JP2016526014A5 - - Google Patents

Info

Publication number

JP2016526014A5

JP2016526014A5 JP2016510767A JP2016510767A JP2016526014A5 JP 2016526014 A5 JP2016526014 A5 JP 2016526014A5 JP 2016510767 A JP2016510767 A JP 2016510767A JP 2016510767 A JP2016510767 A JP 2016510767A JP 2016526014 A5 JP2016526014 A5 JP 2016526014A5

Authority

JP

Japan

Prior art keywords

peptide

amino acid

antibody

substitution

helix

Prior art date

2014-04-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 114
• 238000006467 substitution reaction Methods 0.000 claims 38
• 125000000539 amino acid group Chemical group 0.000 claims 32
• 239000008194 pharmaceutical composition Substances 0.000 claims 29
• 125000003275 alpha amino acid group Chemical group 0.000 claims 23
• 108091005601 modified peptides Proteins 0.000 claims 21
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 19
• 208000035475 disorder Diseases 0.000 claims 11
• 230000004048 modification Effects 0.000 claims 10
• 238000012986 modification Methods 0.000 claims 10
• 229920001223 polyethylene glycol Polymers 0.000 claims 9
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
• 201000010099 disease Diseases 0.000 claims 8
• 238000012216 screening Methods 0.000 claims 6
• 230000004071 biological effect Effects 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 5
• 230000000694 effects Effects 0.000 claims 5
• 239000000178 monomer Substances 0.000 claims 5
• 102000039446 nucleic acids Human genes 0.000 claims 5
• 108020004707 nucleic acids Proteins 0.000 claims 5
• 150000007523 nucleic acids Chemical class 0.000 claims 5
• 230000000704 physical effect Effects 0.000 claims 5
• 229940124597 therapeutic agent Drugs 0.000 claims 5
• 102000003814 Interleukin-10 Human genes 0.000 claims 4
• 108090000174 Interleukin-10 Proteins 0.000 claims 4
• 210000001744 T-lymphocyte Anatomy 0.000 claims 4
• 238000007792 addition Methods 0.000 claims 4
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• 238000000099 in vitro assay Methods 0.000 claims 4
• 238000002347 injection Methods 0.000 claims 4
• 239000007924 injection Substances 0.000 claims 4
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• 102000005962 receptors Human genes 0.000 claims 3
• 108020003175 receptors Proteins 0.000 claims 3
• 230000001954 sterilising effect Effects 0.000 claims 3
• 238000004659 sterilization and disinfection Methods 0.000 claims 3
• 239000013598 vector Substances 0.000 claims 3
• 102000009027 Albumins Human genes 0.000 claims 2
• 108010088751 Albumins Proteins 0.000 claims 2
• 208000024172 Cardiovascular disease Diseases 0.000 claims 2
• 101001033233 Homo sapiens Interleukin-10 Proteins 0.000 claims 2
• 102000007562 Serum Albumin Human genes 0.000 claims 2
• 108010071390 Serum Albumin Proteins 0.000 claims 2
• 210000003719 b-lymphocyte Anatomy 0.000 claims 2
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• 208000024827 Alzheimer disease Diseases 0.000 claims 1
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• 241000711549 Hepacivirus C Species 0.000 claims 1
• 241000700721 Hepatitis B virus Species 0.000 claims 1
• 241000725303 Human immunodeficiency virus Species 0.000 claims 1
• 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• 201000004681 Psoriasis Diseases 0.000 claims 1
• 208000007536 Thrombosis Diseases 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
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• 150000001720 carbohydrates Chemical group 0.000 claims 1
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• 239000013603 viral vector Substances 0.000 claims 1