JP2016535758A5 - - Google Patents
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- Publication number
- JP2016535758A5 JP2016535758A5 JP2016534884A JP2016534884A JP2016535758A5 JP 2016535758 A5 JP2016535758 A5 JP 2016535758A5 JP 2016534884 A JP2016534884 A JP 2016534884A JP 2016534884 A JP2016534884 A JP 2016534884A JP 2016535758 A5 JP2016535758 A5 JP 2016535758A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- conh
- haloalkyl
- con
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(*)(C(*=*ICC#C*I)=**)N(*)* Chemical compound *C(*)(C(*=*ICC#C*I)=**)N(*)* 0.000 description 1
- VHZYAZSJQQFLNK-UHFFFAOYSA-N CC(C(C)(C)C(NO)=O)O Chemical compound CC(C(C)(C)C(NO)=O)O VHZYAZSJQQFLNK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361866823P | 2013-08-16 | 2013-08-16 | |
| US61/866,823 | 2013-08-16 | ||
| US201361867933P | 2013-08-20 | 2013-08-20 | |
| US61/867,933 | 2013-08-20 | ||
| PCT/US2014/051459 WO2015024010A2 (en) | 2013-08-16 | 2014-08-18 | Substituted hydroxamic acid compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018224004A Division JP2019077688A (ja) | 2013-08-16 | 2018-11-29 | 置換されたヒドロキサム酸化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016535758A JP2016535758A (ja) | 2016-11-17 |
| JP2016535758A5 true JP2016535758A5 (https=) | 2017-09-28 |
| JP6458270B2 JP6458270B2 (ja) | 2019-01-30 |
Family
ID=52468825
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016534884A Expired - Fee Related JP6458270B2 (ja) | 2013-08-16 | 2014-08-18 | 置換されたヒドロキサム酸化合物 |
| JP2018224004A Pending JP2019077688A (ja) | 2013-08-16 | 2018-11-29 | 置換されたヒドロキサム酸化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018224004A Pending JP2019077688A (ja) | 2013-08-16 | 2018-11-29 | 置換されたヒドロキサム酸化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10647664B2 (https=) |
| EP (1) | EP3041354A4 (https=) |
| JP (2) | JP6458270B2 (https=) |
| AU (1) | AU2014306451B2 (https=) |
| CA (1) | CA2921427A1 (https=) |
| WO (1) | WO2015024010A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10647664B2 (en) * | 2013-08-16 | 2020-05-12 | Duke University | Substituted hydroxamic acid compounds |
| CA2948077A1 (en) | 2014-05-16 | 2015-11-19 | Actelion Pharmaceuticals Ltd | Antibacterial quinazoline-4(3h)-one derivatives |
| EP3374350B1 (en) | 2015-11-09 | 2022-01-05 | Forge Therapeutics, Inc. | Hydroxypyridinone and hydroxypyrimidinone based compounds for treating bacterial infections |
| WO2017083434A1 (en) | 2015-11-09 | 2017-05-18 | Forge Therapeutics, Inc. | Pyrone based compounds for treating bacterial infections |
| EP4286001A3 (en) | 2016-04-25 | 2024-07-17 | Duke University | Benzoylglycine derivatives and methods of making and using same |
| MX388647B (es) * | 2016-12-23 | 2025-03-20 | Intervet Int Bv | Compuestos utiles para el tratamiento de una infeccion por mannheimia haemolytica o histophilus somni. |
| US11021471B2 (en) | 2017-05-10 | 2021-06-01 | Forge Therapeutics, Inc. | Antibacterial compounds |
| BR112020016270A2 (pt) * | 2018-02-10 | 2020-12-15 | Kbp Biosciences Co., Ltd. | Composto atuando como antibióticos |
| AU2019345150A1 (en) | 2018-09-20 | 2021-05-13 | Blacksmith Medicines, Inc. | Antibacterial compounds |
| WO2021195260A1 (en) | 2020-03-25 | 2021-09-30 | Forge Therapeutics, Inc. | Lpxc inhibitor and methods of making |
| CA3191084A1 (en) | 2020-09-09 | 2022-03-17 | Gerald Burke | Formulations of a somatostatin modulator |
| TW202322818A (zh) | 2021-09-28 | 2023-06-16 | 美商福吉醫療公司 | Lpxc抑制劑及其用途 |
| WO2024077160A2 (en) * | 2022-10-05 | 2024-04-11 | Duke University | Compositions comprising prodrugs of hydroxyamate-based compounds and methods of making and using same |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3351293A (en) | 1992-01-21 | 1993-08-03 | Glaxo Group Limited | Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation |
| TW448172B (en) | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
| US5925659A (en) | 1996-05-07 | 1999-07-20 | Merck & Co., Inc. | Antibacterial agents |
| GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
| JP2000344752A (ja) * | 1999-04-01 | 2000-12-12 | Sumitomo Pharmaceut Co Ltd | 点眼剤 |
| US6511993B1 (en) | 1999-06-03 | 2003-01-28 | Kevin Neil Dack | Metalloprotease inhibitors |
| CN100410236C (zh) * | 2002-01-29 | 2008-08-13 | 雪兰诺实验室有限公司 | 作为蛋白酪氨酸磷酸酶调节剂的取代亚甲基酰胺衍生物 |
| WO2003091247A2 (en) | 2002-04-25 | 2003-11-06 | Pharmacia Corporation | Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
| EP1539744A4 (en) | 2002-07-11 | 2007-06-06 | Vicuron Pharm Inc | N-HYDROXYAMIDE DERIVATIVES WITH ANTIBACTERIAL EFFECT |
| KR101076018B1 (ko) * | 2003-01-08 | 2011-10-21 | 유니버시티 오브 워싱톤 | 항균제 |
| US20050154022A1 (en) | 2004-01-14 | 2005-07-14 | H. Lundbeck A/S | 4-aryl piperidines |
| US7638513B2 (en) | 2004-06-02 | 2009-12-29 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| AT502219B1 (de) | 2005-08-04 | 2007-04-15 | Sanochemia Pharmazeutika Ag | Verfahren zur reindarstellung von 5-substituierten tetrazolen |
| KR20080070876A (ko) | 2005-12-01 | 2008-07-31 | 쉐링 코포레이션 | 염증 질환 및 미생물 질병 치료용 조성물 |
| WO2008027466A1 (en) | 2006-08-31 | 2008-03-06 | Schering Corporation | Hydantoin derivatives useful as antibacterial agents |
| JP5227304B2 (ja) | 2007-02-28 | 2013-07-03 | 大正製薬株式会社 | 新規なヒドロキサム酸誘導体 |
| TWI519508B (zh) | 2007-06-12 | 2016-02-01 | Achaogen Inc | 抗菌劑 |
| US20110212078A1 (en) | 2008-06-25 | 2011-09-01 | Reddy Panduranga Adulla P | Synthesis and use of heterocyclic antibacterial agents |
| WO2010017060A1 (en) | 2008-08-04 | 2010-02-11 | Schering Corporation | Urea derivatives as antibacterial agents |
| JP5455913B2 (ja) | 2008-08-27 | 2014-03-26 | 大正製薬株式会社 | ナフチリジン−ｎ−オキシドを有する新規ヒドロキサム酸誘導体 |
| US8372885B2 (en) * | 2008-09-17 | 2013-02-12 | Novartis Ag | Organic compounds and their uses |
| WO2010100475A1 (en) | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
| WO2011005355A1 (en) | 2009-05-07 | 2011-01-13 | Achaogen, Inc. | Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria |
| WO2011045703A2 (en) | 2009-10-13 | 2011-04-21 | Pfizer Inc. | C-linked hydroxamic acid derivatives useful as antibacterial agents |
| US8389536B2 (en) | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
| WO2011073845A1 (en) | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| WO2011132712A1 (ja) | 2010-04-20 | 2011-10-27 | 大正製薬株式会社 | 新規なヒドロキサム酸誘導体 |
| WO2012031298A2 (en) * | 2010-09-03 | 2012-03-08 | Duke University | Ethynylbenzene derivatives |
| US8772300B2 (en) * | 2011-04-19 | 2014-07-08 | Hoffmann-La Roche Inc. | Phenyl or pyridinyl-ethynyl derivatives |
| WO2013049255A1 (en) * | 2011-09-26 | 2013-04-04 | Vanderbilt University | Substitued 5-(prop-1-yn-1-yl)picolinamide analogs as allosteric modulators of mglur5 receptors |
| JP6006609B2 (ja) * | 2011-10-19 | 2016-10-12 | 大正製薬株式会社 | 新規なヒドロキサム酸誘導体を含有する医薬 |
| EP2847168A1 (en) * | 2012-05-10 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| DK2975022T3 (da) * | 2013-03-15 | 2019-07-15 | Fujifilm Toyama Chemical Co Ltd | Hidtil ukendt hydroxaminsyrederivat eller salt deraf |
| US10647664B2 (en) * | 2013-08-16 | 2020-05-12 | Duke University | Substituted hydroxamic acid compounds |
-
2014
- 2014-08-18 US US14/912,134 patent/US10647664B2/en not_active Expired - Fee Related
- 2014-08-18 JP JP2016534884A patent/JP6458270B2/ja not_active Expired - Fee Related
- 2014-08-18 WO PCT/US2014/051459 patent/WO2015024010A2/en not_active Ceased
- 2014-08-18 AU AU2014306451A patent/AU2014306451B2/en not_active Ceased
- 2014-08-18 EP EP14836244.5A patent/EP3041354A4/en not_active Withdrawn
- 2014-08-18 CA CA2921427A patent/CA2921427A1/en not_active Abandoned
-
2018
- 2018-11-29 JP JP2018224004A patent/JP2019077688A/ja active Pending
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