JP2016525535A - 昆虫メタロプロテイナーゼ阻害剤 - Google Patents

昆虫メタロプロテイナーゼ阻害剤 Download PDF

Info

Publication number
JP2016525535A
JP2016525535A JP2016528557A JP2016528557A JP2016525535A JP 2016525535 A JP2016525535 A JP 2016525535A JP 2016528557 A JP2016528557 A JP 2016528557A JP 2016528557 A JP2016528557 A JP 2016528557A JP 2016525535 A JP2016525535 A JP 2016525535A
Authority
JP
Japan
Prior art keywords
amino acid
impiα
polypeptide
group
polar amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2016528557A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016525535A5 (enExample
Inventor
アンドレアス ヴィルキンスカス、
アンドレアス ヴィルキンスカス、
マーク ザルツィヒ、
マーク ザルツィヒ、
ライナー フィッシャー、
ライナー フィッシャー、
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Original Assignee
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV filed Critical Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Publication of JP2016525535A publication Critical patent/JP2016525535A/ja
Publication of JP2016525535A5 publication Critical patent/JP2016525535A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96402—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals
    • G01N2333/96405—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general
    • G01N2333/96408—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general with EC number
    • G01N2333/96419—Metalloendopeptidases (3.4.24)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Hematology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Urology & Nephrology (AREA)
JP2016528557A 2013-07-26 2014-07-28 昆虫メタロプロテイナーゼ阻害剤 Ceased JP2016525535A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13178180.9 2013-07-26
EP13178180 2013-07-26
PCT/EP2014/066165 WO2015011293A1 (en) 2013-07-26 2014-07-28 Insect metalloproteinase inhibitors

Publications (2)

Publication Number Publication Date
JP2016525535A true JP2016525535A (ja) 2016-08-25
JP2016525535A5 JP2016525535A5 (enExample) 2017-07-27

Family

ID=48874200

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016528557A Ceased JP2016525535A (ja) 2013-07-26 2014-07-28 昆虫メタロプロテイナーゼ阻害剤

Country Status (8)

Country Link
US (1) US20160159885A1 (enExample)
EP (1) EP3024481B1 (enExample)
JP (1) JP2016525535A (enExample)
KR (1) KR20160037899A (enExample)
BR (1) BR112016001145A2 (enExample)
CA (1) CA2917278A1 (enExample)
DK (1) DK3024481T3 (enExample)
WO (1) WO2015011293A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017521495A (ja) * 2014-07-03 2017-08-03 フラウンホーファーゲゼルシャフト ツール フォルデルング デル アンゲヴァンテン フォルシユング エー．フアー． 細菌感染に対するメタロプロテイナーゼインヒビターの使用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201708339D0 (en) * 2017-05-24 2017-07-05 Univ Court Univ Of Glasgow Metabolite detection apparatus and method of detecting metabolites

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CURRENT PHARMACEUTICAL DESIGN, vol. 17, JPN6018027668, 2011, pages 1240 - 1245, ISSN: 0003840922 *
EUR.J.BIOCHEM., vol. 255, JPN6018027667, 1998, pages 535 - 543, ISSN: 0003840920 *
THE BIOCHEMICAL JOURNAL, vol. V382, JPN5016008524, 15 August 2004 (2004-08-15), pages 315 - 322, ISSN: 0003840921 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017521495A (ja) * 2014-07-03 2017-08-03 フラウンホーファーゲゼルシャフト ツール フォルデルング デル アンゲヴァンテン フォルシユング エー．フアー． 細菌感染に対するメタロプロテイナーゼインヒビターの使用

Also Published As

Publication number Publication date
CA2917278A1 (en) 2015-01-29
KR20160037899A (ko) 2016-04-06
EP3024481B1 (en) 2018-07-11
BR112016001145A2 (pt) 2017-08-29
US20160159885A1 (en) 2016-06-09
DK3024481T3 (en) 2018-09-03
EP3024481A1 (en) 2016-06-01
WO2015011293A1 (en) 2015-01-29

Similar Documents

Publication Publication Date Title
Dekker et al. Substrate specificity of the integral membrane protease OmpT determined by spatially addressed peptide libraries
US20230357742A1 (en) Novel recombinant factor c and method for producing the same, and method for measuring endotoxin
Auer et al. High-yield expression and functional analysis of Escherichia coli glycerol-3-phosphate transporter
KR102083373B1 (ko) 단백질 가수분해 처리된 폴리펩티드의 제조방법
Stack et al. Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase: a protease involved in amino acid regulation with potential for antimalarial drug development
US7132259B1 (en) Activatable recombinant neurotoxins
De Marco Verissimo et al. Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases
CN104884616B (zh) 在原生动物中重组制备鲎c因子蛋白的方法
US8568714B2 (en) Lys K endolysin is synergistic with lysostaphin against MRSA
Wetsaphan et al. PmSERPIN3 from black tiger shrimp Penaeus monodon is capable of controlling the proPO system
Mourão et al. Head-to-tail cyclization after interaction with trypsin: a scorpion venom peptide that resembles plant cyclotides
Yang et al. In search of a function of Manduca sexta hemolymph protease-1 in the innate immune system
TW201639876A (zh) 嵌合多肽
Portaro et al. The Mycobacterium leprae hsp65 displays proteolytic activity. Mutagenesis studies indicate that the M. leprae hsp65 proteolytic activity is catalytically related to the HslVU protease
Courrol et al. Leptolysin, a Leptospira secreted metalloprotease of the pappalysin family with broad-spectrum activity
WO2014188163A1 (en) Enzyme and uses thereof
Molehin et al. Characterisation of a secretory serine protease inhibitor (SjB6) from Schistosoma japonicum
JP2016525535A (ja) 昆虫メタロプロテイナーゼ阻害剤
US20100322957A1 (en) Secretion-related bacterial proteins for nlrc4 stimulation
Zhang et al. Enzyme activity of Schistosoma japonicum cercarial elastase SjCE-2b ascertained by in vitro refolded recombinant protein
JP4498444B2 (ja) 抗細菌治療剤
Jin et al. Serine protease homolog pairs CLIPA4-A6, A4-A7Δ, and A4-A12 act as cofactors for proteolytic activation of prophenoloxidase-2 and-7 in Anopheles gambiae
Wang et al. A novel trypsin inhibitor-like cysteine-rich peptide from the frog Lepidobatrachus laevis containing proteinase-inhibiting activity
Luke et al. Thermostable tag (TST) protein expression system: Engineering thermotolerant recombinant proteins and vaccines
Santos et al. Hydrolytic properties and substrate specificity of the foot-and-mouth disease leader protease

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170616

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170616

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180724

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20181024

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181207

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190521

A045 Written measure of dismissal of application [lapsed due to lack of payment]

Free format text: JAPANESE INTERMEDIATE CODE: A045

Effective date: 20190917