JP2016521607A - 照明及び画像化のためのデュアルビュープローブとその使用方法 - Google Patents
照明及び画像化のためのデュアルビュープローブとその使用方法 Download PDFInfo
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Abstract
Description
を参照のこと。逆行視装置は、結腸内の腺腫の検出を改善する(a prospective efficacy evaluation (with videos). Gastrointestinal Endoscopy. Mar 2010;71(3):551−556)。現行の内視鏡に容易に組み込んで、病変検出を改善し、がんをさらに防止し、スクリーニング間隔を長くすることができる、内視鏡または内視鏡用プローブの使用を容易にするために、満たされていない要求がある。さらに、腹腔鏡手術、ロボットによる手術、関節鏡検査、及び副鼻腔等の体腔の画像を含む医療的処置中に、後方向及び/または横方向の視野を提供するための要求がある。
内視鏡用画像化、たとえば狭帯域撮像(narrow band imaging(NBI))及びフレキシブルイメージングカラーエンハンスメント(FICE)の近年の進化は、高解像度白色光内視鏡によって達成されたもの以上にはポリープ検出率を改善していない。リスクの高い鋸歯状病変は、無茎性または平坦である傾向があり、カラーコントラストが弱いために発見されにくい。色素内視鏡検査は、そのような腫瘍の検出を向上させることができるが、時間がかかり、習得が困難であり、また手順に限られた時間を有する腹腔鏡使用者による臨床実務において受け入れられていない。コントラストの弱いポリープ及び腫瘍検出を支援するために、自動蛍光画像化を具備する内視鏡が開発されてきた。小規模な試験によって、自動蛍光内視鏡がポリープ検出を改善することができることが示されてきたが、その結果は、デュアルビュー能力によってさらに改善されることができる。
図2に示しかつ上述したように、CMOSセンサ66の中央部66aは、前側レンズ群62を通して画像をキャプチャし、外側部分66bは、好ましくは非球面である反射器68を通して前方視野から画像を取得する。前方及び後方視野を表す、中央及び外側部分からの出力信号80、82は、その後プロセッサ84によって処理されることができ、プロセッサは、前方及び後方視野を共に同じ画像88で表示するために、ディスプレイ86に信号を送る。ここでは、前方向(F)及び後方(B)視野を、前方視野のための中央領域と、360度全方向後方視野のための外側リングとを有するモニタ(図2)上に同時に表示する。FR画像88は、カラー画像と交互に、同じモニタ84上に表示される。後方視野が大きい範囲では、側方視野の多くをカバーする。前方及び後方群62、64の1以上の対物レンズは、ズームレンズであってもよく、そのため、照明及び画像化のためのプローブの前方向及び後方向視野の倍率及び角度は、所望のように調整されてもよい。照明及び画像化のためのプローブの前方向及び後方向視野の倍率及び角度は、図1及び2の前方及び/または後方レンズ群62及び64の1以上のレンズ、及び図5A、5Bのレンズ152を動かすことによって、調整されてもよい。
2及び3光子(多光子)検鏡法については、細胞または組織は、2つ/3つの長波長のほぼ同時吸収によって励起される。たとえば、2光子検鏡では、2つの光子は、2倍のエネルギで半分の波長の単一の光子と同じ効果を有する。多光子画像化でより長い波長を用いることによって、焦平面における細胞に対してより少ない損傷で、組織により深く貫入することが可能になる。外生的な蛍光タグ及び先天的な蛍光をターゲットにして、高解像度、高コントラストな組織画像を作り出すことができる。このことは、画像化に対して急速に開発されており、光ファイバ生体顕微鏡が含まれる。このように、前方及び後方視野照明のための適切な波長を選択して、本発明の任意の1以上の実施形態における多光子検鏡法を可能にし得る。
プローブ10は、親機または接続機器にくりかえし挿脱されて、生検及び手術が内視鏡の同じ(単一の)操作チャネルを通して行われることを可能にすることができる。これによって、内視鏡の単一のチャネルが、デュアルビュー画像化のために、及び1つの手順中の生検または摘除の間に共有されることが可能になる。
Claims (27)
- 画像化プローブであって、
プローブの前の前方視野空間を照明するために、前方向経路に電磁放射を供給する円筒型導光部と、
前記円筒型導光部を取り囲む光ファイバのアレイと、
後方向経路内で、前記プローブの傍らの後方視野空間を照明するための前記アレイからの電磁放射を反射するリング反射器と、
画像センサと、
前記画像センサ上に前方及び後方視野を画像化して、前記前方及び後方視野が、前記画像センサ上に、互いに対して固定された空間的関係で登録されるようにする、画像化経路内の対物レンズであって、前記前方向経路、前記後方向経路、及び前記画像化経路が、プローブのいかなるコンポーネントによっても妨げられない、対物レンズと、
を含む、画像化プローブ。 - 画像化プローブであって、
前記プローブの前の空間の前方視野を照明するために、前方向経路内に電磁放射を供給する第1の要素と、
前記プローブと並行する空間の後方視野を照明するために、後方向経路内に電磁放射を供給する第2の要素と、
画像センサと、
画像センサ上に前方及び後方視野を画像化する、画像化経路内の画像化装置であって、前記前方向経路、前記後方向経路、及び前記画像化経路が、前記プローブのいかなるコンポーネントによっても妨げられない、画像化装置と、
を含む、画像化プローブ。 - 前記画像化装置が、複数の対物レンズを含み、前記前方及び後方視野が、前記画像化装置の同じ対物レンズによって、前記画像センサ上に画像化される、請求項2記載のプローブ。
- 前記画像化装置が、透過型の中央部と、反射型の周縁部とを有する要素を含む、請求項3記載のプローブ。
- 前記透過部が、プローブの前の前方視野に、電磁放射を透過させ、前記周縁部が、前記プローブと並行する空間の後方視野に、電磁放射を反射する、請求項4記載のプローブ。
- 前記画像化装置が、完全には同じではない第1及び第2の対物レンズ群を含み、前記前方及び後方視野が、それぞれ第1及び第2の対物レンズ群によって、画像センサ上に画像化される、請求項2記載のプローブ。
- 前記第2の対物レンズ群が、リング反射器を含む、請求項6記載のプローブ。
- 前記画像化装置が、前方及び後方視野を画像化して、前記前方及び後方視野が、互いに対して固定された空間的関係で画像センサ上に登録されるようにする、請求項2記載のプローブ。
- 前記登録された前方及び後方視野を構成して、ディスプレイ上に表示するプロセッサをさらに含む、請求項8記載のプローブ。
- 前記画像化装置が、画像化装置の倍率が調節可能になるズームレンズを含む、請求項2記載のプローブ。
- 前記第1の及び第2の要素が、導光部を各々含み、前記プローブが、第1及び第2の要素の導光部の近傍に位置するLEDをさらに含む、請求項2記載のプローブ。
- 前記第1の及び第2の要素が、各々少なくとも1つのLEDを含む、請求項2記載のプローブ。
- 前記後方視野が、全方向性である、請求項2記載のプローブ。
- 前記プローブと並行する空間を照明するために、前記第2の要素によって供給された前記電磁放射が、全方向性である、請求項2記載のプローブ。
- 前記第1または第2の要素が、照明または励起フィルタを含む、請求項2記載のプローブ。
- 前記画像化装が、エミッションフィルタを含む、請求項2記載のプローブ。
- 前方向または後方向経路に供給された前記電磁放射が、偏光される、請求項2記載のプローブ。
- 画像化プローブであって、
前記プローブの前の空間の前方視野を照明するために、前方向経路に電磁放射を供給する第1の要素と、
前記プローブと並行した空間の後方視野を照明するために、後方向経路に電磁放射を供給する第2の要素と、
画像センサと、
画像センサ上に前方及び後方視野を画像化して、前記前方及び後方視野が、互いに対して固定された空間的関係で画像センサ上に登録されるようにする画像化装置と、
を含む、プローブ。 - 前記前方向経路、前記後方向経路、及び画像化経路が、前記プローブのいかなるコンポーネントによっても妨げられない、請求項18記載のプローブ。
- 医療機器であって、
(a)内部に複数の通路を画定する筐体と、
(b)前記通路のうち1つの中にあるか、または前記筐体に取り付けられた画像化プローブであって、
前記プローブの前の空間の前方視野を照明するために、前方向経路内に電磁放射を供給する第1の要素と、
前記プローブと並行する空間の後方視野を照明するために、後方向経路内に電磁放射を供給する第2の要素と、
画像センサと、
画像センサ上に前方及び後方視野を画像化する、画像化経路内の画像化装置であって、前記前方向経路、前記後方向経路、及び前記画像化経路が、前記プローブのいかなるコンポーネントによっても妨げられない、画像化装置と、
を含む、画像化プローブと、
を含む、医療機器。 - 前記機器が、内視鏡、腹腔鏡、または関節鏡である、請求項20記載の医療機器。
- 前記プローブの前の空間の前方視野を照明するために、前方向経路内に電磁放射を供給することと、
前記プローブと並行した空間の後方視野を照明するために、後方向経路に電磁放射を供給することと、
画像センサ上に前方及び後方視野を画像化経路に沿って画像化して、前記前方及び後方視野及び画像化経路が妨げられていない、
を含む、画像化方法。 - 前方向及び後方向経路に供給される前記電磁放射が、白色光、偏光電磁放射、狭帯域電磁放射、蛍光、又は多光子画像化のために選択された電磁放射である、請求項22記載の方法。
- 前記画像化の倍率を調節することをさらに含む、請求項22記載の方法。
- 前記調節することが、ズームレンズを調節することによる、請求項24記載の方法。
- 前記プローブの前の空間の前方視野か、または前記プローブと並行した空間の後方視野か、もしくは両方を調節することをさらに含む、請求項22記載の方法。
- 前記調節することが、前方向、後方向、及び画像化経路で1以上の対物レンズを動かすことによる、請求項26記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201361831438P | 2013-06-05 | 2013-06-05 | |
US61/831,438 | 2013-06-05 | ||
PCT/US2014/039619 WO2014197241A1 (en) | 2013-06-05 | 2014-05-27 | Dual-view probe for illumination and imaging, and use thereof |
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- 2014-05-27 CN CN201480037378.7A patent/CN105358044A/zh active Pending
- 2014-05-27 JP JP2016518345A patent/JP6599317B2/ja not_active Expired - Fee Related
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JPWO2019064977A1 (ja) * | 2017-09-28 | 2020-12-17 | 富士フイルム株式会社 | 光学系、投影装置及び撮像装置 |
US11269249B2 (en) | 2017-09-28 | 2022-03-08 | Fujifilm Corporation | Optical system, projection apparatus, and imaging apparatus |
US11344186B2 (en) | 2018-04-19 | 2022-05-31 | Fujifilm Corporation | Endoscope optical system and endoscope |
Also Published As
Publication number | Publication date |
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US20160088204A1 (en) | 2016-03-24 |
CN105358044A (zh) | 2016-02-24 |
WO2014197241A1 (en) | 2014-12-11 |
US10536617B2 (en) | 2020-01-14 |
EP3003120A4 (en) | 2017-01-18 |
EP3003120A1 (en) | 2016-04-13 |
JP6599317B2 (ja) | 2019-10-30 |
TW201509361A (zh) | 2015-03-16 |
CA2914631A1 (en) | 2014-12-11 |
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