JP2016537069A - 光生理センサ及び組み立て方法 - Google Patents
光生理センサ及び組み立て方法 Download PDFInfo
- Publication number
- JP2016537069A JP2016537069A JP2016524474A JP2016524474A JP2016537069A JP 2016537069 A JP2016537069 A JP 2016537069A JP 2016524474 A JP2016524474 A JP 2016524474A JP 2016524474 A JP2016524474 A JP 2016524474A JP 2016537069 A JP2016537069 A JP 2016537069A
- Authority
- JP
- Japan
- Prior art keywords
- sensor
- photodetector
- optical
- light
- light source
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 53
- 230000003287 optical effect Effects 0.000 claims abstract description 93
- 238000013461 design Methods 0.000 claims abstract description 23
- 230000035479 physiological effects, processes and functions Effects 0.000 claims abstract description 8
- 238000005259 measurement Methods 0.000 claims description 20
- 230000003068 static effect Effects 0.000 claims description 15
- 230000005855 radiation Effects 0.000 claims description 13
- 239000013598 vector Substances 0.000 claims description 9
- 238000010521 absorption reaction Methods 0.000 claims description 7
- 238000001514 detection method Methods 0.000 claims description 7
- 230000004044 response Effects 0.000 claims description 5
- 230000010349 pulsation Effects 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 83
- 239000008280 blood Substances 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 13
- 230000033001 locomotion Effects 0.000 description 13
- 238000012545 processing Methods 0.000 description 13
- 238000012544 monitoring process Methods 0.000 description 11
- 230000008569 process Effects 0.000 description 9
- 238000005286 illumination Methods 0.000 description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 7
- 230000005540 biological transmission Effects 0.000 description 7
- 229910052760 oxygen Inorganic materials 0.000 description 7
- 239000001301 oxygen Substances 0.000 description 7
- 238000013186 photoplethysmography Methods 0.000 description 6
- 238000013442 quality metrics Methods 0.000 description 5
- 238000004891 communication Methods 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 238000013523 data management Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 3
- 230000036760 body temperature Effects 0.000 description 3
- 210000004207 dermis Anatomy 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 210000004243 sweat Anatomy 0.000 description 3
- 208000017667 Chronic Disease Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000013500 data storage Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 230000036651 mood Effects 0.000 description 2
- 238000002106 pulse oximetry Methods 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 230000036387 respiratory rate Effects 0.000 description 2
- 239000002884 skin cream Substances 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 210000000617 arm Anatomy 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000003811 finger Anatomy 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000012623 in vivo measurement Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000013441 quality evaluation Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 244000005714 skin microbiome Species 0.000 description 1
- 230000037078 sports performance Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000005308 sum rule Methods 0.000 description 1
- 208000013460 sweaty Diseases 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/02416—Detecting, measuring or recording pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
- A61B5/02427—Details of sensor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/1032—Determining colour for diagnostic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
- A61B5/7207—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts
- A61B5/7214—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts using signal cancellation, e.g. based on input of two identical physiological sensors spaced apart, or based on two signals derived from the same sensor, for different optical wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7225—Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient ; user input means
- A61B5/742—Details of notification to user or communication with user or patient ; user input means using visual displays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient ; user input means
- A61B5/7475—User input or interface means, e.g. keyboard, pointing device, joystick
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F30/00—Computer-aided design [CAD]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
- A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/02405—Determining heart rate variability
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/0816—Measuring devices for examining respiratory frequency
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7221—Determining signal validity, reliability or quality
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
Abstract
Description
(i)例えばスポーツパフォーマンスのためか、もしくは一般的な健康、フィットネスレベルを維持又は向上させる自己モニタリング;および
(ii)慢性疾患患者又は術後ケアを受けたものの重要なヘルスパラメータを捕捉する臨床医のモニタリング。
さらに、モニタリングは、基礎となる疾患を同定又は確認するために行ってもよく、又は、根底にある状態を追跡して悪化を防ぐために早期警告信号を提供するためにリスクの患者の重要なパラメータをモニタする。
モニタすべき少なくとも1つの生体組織タイプの光生理学的特性をモデル化することと、
モデルの適用により、操作可能な光生理(OP)センサのための最適な光学設計を決定することと、
少なくとも1つの生体組織タイプの光生理学的性質をモニタすることと、
決定された光学設計に対してOPセンサを作成することとを含み、
前記OPセンサのための最適な光学設計は、
各光源からモニタすべき生体組織タイプを介して光検出器へ伝送する光に対するモデル化された光路長に基づいて、光検出器からの複数の光源の最適な間隔を決定することと、
前記光検出器から異なる距離で異なる波長の光源を配置することとを含む。
複数の光源と、
上記光源からの光がモニタ対象の生体組織タイプを介して伝送した後に、1つ以上の光源から放射された放射線を捕捉するように構成された少なくとも1つの光検出器と、
上記複数の光源は、モニタ対象の生体組織タイプの光生理学的特性のモデルによって決定される位置において光検出器に対して相対的に配置され、
前記光検出器からの各光源の最適な間隔は、各光源からの光がモニタすべき生体組織タイプを介して光検出器に伝送するモデル化された光路長に基づいており、
前記異なる波長の光源は光検出器から異なる距離に配置される。
上記方法は、
少なくとも1つの光検出器からの出力に、各個々の光源の寄与から独立した信号を得ることと、
それぞれの独立した信号の信号品質の1つ以上の測定を実行することと、
各個々の光源の照射強度を変更し、信号品質の測定を繰り返すことと、
独立した信号の信号品質の上昇を受けている個々の光源の強度を変更して信号品質の測定を繰り返すことと、
独立した信号の信号品質の低下を受けている個々の光源の強度の変更を逆転して信号品質の測定を繰り返すことと、
信号に対応する信号品質がピークに達するときの個々の光源の強度を固定することと、
独立した信号がしきい値以下である複数の光源を選択的に不活性化することを含む。
本発明の第2又は第3の態様に係る光生理(OP)センサと、
光検出器によって測定された信号を分析して少なくとも1つの生理的パラメータを決定するように構成された分析器とを備える。
(i)本明細書で詳述した複数の式、それらの置換、又はそれらの個別の派生物(すなわち、数値的に解ける式)の1つ又はそれ以上の式;
(ii)それらの発光波長及び空間分布を含む1つ以上の光源の数値又は数学的記述。
(iii)組織の層の組の、厚さと静的及び動的な光学特性を含む生体組織部位の数値又は数学的記述(例えば、表皮、真皮表面、表面的な皮膚叢、深い真皮、深い真皮叢、皮下脂肪);
(iv)光源−検出器の間隔ls−d及び散乱係数μsの関数としての有効な光路長Lの数値又は数学的記述。これらは例えば、放射輸送方程式又はP1(拡散)近似式の有限要素解を使用して、関心対象の生体組織部位の3次元幾何学モデルに適用される。
(1)光検出器30から出力までの各光源28の寄与から独立した信号を得る。
(2)それぞれの独立した信号の信号品質の1つ以上の測定を実行する。
(3)各個々の光源28の照明強度を変更して信号品質の測定を繰り返す。
(4)さらに、個々の光源28の強度を変更する。
(5)その独立した信号の信号品質の上昇を受けて、信号品質の測定を繰り返す。
(6)個々の光源28の強度の変更を逆転させる。
(7)その独立した信号の信号品質の低下を受けていると信号品質の測定を繰り返す。
(8)信号に対応する信号品質がピークに達したときに個々の光源28の強度を修正する。
(9)独立した信号がしきい値以下であるときに選択的に光源28を無効化する。
従って、コントローラ48は、個々の光源28からの信号強度を最適化するように構成されてもよい。これは、図6に関連して以下に説明する信号品質の評価と同様に処理する別の処理の前に、各光源が定常状態で動作していることを確実にするために初期化ステップとして実行することができる。
Claims (18)
- 光生理(OP)センサを組み立てる方法であって、
前記方法は、
モニタすべき少なくとも1つの生体組織タイプの光生理学的特性をモデル化することと、
モデルの適用により、操作可能な光生理(OP)センサのための最適な光学設計を決定して少なくとも1つの生体組織タイプの光生理学的性質をモニタすることと、
決定された光学設計に対してOPセンサを作成することとを含み、
前記OPセンサのための最適な光学設計は、
各光源からモニタすべき生体組織タイプを介して光検出器への光のモデル化された光路長に基づいて、前記光検出器からの複数の光源のそれぞれの最適な間隔を決定することと、
前記光検出器から異なる距離で異なる波長の光源を配置することとを含む光生理(OP)センサの組み立て方法。 - 前記OPセンサのための最適な光学設計は、同一の波長又は波長帯の光を生成するように構成された複数の光源を使用することを含み、
前記センサは、前記光検出器で捕捉された放射線の品質に基づき、光生理学的測定において使用するための1つ以上の前記複数の光源を選択するように構成される請求項1に記載の方法。 - 前記少なくとも1つの生体組織タイプは、組織部位、組織の色、組織厚み、組織年齢及び組織状態のうちの1つ以上を含み、
前記少なくとも1つの生体組織タイプの光生理学的特性は、吸収係数、散乱係数、屈折率及び光学密度のうちの1つ以上を含む請求項1又は2に記載の方法。 - 前記モデルは微小光パワーdPを含むことを定義することと、
前記微小光パワーdPは式10に従って生体組織タイプの表面上の点(x,y)を透過し、
光源−検出器の間隔は次式のように、生体組織タイプの表面上における、光源の点(xs,ys)と、任意の検出器の点(x,y)で定義され、
- 請求項1〜9のうちのいずれか1つに記載の方法により組み立てられた光生理(OP)センサ。
- 複数の光源と、
前記光源からの光がモニタすべき生体組織タイプを介して伝送した後、1つ以上の光源から放射される放射線を捕捉するように構成された少なくとも1つの光検出器とを備えた光生理(OP)センサであって、
前記複数の光源はそれぞれ、モニタすべき生体組織タイプの光生理学的特性のモデルによって決定される位置の光検出器に対して相対的に配置され、
前記光検出器からの各光源の最適な間隔は、各光源からモニタすべき生体組織タイプを介して前記光検出器まで伝送する光に対してモデル化された複数の光路長に基づき、
異なる複数の波長の複数の光源は前記光検出器から異なる複数の距離に配置される光生理(OP)センサ。 - 複数の光源は同一の波長又は同一の波長帯の光を発生するように構成され、
前記センサは捕捉された放射線の品質に基づて光生理学的測定において使用するための1つ以上の前記複数の光源を選択するように動作可能である、
請求項11に記載のOPセンサ。 - 前記各光源は、前記光検出器を中心とする円の円周上に配置され、
前記各円の半径はそれぞれの光源の波長の関数である、
請求項11に記載のOPセンサ。 - 前記OPセンサはさらに、前記光検出器からの測定信号に基づいて、前記複数の光源を活性化及び非活性化するように動作可能なコントローラを備える、
請求項11〜13のうちのいずれか1つに記載のOPセンサ。 - 請求項10〜14のうちのいずれか1つに記載の光生理(OP)センサと、
前記光検出器によって測定された信号を分析して前記光検出器からの少なくとも1つの生理的パラメータを決定する分析器とを備える、
光生理(OP)システム。 - 添付図面を参照してここで実質的に記載される、光生理(OP)センサを組み立てる方法。
- 添付図面を参照してここで実質的に記載される、光生理(OP)センサ。
- 添付図面を参照してここで実質的に記載される、光生理(OP)システム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1318390.0A GB2519335A (en) | 2013-10-17 | 2013-10-17 | Opto-physiological sensor and method of design |
GB1318390.0 | 2013-10-17 | ||
PCT/GB2014/053095 WO2015056007A1 (en) | 2013-10-17 | 2014-10-15 | Opto-physiological sensor and method of assembly |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016537069A true JP2016537069A (ja) | 2016-12-01 |
JP6548639B2 JP6548639B2 (ja) | 2019-07-24 |
Family
ID=49726944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016524474A Active JP6548639B2 (ja) | 2013-10-17 | 2014-10-15 | 光生理センサ及び組み立て方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US10327652B2 (ja) |
EP (1) | EP3057497B1 (ja) |
JP (1) | JP6548639B2 (ja) |
CN (1) | CN105636511B (ja) |
AU (1) | AU2014335940A1 (ja) |
CA (1) | CA2927310A1 (ja) |
GB (4) | GB2519335A (ja) |
HK (1) | HK1219642A1 (ja) |
WO (1) | WO2015056007A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022059063A1 (ja) * | 2020-09-15 | 2022-03-24 | 日本電気株式会社 | 生体情報取得装置、システム、生体情報取得方法、および記録媒体 |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160029898A1 (en) | 2014-07-30 | 2016-02-04 | Valencell, Inc. | Physiological Monitoring Devices and Methods Using Optical Sensors |
WO2016040263A1 (en) * | 2014-09-08 | 2016-03-17 | Braintree Analytics Llc | Wrist worn accelerometer for pulse transit time (ptt) measurements of blood pressure |
WO2016176218A1 (en) * | 2015-04-27 | 2016-11-03 | Apple Inc. | Dynamically reconfigurable apertures for optimization of ppg signal and ambient light mitigation |
KR102434698B1 (ko) | 2015-07-03 | 2022-08-22 | 삼성전자주식회사 | 생체 정보 검출 장치 및 방법 |
US10695000B2 (en) | 2015-09-02 | 2020-06-30 | Metronom Health, Inc. | Systems and methods for continuous health monitoring using an opto-enzymatic analyte sensor |
US10271745B2 (en) | 2016-06-17 | 2019-04-30 | Qualcomm Incorporated | Monolithic integrated emitter-detector array in a flexible substrate for biometric sensing |
CN106175741A (zh) * | 2016-07-13 | 2016-12-07 | 北京贞正物联网技术有限公司 | 一种用于足部的心率检测方法、检测系统及其鞋垫、智能鞋 |
EP3342337B1 (en) * | 2016-12-29 | 2020-11-04 | Nokia Technologies Oy | Sensor arrangement for a physiological measurement sensor |
JP6747344B2 (ja) * | 2017-03-14 | 2020-08-26 | オムロンヘルスケア株式会社 | 血圧データ処理装置、血圧データ処理方法および血圧データ処理プログラム |
KR102374990B1 (ko) * | 2017-03-21 | 2022-03-16 | 삼성전자 주식회사 | 피부 관련 정보를 제공하는 방법 및 이를 사용하는 전자 장치 |
EP3624682A4 (en) * | 2017-05-18 | 2021-01-27 | Wear2b Ltd | DEVICE, SYSTEM AND METHOD FOR NON-INVASIVE SURVEILLANCE OF PHYSIOLOGICAL MEASUREMENTS |
JP6925893B2 (ja) * | 2017-07-05 | 2021-08-25 | 日本光電工業株式会社 | 生体情報検出センサ無線システム、生体情報検出センサ無線方法、及び、生体情報検出センサ |
US10555670B2 (en) * | 2017-07-10 | 2020-02-11 | International Business Machines Corporation | Adaptive filtration of sweat artifacts during electronic brain monitoring |
CN107684433B (zh) * | 2017-07-24 | 2019-12-10 | 浙江大学 | 一种同时检测创面多种生理参数指标的装置及方法 |
JP6918616B2 (ja) * | 2017-07-28 | 2021-08-11 | 愛知時計電機株式会社 | 計測装置 |
CN107491607B (zh) * | 2017-08-17 | 2020-08-25 | 中国科学院合肥物质科学研究院 | 用于直流大电流测量的矩形霍尔传感器阵列结构设计方法 |
JP6966039B2 (ja) * | 2017-10-25 | 2021-11-10 | 住友電工デバイス・イノベーション株式会社 | 試験装置 |
EP3527122A1 (en) * | 2018-02-14 | 2019-08-21 | Koninklijke Philips N.V. | Modelling and extracting information from a photoplethysmography, ppg, signal |
CN107788951A (zh) * | 2017-11-23 | 2018-03-13 | 加动健康科技(芜湖)有限公司 | 用于健康检测的光谱发射装置 |
WO2019170903A1 (en) * | 2018-03-08 | 2019-09-12 | Biostealth Limited | Cardiovascular health monitoring |
CN108968926A (zh) * | 2018-06-26 | 2018-12-11 | 博脉有限公司 | 辨别脉象的方法、采集装置和系统 |
CN109602395B (zh) * | 2018-12-26 | 2023-09-01 | 感易(上海)传感技术有限公司 | 一种无创多通道动脉系统检测方法及装置 |
TWI788673B (zh) * | 2020-06-10 | 2023-01-01 | 國立陽明交通大學 | 具有可撓式感測貼片的橈動脈訊號量測裝置 |
KR20230030073A (ko) * | 2021-08-23 | 2023-03-06 | 주식회사 솔탑 | 생체신호 측정장치와 생체신호 영상화장치 그리고 뇌영상 기반 뇌질환 진단 시스템 |
GB2622396A (en) * | 2022-09-14 | 2024-03-20 | Carelight Ltd | Real time opto-physiological monitoring method and system |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04215742A (ja) * | 1990-02-15 | 1992-08-06 | Hewlett Packard Co <Hp> | 酸素飽和度非観血測定のためのセンサ及び酸素飽和度測定装置 |
JP2001041883A (ja) * | 1999-07-27 | 2001-02-16 | Matsushita Electric Works Ltd | 体液成分濃度の分析装置 |
US20090253968A1 (en) * | 2005-08-09 | 2009-10-08 | Ok Kyung Cho | Medical Measuring Device |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3624674A1 (de) * | 1986-07-22 | 1988-02-04 | Pierre Nicolas Foss | Vorrichtung zum objektiven erfassen von veraenderungen der haut |
US6662033B2 (en) * | 1994-04-01 | 2003-12-09 | Nellcor Incorporated | Pulse oximeter and sensor optimized for low saturation |
US5421329A (en) * | 1994-04-01 | 1995-06-06 | Nellcor, Inc. | Pulse oximeter sensor optimized for low saturation |
DE19844045A1 (de) | 1998-09-25 | 2000-03-30 | Panz Ulla Monika | Anordnung und Verfahren zum Beleuchten einer Hautpartie eines Probanden |
US7299080B2 (en) * | 1999-10-08 | 2007-11-20 | Sensys Medical, Inc. | Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy |
US7133710B2 (en) | 2002-03-08 | 2006-11-07 | Sensys Medical, Inc. | Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy |
JP4230736B2 (ja) * | 2002-08-20 | 2009-02-25 | 株式会社日立メディコ | 画像診断装置 |
WO2007097702A1 (en) * | 2006-02-21 | 2007-08-30 | Lindberg Lars-Goeran | Non-invasive monitoring of blood flow in deep tissue |
GB0717365D0 (en) | 2007-09-07 | 2007-10-17 | Univ Loughborough | Imaging |
US8112375B2 (en) * | 2008-03-31 | 2012-02-07 | Nellcor Puritan Bennett Llc | Wavelength selection and outlier detection in reduced rank linear models |
US8410951B2 (en) | 2008-09-30 | 2013-04-02 | Covidien Lp | Detecting a signal quality decrease in a measurement system |
US8914088B2 (en) * | 2008-09-30 | 2014-12-16 | Covidien Lp | Medical sensor and technique for using the same |
US20120095305A1 (en) | 2009-06-15 | 2012-04-19 | O2 Medtech, Inc. | Spectrophotometric Monitoring Of Multiple Layer Tissue Structures |
WO2011026669A1 (en) | 2009-09-03 | 2011-03-10 | Csem Sa | Monitoring device and method for estimating blood constituent concentration for tissues with low perfusion |
KR101138717B1 (ko) * | 2009-11-17 | 2012-04-24 | 재단법인 철원플라즈마 산업기술연구원 | 피부 진단 및 치료 장치와 이를 이용한 피부 진단 및 치료 방법 |
EP2679981A4 (en) | 2011-02-23 | 2015-08-19 | Univ Shizuoka Nat Univ Corp | OPTICAL MEASURING DEVICE |
-
2013
- 2013-10-17 GB GB1318390.0A patent/GB2519335A/en not_active Withdrawn
-
2014
- 2014-10-15 GB GB1418267.9A patent/GB2522298B/en active Active
- 2014-10-15 WO PCT/GB2014/053095 patent/WO2015056007A1/en active Application Filing
- 2014-10-15 JP JP2016524474A patent/JP6548639B2/ja active Active
- 2014-10-15 AU AU2014335940A patent/AU2014335940A1/en not_active Abandoned
- 2014-10-15 CA CA2927310A patent/CA2927310A1/en not_active Abandoned
- 2014-10-15 CN CN201480056607.XA patent/CN105636511B/zh active Active
- 2014-10-15 GB GB1511448.1A patent/GB2524919B/en active Active
- 2014-10-15 EP EP14787033.1A patent/EP3057497B1/en active Active
- 2014-10-15 US US15/029,984 patent/US10327652B2/en active Active
- 2014-10-15 GB GB1517104.4A patent/GB2527974B/en active Active
-
2016
- 2016-07-05 HK HK16107832.9A patent/HK1219642A1/zh unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04215742A (ja) * | 1990-02-15 | 1992-08-06 | Hewlett Packard Co <Hp> | 酸素飽和度非観血測定のためのセンサ及び酸素飽和度測定装置 |
JP2001041883A (ja) * | 1999-07-27 | 2001-02-16 | Matsushita Electric Works Ltd | 体液成分濃度の分析装置 |
US20090253968A1 (en) * | 2005-08-09 | 2009-10-08 | Ok Kyung Cho | Medical Measuring Device |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022059063A1 (ja) * | 2020-09-15 | 2022-03-24 | 日本電気株式会社 | 生体情報取得装置、システム、生体情報取得方法、および記録媒体 |
Also Published As
Publication number | Publication date |
---|---|
US10327652B2 (en) | 2019-06-25 |
AU2014335940A1 (en) | 2016-04-28 |
EP3057497B1 (en) | 2024-02-14 |
GB2522298B (en) | 2015-12-16 |
GB201517104D0 (en) | 2015-11-11 |
GB2519335A8 (en) | 2015-12-23 |
GB2522298A (en) | 2015-07-22 |
GB2527974A (en) | 2016-01-06 |
GB201318390D0 (en) | 2013-12-04 |
GB201418267D0 (en) | 2014-11-26 |
GB2524919B (en) | 2015-12-09 |
EP3057497A1 (en) | 2016-08-24 |
US20160278646A1 (en) | 2016-09-29 |
GB2524919A (en) | 2015-10-07 |
WO2015056007A1 (en) | 2015-04-23 |
GB2527974B (en) | 2016-04-06 |
CA2927310A1 (en) | 2015-04-23 |
JP6548639B2 (ja) | 2019-07-24 |
GB201511448D0 (en) | 2015-08-12 |
HK1219642A1 (zh) | 2017-04-13 |
CN105636511B (zh) | 2020-03-06 |
CN105636511A (zh) | 2016-06-01 |
GB2522298A8 (en) | 2015-12-23 |
GB2519335A (en) | 2015-04-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6548639B2 (ja) | 光生理センサ及び組み立て方法 | |
Ray et al. | A review of wearable multi-wavelength photoplethysmography | |
JP6615176B2 (ja) | 非干渉的な皮膚組織ハイドレーション測定デバイス及び関連方法 | |
US10194808B1 (en) | Correlated hemodynamic measurements | |
CN104968259B (zh) | 用于确定对象的生命体征信息的系统和方法 | |
CN105009173B (zh) | 用于确定对象的动脉血氧饱和度的设备和方法 | |
US20160022223A1 (en) | Multi-modal depth-resolved tissue status monitor | |
WO2018064569A1 (en) | Multi-modal depth-resolved tissue status and contact pressure monitor | |
Chacon et al. | A wearable pulse oximeter with wireless communication and motion artifact tailoring for continuous use | |
EP3380002A1 (en) | Wearable device and system for acquiring physiological information of a subject | |
US20190343432A1 (en) | Non-invasive hemoglobin and white blood cell sensors | |
US20220369942A1 (en) | Light-based non-invasive blood pressure systems and methods | |
US11304634B2 (en) | Non-invasive blood glucose sensor | |
Kao et al. | Towards maximizing the sensing accuracy of an cuffless, optical blood pressure sensor using a high-order front-end filter | |
Lu et al. | A prototype of reflection pulse oximeter designed for mobile healthcare | |
US10595755B2 (en) | System and method for monitoring glucose level | |
Mouradian et al. | Continuous wearable health monitoring using novel PPG optical sensor and device | |
Dzundza et al. | Principles of construction of hybrid microsystems for biomedical applications | |
Li et al. | A reflectance model for non-contact mapping of venous oxygen saturation using a CCD camera | |
US20240081696A1 (en) | Pulse oximetry methods, devices and systems | |
US10506961B1 (en) | Diagnostic transducer and method | |
Badiola et al. | Accuracy enhancement in reflective pulse oximetry by considering wavelength-dependent pathlengths | |
US10448843B1 (en) | Flow detection | |
RU2793540C1 (ru) | Портативное устройство и способ для неинвазивного измерения элементов крови | |
Mapar | Wearable Sensor for Continuously Vigilant Blood Perfusion and Oxygenation Monitoring |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20170926 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20180718 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180821 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20181022 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20181219 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190528 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190625 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6548639 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |