JP2016535601A5 - - Google Patents
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- JP2016535601A5 JP2016535601A5 JP2016552246A JP2016552246A JP2016535601A5 JP 2016535601 A5 JP2016535601 A5 JP 2016535601A5 JP 2016552246 A JP2016552246 A JP 2016552246A JP 2016552246 A JP2016552246 A JP 2016552246A JP 2016535601 A5 JP2016535601 A5 JP 2016535601A5
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- Prior art keywords
- cell line
- paralog
- histone
- reagent
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 27
- 210000004027 cell Anatomy 0.000 claims 11
- 239000003153 chemical reaction reagent Substances 0.000 claims 8
- -1 BIO Chemical compound 0.000 claims 7
- 235000013622 meat product Nutrition 0.000 claims 6
- 230000006718 epigenetic regulation Effects 0.000 claims 5
- 230000004156 Wnt signaling pathway Effects 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 244000144972 livestock Species 0.000 claims 4
- 230000001114 myogenic effect Effects 0.000 claims 4
- AQGNHMOJWBZFQQ-UHFFFAOYSA-N CT 99021 Chemical compound CC1=CNC(C=2C(=NC(NCCNC=3N=CC(=CC=3)C#N)=NC=2)C=2C(=CC(Cl)=CC=2)Cl)=N1 AQGNHMOJWBZFQQ-UHFFFAOYSA-N 0.000 claims 3
- 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 claims 3
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 claims 3
- 108091023040 Transcription factor Proteins 0.000 claims 3
- 102000040945 Transcription factor Human genes 0.000 claims 3
- 108010077544 Chromatin Proteins 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 102000016680 Dioxygenases Human genes 0.000 claims 2
- 108010028143 Dioxygenases Proteins 0.000 claims 2
- 102000008157 Histone Demethylases Human genes 0.000 claims 2
- 108010074870 Histone Demethylases Proteins 0.000 claims 2
- 102000011787 Histone Methyltransferases Human genes 0.000 claims 2
- 108010036115 Histone Methyltransferases Proteins 0.000 claims 2
- 102000003893 Histone acetyltransferases Human genes 0.000 claims 2
- 108090000246 Histone acetyltransferases Proteins 0.000 claims 2
- 102000003964 Histone deacetylase Human genes 0.000 claims 2
- 108090000353 Histone deacetylase Proteins 0.000 claims 2
- 108010033040 Histones Proteins 0.000 claims 2
- 101001023043 Homo sapiens Myoblast determination protein 1 Proteins 0.000 claims 2
- 108060004795 Methyltransferase Proteins 0.000 claims 2
- 102000016397 Methyltransferase Human genes 0.000 claims 2
- 102100035077 Myoblast determination protein 1 Human genes 0.000 claims 2
- 210000003483 chromatin Anatomy 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims 2
- 210000001087 myotubule Anatomy 0.000 claims 2
- 244000144977 poultry Species 0.000 claims 2
- 238000007634 remodeling Methods 0.000 claims 2
- HPTXLHAHLXOAKV-INIZCTEOSA-N (2S)-2-(1,3-dioxo-2-isoindolyl)-3-(1H-indol-3-yl)propanoic acid Chemical compound O=C1C2=CC=CC=C2C(=O)N1[C@H](C(=O)O)CC1=CNC2=CC=CC=C12 HPTXLHAHLXOAKV-INIZCTEOSA-N 0.000 claims 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
- DXYYSGDWQCSKKO-UHFFFAOYSA-N 2-methylbenzothiazole Chemical compound C1=CC=C2SC(C)=NC2=C1 DXYYSGDWQCSKKO-UHFFFAOYSA-N 0.000 claims 1
- MDYDGUOQFUQOGE-UHFFFAOYSA-N 2-methylpropanethioic acid S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester Chemical compound S1C(NC(=O)CCCCCCSC(=O)C(C)C)=NC(C=2C=CC=CC=2)=C1 MDYDGUOQFUQOGE-UHFFFAOYSA-N 0.000 claims 1
- MAUCONCHVWBMHK-UHFFFAOYSA-N 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)-oxomethyl]phenoxy]ethyl]-2-benzofurancarboxamide Chemical compound O1C2=CC=CC=C2C(CN(C)C)=C1C(=O)NCCOC1=CC=C(C(=O)NO)C=C1 MAUCONCHVWBMHK-UHFFFAOYSA-N 0.000 claims 1
- VPVLEBIVXZSOMQ-UHFFFAOYSA-N 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol Chemical compound NC1=CC=CC(C=2NC3=NC=NC(OC=4C=C(O)C=CC=4)=C3C=2)=C1 VPVLEBIVXZSOMQ-UHFFFAOYSA-N 0.000 claims 1
- JHSXDAWGLCZYSM-UHFFFAOYSA-N 4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide Chemical compound CC1=CC(Cl)=CC=C1OCCCC(=O)NO JHSXDAWGLCZYSM-UHFFFAOYSA-N 0.000 claims 1
- DVNYTAVYBRSTGK-UHFFFAOYSA-N 5-aminoimidazole-4-carboxamide Chemical compound NC(=O)C=1N=CNC=1N DVNYTAVYBRSTGK-UHFFFAOYSA-N 0.000 claims 1
- RZWRYPGAUIOOMK-UHFFFAOYSA-N 5-nitroso-8-quinolinol Chemical compound C1=CN=C2C(O)=CC=C(N=O)C2=C1 RZWRYPGAUIOOMK-UHFFFAOYSA-N 0.000 claims 1
- JTDYUFSDZATMKU-UHFFFAOYSA-N 6-(1,3-dioxo-2-benzo[de]isoquinolinyl)-N-hydroxyhexanamide Chemical compound C1=CC(C(N(CCCCCC(=O)NO)C2=O)=O)=C3C2=CC=CC3=C1 JTDYUFSDZATMKU-UHFFFAOYSA-N 0.000 claims 1
- VUWMSJQZENJPHO-UHFFFAOYSA-N 7-oxo-7-(n-phenylanilino)heptanoic acid Chemical compound C=1C=CC=CC=1N(C(=O)CCCCCC(=O)O)C1=CC=CC=C1 VUWMSJQZENJPHO-UHFFFAOYSA-N 0.000 claims 1
- 241001550224 Apha Species 0.000 claims 1
- RFLHBLWLFUFFDZ-UHFFFAOYSA-N BML-210 Chemical compound NC1=CC=CC=C1NC(=O)CCCCCCC(=O)NC1=CC=CC=C1 RFLHBLWLFUFFDZ-UHFFFAOYSA-N 0.000 claims 1
- MDZCSIDIPDZWKL-UHFFFAOYSA-N CHIR-98014 Chemical compound C1=C([N+]([O-])=O)C(N)=NC(NCCNC=2N=C(C(=CN=2)N2C=NC=C2)C=2C(=CC(Cl)=CC=2)Cl)=C1 MDZCSIDIPDZWKL-UHFFFAOYSA-N 0.000 claims 1
- 102100028914 Catenin beta-1 Human genes 0.000 claims 1
- 230000007067 DNA methylation Effects 0.000 claims 1
- 102000001267 GSK3 Human genes 0.000 claims 1
- 108060006662 GSK3 Proteins 0.000 claims 1
- 102000006947 Histones Human genes 0.000 claims 1
- 101000916173 Homo sapiens Catenin beta-1 Proteins 0.000 claims 1
- 101000958865 Homo sapiens Myogenic factor 5 Proteins 0.000 claims 1
- 101000958866 Homo sapiens Myogenic factor 6 Proteins 0.000 claims 1
- 101000589002 Homo sapiens Myogenin Proteins 0.000 claims 1
- 101000613490 Homo sapiens Paired box protein Pax-3 Proteins 0.000 claims 1
- 101000601661 Homo sapiens Paired box protein Pax-7 Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 102100038380 Myogenic factor 5 Human genes 0.000 claims 1
- 102100038379 Myogenic factor 6 Human genes 0.000 claims 1
- 102100032970 Myogenin Human genes 0.000 claims 1
- HRNLUBSXIHFDHP-UHFFFAOYSA-N N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]benzamide Chemical compound NC1=CC=CC=C1NC(=O)C(C=C1)=CC=C1CNC1=NC=CC(C=2C=NC=CC=2)=N1 HRNLUBSXIHFDHP-UHFFFAOYSA-N 0.000 claims 1
- YALNUENQHAQXEA-UHFFFAOYSA-N N-[4-[(hydroxyamino)-oxomethyl]phenyl]carbamic acid [6-(diethylaminomethyl)-2-naphthalenyl]methyl ester Chemical compound C1=CC2=CC(CN(CC)CC)=CC=C2C=C1COC(=O)NC1=CC=C(C(=O)NO)C=C1 YALNUENQHAQXEA-UHFFFAOYSA-N 0.000 claims 1
- WWGBHDIHIVGYLZ-UHFFFAOYSA-N N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester Chemical compound C1=CC(NC(=O)OC(C)(C)C)=CC=C1C1=CC(C(=O)NCCCCCCC(=O)NO)=NO1 WWGBHDIHIVGYLZ-UHFFFAOYSA-N 0.000 claims 1
- 102100040891 Paired box protein Pax-3 Human genes 0.000 claims 1
- 102100037503 Paired box protein Pax-7 Human genes 0.000 claims 1
- RTKIYFITIVXBLE-UHFFFAOYSA-N Trichostatin A Natural products ONC(=O)C=CC(C)=CC(C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-UHFFFAOYSA-N 0.000 claims 1
- 229950008805 abexinostat Drugs 0.000 claims 1
- NCNRHFGMJRPRSK-MDZDMXLPSA-N belinostat Chemical compound ONC(=O)\C=C\C1=CC=CC(S(=O)(=O)NC=2C=CC=CC=2)=C1 NCNRHFGMJRPRSK-MDZDMXLPSA-N 0.000 claims 1
- 229960003094 belinostat Drugs 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229960003722 doxycycline Drugs 0.000 claims 1
- XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- INVTYAOGFAGBOE-UHFFFAOYSA-N entinostat Chemical compound NC1=CC=CC=C1NC(=O)C(C=C1)=CC=C1CNC(=O)OCC1=CC=CN=C1 INVTYAOGFAGBOE-UHFFFAOYSA-N 0.000 claims 1
- 210000000646 extraembryonic cell Anatomy 0.000 claims 1
- 235000012631 food intake Nutrition 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 238000010362 genome editing Methods 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000000663 muscle cell Anatomy 0.000 claims 1
- 210000000107 myocyte Anatomy 0.000 claims 1
- YAEMHJKFIIIULI-UHFFFAOYSA-N n-(4-methoxybenzyl)-n'-(5-nitro-1,3-thiazol-2-yl)urea Chemical compound C1=CC(OC)=CC=C1CNC(=O)NC1=NC=C([N+]([O-])=O)S1 YAEMHJKFIIIULI-UHFFFAOYSA-N 0.000 claims 1
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 claims 1
- OYKBQNOPCSXWBL-SNAWJCMRSA-N n-hydroxy-3-[(e)-3-(hydroxyamino)-3-oxoprop-1-enyl]benzamide Chemical compound ONC(=O)\C=C\C1=CC=CC(C(=O)NO)=C1 OYKBQNOPCSXWBL-SNAWJCMRSA-N 0.000 claims 1
- 229960005184 panobinostat Drugs 0.000 claims 1
- FWZRWHZDXBDTFK-ZHACJKMWSA-N panobinostat Chemical compound CC1=NC2=CC=C[CH]C2=C1CCNCC1=CC=C(\C=C\C(=O)NO)C=C1 FWZRWHZDXBDTFK-ZHACJKMWSA-N 0.000 claims 1
- MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 claims 1
- 210000001082 somatic cell Anatomy 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- VAZAPHZUAVEOMC-UHFFFAOYSA-N tacedinaline Chemical compound C1=CC(NC(=O)C)=CC=C1C(=O)NC1=CC=CC=C1N VAZAPHZUAVEOMC-UHFFFAOYSA-N 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 claims 1
- GOVYBPLHWIEHEJ-UHFFFAOYSA-N tubastatin A Chemical compound C1N(C)CCC2=C1C1=CC=CC=C1N2CC1=CC=C(C(=O)NO)C=C1 GOVYBPLHWIEHEJ-UHFFFAOYSA-N 0.000 claims 1
- WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims 1
- 229960000237 vorinostat Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361962068P | 2013-10-30 | 2013-10-30 | |
| US61/962,068 | 2013-10-30 | ||
| PCT/US2014/063250 WO2015066377A1 (en) | 2013-10-30 | 2014-10-30 | Method for scalable skeletal muscle lineage specification and cultivation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020005873A Division JP2020089381A (ja) | 2013-10-30 | 2020-01-17 | 拡張性のある骨格筋系譜形成及び培養の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016535601A JP2016535601A (ja) | 2016-11-17 |
| JP2016535601A5 true JP2016535601A5 (cg-RX-API-DMAC7.html) | 2017-12-07 |
| JP6728049B2 JP6728049B2 (ja) | 2020-07-22 |
Family
ID=53005145
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552246A Active JP6728049B2 (ja) | 2013-10-30 | 2014-10-30 | 拡張性のある骨格筋系譜形成及び培養の方法 |
| JP2020005873A Pending JP2020089381A (ja) | 2013-10-30 | 2020-01-17 | 拡張性のある骨格筋系譜形成及び培養の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020005873A Pending JP2020089381A (ja) | 2013-10-30 | 2020-01-17 | 拡張性のある骨格筋系譜形成及び培養の方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20160251625A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3071040B2 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6728049B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN111154726A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2014342180B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016009803B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2928726A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2782380T5 (cg-RX-API-DMAC7.html) |
| IL (2) | IL296889A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015066377A1 (cg-RX-API-DMAC7.html) |
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| EP4424837A3 (en) | 2017-05-06 | 2024-12-11 | Upside Foods, Inc. | Compositions and methods for increasing the culture density of a cellular biomass within a cultivation infrastructure |
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-
2014
- 2014-10-30 CN CN202010084479.7A patent/CN111154726A/zh active Pending
- 2014-10-30 EP EP14858383.4A patent/EP3071040B2/en active Active
- 2014-10-30 CA CA2928726A patent/CA2928726A1/en active Pending
- 2014-10-30 IL IL296889A patent/IL296889A/en unknown
- 2014-10-30 CN CN201480061537.7A patent/CN105899079A/zh not_active Withdrawn
- 2014-10-30 US US15/033,207 patent/US20160251625A1/en not_active Abandoned
- 2014-10-30 AU AU2014342180A patent/AU2014342180B2/en not_active Ceased
- 2014-10-30 ES ES14858383T patent/ES2782380T5/es active Active
- 2014-10-30 WO PCT/US2014/063250 patent/WO2015066377A1/en not_active Ceased
- 2014-10-30 BR BR112016009803-0A patent/BR112016009803B1/pt active IP Right Grant
- 2014-10-30 JP JP2016552246A patent/JP6728049B2/ja active Active
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2016
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2020
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2021
- 2021-02-12 US US17/175,324 patent/US20210171912A1/en not_active Abandoned
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