JP2016529254A5 - - Google Patents
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- Publication number
- JP2016529254A5 JP2016529254A5 JP2016533950A JP2016533950A JP2016529254A5 JP 2016529254 A5 JP2016529254 A5 JP 2016529254A5 JP 2016533950 A JP2016533950 A JP 2016533950A JP 2016533950 A JP2016533950 A JP 2016533950A JP 2016529254 A5 JP2016529254 A5 JP 2016529254A5
- Authority
- JP
- Japan
- Prior art keywords
- vaginal
- composition according
- administration
- mip
- semen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 7
- 210000001161 mammalian embryo Anatomy 0.000 claims 6
- -1 IL-2ra Proteins 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 210000000582 semen Anatomy 0.000 claims 4
- 230000006058 immune tolerance Effects 0.000 claims 3
- 230000009027 insemination Effects 0.000 claims 3
- 230000008774 maternal effect Effects 0.000 claims 3
- 230000035935 pregnancy Effects 0.000 claims 3
- 108010065805 Interleukin-12 Proteins 0.000 claims 2
- 102000013462 Interleukin-12 Human genes 0.000 claims 2
- 102100023487 Lens fiber major intrinsic protein Human genes 0.000 claims 2
- 108010047660 Mitochondrial intermediate peptidase Proteins 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 210000001215 vagina Anatomy 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 102100023995 Beta-nerve growth factor Human genes 0.000 claims 1
- 101710129634 Beta-nerve growth factor Proteins 0.000 claims 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 1
- 102100021936 C-C motif chemokine 27 Human genes 0.000 claims 1
- 101710112538 C-C motif chemokine 27 Proteins 0.000 claims 1
- 102100032367 C-C motif chemokine 5 Human genes 0.000 claims 1
- 102100032366 C-C motif chemokine 7 Human genes 0.000 claims 1
- 101710155834 C-C motif chemokine 7 Proteins 0.000 claims 1
- 102100036170 C-X-C motif chemokine 9 Human genes 0.000 claims 1
- 101710085500 C-X-C motif chemokine 9 Proteins 0.000 claims 1
- 108010055166 Chemokine CCL5 Proteins 0.000 claims 1
- 108010014419 Chemokine CXCL1 Proteins 0.000 claims 1
- 102000016950 Chemokine CXCL1 Human genes 0.000 claims 1
- 108010008951 Chemokine CXCL12 Proteins 0.000 claims 1
- 102000006573 Chemokine CXCL12 Human genes 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102100023688 Eotaxin Human genes 0.000 claims 1
- 101710139422 Eotaxin Proteins 0.000 claims 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 102100021866 Hepatocyte growth factor Human genes 0.000 claims 1
- 101000898034 Homo sapiens Hepatocyte growth factor Proteins 0.000 claims 1
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims 1
- 101000868152 Homo sapiens Son of sevenless homolog 1 Proteins 0.000 claims 1
- 101100369992 Homo sapiens TNFSF10 gene Proteins 0.000 claims 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 1
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 102000014158 Interleukin-12 Subunit p40 Human genes 0.000 claims 1
- 108010011429 Interleukin-12 Subunit p40 Proteins 0.000 claims 1
- 102000013691 Interleukin-17 Human genes 0.000 claims 1
- 108050003558 Interleukin-17 Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 108010002386 Interleukin-3 Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 108010002586 Interleukin-7 Proteins 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 108010002335 Interleukin-9 Proteins 0.000 claims 1
- 102000000585 Interleukin-9 Human genes 0.000 claims 1
- 102100020880 Kit ligand Human genes 0.000 claims 1
- 101710177504 Kit ligand Proteins 0.000 claims 1
- 102000016267 Leptin Human genes 0.000 claims 1
- 108010092277 Leptin Proteins 0.000 claims 1
- 102100032352 Leukemia inhibitory factor Human genes 0.000 claims 1
- 108090000581 Leukemia inhibitory factor Proteins 0.000 claims 1
- 102000004083 Lymphotoxin-alpha Human genes 0.000 claims 1
- 108090000542 Lymphotoxin-alpha Proteins 0.000 claims 1
- 102000034655 MIF Human genes 0.000 claims 1
- 108060004872 MIF Proteins 0.000 claims 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108700012411 TNFSF10 Proteins 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 102100024598 Tumor necrosis factor ligand superfamily member 10 Human genes 0.000 claims 1
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 102000009634 interleukin-1 receptor antagonist activity proteins Human genes 0.000 claims 1
- 108040001669 interleukin-1 receptor antagonist activity proteins Proteins 0.000 claims 1
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 claims 1
- 229940039781 leptin Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 229940044952 vaginal foam Drugs 0.000 claims 1
- 239000000259 vaginal foam Substances 0.000 claims 1
- 229940044950 vaginal gel Drugs 0.000 claims 1
- 239000000029 vaginal gel Substances 0.000 claims 1
- 229940044977 vaginal tablet Drugs 0.000 claims 1
- 239000000003 vaginal tablet Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1314452.2A GB201314452D0 (en) | 2013-08-13 | 2013-08-13 | Embryo implantation |
| GB1314452.2 | 2013-08-13 | ||
| PCT/GB2014/052450 WO2015022509A1 (en) | 2013-08-13 | 2014-08-11 | Embryo implantation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016529254A JP2016529254A (ja) | 2016-09-23 |
| JP2016529254A5 true JP2016529254A5 (enExample) | 2017-09-14 |
| JP6405382B2 JP6405382B2 (ja) | 2018-10-17 |
Family
ID=49262086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533950A Expired - Fee Related JP6405382B2 (ja) | 2013-08-13 | 2014-08-11 | 胚移植 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10159712B2 (enExample) |
| EP (1) | EP3033096B1 (enExample) |
| JP (1) | JP6405382B2 (enExample) |
| CN (1) | CN105555298B (enExample) |
| AU (1) | AU2014307714B2 (enExample) |
| CA (1) | CA2920373C (enExample) |
| DK (1) | DK3033096T3 (enExample) |
| ES (1) | ES2698969T3 (enExample) |
| GB (2) | GB201314452D0 (enExample) |
| PL (1) | PL3033096T3 (enExample) |
| PT (1) | PT3033096T (enExample) |
| SG (1) | SG11201600772XA (enExample) |
| WO (1) | WO2015022509A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201314452D0 (en) | 2013-08-13 | 2013-09-25 | Ostara Biomedical Ltd | Embryo implantation |
| GB201501302D0 (en) * | 2015-01-27 | 2015-03-11 | Ostara Biomedical Ltd | Embryo implantation |
| US10722560B2 (en) * | 2015-04-03 | 2020-07-28 | Nanocell Ltd. | Compositions for remodeling extracellular matrix and methods of use thereof |
| GB201517523D0 (en) * | 2015-10-05 | 2015-11-18 | Ostara Biomedical Ltd | Methods and compositions for managing reproduction |
| KR102127290B1 (ko) * | 2018-09-06 | 2020-06-26 | 고려대학교 산학협력단 | Fgf2를 유효성분으로 포함하는 임신촉진용 조성물 |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS563846B2 (enExample) | 1972-10-12 | 1981-01-27 | ||
| US4211769A (en) | 1977-08-24 | 1980-07-08 | Takeda Chemical Industries, Ltd. | Preparations for vaginal administration |
| US5395825A (en) * | 1993-03-10 | 1995-03-07 | Yale University | Fertility regulation with transforming growth factor β |
| GB9406463D0 (en) * | 1994-03-31 | 1994-05-25 | Medical Res Council | Cervical ripening |
| AU4652596A (en) | 1995-01-09 | 1996-07-31 | Atrix Laboratories, Inc. | Liquid polymer delivery system |
| AU6836896A (en) * | 1995-08-28 | 1997-03-19 | Toray Industries, Inc. | Fertility agent |
| AUPO550897A0 (en) * | 1997-03-06 | 1997-03-27 | Luminis Pty Limited | Treatment and diagnosis of an infertility condition |
| AU764479B2 (en) | 1998-10-29 | 2003-08-21 | Bristol-Myers Squibb Company | Compounds derived from an amine nucleus that are inhibitors of IMPDH enzyme |
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| AU2002317377A1 (en) | 2001-07-20 | 2003-03-03 | Cancer Research Technology Limited | Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer |
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| AU2002951531A0 (en) | 2002-09-20 | 2002-10-03 | The University Of Adelaide | Treatment and diagnosis of an infertility condition by measuring or inhibiting interferon-y |
| KR20050094832A (ko) * | 2002-12-31 | 2005-09-28 | 알투스 파마슈티컬스 인코포레이티드 | 단백질 결정과 이온성 중합체를 함유하는 복합체 |
| TW200505902A (en) | 2003-03-20 | 2005-02-16 | Schering Corp | Cannabinoid receptor ligands |
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| CA2540838C (en) | 2003-10-03 | 2014-12-16 | Thorn Bioscience, Llc | Process for the synchronization of ovulation for timed breeding without heat detection |
| US8338373B2 (en) | 2003-10-24 | 2012-12-25 | Nora Therapeutics, Inc. | Method for reducing the risk of spontaneous abortion in a human female subject |
| WO2005115456A2 (en) | 2004-05-28 | 2005-12-08 | President And Fellows Of Harvard College | METHODS OF MODULATING THE REPRODUCTIVE ENDOCRINE SYSTEM BY MODULATION OF TNFαACTIVITY |
| JP2008501035A (ja) * | 2004-05-28 | 2008-01-17 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | 妊孕性関連障害の治療におけるｉｌ−１７の使用 |
| EP2465534B1 (en) * | 2004-06-10 | 2017-03-29 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
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| EP2443230B1 (en) * | 2009-06-18 | 2017-07-26 | Takara Bio Europe AB | 3D CULTURING SYSTEMS FOR GROWTH AND DIFFERENTIATION OF HUMAN PLURIPOTENT STEM (hPS) CELLS |
| US9212177B2 (en) | 2009-08-05 | 2015-12-15 | Versitech Limited | Antiviral compounds and methods of making and using thereof |
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| AU2011256088B2 (en) | 2010-05-20 | 2015-03-26 | University Of Saskatchewan | Use of aromatase inhibitors for synchronizing ovulation, inducing superovulation or double ovulation and improving twinning and fertility in a mammal |
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| ITTO20111183A1 (it) * | 2011-12-21 | 2013-06-22 | Univ Degli Studi Torino | Mezzo condizionato ottenuto da cellule staminali mesenchimali placentari e suo uso nel trattamento terapeutico della preeclampsia |
| ITMI20122063A1 (it) | 2012-12-03 | 2014-06-04 | Marco Sbracia | Gm-csf per l'utilizzo nella prevenzione dell'aborto spontaneo e del fallimento dell'impianto dell'embrione |
| GB201314452D0 (en) | 2013-08-13 | 2013-09-25 | Ostara Biomedical Ltd | Embryo implantation |
| WO2015081157A1 (en) | 2013-11-27 | 2015-06-04 | Jbs United Animal Health Ii Llc | Method and composition for synchronizing time of insemination in gilts |
| GB201501302D0 (en) | 2015-01-27 | 2015-03-11 | Ostara Biomedical Ltd | Embryo implantation |
| GB201517523D0 (en) | 2015-10-05 | 2015-11-18 | Ostara Biomedical Ltd | Methods and compositions for managing reproduction |
-
2013
- 2013-08-13 GB GBGB1314452.2A patent/GB201314452D0/en not_active Ceased
-
2014
- 2014-08-11 JP JP2016533950A patent/JP6405382B2/ja not_active Expired - Fee Related
- 2014-08-11 CN CN201480052022.0A patent/CN105555298B/zh not_active Expired - Fee Related
- 2014-08-11 AU AU2014307714A patent/AU2014307714B2/en not_active Ceased
- 2014-08-11 ES ES14750630T patent/ES2698969T3/es active Active
- 2014-08-11 PL PL14750630T patent/PL3033096T3/pl unknown
- 2014-08-11 EP EP14750630.7A patent/EP3033096B1/en not_active Not-in-force
- 2014-08-11 WO PCT/GB2014/052450 patent/WO2015022509A1/en not_active Ceased
- 2014-08-11 PT PT14750630T patent/PT3033096T/pt unknown
- 2014-08-11 CA CA2920373A patent/CA2920373C/en not_active Expired - Fee Related
- 2014-08-11 DK DK14750630.7T patent/DK3033096T3/en active
- 2014-08-11 SG SG11201600772XA patent/SG11201600772XA/en unknown
- 2014-08-12 US US14/457,360 patent/US10159712B2/en not_active Expired - Fee Related
- 2014-08-12 GB GB1414258.2A patent/GB2521709B/en not_active Expired - Fee Related
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