JP2016523895A - 脂質低下剤を含む製剤 - Google Patents
脂質低下剤を含む製剤 Download PDFInfo
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- JP2016523895A JP2016523895A JP2016522969A JP2016522969A JP2016523895A JP 2016523895 A JP2016523895 A JP 2016523895A JP 2016522969 A JP2016522969 A JP 2016522969A JP 2016522969 A JP2016522969 A JP 2016522969A JP 2016523895 A JP2016523895 A JP 2016523895A
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- calcium
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- 238000009472 formulation Methods 0.000 title claims abstract description 48
- 239000003524 antilipemic agent Substances 0.000 title abstract description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 36
- 150000003839 salts Chemical class 0.000 claims abstract description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 31
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 28
- -1 chlorambutol Chemical compound 0.000 claims description 27
- 239000003826 tablet Substances 0.000 claims description 25
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18
- 230000003113 alkalizing effect Effects 0.000 claims description 17
- 239000002775 capsule Substances 0.000 claims description 16
- 239000003963 antioxidant agent Substances 0.000 claims description 14
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- 239000011777 magnesium Substances 0.000 claims description 10
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 10
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 10
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- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
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- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 claims description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 6
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 6
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- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 6
- 239000008120 corn starch Substances 0.000 claims description 6
- 239000000314 lubricant Substances 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 6
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
- 108010010803 Gelatin Proteins 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 5
- 235000021355 Stearic acid Nutrition 0.000 claims description 5
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 5
- 125000002252 acyl group Chemical group 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 5
- 125000005110 aryl thio group Chemical group 0.000 claims description 5
- 125000004104 aryloxy group Chemical group 0.000 claims description 5
- 239000000440 bentonite Substances 0.000 claims description 5
- 229910000278 bentonite Inorganic materials 0.000 claims description 5
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 5
- 229910052791 calcium Inorganic materials 0.000 claims description 5
- 235000001465 calcium Nutrition 0.000 claims description 5
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical group [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 5
- 235000013539 calcium stearate Nutrition 0.000 claims description 5
- 239000008116 calcium stearate Substances 0.000 claims description 5
- 150000001768 cations Chemical class 0.000 claims description 5
- 239000008273 gelatin Substances 0.000 claims description 5
- 229920000159 gelatin Polymers 0.000 claims description 5
- 235000019322 gelatine Nutrition 0.000 claims description 5
- 235000011852 gelatine desserts Nutrition 0.000 claims description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 5
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 5
- 235000019359 magnesium stearate Nutrition 0.000 claims description 5
- 229910052751 metal Inorganic materials 0.000 claims description 5
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 5
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- 238000005550 wet granulation Methods 0.000 claims description 5
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 4
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 3
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
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- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 claims description 3
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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| EP2670486B1 (en) | 2011-01-31 | 2016-04-06 | Cadila Healthcare Limited | Treatment for lipodystrophy |
| AU2013387996B2 (en) | 2013-04-22 | 2015-12-10 | Cadila Healthcare Limited | A novel composition for nonalcoholic fatty liver disease (NAFLD) |
| MX2015016403A (es) | 2013-05-30 | 2016-04-11 | Cadila Healthcare Ltd | Proceso para la preparacion de pirroles que tienen actividad hipolipidemica e hipocolesterolemica. |
| TW201636015A (zh) | 2013-07-05 | 2016-10-16 | 卡地拉保健有限公司 | 協同性組成物 |
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| US10112898B2 (en) | 2013-09-06 | 2018-10-30 | Cadila Healthcare Limited | Process for the preparation of saroglitazar pharmaceutical salts |
| US10385017B2 (en) | 2015-10-14 | 2019-08-20 | Cadila Healthcare Limited | Pyrrole compound, compositions and process for preparation thereof |
| KR101913830B1 (ko) * | 2016-12-05 | 2018-10-31 | 주식회사 코쿤디자인 | 기능성 led 어셈블리를 이용한 디스플레이 장치 |
| MX382765B (es) | 2016-12-09 | 2025-03-13 | Zydus Lifesciences Ltd | Tratamiento para la colangitis biliar primaria. |
| EP3923932A4 (en) * | 2019-02-13 | 2022-11-16 | Cadila Healthcare Limited | Treatment for polycystic ovarian syndrome (pcos) |
| WO2020183379A1 (en) * | 2019-03-11 | 2020-09-17 | Cadila Healthcare Limited | Novel salts, crystalline forms and premix of hypolipidemic agent |
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2014
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- 2014-07-24 EP EP14787059.6A patent/EP3024446A1/en not_active Withdrawn
- 2014-07-24 WO PCT/IN2014/000489 patent/WO2015011730A1/en active Application Filing
- 2014-07-24 HK HK16107193.2A patent/HK1219222A1/zh unknown
- 2014-07-24 US US14/899,912 patent/US9610277B2/en active Active
- 2014-07-24 KR KR1020157036380A patent/KR101786843B1/ko not_active Expired - Fee Related
- 2014-07-24 TW TW103125304A patent/TW201545773A/zh unknown
- 2014-07-24 BR BR112015031878A patent/BR112015031878A2/pt not_active IP Right Cessation
- 2014-07-24 MX MX2015016971A patent/MX374628B/es active IP Right Grant
- 2014-07-24 AU AU2014294548A patent/AU2014294548B2/en not_active Expired - Fee Related
- 2014-07-24 JP JP2016522969A patent/JP2016523895A/ja active Pending
- 2014-07-24 CA CA2917923A patent/CA2917923A1/en not_active Abandoned
- 2014-07-24 CN CN201480041453.7A patent/CN105407873A/zh active Pending
- 2014-07-24 NZ NZ714558A patent/NZ714558A/en not_active IP Right Cessation
- 2014-07-24 MA MA38865A patent/MA38865A1/fr unknown
- 2014-07-24 SG SG11201509798PA patent/SG11201509798PA/en unknown
- 2014-07-25 AR ARP140102777A patent/AR097067A1/es unknown
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| ZA201508682B (en) | 2017-03-29 |
| AP2015008876A0 (en) | 2015-11-30 |
| KR101786843B1 (ko) | 2017-10-18 |
| TW201545773A (zh) | 2015-12-16 |
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| US20160136131A1 (en) | 2016-05-19 |
| AR097067A1 (es) | 2016-02-17 |
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| EP3024446A1 (en) | 2016-06-01 |
| AU2014294548B2 (en) | 2017-08-10 |
| CN105407873A (zh) | 2016-03-16 |
| SG11201509798PA (en) | 2016-02-26 |
| US9610277B2 (en) | 2017-04-04 |
| AU2014294548A1 (en) | 2015-12-17 |
| NZ714558A (en) | 2017-02-24 |
| HK1219222A1 (zh) | 2017-03-31 |
| US10098868B2 (en) | 2018-10-16 |
| EA201690072A1 (ru) | 2016-06-30 |
| MA38865A1 (fr) | 2017-12-29 |
| MX2015016971A (es) | 2016-04-25 |
| IN2013MU02470A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-06-26 |
| US20170266158A1 (en) | 2017-09-21 |
| WO2015011730A1 (en) | 2015-01-29 |
| BR112015031878A2 (pt) | 2017-07-25 |
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