JP2016529057A5 - - Google Patents
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- JP2016529057A5 JP2016529057A5 JP2016540309A JP2016540309A JP2016529057A5 JP 2016529057 A5 JP2016529057 A5 JP 2016529057A5 JP 2016540309 A JP2016540309 A JP 2016540309A JP 2016540309 A JP2016540309 A JP 2016540309A JP 2016529057 A5 JP2016529057 A5 JP 2016529057A5
- Authority
- JP
- Japan
- Prior art keywords
- extracellular matrix
- tissue material
- matrix tissue
- collagen
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000002744 extracellular matrix Anatomy 0.000 claims 56
- 239000000463 material Substances 0.000 claims 53
- 239000000203 mixture Substances 0.000 claims 38
- 102000008186 Collagen Human genes 0.000 claims 34
- 108010035532 Collagen Proteins 0.000 claims 34
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 21
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 21
- 229940112869 bone morphogenetic protein Drugs 0.000 claims 21
- 238000000034 method Methods 0.000 claims 21
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 15
- 229920000669 heparin Polymers 0.000 claims 15
- 229960002897 heparin Drugs 0.000 claims 15
- 239000001506 calcium phosphate Substances 0.000 claims 11
- 229920001436 collagen Polymers 0.000 claims 11
- 210000001519 tissue Anatomy 0.000 claims 10
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 9
- 235000011010 calcium phosphates Nutrition 0.000 claims 9
- 229920002971 Heparan sulfate Polymers 0.000 claims 6
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 6
- -1 calcium phosphate compound Chemical class 0.000 claims 5
- 230000009969 flowable effect Effects 0.000 claims 5
- 230000002188 osteogenic effect Effects 0.000 claims 5
- 102000003951 Erythropoietin Human genes 0.000 claims 4
- 108090000394 Erythropoietin Proteins 0.000 claims 4
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 4
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 4
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 4
- 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 claims 4
- 229940105423 erythropoietin Drugs 0.000 claims 4
- 239000000835 fiber Substances 0.000 claims 4
- 102000045896 human BMP2 Human genes 0.000 claims 4
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 102000003886 Glycoproteins Human genes 0.000 claims 2
- 108090000288 Glycoproteins Proteins 0.000 claims 2
- 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 claims 2
- 101000920686 Homo sapiens Erythropoietin Proteins 0.000 claims 2
- 102000016611 Proteoglycans Human genes 0.000 claims 2
- 108010067787 Proteoglycans Proteins 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 102000044890 human EPO Human genes 0.000 claims 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical group S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims 2
- 235000019731 tricalcium phosphate Nutrition 0.000 claims 2
- 229940078499 tricalcium phosphate Drugs 0.000 claims 2
- 208000010392 Bone Fractures Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 230000008468 bone growth Effects 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 231100001055 skeletal defect Toxicity 0.000 claims 1
- 210000004876 tela submucosa Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361872827P | 2013-09-02 | 2013-09-02 | |
| US61/872,827 | 2013-09-02 | ||
| PCT/US2014/053671 WO2015031882A1 (en) | 2013-09-02 | 2014-09-02 | Products comprising an extracellular matrix tissue material and osteogenic protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019073652A Division JP6882361B2 (ja) | 2013-09-02 | 2019-04-08 | 細胞外マトリックス組織物質および骨原性タンパク質を含む生成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016529057A JP2016529057A (ja) | 2016-09-23 |
| JP2016529057A5 true JP2016529057A5 (cg-RX-API-DMAC10.html) | 2017-08-31 |
Family
ID=52584065
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540309A Pending JP2016529057A (ja) | 2013-09-02 | 2014-09-02 | 細胞外マトリックス組織物質および骨原性タンパク質を含む生成物 |
| JP2019073652A Active JP6882361B2 (ja) | 2013-09-02 | 2019-04-08 | 細胞外マトリックス組織物質および骨原性タンパク質を含む生成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019073652A Active JP6882361B2 (ja) | 2013-09-02 | 2019-04-08 | 細胞外マトリックス組織物質および骨原性タンパク質を含む生成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20150065425A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3041483B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP2016529057A (cg-RX-API-DMAC10.html) |
| CN (1) | CN105636598B (cg-RX-API-DMAC10.html) |
| CA (1) | CA2923002C (cg-RX-API-DMAC10.html) |
| WO (1) | WO2015031882A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016274785A1 (en) * | 2015-06-09 | 2017-12-07 | Orthocyte Corporation | Osteogenic graft forming unit |
| WO2017003877A1 (en) * | 2015-06-30 | 2017-01-05 | Lattice Biologics Inc. | Modified extracellular matrix for enhanced stem cell homing and engraftment |
| CN106913908B (zh) * | 2015-12-25 | 2020-05-26 | 北京瑞健高科生物科技有限公司 | 一种具有结构记忆特性的细胞生长支架 |
| CN107913436A (zh) * | 2016-10-09 | 2018-04-17 | 刘英芹 | 作用于伤残组织原位的骨与软组织同步再生诱导剂 |
| KR20180133172A (ko) * | 2017-06-05 | 2018-12-13 | 주식회사 티앤알바이오팹 | 골 이식재 고정용 주사형 접착제 조성물의 제조방법 및 이를 통해 제조된 골 이식재 고정용 주사형 접착제 조성물 |
| US11464888B2 (en) | 2017-06-12 | 2022-10-11 | Warsaw Orthopedic, Inc. | Moldable formulations containing an oxysterol in an acellular tissue matrix |
| US20190091372A1 (en) * | 2017-09-27 | 2019-03-28 | Globus Medical, Inc. | Coagulum-based biomaterial compositions and methods thereof |
| CA3124677A1 (en) | 2018-12-25 | 2020-07-02 | Orthorebirth Co., Ltd. | A bone regeneration material having a cotton-wool like structure formed of a plurality of electrospun fibers |
| CN111500533B (zh) * | 2019-01-31 | 2024-07-16 | 华东理工大学 | 干细胞发生器及其构建方法 |
| CN111494711B (zh) | 2019-01-31 | 2023-06-23 | 华东理工大学 | 干细胞发生器产生的干细胞用于治疗造血损伤 |
| CN110585484A (zh) * | 2019-10-12 | 2019-12-20 | 上海白衣缘生物工程有限公司 | 一种骨组织用复合骨粉及其制备方法和应用 |
| CN114984327B (zh) * | 2022-06-18 | 2023-04-25 | 广州医科大学 | 一种复合骨缺损填补剂及其制备方法 |
| CN116370715B (zh) * | 2023-05-10 | 2024-05-17 | 首都医科大学附属北京口腔医院 | 一种含他汀类药物的可塑形多孔生物复合骨充填材料及制备方法 |
| CN120189435A (zh) * | 2023-12-04 | 2025-06-24 | 桂林医学院 | 关节结构重建诱导剂及其使用方法和用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2206509T3 (es) * | 1994-06-06 | 2004-05-16 | Case Western Reserve University | Biomatriz para la regeneracion de tejidos. |
| US6180606B1 (en) * | 1994-09-28 | 2001-01-30 | Gensci Orthobiologics, Inc. | Compositions with enhanced osteogenic potential, methods for making the same and uses thereof |
| US5711969A (en) * | 1995-04-07 | 1998-01-27 | Purdue Research Foundation | Large area submucosal tissue graft constructs |
| US5755791A (en) * | 1996-04-05 | 1998-05-26 | Purdue Research Foundation | Perforated submucosal tissue graft constructs |
| DE19816858A1 (de) * | 1998-04-16 | 1999-10-21 | Merck Patent Gmbh | Tricalciumphosphathaltige Biozementpasten mit Kohäsionspromotoren |
| CA2412012C (en) * | 2001-11-20 | 2011-08-02 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage |
| US7105001B2 (en) * | 2003-05-21 | 2006-09-12 | Mandelbaum Jon A | Surgical method and composition utilizing submucosal tissue to prevent incisional hernias |
| US20080274184A1 (en) * | 2004-03-31 | 2008-11-06 | Hunt James B | Ecm-Based Graft Material |
| CA2637616A1 (en) * | 2006-01-19 | 2007-07-26 | Osteotech, Inc. | Injectable and moldable bone substitute materials |
| EP1964583A1 (en) * | 2007-02-09 | 2008-09-03 | Royal College of Surgeons in Ireland | Process for producing a collagen/hydroxyapatite composite scaffold |
| JP2011513034A (ja) * | 2008-03-10 | 2011-04-28 | マーフライ・２・リミテッド・パートナーシップ | 骨セメント組成物 |
| RU2491076C2 (ru) * | 2008-03-31 | 2013-08-27 | Аугустинус БАДЕР | Способ и композиция для регенерации тканей с помощью стволовых или костномозговых клеток |
| WO2011115812A2 (en) * | 2010-03-16 | 2011-09-22 | Advanced Technologies And Regenerative Medicine, Llc | Affinity peptides toward bmp-2 |
| US20150065947A1 (en) * | 2013-09-02 | 2015-03-05 | Muffin Incorporated | Cell-seeded compositions and methods useful for treating bone regions |
-
2014
- 2014-09-02 US US14/474,722 patent/US20150065425A1/en not_active Abandoned
- 2014-09-02 CN CN201480056459.1A patent/CN105636598B/zh active Active
- 2014-09-02 CA CA2923002A patent/CA2923002C/en active Active
- 2014-09-02 EP EP14839440.6A patent/EP3041483B1/en active Active
- 2014-09-02 JP JP2016540309A patent/JP2016529057A/ja active Pending
- 2014-09-02 WO PCT/US2014/053671 patent/WO2015031882A1/en not_active Ceased
-
2016
- 2016-03-02 US US15/058,329 patent/US9993580B2/en active Active
-
2019
- 2019-04-08 JP JP2019073652A patent/JP6882361B2/ja active Active
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