JP2016523511A5 - - Google Patents
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- JP2016523511A5 JP2016523511A5 JP2016506657A JP2016506657A JP2016523511A5 JP 2016523511 A5 JP2016523511 A5 JP 2016523511A5 JP 2016506657 A JP2016506657 A JP 2016506657A JP 2016506657 A JP2016506657 A JP 2016506657A JP 2016523511 A5 JP2016523511 A5 JP 2016523511A5
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- JP
- Japan
- Prior art keywords
- pairs
- indicator
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- cancer cells
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019085187A JP7522539B2 (ja) | 2013-04-05 | 2019-04-26 | 相同組換え欠損を評価するための方法および材料 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361809105P | 2013-04-05 | 2013-04-05 | |
| US61/809,105 | 2013-04-05 | ||
| US201361913762P | 2013-12-09 | 2013-12-09 | |
| US61/913,762 | 2013-12-09 | ||
| PCT/US2014/033014 WO2014165785A2 (en) | 2013-04-05 | 2014-04-04 | Methods and materials for assessing homologous recombination deficiency |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019085187A Division JP7522539B2 (ja) | 2013-04-05 | 2019-04-26 | 相同組換え欠損を評価するための方法および材料 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016523511A JP2016523511A (ja) | 2016-08-12 |
| JP2016523511A5 true JP2016523511A5 (https=) | 2017-03-16 |
| JP6625045B2 JP6625045B2 (ja) | 2019-12-25 |
Family
ID=51659359
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016506657A Active JP6625045B2 (ja) | 2013-04-05 | 2014-04-04 | 相同組換え欠損を評価するための方法および材料 |
| JP2019085187A Active JP7522539B2 (ja) | 2013-04-05 | 2019-04-26 | 相同組換え欠損を評価するための方法および材料 |
| JP2020194936A Active JP7522643B2 (ja) | 2013-04-05 | 2020-11-25 | 相同組換え欠損を評価するための方法および材料 |
| JP2022169085A Active JP7641938B2 (ja) | 2013-04-05 | 2022-10-21 | 相同組換え欠損を評価するための方法および材料 |
| JP2025027653A Pending JP2025090619A (ja) | 2013-04-05 | 2025-02-25 | 相同組換え欠損を評価するための方法および材料 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019085187A Active JP7522539B2 (ja) | 2013-04-05 | 2019-04-26 | 相同組換え欠損を評価するための方法および材料 |
| JP2020194936A Active JP7522643B2 (ja) | 2013-04-05 | 2020-11-25 | 相同組換え欠損を評価するための方法および材料 |
| JP2022169085A Active JP7641938B2 (ja) | 2013-04-05 | 2022-10-21 | 相同組換え欠損を評価するための方法および材料 |
| JP2025027653A Pending JP2025090619A (ja) | 2013-04-05 | 2025-02-25 | 相同組換え欠損を評価するための方法および材料 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20140363521A1 (https=) |
| EP (2) | EP2981624B1 (https=) |
| JP (5) | JP6625045B2 (https=) |
| AU (3) | AU2014248007B2 (https=) |
| CA (1) | CA2908745C (https=) |
| DK (1) | DK2981624T3 (https=) |
| ES (1) | ES2777228T3 (https=) |
| PT (1) | PT2981624T (https=) |
| WO (1) | WO2014165785A2 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012027224A1 (en) | 2010-08-24 | 2012-03-01 | Dana-Farber Cancer Institute, Inc. | Methods for predicting anti-cancer response |
| KR102759126B1 (ko) | 2010-12-30 | 2025-01-24 | 파운데이션 메디신 인코포레이티드 | 종양 샘플의 다유전자 분석의 최적화 |
| JP6117194B2 (ja) | 2011-06-17 | 2017-04-19 | ミリアド・ジェネティックス・インコーポレイテッド | アレル不均衡を評価するための方法および材料 |
| BR112014015152A2 (pt) | 2011-12-21 | 2017-07-04 | Myriad Genetics Inc | métodos e materiais para a avaliação da perda de heterozigosidade |
| CA2864481C (en) | 2012-02-23 | 2020-07-14 | Dana-Farber Cancer Institute, Inc. | Methods for predicting anti-cancer response |
| WO2013182645A1 (en) | 2012-06-07 | 2013-12-12 | Institut Curie | Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors |
| AU2014248007B2 (en) * | 2013-04-05 | 2020-03-26 | Myriad Genetics, Inc. | Methods and materials for assessing homologous recombination deficiency |
| WO2015086473A1 (en) | 2013-12-09 | 2015-06-18 | Institut Curie | Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors |
| EP3108246B1 (en) | 2014-02-21 | 2019-10-09 | Epic Sciences, Inc. | Methods for analyzing rare circulating cells |
| CA2958801A1 (en) | 2014-08-15 | 2016-02-18 | Myriad Genetics, Inc. | Methods and materials for assessing homologous recombination deficiency |
| EP3227464B1 (en) * | 2014-12-05 | 2022-04-20 | Foundation Medicine, Inc. | Multigene analysis of tumor samples |
| US20160160294A1 (en) * | 2014-12-08 | 2016-06-09 | Tesaro | Methods and materials for predicting response to niraparib |
| WO2016185406A1 (en) | 2015-05-19 | 2016-11-24 | Nadathur Estates Pvt. Ltd. | Method for identification of a deficient brca1 function |
| EP3371327B1 (en) * | 2015-11-03 | 2024-12-18 | Epic Sciences, Inc. | Single cell genomic profiling of circulating tumor cells (ctcs) in metastatic disease to characterize disease heterogeneity |
| WO2017106365A1 (en) * | 2015-12-14 | 2017-06-22 | Myriad Genetics, Inc. | Methods for measuring mutation load |
| US20190025312A1 (en) * | 2016-01-06 | 2019-01-24 | Epic Sciences, Inc. | Single cell genomic profiling of circulating tumor cells (ctcs) in metastatic disease to characterize disease heterogeneity |
| WO2017165270A1 (en) * | 2016-03-21 | 2017-09-28 | Myriad Genetics, Inc. | Homologous recombination deficiency to predict neoadjuvant chemotherapy necessity in bladder cancer |
| WO2017178509A1 (en) | 2016-04-12 | 2017-10-19 | Xentech | Methods for predicting sensibility to treatment with parp inhibitors in cancerous patients |
| JP7224185B2 (ja) * | 2016-05-01 | 2023-02-17 | ゲノム・リサーチ・リミテッド | Ｄｎａサンプルを特徴付ける方法 |
| GB2555765A (en) | 2016-05-01 | 2018-05-16 | Genome Res Ltd | Method of detecting a mutational signature in a sample |
| EP3452937B1 (en) | 2016-05-01 | 2025-10-22 | Genome Research Limited | Method of characterising a dna sample |
| SG11201811564QA (en) | 2016-06-29 | 2019-01-30 | Tesaro Inc | Methods of treating ovarian cancer |
| BR112020024727A2 (pt) | 2018-06-11 | 2021-03-23 | Foundation Medicine, Inc. | composições e métodos para avaliação de alterações genômicas |
| JPWO2020137076A1 (ja) * | 2018-12-28 | 2021-11-11 | 国立大学法人 東京大学 | Ｐａｒｐ阻害剤に対する癌の感受性の予測方法および相同組換修復不全を有する癌の検出方法 |
| US10975445B2 (en) | 2019-02-12 | 2021-04-13 | Tempus Labs, Inc. | Integrated machine-learning framework to estimate homologous recombination deficiency |
| ES2989374T3 (es) | 2019-12-10 | 2024-11-26 | Tempus Ai Inc | Sistemas y procedimientos para predecir el estado de deficiencia de recombinación homóloga de una muestra |
| WO2021122620A1 (en) * | 2019-12-16 | 2021-06-24 | Agilent Technologies, Inc. | Genomic scarring assays and related methods |
| EP3945525A1 (en) | 2020-07-27 | 2022-02-02 | Sophia Genetics S.A. | Methods for identifying chromosomal spatial instability such as homologous repair deficiency in low coverage next-generation sequencing data |
| CN111883211B (zh) * | 2020-08-07 | 2021-04-23 | 张哲� | 一种表征hrd同源重组修复缺陷的基因瘢痕及鉴定方法 |
| US11718869B2 (en) * | 2020-08-12 | 2023-08-08 | Zhenyue Biotechnology Jiangsu Co., Ltd. | Method and kit for determining genome instability based on next generation sequencing (NGS) |
| CN112410423B (zh) * | 2020-11-03 | 2021-08-13 | 南京世和基因生物技术股份有限公司 | 同源重组缺失的标志物、检测方法以及检测系统 |
| JP7585015B2 (ja) | 2020-12-04 | 2024-11-18 | 株式会社東芝 | 核酸構築物のセット、キット、検出方法及び薬剤効果予測方法 |
| US20240026462A1 (en) * | 2021-01-10 | 2024-01-25 | Ying Ja CHEN | Homologous recombination deficiency determining method and kit thereof |
| BE1029144B1 (fr) | 2021-02-25 | 2022-09-20 | Oncodna | Méthode de caracterisation d'une tumeur à l'aide d'un séquençage ciblé |
| CN112820351A (zh) * | 2021-03-01 | 2021-05-18 | 江苏医联生物科技有限公司 | 检测肿瘤患者的突变和hrd评分指导用药的方法 |
| TW202317774A (zh) * | 2021-06-25 | 2023-05-01 | 美商方得生醫療公司 | 分類同源修復缺陷之系統及方法 |
| CN118369439A (zh) * | 2021-12-08 | 2024-07-19 | 麦利亚德基因公司 | 用于评估乳腺癌亚型中同源重组缺陷的方法和材料 |
| KR102523938B1 (ko) * | 2022-02-04 | 2023-04-19 | 가톨릭대학교 산학협력단 | 상동 재조합 결핍증 예측 모델의 모델링 방법 |
| EP4605937A1 (en) | 2022-10-19 | 2025-08-27 | Vib Vzw | Method of determining loss of heterozygosity status of a tumor |
| WO2025078387A1 (en) | 2023-10-10 | 2025-04-17 | Vib Vzw | Method of detecting loss of heterozygosity status of a tumor |
| WO2025078404A1 (en) | 2023-10-10 | 2025-04-17 | Vib Vzw | Methods of determining response of a tumor to dna-damaging agents or to agents inhibiting or impairing dna repair |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU33730B (en) | 1967-04-18 | 1978-02-28 | Farmaceutici Italia | Process for preparing a novel antibiotic substance and salts thereof |
| GB1432562A (en) | 1972-04-10 | 1976-04-22 | Rustenburg Platinum Mines Ltd | Platinum co-ordination compounds |
| GB1432563A (en) | 1972-04-10 | 1976-04-22 | Rustenburg Platinum Mines Ltd | Platinum- co-ordination compounds |
| ES444380A1 (es) | 1976-01-16 | 1977-06-16 | Gosalvez Mario | Un procedimiento para preparar derivados metalicos antraci- clinicos. |
| US4950738A (en) | 1984-09-13 | 1990-08-21 | Cytogen Corporation | Amine derivatives of anthracycline antibiotics |
| US5977082A (en) | 1985-08-02 | 1999-11-02 | Pharmacia & Upjohn Company | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| US5177075A (en) | 1988-08-19 | 1993-01-05 | Warner-Lambert Company | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process |
| US5295944A (en) | 1991-05-14 | 1994-03-22 | Dana-Farber Cancer Institute | Method for treating a tumor with ionizing radiation |
| ATE247471T1 (de) | 1991-11-15 | 2003-09-15 | Smithkline Beecham Corp | Cisplatin und topotecan enthaltende zusammensetzung als antitumor. |
| GB9806324D0 (en) | 1998-03-24 | 1998-05-20 | Pharmacia & Upjohn Spa | Antitumour synergetic composition |
| JP4323802B2 (ja) | 2000-12-01 | 2009-09-02 | エムジーアイ・ジーピー・インコーポレーテッド | 化合物およびその使用 |
| GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| WO2005002508A2 (en) | 2003-06-11 | 2005-01-13 | Access Pharmaceuticals, Inc. | Macromolecular platinum chelates |
| CN100412084C (zh) | 2003-07-02 | 2008-08-20 | 獀洛克斯股份有限公司 | 热稳定的结晶盐酸表柔比星及其制造方法 |
| US7531530B2 (en) | 2003-07-25 | 2009-05-12 | Cancer Research Technology Limited | Therapeutic compounds |
| AU2004270655B2 (en) | 2003-08-13 | 2011-03-24 | University Of South Florida | Methods for inhibiting tumor cell proliferation |
| ATE488507T1 (de) | 2005-06-30 | 2010-12-15 | Bionumerik Pharmaceuticals Inc | Platinanaloga mit monoazolligand |
| KR100925337B1 (ko) * | 2009-05-25 | 2009-11-09 | 주식회사 마크로젠 | 염색체 수 이상 검출을 통한 유방암 약물 반응성 예측 |
| EP3012329B1 (en) * | 2010-06-18 | 2017-10-25 | Myriad Genetics, Inc. | Methods and materials for assessing loss of heterozygosity |
| WO2012027224A1 (en) * | 2010-08-24 | 2012-03-01 | Dana-Farber Cancer Institute, Inc. | Methods for predicting anti-cancer response |
| CA2864481C (en) * | 2012-02-23 | 2020-07-14 | Dana-Farber Cancer Institute, Inc. | Methods for predicting anti-cancer response |
| AU2014248007B2 (en) * | 2013-04-05 | 2020-03-26 | Myriad Genetics, Inc. | Methods and materials for assessing homologous recombination deficiency |
-
2014
- 2014-04-04 AU AU2014248007A patent/AU2014248007B2/en active Active
- 2014-04-04 JP JP2016506657A patent/JP6625045B2/ja active Active
- 2014-04-04 US US14/245,576 patent/US20140363521A1/en not_active Abandoned
- 2014-04-04 EP EP14779403.6A patent/EP2981624B1/en active Active
- 2014-04-04 WO PCT/US2014/033014 patent/WO2014165785A2/en not_active Ceased
- 2014-04-04 ES ES14779403T patent/ES2777228T3/es active Active
- 2014-04-04 PT PT147794036T patent/PT2981624T/pt unknown
- 2014-04-04 CA CA2908745A patent/CA2908745C/en active Active
- 2014-04-04 EP EP19216740.1A patent/EP3693475A1/en active Pending
- 2014-04-04 DK DK14779403.6T patent/DK2981624T3/da active
-
2017
- 2017-07-17 US US15/651,652 patent/US20180030544A1/en not_active Abandoned
-
2019
- 2019-04-26 JP JP2019085187A patent/JP7522539B2/ja active Active
-
2020
- 2020-06-17 AU AU2020204028A patent/AU2020204028B2/en active Active
- 2020-11-25 JP JP2020194936A patent/JP7522643B2/ja active Active
-
2021
- 2021-06-21 US US17/353,279 patent/US20210310079A1/en active Pending
-
2022
- 2022-08-04 AU AU2022211880A patent/AU2022211880B2/en active Active
- 2022-10-21 JP JP2022169085A patent/JP7641938B2/ja active Active
-
2025
- 2025-02-25 JP JP2025027653A patent/JP2025090619A/ja active Pending
- 2025-03-24 US US19/088,496 patent/US20250223655A1/en active Pending
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