JP2016530297A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016530297A5 JP2016530297A5 JP2016540381A JP2016540381A JP2016530297A5 JP 2016530297 A5 JP2016530297 A5 JP 2016530297A5 JP 2016540381 A JP2016540381 A JP 2016540381A JP 2016540381 A JP2016540381 A JP 2016540381A JP 2016530297 A5 JP2016530297 A5 JP 2016530297A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- groups selected
- aryl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 76
- 229910052760 oxygen Inorganic materials 0.000 claims 49
- 229910052717 sulfur Inorganic materials 0.000 claims 48
- 229910052757 nitrogen Inorganic materials 0.000 claims 38
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 37
- 125000000623 heterocyclic group Chemical group 0.000 claims 28
- 229910052799 carbon Inorganic materials 0.000 claims 27
- 125000003545 alkoxy group Chemical group 0.000 claims 26
- 125000003118 aryl group Chemical group 0.000 claims 23
- 125000001072 heteroaryl group Chemical group 0.000 claims 23
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 125000003342 alkenyl group Chemical group 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 12
- 125000001475 halogen functional group Chemical group 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 125000000304 alkynyl group Chemical group 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 10
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 10
- 125000000262 haloalkenyl group Chemical group 0.000 claims 10
- 125000000232 haloalkynyl group Chemical group 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 8
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000006642 (C1-C6) cyanoalkyl group Chemical group 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 206010012434 Dermatitis allergic Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000006045 Spondylarthropathies Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- MKCBRYIXFFGIKN-UHFFFAOYSA-N bicyclo[1.1.1]pentane Chemical compound C1C2CC1C2 MKCBRYIXFFGIKN-UHFFFAOYSA-N 0.000 claims 1
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 230000000366 juvenile effect Effects 0.000 claims 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000005671 spondyloarthropathy Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 0 C*C(C)=*C(C(C)(*)C*1C(*(*)C(C)(C)*)=O)=C1N=C Chemical compound C*C(C)=*C(C(C)(*)C*1C(*(*)C(C)(C)*)=O)=C1N=C 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361874005P | 2013-09-05 | 2013-09-05 | |
| US61/874,005 | 2013-09-05 | ||
| PCT/US2014/054070 WO2015035032A1 (en) | 2013-09-05 | 2014-09-04 | Bicylic compounds as modulators of rorgamma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016530297A JP2016530297A (ja) | 2016-09-29 |
| JP2016530297A5 true JP2016530297A5 (https=) | 2017-10-12 |
| JP6501782B2 JP6501782B2 (ja) | 2019-04-17 |
Family
ID=51541378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540381A Active JP6501782B2 (ja) | 2013-09-05 | 2014-09-04 | Ｒｏｒガンマのモジュレーターとしての二環式化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9745267B2 (https=) |
| EP (1) | EP3041821B1 (https=) |
| JP (1) | JP6501782B2 (https=) |
| WO (1) | WO2015035032A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3027616B1 (en) * | 2013-07-30 | 2018-01-10 | Boehringer Ingelheim International GmbH | Azaindole compounds as modulators of rorc |
| AU2015210833B2 (en) | 2014-02-03 | 2019-01-03 | Vitae Pharmaceuticals, Llc | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| SI3294713T1 (sl) * | 2015-05-15 | 2021-08-31 | Aurigene Discovery Technologies Limited, | Nadomeščene spojine tetrahidrokinolinona kot ROR gama modulatorji |
| MA53943A (fr) | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals Llc | Modulateurs de ror-gamma |
| CN109071516B (zh) | 2015-12-15 | 2021-08-31 | 阿斯利康(瑞典)有限公司 | 新颖的化合物 |
| US11358967B2 (en) | 2016-01-20 | 2022-06-14 | Boehringer Ingelheim International Gmbh | Substituted pyrazino[2,3-b]pyrazines and pyrazino[2,3-c]pyridazines as modulators of ROR gamma |
| WO2018229155A1 (en) | 2017-06-14 | 2018-12-20 | Astrazeneca Ab | 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| WO2025090460A1 (en) * | 2023-10-23 | 2025-05-01 | The Regents Of The University Of California | Compounds and methods for treating cancer |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8211919B2 (en) * | 2005-09-02 | 2012-07-03 | Astellas Pharma Inc. | Amide derivatives as rock inhibitors |
| AU2009303444A1 (en) * | 2008-10-16 | 2010-04-22 | Schering Corporation | Azine derivatives and methods of use thereof |
| EP2459184A1 (en) | 2009-07-31 | 2012-06-06 | The Brigham and Women's Hospital, Inc. | Modulation of sgk1 expression in th17 cells to modulate th17-mediated immune responses |
| EP2487159A1 (en) * | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
| PE20141637A1 (es) * | 2011-04-28 | 2014-11-20 | Japan Tobacco Inc | Compuesto de amida y aplicacion farmaceutica para el mismo |
| US20140155381A1 (en) * | 2011-07-29 | 2014-06-05 | Erkan Baloglu | Compounds and methods |
| EP3027616B1 (en) * | 2013-07-30 | 2018-01-10 | Boehringer Ingelheim International GmbH | Azaindole compounds as modulators of rorc |
-
2014
- 2014-09-04 EP EP14766349.6A patent/EP3041821B1/en active Active
- 2014-09-04 WO PCT/US2014/054070 patent/WO2015035032A1/en not_active Ceased
- 2014-09-04 US US14/916,576 patent/US9745267B2/en active Active
- 2014-09-04 JP JP2016540381A patent/JP6501782B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016530297A5 (https=) | ||
| JP2017511357A5 (https=) | ||
| AR078012A1 (es) | Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus | |
| HRP20191579T1 (hr) | Spojevi kao modulatori za ror gama | |
| ES2618003T3 (es) | Compuestos tricíclicos sustituidos como inhibidores de FGFR | |
| AR081587A1 (es) | DERIVADOS DE 5,6-DIHIDRO-2H-[1,4]OXAZIN-3-IL-AMINA UTILES COMO INHIBIDORES DE LA b-SECRETASA (BACE) | |
| AR083946A1 (es) | Metodos de tratamiento con inhibidores selectivos de bcl-2 | |
| AR077417A1 (es) | Compuesto triazolopiridina y su accion como inhibidor de prolil hidroxilasa o agente inductor de la produccion de eritropoyetina | |
| AR075854A1 (es) | Inhibidores de beta- secretasa | |
| ME02667B (me) | Spiro-prstenasti spoj koji sadrži dušik i njegova upotreba u medicini | |
| JP2013533883A5 (https=) | ||
| AR080785A1 (es) | Derivados de imidazo[1,2-a]pirimidina ,proceso para prepararlos e intermediarios de dicha sintesis, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de patologias del sistema nervioso central,tales como esquizofrenia y parkinson, entre otros. | |
| ES2603931T3 (es) | Compuestos de triazolo | |
| RU2016118768A (ru) | Композиции, пригодные для лечения расстройств, связанных с kit | |
| AR076171A1 (es) | Pirazolopirimidinonas 1,6-disustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento del alzheimer, epilepsia y otras enfermedades del sistema nervioso central. | |
| AR086983A1 (es) | Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak | |
| MX2015015893A (es) | 2-fenilimidazo[1,2-a]pirimidinas como agentes formadores de imagen. | |
| AR080940A1 (es) | Compuestos heterociclicos utiles como inhibidores de quinasa | |
| MX2009008509A (es) | Compuesto de anillo puenteado-aza. | |
| JP2016507581A5 (https=) | ||
| MX373022B (es) | Inhibidores de kv1.3 y su aplicacion medica. | |
| RU2016135922A (ru) | Терапевтические соединения и композиции | |
| JP2021508318A5 (https=) | ||
| JP2016540803A5 (https=) | ||
| RU2018109761A (ru) | Способ получения (4s)-4-(4-циано-2-метоксифенил)-5-этокси-2,8-диметил-1,4-дигидро-1,6-нафтиридин-3-карбоксамида и его очистка для применения в качестве фармацевтического биологически активного вещества |