JP2016523079A5 - - Google Patents

Info

Publication number

JP2016523079A5

JP2016523079A5 JP2016521251A JP2016521251A JP2016523079A5 JP 2016523079 A5 JP2016523079 A5 JP 2016523079A5 JP 2016521251 A JP2016521251 A JP 2016521251A JP 2016521251 A JP2016521251 A JP 2016521251A JP 2016523079 A5 JP2016523079 A5 JP 2016523079A5

Authority

JP

Japan

Prior art keywords

cancer stem

cell culture

glycosaminoglycan

culture substrate

selecting

Prior art date

2014-06-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 23
• 206010028980 Neoplasm Diseases 0.000 claims 20
• 201000011510 cancer Diseases 0.000 claims 20
• 210000000130 stem cell Anatomy 0.000 claims 16
• 238000004113 cell culture Methods 0.000 claims 14
• 239000000758 substrate Substances 0.000 claims 14
• 229920002683 Glycosaminoglycan Polymers 0.000 claims 13
• 239000003550 marker Substances 0.000 claims 5
• 239000002246 antineoplastic agent Substances 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 4
• 238000012258 culturing Methods 0.000 claims 3
• 108020003175 receptors Proteins 0.000 claims 3
• DZGWFCGJZKJUFP-UHFFFAOYSA-O tyraminium Chemical compound [NH3+]CCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-O 0.000 claims 3
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
• BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Chemical class NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 claims 2
• DZGWFCGJZKJUFP-UHFFFAOYSA-N Tyramine Natural products NCCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-N 0.000 claims 2
• 239000003446 ligand Substances 0.000 claims 2
• 238000012216 screening Methods 0.000 claims 2
• 229960003732 tyramine Drugs 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• KZMAWJRXKGLWGS-UHFFFAOYSA-N 2-chloro-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-n-(3-methoxypropyl)acetamide Chemical compound S1C(N(C(=O)CCl)CCCOC)=NC(C=2C=CC(OC)=CC=2)=C1 KZMAWJRXKGLWGS-UHFFFAOYSA-N 0.000 claims 1
• WGTASENVNYJZBK-UHFFFAOYSA-N 3,4,5-trimethoxyamphetamine Chemical compound COC1=CC(CC(C)N)=CC(OC)=C1OC WGTASENVNYJZBK-UHFFFAOYSA-N 0.000 claims 1
• AGNFWIZBEATIAK-UHFFFAOYSA-N 4-phenylbutylamine Chemical compound NCCCCC1=CC=CC=C1 AGNFWIZBEATIAK-UHFFFAOYSA-N 0.000 claims 1
• 102100032912 CD44 antigen Human genes 0.000 claims 1
• 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
• 102100027735 Hyaluronan mediated motility receptor Human genes 0.000 claims 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
• 229960004316 cisplatin Drugs 0.000 claims 1
• 229960004679 doxorubicin Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 108010003425 hyaluronan-mediated motility receptor Proteins 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• 230000003834 intracellular effect Effects 0.000 claims 1
• GHFGJTVYMNRGBY-UHFFFAOYSA-N m-tyramine Chemical compound NCCC1=CC=CC(O)=C1 GHFGJTVYMNRGBY-UHFFFAOYSA-N 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 230000004899 motility Effects 0.000 claims 1
• 229940117803 phenethylamine Drugs 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 230000004083 survival effect Effects 0.000 claims 1