JP2017002009A - 免疫賦活剤 - Google Patents
免疫賦活剤 Download PDFInfo
- Publication number
- JP2017002009A JP2017002009A JP2015120508A JP2015120508A JP2017002009A JP 2017002009 A JP2017002009 A JP 2017002009A JP 2015120508 A JP2015120508 A JP 2015120508A JP 2015120508 A JP2015120508 A JP 2015120508A JP 2017002009 A JP2017002009 A JP 2017002009A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- lactoferrin
- immunostimulant
- acid
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 102000010445 Lactoferrin Human genes 0.000 claims abstract description 60
- 108010063045 Lactoferrin Proteins 0.000 claims abstract description 60
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020122100A1 (ja) * | 2018-12-12 | 2020-06-18 | 森永乳業株式会社 | ポリメトキシフラボノイドの溶解性向上方法 |
| JP2021059519A (ja) * | 2019-10-09 | 2021-04-15 | 株式会社東洋新薬 | 経口組成物 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009509960A (ja) * | 2005-09-22 | 2009-03-12 | 三井農林株式会社 | 紅茶ポリフェノール及びその使用 |
| JP2010526873A (ja) * | 2007-05-14 | 2010-08-05 | フォンテラ コ−オペレイティブ グループ リミティド | 免疫又は血液学的増強、腫瘍の形成又は成長の阻害、及び、癌、癌症状又は癌治療の症状の治療又は予防の方法 |
| JP2012031089A (ja) * | 2010-07-30 | 2012-02-16 | Shiibaion:Kk | 免疫賦活剤 |
-
2015
- 2015-06-15 JP JP2015120508A patent/JP2017002009A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009509960A (ja) * | 2005-09-22 | 2009-03-12 | 三井農林株式会社 | 紅茶ポリフェノール及びその使用 |
| JP2010526873A (ja) * | 2007-05-14 | 2010-08-05 | フォンテラ コ−オペレイティブ グループ リミティド | 免疫又は血液学的増強、腫瘍の形成又は成長の阻害、及び、癌、癌症状又は癌治療の症状の治療又は予防の方法 |
| JP2012031089A (ja) * | 2010-07-30 | 2012-02-16 | Shiibaion:Kk | 免疫賦活剤 |
Non-Patent Citations (6)
| Title |
|---|
| AMERICAN JOURNAL OF GASTROINTESTINAL AND LIVER PHYSIOLOGY, vol. 281, JPN6019014016, pages 1140 - 1150, ISSN: 0004138865 * |
| BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, vol. 43, no. 1, JPN6019040863, 1997, pages 79 - 87, ISSN: 0004256061 * |
| PHYTOCHEMISTRY, vol. 69, JPN6019014017, 2008, pages 3103 - 3110, ISSN: 0004138866 * |
| PLANTA MEDICA, vol. 70, JPN6019040866, 2004, pages 924 - 928, ISSN: 0004256062 * |
| 分析化学, vol. 62, no. 1, JPN6019014015, 2013, pages 51 - 55, ISSN: 0004256060 * |
| 日本食品科学工学会誌, vol. 59, no. 7, JPN6019014014, 2012, pages 326 - 330, ISSN: 0004256059 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020122100A1 (ja) * | 2018-12-12 | 2020-06-18 | 森永乳業株式会社 | ポリメトキシフラボノイドの溶解性向上方法 |
| JPWO2020122100A1 (ja) * | 2018-12-12 | 2021-10-21 | 森永乳業株式会社 | ポリメトキシフラボノイドの溶解性向上方法 |
| JP7458990B2 (ja) | 2018-12-12 | 2024-04-01 | 森永乳業株式会社 | ポリメトキシフラボノイドの溶解性向上方法 |
| JP2021059519A (ja) * | 2019-10-09 | 2021-04-15 | 株式会社東洋新薬 | 経口組成物 |
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