DK3024481T3 - INSECT METALOPROTEINASE INHIBITORS - Google Patents

INSECT METALOPROTEINASE INHIBITORS Download PDF

Info

Publication number
DK3024481T3
DK3024481T3 DK14744338.6T DK14744338T DK3024481T3 DK 3024481 T3 DK3024481 T3 DK 3024481T3 DK 14744338 T DK14744338 T DK 14744338T DK 3024481 T3 DK3024481 T3 DK 3024481T3
Authority
DK
Denmark
Prior art keywords
cys
asp
lie
gly
lys
Prior art date
Application number
DK14744338.6T
Other languages
Danish (da)
English (en)
Inventor
Andreas Vilcinskas
Rainer Fischer
Original Assignee
Fraunhofer Ges Forschung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Ges Forschung filed Critical Fraunhofer Ges Forschung
Application granted granted Critical
Publication of DK3024481T3 publication Critical patent/DK3024481T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96402—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals
    • G01N2333/96405—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general
    • G01N2333/96408—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general with EC number
    • G01N2333/96419—Metalloendopeptidases (3.4.24)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Urology & Nephrology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Hematology (AREA)
DK14744338.6T 2013-07-26 2014-07-28 INSECT METALOPROTEINASE INHIBITORS DK3024481T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13178180 2013-07-26
PCT/EP2014/066165 WO2015011293A1 (en) 2013-07-26 2014-07-28 Insect metalloproteinase inhibitors

Publications (1)

Publication Number Publication Date
DK3024481T3 true DK3024481T3 (en) 2018-09-03

Family

ID=48874200

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14744338.6T DK3024481T3 (en) 2013-07-26 2014-07-28 INSECT METALOPROTEINASE INHIBITORS

Country Status (8)

Country Link
US (1) US20160159885A1 (enExample)
EP (1) EP3024481B1 (enExample)
JP (1) JP2016525535A (enExample)
KR (1) KR20160037899A (enExample)
BR (1) BR112016001145A2 (enExample)
CA (1) CA2917278A1 (enExample)
DK (1) DK3024481T3 (enExample)
WO (1) WO2015011293A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3164151A1 (en) * 2014-07-03 2017-05-10 Fraunhofer Gesellschaft zur Förderung der angewandten Forschung E.V. Use of metalloproteinase inhibitors against bacterial infections
GB201708339D0 (en) * 2017-05-24 2017-07-05 Univ Court Univ Of Glasgow Metabolite detection apparatus and method of detecting metabolites

Also Published As

Publication number Publication date
KR20160037899A (ko) 2016-04-06
CA2917278A1 (en) 2015-01-29
WO2015011293A1 (en) 2015-01-29
JP2016525535A (ja) 2016-08-25
EP3024481A1 (en) 2016-06-01
BR112016001145A2 (pt) 2017-08-29
US20160159885A1 (en) 2016-06-09
EP3024481B1 (en) 2018-07-11

Similar Documents

Publication Publication Date Title
CN104870468B (zh) 用于制备经蛋白水解处理的多肽的方法
US7132259B1 (en) Activatable recombinant neurotoxins
KR101454273B1 (ko) 페그화된 돌연변이 클로스트리디움 보툴리눔 독소
JP4423542B2 (ja) 抗菌性ポリペプチド及びその利用
TW201718627A (zh) 重組梭菌神經毒素及其使用與形成方法、包括其之醫藥組合物及對應其之前驅物、編碼前驅物之核酸序列及其獲得方法與前驅物之形成方法、載體與包括核酸序列之重組宿主細胞
KR20220061126A (ko) 카스파제-2 변이체
TW201639876A (zh) 嵌合多肽
RU2601161C2 (ru) БИОЛОГИЧЕСКИ АКТИВНЫЙ РАДИОАКТИВНО-МЕЧЕНЫЙ Cry1Fa И СПОСОБЫ ПРОВЕДЕНИЯ ЭКСПЕРИМЕНТОВ СВЯЗЫВАНИЯ С РЕЦЕПТОРОМ
Liu et al. Snake venom-like waprin from the frog of Ceratophrys calcarata contains antimicrobial function
DK3024481T3 (en) INSECT METALOPROTEINASE INHIBITORS
Salwan et al. Heterologous expression and structure-function relationship of low-temperature and alkaline active protease from Acinetobacter sp. IHB B 5011 (MN12)
Scott et al. Functional properties of a recombinant bacterial DING protein: comparison with a homologous human protein
Wang et al. Identification and molecular cloning of a novel amphibian Bowman Birk-type trypsin inhibitor from the skin of the Hejiang Odorous Frog; Odorrana hejiangensis
CN102532305B (zh) 蛋白酶抑制剂BmSPI38及其制备方法和应用
CN102584987A (zh) 蛋白酶抑制剂BmSPI39及其制备方法和应用
US8383400B2 (en) Kits for producing recombinant polypeptides via cysteine protease autoprocessing of fusion proteins
Sabotič et al. Comparison of natural and recombinant clitocypins, the fungal cysteine protease inhibitors
Wang et al. A novel trypsin inhibitor-like cysteine-rich peptide from the frog Lepidobatrachus laevis containing proteinase-inhibiting activity
Zhang et al. Enzyme activity of Schistosoma japonicum cercarial elastase SjCE-2b ascertained by in vitro refolded recombinant protein
Choi et al. Functional characterization of the C-terminus of YhaV in the Escherichia coli PrlF-YhaV toxin-antitoxin system
US7465457B2 (en) Method for preparing botulinum neurotoxin type A light chain
KR20180072715A (ko) 조절가능한 리보솜 번역 속도를 위한 조성물 및 사용 방법
KR20180110032A (ko) 베타-락타마제 변이체
De Roca et al. Cleavage specificity of Enterococcus faecalis EnpA (EF1473), a peptidoglycan endopeptidase related to the LytM/lysostaphin family of metallopeptidases
Pauwels et al. Affinity-based isolation of a bacterial lipase through steric chaperone interactions