JP2016528258A - 非コードｒｎａを形成するヘテロクロマチン - Google Patents
非コードｒｎａを形成するヘテロクロマチン Download PDFInfo
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- C12N15/09—Recombinant DNA-technology
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361866894P | 2013-08-16 | 2013-08-16 | |
| US61/866,894 | 2013-08-16 | ||
| PCT/US2014/051257 WO2015023937A1 (fr) | 2013-08-16 | 2014-08-15 | Arn non codant formant de l'hétérochromatine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2016528258A true JP2016528258A (ja) | 2016-09-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2016534865A Pending JP2016528258A (ja) | 2013-08-16 | 2014-08-15 | 非コードｒｎａを形成するヘテロクロマチン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20150225722A1 (fr) |
| EP (1) | EP3033114A4 (fr) |
| JP (1) | JP2016528258A (fr) |
| CN (1) | CN105682687A (fr) |
| CA (1) | CA2921457A1 (fr) |
| WO (1) | WO2015023937A1 (fr) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021532832A (ja) * | 2018-08-02 | 2021-12-02 | ダイン セラピューティクス, インコーポレーテッドDyne Therapeutics, Inc. | フリートライヒ運動失調症を処置するための筋標的化複合体およびそれらの使用 |
| US11844843B2 (en) | 2021-07-09 | 2023-12-19 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US11911484B2 (en) | 2018-08-02 | 2024-02-27 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US11931421B2 (en) | 2022-04-15 | 2024-03-19 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations for treating myotonic dystrophy |
| US12012460B2 (en) | 2018-08-02 | 2024-06-18 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| US12097263B2 (en) | 2024-01-19 | 2024-09-24 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015023941A1 (fr) | 2013-08-16 | 2015-02-19 | Rana Therapeutics, Inc. | Oligonucléotides ciblant des régions de l'euchromatine de gènes |
| EP3218483A4 (fr) | 2014-11-14 | 2018-07-18 | Ionis Pharmaceuticals, Inc. | Composés et procédés de modulation des protéines |
| US12011488B2 (en) | 2016-03-23 | 2024-06-18 | The Regents Of The University Of California | Methods of treating mitochondrial disorders |
| CA3018729A1 (fr) | 2016-03-23 | 2017-09-28 | The Regents Of The University Of California | Methodes de traitement de troubles mitochondriaux |
| JP2019535839A (ja) | 2016-11-29 | 2019-12-12 | ピュアテック ヘルス エルエルシー | 治療剤の送達のためのエクソソーム |
| WO2019126641A2 (fr) * | 2017-12-21 | 2019-06-27 | Ionis Pharmaceuticals, Inc. | Modulation de l'expression de la frataxine |
| CA3171432A1 (fr) * | 2020-03-16 | 2021-09-23 | Stephanie CHERQUI | Methodes de traitement de troubles mitochondriaux |
| IL313726A (en) * | 2021-12-23 | 2024-08-01 | Univ Massachusetts | Medical treatment of fragile X-linked disorder |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3329892A1 (de) * | 1983-08-18 | 1985-03-07 | Köster, Hubert, Prof. Dr., 2000 Hamburg | Verfahren zur herstellung von oligonucleotiden |
| RU2377301C2 (ru) * | 2003-12-23 | 2009-12-27 | Сантарис Фарма А/С | ОЛИГОМЕРНОЕ СОЕДИНЕНИЕ, ПОНИЖАЮЩЕЕ ЭКСПРЕССИЮ ЧЕЛОВЕЧЕСКОГО ГЕНА Bcl-2, КОНЪЮГАТ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ПРИМЕНЕНИЕ ОЛИГОМЕРНОГО СОЕДИНЕНИЯ ДЛЯ ЛЕЧЕНИЯ РАКА |
| WO2006063356A1 (fr) * | 2004-12-10 | 2006-06-15 | Isis Phamaceuticals, Inc. | Regulation du controle epigenetique de l'expression genique |
| CN101501193B (zh) * | 2006-08-11 | 2013-07-03 | 普罗森那技术公司 | 用于治疗与dna重复不稳定性相关的遗传病的方法和手段 |
| WO2009090182A1 (fr) * | 2008-01-14 | 2009-07-23 | Santaris Pharma A/S | Oligonucléotides de type « gapmère » de nucléotide d'adn substitué en c4' |
| CN101980726A (zh) * | 2008-02-08 | 2011-02-23 | 普罗森那控股公司 | 治疗与dna重复不稳定性相关的遗传病症的方法和装置 |
| KR20110091796A (ko) * | 2008-12-04 | 2011-08-12 | 오피케이오 큐알엔에이, 엘엘씨 | 종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료 |
| GB201010557D0 (en) * | 2010-06-23 | 2010-08-11 | Mina Therapeutics Ltd | RNA molecules and uses thereof |
| CN106434648A (zh) * | 2010-07-19 | 2017-02-22 | F·C·贝内特 | 肌强直性营养障碍蛋白激酶(dmpk)表达的调节 |
| JP6188686B2 (ja) * | 2011-06-09 | 2017-08-30 | カッパーアールエヌエー，インコーポレイテッド | フラタキシン（ｆｘｎ）への天然アンチセンス転写物の阻害によるｆｘｎ関連疾患の治療 |
| EP2751269B1 (fr) * | 2011-08-29 | 2016-03-23 | Ionis Pharmaceuticals, Inc. | Procédés et composés utiles dans des pathologies associées à des expansions répétées |
| JP6129844B2 (ja) * | 2011-09-14 | 2017-05-17 | ラナ セラピューティクス インコーポレイテッド | 多量体オリゴヌクレオチド化合物 |
| US20160201064A1 (en) * | 2013-08-16 | 2016-07-14 | Rana Therapeutics, Inc. | Compositions and methods for modulating expression of frataxin |
-
2014
- 2014-08-15 WO PCT/US2014/051257 patent/WO2015023937A1/fr active Application Filing
- 2014-08-15 EP EP14836175.1A patent/EP3033114A4/fr not_active Withdrawn
- 2014-08-15 CA CA2921457A patent/CA2921457A1/fr active Pending
- 2014-08-15 JP JP2016534865A patent/JP2016528258A/ja active Pending
- 2014-08-15 CN CN201480056984.3A patent/CN105682687A/zh active Pending
-
2015
- 2015-04-29 US US14/699,130 patent/US20150225722A1/en not_active Abandoned
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021532832A (ja) * | 2018-08-02 | 2021-12-02 | ダイン セラピューティクス, インコーポレーテッドDyne Therapeutics, Inc. | フリートライヒ運動失調症を処置するための筋標的化複合体およびそれらの使用 |
| US11911484B2 (en) | 2018-08-02 | 2024-02-27 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US12012460B2 (en) | 2018-08-02 | 2024-06-18 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| US11844843B2 (en) | 2021-07-09 | 2023-12-19 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US11931421B2 (en) | 2022-04-15 | 2024-03-19 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations for treating myotonic dystrophy |
| US12097263B2 (en) | 2024-01-19 | 2024-09-24 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2921457A1 (fr) | 2015-02-19 |
| US20150225722A1 (en) | 2015-08-13 |
| CN105682687A (zh) | 2016-06-15 |
| EP3033114A4 (fr) | 2017-04-05 |
| EP3033114A1 (fr) | 2016-06-22 |
| WO2015023937A1 (fr) | 2015-02-19 |
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