JP2016535758A5 - - Google Patents
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- Publication number
- JP2016535758A5 JP2016535758A5 JP2016534884A JP2016534884A JP2016535758A5 JP 2016535758 A5 JP2016535758 A5 JP 2016535758A5 JP 2016534884 A JP2016534884 A JP 2016534884A JP 2016534884 A JP2016534884 A JP 2016534884A JP 2016535758 A5 JP2016535758 A5 JP 2016535758A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- conh
- haloalkyl
- con
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(*)(C(*=*ICC#C*I)=**)N(*)* Chemical compound *C(*)(C(*=*ICC#C*I)=**)N(*)* 0.000 description 1
- VHZYAZSJQQFLNK-UHFFFAOYSA-N CC(C(C)(C)C(NO)=O)O Chemical compound CC(C(C)(C)C(NO)=O)O VHZYAZSJQQFLNK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361866823P | 2013-08-16 | 2013-08-16 | |
| US61/866,823 | 2013-08-16 | ||
| US201361867933P | 2013-08-20 | 2013-08-20 | |
| US61/867,933 | 2013-08-20 | ||
| PCT/US2014/051459 WO2015024010A2 (en) | 2013-08-16 | 2014-08-18 | Substituted hydroxamic acid compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018224004A Division JP2019077688A (ja) | 2013-08-16 | 2018-11-29 | 置換されたヒドロキサム酸化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016535758A JP2016535758A (ja) | 2016-11-17 |
| JP2016535758A5 true JP2016535758A5 (https=) | 2017-09-28 |
| JP6458270B2 JP6458270B2 (ja) | 2019-01-30 |
Family
ID=52468825
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016534884A Expired - Fee Related JP6458270B2 (ja) | 2013-08-16 | 2014-08-18 | 置換されたヒドロキサム酸化合物 |
| JP2018224004A Pending JP2019077688A (ja) | 2013-08-16 | 2018-11-29 | 置換されたヒドロキサム酸化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018224004A Pending JP2019077688A (ja) | 2013-08-16 | 2018-11-29 | 置換されたヒドロキサム酸化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10647664B2 (https=) |
| EP (1) | EP3041354A4 (https=) |
| JP (2) | JP6458270B2 (https=) |
| AU (1) | AU2014306451B2 (https=) |
| CA (1) | CA2921427A1 (https=) |
| WO (1) | WO2015024010A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2921427A1 (en) * | 2013-08-16 | 2015-02-19 | Duke University | Substituted hydroxamic acid compounds |
| ES2687040T3 (es) | 2014-05-16 | 2018-10-23 | Idorsia Pharmaceuticals Ltd | Derivados antibacterianos de quinazolin4(3H)ona |
| WO2017083431A2 (en) | 2015-11-09 | 2017-05-18 | Forge Therapeutics, Inc. | Hydroxypyridinone and hydroxypyrimidinone based compounds for treating bacterial infections |
| EP3374355A4 (en) | 2015-11-09 | 2019-04-17 | Forge Therapeutics, Inc. | COMPOUNDS BASED ON PYRONE AND METHOD FOR THE TREATMENT OF BACTERIAL INFECTIONS |
| EP3448375B1 (en) * | 2016-04-25 | 2023-09-27 | Duke University | Benzoylglycine derivatives and methods of making and using same |
| EP3558939A1 (en) * | 2016-12-23 | 2019-10-30 | Intervet International B.V. | Compounds useful for treating a mannheimia haemolytica or histophilus somni infection |
| EP3621962A4 (en) | 2017-05-10 | 2020-12-09 | Forge Therapeutics, Inc. | ANTIBACTERIAL COMPOUNDS |
| WO2019154412A1 (zh) * | 2018-02-10 | 2019-08-15 | 山东亨利医药科技有限责任公司 | 作为抗菌素的化合物 |
| IL281614B2 (en) * | 2018-09-20 | 2024-12-01 | Blacksmith Medicines Inc | Antibacterial compounds |
| WO2021195260A1 (en) | 2020-03-25 | 2021-09-30 | Forge Therapeutics, Inc. | Lpxc inhibitor and methods of making |
| FI4210700T3 (fi) | 2020-09-09 | 2025-09-16 | Crinetics Pharmaceuticals Inc | Somatostatiinimodulaatorin formulaatioita |
| JP2024536864A (ja) | 2021-09-28 | 2024-10-08 | ブラックスミス メディシンズ，インク． | Ｌｐｘｃ阻害剤およびその使用 |
| WO2024077160A2 (en) * | 2022-10-05 | 2024-04-11 | Duke University | Compositions comprising prodrugs of hydroxyamate-based compounds and methods of making and using same |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3351293A (en) | 1992-01-21 | 1993-08-03 | Glaxo Group Limited | Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation |
| TW448172B (en) | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
| US5925659A (en) | 1996-05-07 | 1999-07-20 | Merck & Co., Inc. | Antibacterial agents |
| GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
| JP2000344752A (ja) * | 1999-04-01 | 2000-12-12 | Sumitomo Pharmaceut Co Ltd | 点眼剤 |
| US6511993B1 (en) | 1999-06-03 | 2003-01-28 | Kevin Neil Dack | Metalloprotease inhibitors |
| CN100410236C (zh) * | 2002-01-29 | 2008-08-13 | 雪兰诺实验室有限公司 | 作为蛋白酪氨酸磷酸酶调节剂的取代亚甲基酰胺衍生物 |
| MXPA04010555A (es) | 2002-04-25 | 2005-02-17 | Pharmacia Corp | Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa. |
| KR101011373B1 (ko) | 2002-07-11 | 2011-01-28 | 비큐론 파마슈티컬스 인코포레이티드 | 항균작용을 갖는 ｎ-히드록시아미드 유도체 |
| CA2851462A1 (en) | 2003-01-08 | 2004-07-29 | University Of Washington | Antibacterial agents |
| US20050154022A1 (en) | 2004-01-14 | 2005-07-14 | H. Lundbeck A/S | 4-aryl piperidines |
| US7638513B2 (en) | 2004-06-02 | 2009-12-29 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| AT502219B1 (de) | 2005-08-04 | 2007-04-15 | Sanochemia Pharmazeutika Ag | Verfahren zur reindarstellung von 5-substituierten tetrazolen |
| WO2007064732A1 (en) | 2005-12-01 | 2007-06-07 | Schering Corporation | Compounds for the treatment of inflammatory disorders and microbial diseases |
| EP2057127B1 (en) | 2006-08-31 | 2012-01-11 | Schering Corporation | Hydantoin derivatives useful as antibacterial agents |
| WO2008105515A1 (ja) | 2007-02-28 | 2008-09-04 | Taisho Pharmaceutical Co., Ltd. | 新規なヒドロキサム酸誘導体 |
| JP5539864B2 (ja) | 2007-06-12 | 2014-07-02 | アカオゲン，インコーポレーテッド | 抗菌剤 |
| ES2408932T3 (es) | 2008-06-25 | 2013-06-24 | Merck Sharp & Dohme Corp. | Síntesis y uso de agentes antibacterianos heterocíclicos |
| EP2315746A1 (en) | 2008-08-04 | 2011-05-04 | Schering Corporation | Urea derivatives as antibacterial agents |
| JP5455913B2 (ja) | 2008-08-27 | 2014-03-26 | 大正製薬株式会社 | ナフチリジン−ｎ−オキシドを有する新規ヒドロキサム酸誘導体 |
| US8372885B2 (en) * | 2008-09-17 | 2013-02-12 | Novartis Ag | Organic compounds and their uses |
| WO2010100475A1 (en) | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
| WO2011005355A1 (en) | 2009-05-07 | 2011-01-13 | Achaogen, Inc. | Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria |
| WO2011045703A2 (en) | 2009-10-13 | 2011-04-21 | Pfizer Inc. | C-linked hydroxamic acid derivatives useful as antibacterial agents |
| US8389536B2 (en) | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
| DK2512474T3 (en) | 2009-12-16 | 2014-12-01 | Pfizer | N-linked hydroxamic acid derivatives which can be used as antibacterial agents |
| CA2796750C (en) | 2010-04-20 | 2017-09-19 | Taisho Pharmaceutical Co., Ltd. | Novel hydroxamic acid derivative |
| WO2012031298A2 (en) | 2010-09-03 | 2012-03-08 | Duke University | Ethynylbenzene derivatives |
| US8772300B2 (en) * | 2011-04-19 | 2014-07-08 | Hoffmann-La Roche Inc. | Phenyl or pyridinyl-ethynyl derivatives |
| WO2013049255A1 (en) * | 2011-09-26 | 2013-04-04 | Vanderbilt University | Substitued 5-(prop-1-yn-1-yl)picolinamide analogs as allosteric modulators of mglur5 receptors |
| JP6006609B2 (ja) * | 2011-10-19 | 2016-10-12 | 大正製薬株式会社 | 新規なヒドロキサム酸誘導体を含有する医薬 |
| WO2013170165A1 (en) * | 2012-05-10 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
| JP6259814B2 (ja) * | 2013-03-15 | 2018-01-10 | 富山化学工業株式会社 | 新規なヒドロキサム酸誘導体またはその塩 |
| CA2921427A1 (en) * | 2013-08-16 | 2015-02-19 | Duke University | Substituted hydroxamic acid compounds |
-
2014
- 2014-08-18 CA CA2921427A patent/CA2921427A1/en not_active Abandoned
- 2014-08-18 EP EP14836244.5A patent/EP3041354A4/en not_active Withdrawn
- 2014-08-18 WO PCT/US2014/051459 patent/WO2015024010A2/en not_active Ceased
- 2014-08-18 JP JP2016534884A patent/JP6458270B2/ja not_active Expired - Fee Related
- 2014-08-18 AU AU2014306451A patent/AU2014306451B2/en not_active Ceased
- 2014-08-18 US US14/912,134 patent/US10647664B2/en not_active Expired - Fee Related
-
2018
- 2018-11-29 JP JP2018224004A patent/JP2019077688A/ja active Pending
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