JP2016530316A5 - - Google Patents

Info

Publication number

JP2016530316A5

JP2016530316A5 JP2016542091A JP2016542091A JP2016530316A5 JP 2016530316 A5 JP2016530316 A5 JP 2016530316A5 JP 2016542091 A JP2016542091 A JP 2016542091A JP 2016542091 A JP2016542091 A JP 2016542091A JP 2016530316 A5 JP2016530316 A5 JP 2016530316A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

liquid pharmaceutical

composition according

water

oxo

Prior art date

2014-09-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000007788 liquid Substances 0.000 claims 20
• 239000008194 pharmaceutical composition Substances 0.000 claims 20
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 10
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 9
• 239000000203 mixture Substances 0.000 claims 7
• 239000004094 surface-active agent Substances 0.000 claims 7
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 6
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 6
• 229960000502 poloxamer Drugs 0.000 claims 6
• 229920001983 poloxamer Polymers 0.000 claims 6
• -1 Oxo-1 ′, 2 ′, 5,7-tetrahydrospiro [cyclopenta [b] pyridine-6,3′-pyrrolo [2,3-b] pyridine] -3-carboxamide trihydrate Chemical compound 0.000 claims 5
• DDOOFTLHJSMHLN-ZQHRPCGSSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=CC=CC=C1 DDOOFTLHJSMHLN-ZQHRPCGSSA-N 0.000 claims 3
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
• 229920001213 Polysorbate 20 Polymers 0.000 claims 3
• LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims 3
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 3
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 3
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 3
• 229920000053 polysorbate 80 Polymers 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 235000011067 sorbitan monolaureate Nutrition 0.000 claims 3
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
• 208000019695 Migraine disease Diseases 0.000 claims 2
• 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 239000012052 hydrophilic carrier Substances 0.000 claims 2
• 206010027599 migraine Diseases 0.000 claims 2
• URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical group CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 2
• NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 1
• NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 1
• 235000006679 Mentha X verticillata Nutrition 0.000 claims 1
• 235000002899 Mentha suaveolens Nutrition 0.000 claims 1
• 235000001636 Mentha x rotundifolia Nutrition 0.000 claims 1
• WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
• 239000004376 Sucralose Substances 0.000 claims 1
• DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 1
• 230000002821 anti-nucleating effect Effects 0.000 claims 1
• 239000003963 antioxidant agent Substances 0.000 claims 1
• 239000002738 chelating agent Substances 0.000 claims 1
• 239000003086 colorant Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 235000003599 food sweetener Nutrition 0.000 claims 1
• 150000002314 glycerols Chemical class 0.000 claims 1
• 239000001087 glyceryl triacetate Substances 0.000 claims 1
• 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
• 229940041616 menthol Drugs 0.000 claims 1
• 239000008368 mint flavor Substances 0.000 claims 1
• 150000007524 organic acids Chemical class 0.000 claims 1
• 235000005985 organic acids Nutrition 0.000 claims 1
• 239000007967 peppermint flavor Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 229920001223 polyethylene glycol Polymers 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
• 229940069328 povidone Drugs 0.000 claims 1
• 239000011780 sodium chloride Substances 0.000 claims 1
• BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims 1
• 235000019408 sucralose Nutrition 0.000 claims 1
• 239000003765 sweetening agent Substances 0.000 claims 1
• 229960002622 triacetin Drugs 0.000 claims 1
• 239000001069 triethyl citrate Substances 0.000 claims 1
• VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 1
• 235000013769 triethyl citrate Nutrition 0.000 claims 1