of the hydrophobically modified alkyl cellulose. More preferably, about 30-70 mass parts is more preferable.

2. External preparation The external preparation of this invention contains the said composition for external preparations. The external preparation of the present invention may be in a usage form containing 100% by mass of the external preparation composition. When the external preparation of the present invention is in a use form containing 100% by mass of the composition for external preparation, the content of petrolatum, hydrophobically modified alkyl cellulose, stearic acid (salt), etc. in the external preparation is the above-mentioned external preparation. As described in the composition for use.

  The external preparation of the present invention may further contain a fragrance, a pH adjuster or the like in the external preparation composition. In addition, polyhydric alcohols, liquid fats and oils, solid fats and oils, waxes, higher alcohols, synthetic ester oils, silicone oils, lipophilic nonionic surfactants, hydrophilic nonionic surfactants described in the composition for external preparations , Anionic surfactants, cationic surfactants, amphoteric surfactants, lower alcohols, water-soluble polymers, sequestering agents, other powder components, UV absorbers, antioxidants, pH adjusters, organic amines , Preservatives, bactericides, anti-inflammatory agents, astringents, whitening agents, vitamins, amino acids, blood circulation promoters, activators, excipients, refreshing agents, various extracts, fragrances, water, etc. good.

  Further, components such as commonly used external bases, fats and oils, humectants, stabilizers, stabilizers, pigments and fragrances, refreshing agents, thickeners, antioxidants and the like can be blended. Examples of the base for external use include liquid paraffin, squalene, squalane, polyhydric alcohol fatty acid ester, fatty acid ester, medium chain fatty acid triglyceride and the like. Examples of the humectant include glycerin, propylene glycol, dipropylene glycol, sodium hyaluronate, cholesterol pullulan and the like. Examples of the stabilizer and stabilizer include EDTA, citric acid, sodium citrate, L-arginine, tocophenol, silicone, polyoxyethylene sorbitan fatty acid ester and the like. Examples of the preservative include p-hydroxybenzoate ester, sorbic acid, phenol, phenoxyethanol and the like. Examples of the refreshing agent include camphor, menthol, plant extract flavor, and the like. Examples of the thickener include gum arabic, guar gum, carrageenan, carboxyvinyl polymer, cellulose, polyacrylate, and the like. Examples of the antioxidant include dibutylhydroxytoluene and natural vitamin E. Examples of the whitening agent include ascorbic acid and its derivatives or kojic acid and its derivatives. Examples of the ultraviolet absorber include octyl methoxycinnamate.

  Even if the external preparation of the present invention contains the composition for external preparations and further contains optional components, the contents of petrolatum, hydrophobically modified alkyl cellulose, stearic acid (salt) and the like in the external preparation are: The range is preferably as described in the composition for external preparation.

3. Method for producing composition for external preparation (external preparation) The composition for external preparation (external preparation) containing the hydrophobized modified alkylcellulose and petrolatum of the present invention is obtained by adding powdered hydrophobized modified alkylcellulose to petrolatum. Can be manufactured. As a result, it is possible to produce a composition for external use that can be easily applied to the skin with a good feeling of stickiness while being pasty.

  The composition for external preparations (external preparation) of the present invention is characterized in that powdered hydrophobically modified alkyl cellulose is added to petrolatum. Originally, hydrophobically modified alkyl cellulose is soluble in water-containing alcohols such as water, water-containing methanol, water-containing ethanol, and water-containing isopropyl alcohol. However, hydrophobically modified alkylcellulose does not dissolve in oil. Vaseline, on the other hand, is obtained by decolorizing and purifying a mixture of hydrocarbons obtained from petroleum, so it is oily and does not dissolve in water at all. That is, conventionally, it has not been known to use a mixture of hydrophobically modified alkyl cellulose that is soluble only in water or the like and petroleum jelly that is insoluble in water. The composition for external preparation of the present invention is a dispersion in which hydrophobically modified alkyl cellulose is uniformly dispersed in a solid (powder) form in petrolatum. In the hydrophobized modified alkylcellulose-peterine dispersion, the hydrophobized modified alkylcellulose is well dispersed in petrolatum.

  Since hydrophobically modified alkylcellulose does not dissolve in oil, conventionally, an aqueous solution of hydrophobically modified alkylcellulose is prepared and an emulsion of the aqueous solution is formed in oil.

  The composition for external preparation of the present invention (external preparation) is prepared by adding powdered hydrophobized modified alkyl cellulose to petrolatum heated to a melting level, mixing well under heating, and then allowing to cool to room temperature. It is preferable to manufacture by. As another method, a small amount of a suitable solvent is added to and mixed with powdered hydrophobized modified alkyl cellulose, and then the mixture is added to petroleum jelly heated to such an extent that the mixture is melted. It is preferable to produce by allowing to cool. Vaseline has a melting point of 38-60 ° C. When petrolatum is warmed, petrolatum becomes a transparent liquid.

  When a fatty acid (salt) (for example, stearic acid (salt)) is added to the composition for external use (external preparation) of the present invention, a powdered fatty acid (salt) is added to petrolatum heated to a melting level. It is preferable to do. As another method, a small amount of an appropriate solvent may be added to and mixed with the powdered fatty acid (salt), and then the mixture may be added. It is preferable to add powdered fatty acid (salt) to powdered hydrophobically modified alkyl cellulose and add it to petroleum jelly heated to a melting level.

  The temperature for heating the petrolatum may be within the temperature range in which the petrolatum melts, and within the temperature range in which the hydrophobized modified alkyl cellulose (additionally fatty acid (salt)) is uniformly mixed and stirred in the petrolatum. It ’s fine. About 60-90 degreeC is preferable and the temperature which heats petrolatum has more preferable about 70-80 degreeC. In the method for producing an external preparation for skin having the above structure, first, petrolatum and a hydrophobically modified alkyl cellulose (additionally fatty acid (salt)) and the like are mixed and stirred at a temperature of about 60 to 90 ° C. (1 to After that, the mixture is mixed and stirred at a temperature of about 60 to 90 ° C. until the dispersion becomes uniform (about 5 to 15 minutes). By stirring at a temperature of about 60 to 90 ° C., petroleum jelly having a melting point of about 60 ° C. is completely dissolved and can be mixed uniformly. In addition, it is possible to avoid discoloration or thermal decomposition of each component, which may occur by performing high-temperature heating and stirring. As a result, the quality of the external preparation does not deteriorate.

  After the hydrophobically modified alkyl cellulose (additionally fatty acid (salt)) is uniformly mixed and stirred in petrolatum, the dispersion is preferably allowed to cool to room temperature.

  In addition, powdery hydrophobically modified alkyl cellulose (additional fatty acid (salt)) is mixed with a small amount of a suitable solvent if necessary, and then mixed with petroleum jelly heated to about 80 ° C using a paddle mixer or the like. -An external preparation composition can also be produced by adding with stirring and stirring for about 15 minutes, then cooling to room temperature and stirring well until solidified.

  In addition, as needed, it can mix and stir appropriately and appropriately in the cooling process.

  As a solvent to be added to the hydrophobized modified alkyl cellulose, it is easy to mix with petrolatum, there is no stickiness when used as an external preparation, from the viewpoint of ease of application to the skin, good usability, water, ethanol, Propylene glycol, butylene glycol, glycerin and the like are preferable, and water is more preferable.

  The amount of the solvent added to the hydrophobized modified alkyl cellulose is well-mixed with petrolatum, has no stickiness when used as an external preparation, and is hydrophobic in view of ease of application to the skin and ease of use. About 10-100 mass parts is preferable with respect to 100 mass parts of powder (total quantity) of chemical modification alkyl cellulose, About 20-80 mass parts is more preferable, About 30-70 mass parts is more preferable. What is necessary is just to add the mixture of hydrophobic modification | denaturation alkyl cellulose and a solvent to petrolatum heated so that it might melt, so that the blending ratio of hydrophobic modification alkyl cellulose in petrolatum may become the above-mentioned range.

5). Use of external preparation The external preparation of the present invention is preferably used as a skin external preparation. As the dosage form of the external preparation composition, a suitable dosage form can be obtained by using a normal skin external base. That is, examples of the dosage form include liquid, paste, cream or solid. Moreover, it can mix | blend with skin care cosmetics, such as a foundation, moisturizing cream, cold cream, hand cream, and massage. There are no restrictions on the application site of the external preparation for skin, but it can be used as an external preparation for the body (skin care cosmetics) for atopic dermatitis, cuts, abrasions, burns, cracks, dry skin, etc. It is. It is preferable to use the external preparation of the present invention at a site that directly acts to enhance the effect. By applying to the external preparation skin of the present invention, the moisture retention of the skin can be enhanced.

  Further, the external preparation of the present invention can be used as a body external preparation (skin care cosmetic) in a dosage form such as a lotion, emulsion, cream, ointment, or sheet. It is also possible to cover the skin using the external preparation of the present invention as a pack cosmetic. In addition, it is possible to produce a body makeup product using the external preparation composition of the present invention as a makeup composition. Cosmetics such as lotion, serum, pack, mascara, eyeliner, eye shadow, foundation, UV care cosmetics, lip cosmetics such as lipstick, lip balm, lip gloss, lipstick, lip treatment, etc. It can be blended into nail products such as lip pencils, eye pencils, eyebrows makeup products, nail varnishes and nail care products.

  As a method of using the external preparation for skin, for example, as a normal method of use, it is applied to human skin so as to cover the whole affected area of a healthy person or a human having symptoms such as rough skin, eczema, itching, and sores. If possible, lightly imprint. If it is not possible, it is preferable to use gauze or the like coated with a necessary amount of the external preparation for skin according to the symptoms of the affected area approximately 1 to 3 times / day by fastening the affected area with a tape or the like. The composition for external use of the present invention is paste-like and has good elongation, has no sticky feeling or lightness after application, has an effect of protecting the skin and moisturizes the skin, and has a low irritation to the skin and is stable. The property is also good.

  The external preparation of the present invention mainly refers to an external preparation for body (skin care cosmetic), but can also be used as a clinical therapeutic preparation.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.

  Next, the present invention will be specifically described with reference to examples and comparative examples with respect to the preparation form and effects obtained thereby.

Examples and Comparative Examples
Example 1
Weigh 50.2 g of Japanese white petrolatum into a glass bottle with a lid, dissolve it in a water bath at about 65 ° C. (after heating), and then make it into a powdered hydrophobized modified alkyl cellulose (Sangelose 60M [manufactured by Daido Kasei Kogyo Co., Ltd.) ]) 0.5 g was added. Then, after closing the lid, it was quickly dispersed uniformly by hand shaking for about 2-3 minutes. Thereafter, while holding in a water bath at about 65 ° C. for 10 minutes, the hand was occasionally shaken for the purpose of keeping the dispersion as uniform as possible. Subsequently, it was allowed to cool to obtain a sample of petrolatum containing hydrophobically modified alkylcellulose (60M).

Example 2
Weigh 50.2 g of Japanese white petrolatum into a glass bottle with a lid, dissolve in a water bath at about 85 ° C., and then 0.5 g of powdered hydrophobized modified alkylcellulose (Sangelose 60M [Daido Kasei Kogyo Co., Ltd.]) Was added. Then, after closing the lid, it was quickly dispersed uniformly by hand shaking for about 2-3 minutes. Thereafter, while holding in a water bath at about 85 ° C. for 10 minutes, the hand was occasionally shaken for the purpose of keeping the dispersion as uniform as possible. Thereafter, 260 mg of purified water was added to the hydrophobized modified alkylcellulose-peterine dispersion, and then the contents were uniformly dispersed again by hand shaking for about 2 to 3 minutes, and held for 10 minutes in the above water bath with occasional hand shaking. Then, it stood to cool and obtained the test sample of hydrophobic modification | denaturation alkyl cellulose (60M) and petrolatum containing purified water.

  By heating petrolatum at about 85 ° C, powdered hydrophobized modified alkylcellulose can be uniformly mixed and stirred in petrolatum, and a uniform hydrophobized modified alkylcellulose-peterine dispersion can be obtained. It was. Moreover, by adding water, the powdery hydrophobically modified alkylcellulose can be uniformly mixed and stirred in petrolatum, and a uniform hydrophobized modified alkylcellulose-peterine dispersion can be obtained.

Example 3
Weighing 50.1 g of pharmacopoeia white petrolatum into a glass bottle with a lid and dissolving it in a water bath at about 85 ° C., then 0.51 g of powdered hydrophobized modified alkyl cellulose (Sangelose 60 L [manufactured by Daido Kasei Kogyo Co., Ltd.]) Was added. Then, after closing the lid, it was quickly dispersed uniformly by hand shaking for about 2-3 minutes. Thereafter, while holding in a water bath at about 85 ° C. for 10 minutes, the hand was occasionally shaken for the purpose of keeping the dispersion as uniform as possible. Thereafter, the sample was allowed to cool to obtain a sample of petrolatum containing hydrophobically modified alkylcellulose (60 L).

Example 4
Weigh 50.0 g of pharmacopoeia white petrolatum in a glass bottle with a lid, dissolve it in a water bath at about 85 ° C., and then add 0.54 g of powdered hydrophobized modified alkylcellulose (Sangelose 90 L [manufactured by Daido Kasei Kogyo Co., Ltd.]). Was added. Then, after closing the lid, it was quickly dispersed uniformly by hand shaking for about 2-3 minutes. Thereafter, while holding in a water bath at about 85 ° C. for 10 minutes, the hand was occasionally shaken for the purpose of keeping the dispersion as uniform as possible. Thereafter, the sample was allowed to cool to obtain a sample of petrolatum containing hydrophobically modified alkyl cellulose (90 L).

Example 5
Weighing 50.3 g of pharmacopoeia white petrolatum in a glass bottle with a lid and dissolving it in a water bath at about 85 ° C., then 0.52 g of powdered hydrophobized modified alkyl cellulose (Sangelose 90M [Daido Kasei Kogyo Co., Ltd.]) Was added. Next, after closing the lid, it was quickly dispersed uniformly by hand shaking for about 2-3 minutes. Then, while holding in a water bath at about 85 ° C. for 10 minutes, the hand was occasionally shaken for the purpose of keeping the dispersion as uniform as possible. Thereafter, the sample was allowed to cool to obtain a sample of petrolatum containing hydrophobically modified alkylcellulose (90M).

Example 6
Weigh 50.2 g of Japanese white petrolatum in a glass bottle with a lid, dissolve it in a water bath at about 85 ° C., and then add 0.50 g of powdered hydrophobized modified alkyl cellulose (Sangelose 60H [Daido Kasei Kogyo Co., Ltd.]). Was added. Then, after closing the lid, it was quickly dispersed uniformly by hand shaking for about 2-3 minutes. Then, while holding in a water bath at about 85 ° C. for 10 minutes, the hand was occasionally shaken for the purpose of keeping the dispersion as uniform as possible. Thereafter, the sample was allowed to cool to obtain a sample of petrolatum containing hydrophobically modified alkyl cellulose (60H).

Example 7
Weigh 50.0 g of pharmacopoeia white petrolatum in a glass bottle with a lid, dissolve in a water bath at about 85 ° C., and then add 0.52 g of powdered hydrophobized modified alkyl cellulose (Sangelose 90H [Daido Kasei Kogyo Co., Ltd.]). Was added. Then, after closing the lid, it was quickly dispersed uniformly by hand shaking for about 2-3 minutes. Then, while holding in a water bath at about 85 ° C. for 10 minutes, the hand was occasionally shaken for the purpose of keeping the dispersion as uniform as possible. Thereafter, the sample was allowed to cool to obtain a sample of petrolatum containing hydrophobically modified alkyl cellulose (90H).

Comparative Example 1
Weigh 50.0 g of pharmacopoeia white petrolatum in a glass bottle with a lid, dissolve in a water bath at about 85 ° C., and then powder hydroxypropylmethylcellulose (HPMC) (Metroses 60SH, 10,000 [manufactured by Shin-Etsu Chemical Co., Ltd.]) ) 0.50 g was added. Then, after closing the lid, it was quickly dispersed uniformly by hand shaking for about 2-3 minutes. Then, while holding in a water bath at about 85 ° C. for 10 minutes, the hand was occasionally shaken for the purpose of keeping the dispersion as uniform as possible. Then, it stood to cool and obtained the sample sample of petrolatum containing HPMC.

Comparative Example 2
50.2 g of Japanese white petrolatum was weighed into a glass bottle with a lid, dissolved in a water bath at about 85 ° C., and 0.54 g of powdered ethylcellulose (Ethocel STD 7 cps [manufactured by Nisshin Kasei Co., Ltd.]) was added. Then, after closing the lid, it was quickly dispersed uniformly by hand shaking for about 2-3 minutes. Then, while holding in a water bath at about 85 ° C. for 10 minutes, the hand was occasionally shaken for the purpose of keeping the dispersion as uniform as possible. Thereafter, it was allowed to cool to obtain a sample of petrolatum containing ethylcellulose.

Evaluation method 1: Evaluation of stickiness A sensory evaluation was performed using five test subjects (women) as panelists.

  The panelist took about 300 mg of the specimen sample prepared in Examples, Reference Examples and Comparative Examples and applied it to the back of the hand or arm. The panelists evaluated the “stickiness” of the specimen sample compared to the pharmacopeia white petrolatum used as the raw material. The evaluation was made in five stages, whether it was superior, inferior or not different compared to pharmacopoeia white petrolatum.

+2: Very good +1: Excellent 0: No difference -1: Inferior -2: Very inferior The "stickiness" is the evaluation of a specimen sample (comparative specimen sample) containing only local white petrolatum. It was set to “0”. From the characteristics of the above five-level evaluation method, if the average value of the stickiness of the specimen sample (n = 5, 5 panelists) is 0.5 or more, the stickiness feeling compared to the local white petrolatum that is the comparative specimen sample. Was judged to have improved. If the average value of the stickiness of the specimen sample is 0, the stickiness of the same degree as that of the pharmacopeia white petrolatum which is the comparative specimen sample is obtained.

Evaluation result 1: Evaluation evaluation results of stickiness were shown in Tables 2 and 3.

  In the sample sample of HPMC-containing petrolatum of Comparative Example 1, the evaluation result was 0, which was an evaluation result equivalent to the use of pharmacopoeia white petrolatum alone, and the sticky feeling was not improved. Moreover, also in the sample sample of petrolatum containing ethyl cellulose of Comparative Example 2, the evaluation result was 0.4, and the stickiness was not sufficiently improved as compared with the use of pharmacopoeia white petrolatum alone.

  The specimen samples of Examples 1 to 7 were sufficiently improved in stickiness as compared to the comparative specimen sample containing only pharmacopeia white petrolatum. The specimen samples of Examples 1 to 7 were sufficiently improved in stickiness compared to Comparative Examples 1 and 2. Further, even when hydrophobically modified alkyl cellulose having different contents of methoxyl group, hydroxypropoxyl group and stearyloxyhydroxypropoxyl group was used, the stickiness was sufficiently improved.

Evaluation Method 2: Evaluation of Hardness, Elongation, Moistness, and Roughness In the composition for external use of the present invention, improvement of stickiness is the main effect. If the stickiness is improved, the composition of the invention There is no problem. In the evaluation method 2, it was also confirmed that the composition for external preparation of the present invention was further improved in hardness, stretch feeling, moist feeling, and rough feeling.

  In the same way as the “stickiness” evaluation method, the panelists compared the specimen white petrolatum used as a raw material with “hardness”, “elongation”, “moistness” and “roughness”. Was evaluated. The evaluation was made in five stages, whether it was superior, inferior or not different compared to pharmacopoeia white petrolatum.

  The evaluation criteria are the same as the evaluation method for “stickiness”.

+2: Very good +1: Excellent 0: No difference -1: Inferior -2: Very inferior An additional effect such as "hardness" is a specimen sample of only the local white petrolatum (comparative specimen) The evaluation of the sample was “0”. From the characteristics of the above five-step evaluation method, if the average value of the hardness of the specimen sample is 0.2 or more, the hardness etc. tend to be improved compared to the pharmacopeia white petrolatum which is the comparative specimen sample (becomes softer). It was judged that it was improved if it was 0.5 or more. If the average value of the hardness of the specimen sample is 0, it has the same hardness as that of the pharmacopeia white petrolatum which is the comparative specimen sample.

Evaluation results 2: Evaluation evaluation results of hardness, stretch feeling, moist feeling, and rough feeling are shown in Tables 4-7.

  The specimen sample of the example which is a dispersion of hydrophobized modified alkylcellulose-petroleum has sufficiently improved hardness, stretch feeling, moist feeling, and rough feeling as compared with the comparative specimen sample containing only pharmacopeia white petrolatum. . Further, even when hydrophobically modified alkyl cellulose having different contents of methoxyl group, hydroxypropoxyl group and stearyloxyhydroxypropoxyl group was used, the hardness and the like were sufficiently improved.

  Further, in order to further improve the feeling of roughness, it is preferable to add a sample of hydrophobically modified alkylcellulose-peterine (to the dispersion), a small amount of water and sufficiently mix and stir, or further pulverize the powder.

  The composition for external preparation of the present invention (external preparation, external preparation for skin) is composed of a hydrophobically modified alkyl cellulose in addition to petrolatum. It is a thing.

  Moreover, the composition for external preparations of this invention is a composition for external preparations which is excellent in use feeling also from the point that hardness, a feeling of elongation, and a moist feeling are favorable, and there are few rough feelings. The composition for external preparations of the present invention is a composition for external preparations containing petrolatum that has good elongation and can be easily applied to the skin.

  By using the composition for external use of the present invention, the user prepares the skin, keeps the skin smooth, prevents rough skin, gives the skin moisture, keeps the skin moisture and oil, keeps the skin soft. Effects such as maintaining skin, protecting the skin, preventing the skin from drying, softening the skin, and smoothing the skin can be obtained. Moreover, the user can also obtain effects such as adjusting the texture of the skin, tightening the skin, giving the skin to the skin, and giving the skin gloss by using the composition for external preparation of the present invention.

Claims (5)

A composition for external use comprising hydrophobically modified alkyl cellulose and petrolatum. The hydrophobically modified alkyl cellulose is
The following structural formula (1):

[Wherein R ¹ , R ² and R ³ are the same or different and each represents a hydrogen atom, a lower alkyl group,
_{Groups: - [CH 2 CH 2-} k (CH 3) k O] m H,
Or the group: —CH ₂ CH (OH) CH ₂ OC _j H _{2j + 1} .
n is an integer of 100 to 10,000, k is an integer of 0 or 1, m is an integer of 1 to 10,
j represents an integer of 6 to 26. ]
Represented by
The hydrophobized modified alkyl cellulose necessarily contains the group: —CH ₂ CH (OH) CH ₂ OC _j H _{2j + 1} ,
The composition for external preparations of Claim 1. Hydrophobized modified alkyl cellulose represented by the structural formula (1)
Lower alkyl group: 10.0 to 50.0% by mass,
_{Groups: - [CH 2 CH 2-} k (CH 3) k O] m H: 3.0~20.0 wt%, and _{groups: -CH 2 CH (OH) CH} 2 OC j H 2j + 1: 0.1 ~ 10.0 mass%
The composition for external preparations of Claim 2 containing this. The structural formula (1) wherein groups contained in _{formula: -CH 2 CH (OH) CH} 2 OC j H 2j + 1 of the external preparation composition according to claim 2 or 3 values of j is 18. The manufacturing method of the composition for external preparations containing the hydrophobization modified | denatured alkyl cellulose and petrolatum characterized by adding powdery hydrophobization modified alkyl cellulose to petrolatum.