JP2016531924A5 - - Google Patents
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- Publication number
- JP2016531924A5 JP2016531924A5 JP2016540383A JP2016540383A JP2016531924A5 JP 2016531924 A5 JP2016531924 A5 JP 2016531924A5 JP 2016540383 A JP2016540383 A JP 2016540383A JP 2016540383 A JP2016540383 A JP 2016540383A JP 2016531924 A5 JP2016531924 A5 JP 2016531924A5
- Authority
- JP
- Japan
- Prior art keywords
- binding
- heavy chain
- binding molecule
- igm
- chain constant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000008878 coupling Effects 0.000 claims 7
- 238000010168 coupling process Methods 0.000 claims 7
- 238000005859 coupling reaction Methods 0.000 claims 7
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 4
- 102000006240 membrane receptors Human genes 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000005516 engineering process Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 108060003393 Granulin Proteins 0.000 claims 1
- 101000840258 Homo sapiens Immunoglobulin J chain Proteins 0.000 claims 1
- 102100029571 Immunoglobulin J chain Human genes 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361874277P | 2013-09-05 | 2013-09-05 | |
| US201361874284P | 2013-09-05 | 2013-09-05 | |
| US61/874,277 | 2013-09-05 | ||
| US61/874,284 | 2013-09-05 | ||
| PCT/US2014/054079 WO2015053887A1 (en) | 2013-09-05 | 2014-09-04 | Constant chain modified bispecific, penta- and hexavalent ig-m antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531924A JP2016531924A (ja) | 2016-10-13 |
| JP2016531924A5 true JP2016531924A5 (OSRAM) | 2017-10-12 |
| JP6721505B2 JP6721505B2 (ja) | 2020-07-15 |
Family
ID=51542496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540383A Expired - Fee Related JP6721505B2 (ja) | 2013-09-05 | 2014-09-04 | 定常領域が修飾された（ｃｏｎｓｔａｎｔ ｃｈａｉｎ ｍｏｄｉｆｉｅｄ）二重特異性五価及び六価Ｉｇ−Ｍ抗体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10351631B2 (OSRAM) |
| EP (1) | EP3041862B1 (OSRAM) |
| JP (1) | JP6721505B2 (OSRAM) |
| KR (1) | KR102306492B1 (OSRAM) |
| CN (1) | CN105722855B (OSRAM) |
| AU (1) | AU2014332458B2 (OSRAM) |
| CA (1) | CA2922830A1 (OSRAM) |
| DK (1) | DK3041862T3 (OSRAM) |
| WO (1) | WO2015053887A1 (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| BR112013019975A2 (pt) | 2011-02-28 | 2017-08-01 | Hoffmann La Roche | proteínas de ligação de antígeno, composição farmacêutica, uso de uma proteína de ligação de antígeno, método para o tratamento de um paciente e método para a preparação de uma proteína de ligação de antígeno, ácido nucleico, vetor e célula hospedeira" |
| CN103403025B (zh) | 2011-02-28 | 2016-10-12 | 弗·哈夫曼-拉罗切有限公司 | 单价抗原结合蛋白 |
| JP6422956B2 (ja) * | 2013-10-11 | 2018-11-14 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 多重特異性ドメイン交換共通可変軽鎖抗体 |
| EP3105250B1 (en) | 2014-02-10 | 2020-08-05 | IGM Biosciences, Inc. | Iga multi-specific binding molecules |
| WO2015153912A1 (en) | 2014-04-03 | 2015-10-08 | Igm Biosciences, Inc. | Modified j-chain |
| DK3247728T3 (da) | 2015-01-20 | 2020-07-13 | Igm Biosciences Inc | Tumornekrosefaktor-(tnf)-superfamiliereceptorbindende molekyler og anvendelser deraf |
| KR20240135877A (ko) * | 2015-03-04 | 2024-09-12 | 아이쥐엠 바이오사이언스 인코포레이티드 | Ｃｄ20 결합 분자 및 그의 용도 |
| US10604559B2 (en) | 2015-03-25 | 2020-03-31 | Igm Biosciences, Inc. | Multi-valent hepatitis B virus antigen binding molecules and uses thereof |
| CA2983034A1 (en) | 2015-04-17 | 2016-10-20 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| DK3356401T3 (da) * | 2015-09-30 | 2020-09-07 | Igm Biosciences Inc | Bindingsmolekyler med modificeret j-kæde |
| HK1252791A1 (zh) * | 2015-09-30 | 2019-06-06 | Igm Biosciences, Inc. | 具有经修饰的j链的结合分子 |
| SG11201809336QA (en) | 2016-05-09 | 2018-11-29 | Igm Biosciences Inc | Anti-pd-l1 antibodies |
| EP3607091A4 (en) | 2017-04-07 | 2021-01-20 | IGM Biosciences, Inc. | MODIFIED HUMAN CONSTANT IGM REGIONS FOR THE MODULATION OF COMPLEMENT-DEPENDENT CYTOLYSIS EFFECTOR FUNCTION |
| BR112020017296A2 (pt) | 2018-03-01 | 2020-12-29 | Igm Biosciences, Inc. | Mutações de igm fc e de cadeia j que afetam a meia-vida sérica de igm |
| JP2022544405A (ja) | 2019-08-15 | 2022-10-18 | アイジーエム バイオサイエンシズ インコーポレイテッド | 免疫刺激性多量体型結合分子 |
| AU2021260928A1 (en) | 2020-04-22 | 2022-10-27 | Igm Biosciences, Inc. | PD-1 agonist multimeric binding molecules |
| CA3245061A1 (en) | 2022-04-07 | 2023-10-12 | Repertoire Immune Medicines, Inc. | T-CELL RECEIVER MULTIMERS AND THEIR USES |
| JP2025532897A (ja) * | 2022-09-28 | 2025-10-03 | ドレン バイオ， インコーポレイテッド | 多重特異性抗体及びその使用方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8719963D0 (en) | 1987-08-24 | 1987-09-30 | Cattaneo A | Recombinant dna products |
| US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US20020062010A1 (en) * | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| EP1626992B1 (en) | 2003-05-23 | 2010-06-02 | Crucell Holland B.V. | Production of recombinant igm in per.c6 cells |
| CA2580336C (en) * | 2004-07-22 | 2016-07-19 | Roger Kingdon Craig | Vh heavy chain only antibodies, and vh heavy chain only dimer compounds and uses thereof |
| EP1814913B1 (en) | 2004-11-05 | 2015-08-19 | IGM Biosciences, Inc. | Antibody induced cell membrane wounding |
| US8349332B2 (en) * | 2005-04-06 | 2013-01-08 | Ibc Pharmaceuticals, Inc. | Multiple signaling pathways induced by hexavalent, monospecific and bispecific antibodies for enhanced toxicity to B-cell lymphomas and other diseases |
| ES2563027T3 (es) * | 2008-01-07 | 2016-03-10 | Amgen Inc. | Método para fabricación de moléculas heterodímeras Fc de anticuerpos utilizando efectos de conducción electrostática |
| US9676845B2 (en) * | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| US20130129723A1 (en) * | 2009-12-29 | 2013-05-23 | Emergent Product Development Seattle, Llc | Heterodimer Binding Proteins and Uses Thereof |
| WO2013049254A1 (en) | 2011-09-26 | 2013-04-04 | Jn Biosciences Llc | Hybrid constant regions |
| PL2794905T3 (pl) * | 2011-12-20 | 2020-11-02 | Medimmune, Llc | Zmodyfikowane polipeptydy dla rusztowań przeciwciał dwuswoistych |
| JP6335796B2 (ja) | 2012-02-08 | 2018-06-06 | アイジーエム バイオサイエンシズ インク．Ｉｇｍ Ｂｉｏｓｃｉｅｎｃｅｓ Ｉｎｃ． | Ｃｄｉｍ結合タンパク質及びその使用 |
| WO2015107126A1 (en) | 2014-01-16 | 2015-07-23 | Mondelli Mario Umberto Francesco | Neutralizing human monoclonal antibodies against hepatitis b virus surface antigen |
| EP3105250B1 (en) | 2014-02-10 | 2020-08-05 | IGM Biosciences, Inc. | Iga multi-specific binding molecules |
| WO2015153912A1 (en) | 2014-04-03 | 2015-10-08 | Igm Biosciences, Inc. | Modified j-chain |
| DK3247728T3 (da) | 2015-01-20 | 2020-07-13 | Igm Biosciences Inc | Tumornekrosefaktor-(tnf)-superfamiliereceptorbindende molekyler og anvendelser deraf |
| KR20240135877A (ko) | 2015-03-04 | 2024-09-12 | 아이쥐엠 바이오사이언스 인코포레이티드 | Ｃｄ20 결합 분자 및 그의 용도 |
| US10604559B2 (en) | 2015-03-25 | 2020-03-31 | Igm Biosciences, Inc. | Multi-valent hepatitis B virus antigen binding molecules and uses thereof |
| CA2983034A1 (en) | 2015-04-17 | 2016-10-20 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| DK3356401T3 (da) | 2015-09-30 | 2020-09-07 | Igm Biosciences Inc | Bindingsmolekyler med modificeret j-kæde |
| HK1252791A1 (zh) | 2015-09-30 | 2019-06-06 | Igm Biosciences, Inc. | 具有经修饰的j链的结合分子 |
| SG11201809336QA (en) | 2016-05-09 | 2018-11-29 | Igm Biosciences Inc | Anti-pd-l1 antibodies |
| WO2018017763A1 (en) | 2016-07-20 | 2018-01-25 | Igm Biosciences, Inc. | Multimeric cd40 binding molecules and uses thereof |
| CA3030634A1 (en) | 2016-07-20 | 2018-01-25 | Igm Biosciences, Inc. | Multimeric cd137/4-1bb binding molecules and uses thereof |
| WO2018017889A1 (en) | 2016-07-20 | 2018-01-25 | Igm Biosciences, Inc. | Multimeric gitr binding molecules and uses thereof |
| AU2017298483A1 (en) | 2016-07-20 | 2019-02-07 | Igm Biosciences, Inc. | Multimeric OX40 binding molecules and uses thereof |
-
2014
- 2014-09-04 AU AU2014332458A patent/AU2014332458B2/en not_active Ceased
- 2014-09-04 US US14/916,166 patent/US10351631B2/en active Active
- 2014-09-04 EP EP14766628.3A patent/EP3041862B1/en active Active
- 2014-09-04 CA CA2922830A patent/CA2922830A1/en active Pending
- 2014-09-04 JP JP2016540383A patent/JP6721505B2/ja not_active Expired - Fee Related
- 2014-09-04 DK DK14766628.3T patent/DK3041862T3/da active
- 2014-09-04 WO PCT/US2014/054079 patent/WO2015053887A1/en not_active Ceased
- 2014-09-04 CN CN201480051238.5A patent/CN105722855B/zh not_active Expired - Fee Related
- 2014-09-04 KR KR1020167007082A patent/KR102306492B1/ko not_active Expired - Fee Related
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