JP6501782B2 - Ｒｏｒガンマのモジュレーターとしての二環式化合物 - Google Patents

Ｒｏｒガンマのモジュレーターとしての二環式化合物 Download PDF

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JP6501782B2
JP6501782B2 JP2016540381A JP2016540381A JP6501782B2 JP 6501782 B2 JP6501782 B2 JP 6501782B2 JP 2016540381 A JP2016540381 A JP 2016540381A JP 2016540381 A JP2016540381 A JP 2016540381A JP 6501782 B2 JP6501782 B2 JP 6501782B2
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JP2016530297A (ja
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ブライアン ニコラス クック
ブライアン ニコラス クック
ジョン ディー フーバー
ジョン ディー フーバー
ロバート オーウェン ヒューズ
ロバート オーウェン ヒューズ
トーマス マーティン ジュニア カーレイン
トーマス マーティン ジュニア カーレイン
セリナ ラソタ
セリナ ラソタ
シアン リ
シアン リ
シュアン リャン
シュアン リャン
インゴ アンドレアス ムゲ
インゴ アンドレアス ムゲ
チャン ジャン
チャン ジャン
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • C07D209/96—Spiro-condensed ring systems
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
JP2016540381A 2013-09-05 2014-09-04 Ｒｏｒガンマのモジュレーターとしての二環式化合物 Active JP6501782B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361874005P 2013-09-05 2013-09-05
US61/874,005 2013-09-05
PCT/US2014/054070 WO2015035032A1 (en) 2013-09-05 2014-09-04 Bicylic compounds as modulators of rorgamma

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JP2016530297A JP2016530297A (ja) 2016-09-29
JP2016530297A5 JP2016530297A5 (https=) 2017-10-12
JP6501782B2 true JP6501782B2 (ja) 2019-04-17

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US (1) US9745267B2 (https=)
EP (1) EP3041821B1 (https=)
JP (1) JP6501782B2 (https=)
WO (1) WO2015035032A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3027616B1 (en) * 2013-07-30 2018-01-10 Boehringer Ingelheim International GmbH Azaindole compounds as modulators of rorc
AU2015210833B2 (en) 2014-02-03 2019-01-03 Vitae Pharmaceuticals, Llc Dihydropyrrolopyridine inhibitors of ROR-gamma
SI3294713T1 (sl) * 2015-05-15 2021-08-31 Aurigene Discovery Technologies Limited, Nadomeščene spojine tetrahidrokinolinona kot ROR gama modulatorji
MA53943A (fr) 2015-11-20 2021-08-25 Vitae Pharmaceuticals Llc Modulateurs de ror-gamma
CN109071516B (zh) 2015-12-15 2021-08-31 阿斯利康(瑞典)有限公司 新颖的化合物
US11358967B2 (en) 2016-01-20 2022-06-14 Boehringer Ingelheim International Gmbh Substituted pyrazino[2,3-b]pyrazines and pyrazino[2,3-c]pyridazines as modulators of ROR gamma
WO2018229155A1 (en) 2017-06-14 2018-12-20 Astrazeneca Ab 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
WO2025090460A1 (en) * 2023-10-23 2025-05-01 The Regents Of The University Of California Compounds and methods for treating cancer

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8211919B2 (en) * 2005-09-02 2012-07-03 Astellas Pharma Inc. Amide derivatives as rock inhibitors
AU2009303444A1 (en) * 2008-10-16 2010-04-22 Schering Corporation Azine derivatives and methods of use thereof
EP2459184A1 (en) 2009-07-31 2012-06-06 The Brigham and Women's Hospital, Inc. Modulation of sgk1 expression in th17 cells to modulate th17-mediated immune responses
EP2487159A1 (en) * 2011-02-11 2012-08-15 MSD Oss B.V. RorgammaT inhibitors
PE20141637A1 (es) * 2011-04-28 2014-11-20 Japan Tobacco Inc Compuesto de amida y aplicacion farmaceutica para el mismo
US20140155381A1 (en) * 2011-07-29 2014-06-05 Erkan Baloglu Compounds and methods
EP3027616B1 (en) * 2013-07-30 2018-01-10 Boehringer Ingelheim International GmbH Azaindole compounds as modulators of rorc

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US20160251310A1 (en) 2016-09-01
EP3041821A1 (en) 2016-07-13
WO2015035032A1 (en) 2015-03-12
EP3041821B1 (en) 2018-05-30
US9745267B2 (en) 2017-08-29
JP2016530297A (ja) 2016-09-29

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