JP2016536024A - リン酸ジルコニウムの再充電方法及び装置 - Google Patents
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Abstract
Description
リン酸ジルコニウム再充電
再充電溶液送達プロセス流オプション
再充電溶液の実施例
Claims (40)
- 少なくとも1つの再充電流体を格納するように構成される流体源であって、前記流体源が、吸着剤透析での使用のために、少なくとも1つの再充電可能な吸着剤モジュールに流体接続可能である、流体源と、
前記流体源と前記再充電可能な吸着剤モジュールとを流体接続する流体流路であって、前記再充電流体が、前記流体流路内で、前記流体源から前記再充電可能な吸着剤モジュールの入口に流れ入り、次いで前記再充電可能な吸着剤モジュールの出口から流れ出る、流体流路と、を備える、再充電器。 - 前記再充電器が、少なくとも1つの再充電可能な吸着剤モジュールを解放可能に保持するように構成され、前記再充電可能な吸着剤モジュールが、リン酸ジルコニウムを格納する、請求項1に記載の前記再充電器。
- 少なくとも1つの再充電流体を各々格納する複数の流体源を更に備え、前記再充電流体が、前記流体源の各々から前記再充電可能な吸着剤モジュールの前記入口に流れ入り、次いで前記再充電可能な吸着剤モジュールの前記出口から流れ出る、請求項1に記載の前記再充電器。
- 前記再充電流体が前記再充電可能な吸着剤モジュールに流れ入る前に、各流体源からの前記再充電流体流が混合されるように、前記少なくとも2つの流体源と前記再充電可能な吸着剤モジュールとの間の前記流体流路内に位置付けられる混合器を更に備える、請求項3に記載の前記再充電器。
- 前記再充電流体を加熱するための加熱器を更に備える、請求項1に記載の前記再充電器。
- 前記加熱器が、前記流体源内の前記再充電流体を加熱する、請求項5に記載の前記再充電器。
- 前記再充電流体が、前記流体源から、前記加熱器を通り、次いで前記再充電可能な吸着剤モジュールに流れ入るように、前記加熱器が、前記流体源と前記再充電可能な吸着剤モジュールとの間の前記流体流路内に位置付けられる、請求項5に記載の前記再充電器。
- 前記流路に流体接続される水源を更に備え、前記水源からの水が、前記流路内で、再充電可能な吸着剤モジュールに流れ入る、請求項1に記載の前記再充電器。
- 前記再充電流体の特性を測定するための少なくとも1つのセンサを更に備える、請求項1に記載の前記再充電器。
- 前記センサが導電率センサである、請求項8に記載の前記再充電器。
- 前記流体源が貯蔵タンクである、請求項1に記載の前記再充電器。
- 前記貯蔵タンクが、複数の再充電可能な吸着剤モジュールを再充電するための前記再充電流体を格納する、請求項10に記載の前記再充電器。
- 前記再充電器が、少なくとも1つの再充電可能な吸着剤モジュールを解放可能に保持するように構成され、前記再充電可能な吸着剤モジュールが、前記流体源に流体接続可能である、請求項1に記載の前記再充電器。
- 第1の流体源がナトリウム塩を格納し、第2の流体源が塩基を格納し、第3の流体源が酸を格納する、請求項3に記載の前記再充電器。
- a)前記流体源が、塩化ナトリウム、酢酸ナトリウム、及び酢酸を格納する、
b)前記再充電器が、第1の流体源及び第2の流体源を備え、前記第1の流体源が塩化ナトリウム及び酢酸ナトリウムを格納し、前記第2の流体源が酢酸を格納する、
c)前記再充電器が、第1の流体源、第2の流体源、及び第3の流体源を備え、前記第1の流体源がナトリウム塩を格納し、前記第2の流体源が水酸化ナトリウムを格納し、前記第3の流体源が酢酸を格納する、
d)前記再充電器が、第1の流体源、第2の流体源、及び第3の流体源を備え、前記第1の流体源が飽和塩化ナトリウム溶液を格納し、前記第2の流体源が塩基を格納し、前記第3の流体源が酸を格納する、
e)前記再充電器が、第1の流体源及び第2の流体源を備え、前記第1の流体源が塩化ナトリウム及び二酢酸ナトリウムを格納し、前記第2の流体源が酢酸を格納する、
f)前記再充電器が、第1の流体源、第2の流体源、及び第3の流体源を備え、前記第1の流体源がナトリウム塩を格納し、前記第2の流体源が酢酸ナトリウムを格納し、前記第3の流体源が酢酸を格納する、ならびに
g)前記再充電器が、第1の流体源及び第2の流体源を備え、前記第1の流体源が塩化ナトリウム及び塩基を格納し、前記第2の流体源が酸を格納する、のうちのいずれか1つである、請求項1に記載の前記再充電器。 - 前記流体源から前記流体流路に流れ入る前記再充電流体を制御するための少なくとも1つのポンプを更に備える、請求項1に記載の前記再充電器。
- 熱交換器を更に備え、前記熱交換器が少なくとも2つの区画を備え、前記再充電流体が、前記再充電可能な吸着剤モジュールに入る前に、前記流体源から前記熱交換器の第1の区画に流れ入り、かつ前記再充電流体が、前記再充電可能な吸着剤モジュールから流れ出た後に、前記熱交換器の第2の区画に流れ入る、請求項4に記載の前記再充電器。
- 前記再充電器が、少なくとも1つの再充電可能な吸着剤モジュールを解放可能に保持するように構成され、前記再充電可能な吸着剤モジュールが、酸化ジルコニウムを格納する、請求項1に記載の前記再充電器。
- リン酸ジルコニウムを再充電する方法であって、
イオン交換のために、前記リン酸ジルコニウムに単一溶液を通過させることを含み、前記リン酸ジルコニウムに前記単一溶液を通過させることが、透析中に使用される透析液中で実質的に一貫したpHを維持することになるリン酸ジルコニウムをもたらす、前記方法。 - 前記単一溶液が、ナトリウム塩/緩衝溶液を含む、請求項19に記載の前記方法。
- 前記単一溶液のpH値が、次の治療セッション中に所望されるpHプロファイルに従って予め決定される、請求項19に記載の前記方法。
- 前記単一溶液が、所定のナトリウム濃度を有する第1の溶液と、所定の酸濃度を有する第2の溶液とを混合することにより生成される、請求項19に記載の前記方法。
- 前記第1の溶液が、本質的に酢酸ナトリウム及び塩化ナトリウムからなり、前記第2の溶液が、酢酸溶液である、請求項22に記載の前記方法。
- 前記第1の溶液及び前記第2の溶液が各々、所定の濃度で混合器に導入される、請求項22に記載の前記方法。
- 前記単一溶液の温度を制御することを更に含む、請求項22に記載の前記方法。
- 前記単一溶液の前記温度が、混合前に、前記第1の溶液及び前記第2の溶液の温度を制御することによって制御される、請求項25に記載の前記方法。
- 前記単一溶液の前記温度が、混合後に、前記溶液を加熱するための加熱器を制御することによって制御される、請求項25に記載の前記方法。
- 前記単一溶液の1つ以上の成分が、再充電中に1つ以上の再充電器へ提供するために、単一の流体源内に格納される、請求項19に記載の前記方法。
- 第3の溶液が、前記第1の溶液及び前記第2の溶液と混合されて、再充電のための前記単一溶液を生成する、請求項22に記載の前記方法。
- 前記第1及び第2の溶液が、リン酸ジルコニウムの再充電のために使用される再充電器内で混合される、請求項22に記載の前記方法。
- 前記単一溶液の導電率及びpHのうちの少なくとも1つが測定される、請求項19に記載の前記方法。
- 前記リン酸ジルコニウムに前記単一溶液を通過させた後に、前記リン酸ジルコニウムに酸溶液を添加することを更に含む、請求項19に記載の前記方法。
- 前記リン酸ジルコニウムが、吸着剤透析での使用のために、吸着剤カートリッジ内に格納される、請求項19に記載の前記方法。
- 前記再使用可能なモジュールが、前記吸着剤カートリッジから脱離可能である、請求項33に記載の前記方法。
- 前記再使用可能なモジュールが、酸化ジルコニウムを更に格納する、請求項33に記載の前記方法。
- 前記方法が、再充電器を用いて実行される、請求項19に記載の前記方法。
- リン酸ジルコニウムを再充電するための溶液であって、少なくとも1つのナトリウム塩と少なくとも1つの酸との組み合わせを含み、前記溶液がリン酸ジルコニウムを再充電するために使用された後に、前記リン酸ジルコニウムを通過する透析液中で実質的に一貫したpHをもたらす所定のpH値を有する、前記溶液。
- 前記溶液が、酢酸ナトリウム/酢酸溶液、グリコール酸/グリコール酸塩溶液、クエン酸/クエン酸塩溶液、プロピオン酸塩/プロピオン酸溶液、一塩基性リン酸塩溶液、またはそれらの任意の組み合わせからなる群より選択される、請求項37に記載の前記溶液。
- 前記溶液が、塩化ナトリウム、酢酸ナトリウム、及び酢酸から本質的になる、請求項37に記載の前記溶液。
- 前記塩化ナトリウム、前記酢酸ナトリウム、及び前記酢酸の濃度が、それぞれ、約3.60M、0.40M、及び0.40M、またはそれぞれ、約3.88M、0.12M、及び0.40Mである、請求項39に記載の前記溶液。
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US201462016613P | 2014-06-24 | 2014-06-24 | |
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US62/077,159 | 2014-11-07 | ||
US14/642,847 | 2015-03-10 | ||
US14/642,847 US9974896B2 (en) | 2014-06-24 | 2015-03-10 | Method of zirconium phosphate recharging |
PCT/US2015/032494 WO2015199864A1 (en) | 2014-06-24 | 2015-05-26 | Zirconium phosphate recharging method and appartus |
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EP3160610A1 (en) | 2017-05-03 |
CN106470714A (zh) | 2017-03-01 |
EP3160610A4 (en) | 2018-03-14 |
CN106413878B (zh) | 2019-06-14 |
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