JP2016527199A5 - - Google Patents

Download PDF

Info

Publication number
JP2016527199A5
JP2016527199A5 JP2016518595A JP2016518595A JP2016527199A5 JP 2016527199 A5 JP2016527199 A5 JP 2016527199A5 JP 2016518595 A JP2016518595 A JP 2016518595A JP 2016518595 A JP2016518595 A JP 2016518595A JP 2016527199 A5 JP2016527199 A5 JP 2016527199A5
Authority
JP
Japan
Prior art keywords
region
seq
complex
peptide
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016518595A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016527199A (ja
JP6479777B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2014/002029 external-priority patent/WO2015025217A2/en
Publication of JP2016527199A publication Critical patent/JP2016527199A/ja
Publication of JP2016527199A5 publication Critical patent/JP2016527199A5/ja
Priority to JP2019019828A priority Critical patent/JP6942744B2/ja
Application granted granted Critical
Publication of JP6479777B2 publication Critical patent/JP6479777B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

JP2016518595A 2013-06-11 2014-06-11 生物学的に活性な特異的カーゴペプチドと結合したヒト由来の細胞透過性ペプチドの構造、製造および使用 Expired - Fee Related JP6479777B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019019828A JP6942744B2 (ja) 2013-06-11 2019-02-06 生物学的に活性な特異的カーゴペプチドと結合したヒト由来の細胞透過性ペプチドの構造、製造および使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361833819P 2013-06-11 2013-06-11
US61/833,819 2013-06-11
PCT/IB2014/002029 WO2015025217A2 (en) 2013-06-11 2014-06-11 Structure, manufacturing and uses of human-derived cell-permeable peptides conjugated with specific biologically active cargo peptides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019019828A Division JP6942744B2 (ja) 2013-06-11 2019-02-06 生物学的に活性な特異的カーゴペプチドと結合したヒト由来の細胞透過性ペプチドの構造、製造および使用

Publications (3)

Publication Number Publication Date
JP2016527199A JP2016527199A (ja) 2016-09-08
JP2016527199A5 true JP2016527199A5 (enExample) 2017-07-20
JP6479777B2 JP6479777B2 (ja) 2019-03-06

Family

ID=52484225

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016518595A Expired - Fee Related JP6479777B2 (ja) 2013-06-11 2014-06-11 生物学的に活性な特異的カーゴペプチドと結合したヒト由来の細胞透過性ペプチドの構造、製造および使用
JP2019019828A Expired - Fee Related JP6942744B2 (ja) 2013-06-11 2019-02-06 生物学的に活性な特異的カーゴペプチドと結合したヒト由来の細胞透過性ペプチドの構造、製造および使用
JP2021146120A Pending JP2021193112A (ja) 2013-06-11 2021-09-08 生物学的に活性な特異的カーゴペプチドと結合したヒト由来の細胞透過性ペプチドの構造、製造および使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2019019828A Expired - Fee Related JP6942744B2 (ja) 2013-06-11 2019-02-06 生物学的に活性な特異的カーゴペプチドと結合したヒト由来の細胞透過性ペプチドの構造、製造および使用
JP2021146120A Pending JP2021193112A (ja) 2013-06-11 2021-09-08 生物学的に活性な特異的カーゴペプチドと結合したヒト由来の細胞透過性ペプチドの構造、製造および使用

Country Status (12)

Country Link
US (3) US10301629B2 (enExample)
EP (2) EP3007729B1 (enExample)
JP (3) JP6479777B2 (enExample)
CN (1) CN105555317A (enExample)
AU (3) AU2014310360B2 (enExample)
CA (1) CA2915296A1 (enExample)
DK (2) DK3581207T5 (enExample)
ES (2) ES2745566T3 (enExample)
HK (1) HK1223838A1 (enExample)
MX (1) MX2015016588A (enExample)
WO (1) WO2015025217A2 (enExample)
ZA (1) ZA201600162B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014310360B2 (en) * 2013-06-11 2019-10-24 PPL (BVI) Limited Structure, manufacturing and uses of human-derived cell-permeable peptides conjugated with specific biologically active cargo peptides
HK1247933A1 (en) 2015-06-24 2018-10-05 Jcr Pharmaceuticals Co., Ltd. Fusion protein containing bdnf
WO2017189826A1 (en) * 2016-04-29 2017-11-02 Portage Pharmaceuticals Ltd. Use of cell-permeable peptides and non-peptide carriers conjugated with nemo binding domain cargo sequence for the treatment of dry eye disease and uveitis
AU2017358282C1 (en) * 2016-11-09 2020-11-26 Icm Co., Ltd. Nkx3.2 fragment and pharmaceutical composition comprising same as active ingredient
TWI833178B (zh) 2016-12-26 2024-02-21 日商Jcr製藥股份有限公司 通過血腦障壁之新穎抗人類運鐵蛋白受體抗體
TWI791006B (zh) 2016-12-26 2023-02-01 日商Jcr製藥股份有限公司 包含bdnf之融合蛋白質
JP2020508289A (ja) * 2017-01-31 2020-03-19 レジェンクスバイオ インコーポレーテッド 完全ヒトグリコシル化ヒトα−L−イズロニダーゼ(IDUA)を用いたムコ多糖症I型の治療
CN107033217A (zh) * 2017-03-29 2017-08-11 华中科技大学同济医学院附属协和医院 一种可抑制NF‑κB蛋白活化的多肽及检测sORF表达的方法
CN107236023B (zh) * 2017-05-12 2021-05-07 苏州创澜生物科技有限公司 一种用于检测结核感染的抗原组合物及其应用
CN107227343A (zh) * 2017-05-12 2017-10-03 苏州创澜生物科技有限公司 一种检测包含潜伏期结核感染的试剂盒及其引物对和探针
CA3068328A1 (en) 2017-07-06 2019-01-10 The Trustees Of The University Of Pennsylvania Aav9-mediated gene therapy for treating mucopolysaccharidosis type i
JP7727385B2 (ja) 2017-12-18 2025-08-21 ヴェンタナ メディカル システムズ, インク. ペプチド核酸コンジュゲート
US11897924B2 (en) * 2018-03-28 2024-02-13 Bioxodes Anticoagulant fusion proteins and uses thereof
EP3808840A4 (en) * 2018-06-14 2022-03-23 Avixgen Inc. Pharmaceutical composition comprising fusion protein of cell-penetrating peptide and rpe65 for treatment of leber's congenital amaurosis
CN113227121A (zh) * 2018-10-05 2021-08-06 Rnagene公司 通过特异性结合至靶细胞具有增强的多种免疫功能的嵌合抗原及其用途
US12115212B2 (en) * 2019-01-18 2024-10-15 L & J Bio Co., Ltd. Methods of decreasing amyloid beta (Aβ) plaque deposition and hyperphosphorylated tau plaque deposition in Alzheimer's disease using a cystatin C fusion protein
CN113795575A (zh) 2019-02-04 2021-12-14 自由行疗法有限公司 多核苷酸
WO2020163771A1 (en) * 2019-02-08 2020-08-13 Portage Glasgow Limited Structure, manufacturing and uses of hoxd12-pde8a cell-penetrating peptides
SG11202108812SA (en) * 2019-02-15 2021-09-29 Sigma Aldrich Co Llc Crispr/cas fusion proteins and systems
WO2021072056A1 (en) * 2019-10-08 2021-04-15 Portage Glasgow Limited P53 peptide disrupters of f0x04:p53 protein binding, variants and conjugates thereof.
BR112022017715A2 (pt) * 2020-03-04 2022-11-16 Flagship Pioneering Innovations Vi Llc Métodos e composições para modular um genoma
JP7834290B2 (ja) * 2020-12-22 2026-03-24 国立研究開発法人理化学研究所 医薬組成物
US20240316217A1 (en) * 2021-02-05 2024-09-26 Regents Of The University Of Minnesota Methods for preventing cardiac or skeletal defects in diseases including mucopolysaccharidoses
EP4308234A4 (en) * 2021-03-16 2025-01-22 Rush University Medical Center METHODS OF TREATING NEURODEGENERATIVE DISEASES WITH PEPTIDE WITH INTRANASALE NF-KAPPAB ETHER TARGET MODIFIER (NEMO) BINDING DOMAIN (NBD)
WO2023056450A1 (en) * 2021-09-30 2023-04-06 Yale University Compositions and methods for the treatment of autosomal dominant polycystic kidney disease and other diseases having upregulated mtor activity
CN114181318B (zh) * 2021-11-08 2023-08-01 四川大学 一种组织特异性表达穿透血脑屏障的idua融合蛋白的重组腺相关病毒及应用
WO2026080471A2 (en) 2024-10-07 2026-04-16 Flagship Pioneering Innovations Vi, Llc Compositions of trem conjugates and uses thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR519558A (fr) 1917-11-12 1921-06-11 Carl Linde Procédé de fabrication de cordes ou ficelles souples à l'aide de fils de papier
US5723315A (en) * 1996-08-23 1998-03-03 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
GB9718609D0 (en) * 1997-09-02 1997-11-05 Imp College Innovations Ltd Fusion protein
US6669951B2 (en) * 1999-08-24 2003-12-30 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into epithelial tissues
GB0015090D0 (en) * 2000-06-20 2000-08-09 Implyx Ltd Gene-activating conjugates
US20040147027A1 (en) * 2003-01-28 2004-07-29 Troy Carol M. Complex for facilitating delivery of dsRNA into a cell and uses thereof
US20060024331A1 (en) * 2004-08-02 2006-02-02 Ester Fernandez-Salas Toxin compounds with enhanced membrane translocation characteristics
GB0507598D0 (en) * 2005-04-14 2005-05-18 Trojantec Technologies Ltd Composition
WO2007056511A2 (en) * 2005-11-09 2007-05-18 Ontherix, Inc. Metal-binding therapeutic peptides
US8470976B2 (en) * 2006-06-17 2013-06-25 Board Of Regents, The University Of Texas System Methods and compositions for targeting macromolecules into the nucleus
JP2011519558A (ja) * 2008-04-28 2011-07-14 プレシジョン バイオサイエンシズ,インク. 合理的に設計されたdna結合タンパク質とエフェクタードメインとの融合分子
US20100190691A1 (en) 2009-01-27 2010-07-29 Trojan Technologies, Ltd Delivery of nucleic acids using cell-penetrating peptides
KR101106262B1 (ko) * 2009-09-07 2012-01-18 충남대학교산학협력단 인간 호메오 도메인 유전자 유래의 단백질 도입 도메인 및 이를 이용한 단백질 도입 벡터
US9249184B2 (en) * 2010-10-14 2016-02-02 University of Pittsburgh—of the Commonwealth System of Higher Education Cardiac-specific protein targeting domain
WO2013158819A2 (en) * 2012-04-20 2013-10-24 St. Jude Children's Research Hospital Method for generation of conditionally immortalized hematopoietic progenitor cell lines with multiple lineage potential
AU2014310360B2 (en) * 2013-06-11 2019-10-24 PPL (BVI) Limited Structure, manufacturing and uses of human-derived cell-permeable peptides conjugated with specific biologically active cargo peptides

Similar Documents

Publication Publication Date Title
JP6942744B2 (ja) 生物学的に活性な特異的カーゴペプチドと結合したヒト由来の細胞透過性ペプチドの構造、製造および使用
JP5913120B2 (ja) 所定の標的に対して親和性を有するヒトリポカリン2(Lcn2、hNGAL)の突然変異タンパク質
US12384828B2 (en) Engineered extracellular vesicles comprising fusion proteins
US20180296635A1 (en) Protein Particles Comprising Disulfide Crosslinkers and Uses Related Thereto
JP2023516010A (ja) 遺伝子送達システム
JPWO2003055507A1 (ja) 拒食症又は生活習慣病治療薬及びそのスクリーニング方法
KR20210094567A (ko) 평활근 기능장애의 치료를 위한 조성물 및 방법
US7132399B2 (en) Mammalian cell surface DNA receptor
CN102580091B (zh) 增强阿片镇痛剂的镇痛作用的方法及试剂
US12589141B2 (en) DNA vaccine capable of effectively treating and/or preventing type 1 diabetes and use thereof
KR20230074753A (ko) 헤지호그 신호전달 경로의 활성화를 위한 강력한 결합제
JPWO2003030936A1 (ja) 生活習慣病又は拒食症治療薬及びそのスクリーニング方法
CN104105498A (zh) 一种氧化ldl抑制剂
JP2003232790A (ja) C−place1003238に対するリガンドのスクリーニング方法
JPWO2005014809A1 (ja) 肝臓ガン特異的ポリペプチド、該ポリペプチドをコードするポリヌクレオチド、及び該ポリペプチドの発現を抑制するrna分子