JP2016520515A5 - - Google Patents
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- Publication number
- JP2016520515A5 JP2016520515A5 JP2016501157A JP2016501157A JP2016520515A5 JP 2016520515 A5 JP2016520515 A5 JP 2016520515A5 JP 2016501157 A JP2016501157 A JP 2016501157A JP 2016501157 A JP2016501157 A JP 2016501157A JP 2016520515 A5 JP2016520515 A5 JP 2016520515A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- lower alkyl
- heterocycle
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361789867P | 2013-03-15 | 2013-03-15 | |
| US61/789,867 | 2013-03-15 | ||
| PCT/US2014/023135 WO2014150395A1 (en) | 2013-03-15 | 2014-03-11 | Anti-pcsk9 compounds and methods for the treatment and/or prevention of cardiovascular diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016520515A JP2016520515A (ja) | 2016-07-14 |
| JP2016520515A5 true JP2016520515A5 (https=) | 2017-04-13 |
Family
ID=51580758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501157A Pending JP2016520515A (ja) | 2013-03-15 | 2014-03-11 | 抗ｐｃｓｋ９化合物および心血管疾患の治療および／または予防のための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10131637B2 (https=) |
| EP (1) | EP2968318A4 (https=) |
| JP (1) | JP2016520515A (https=) |
| CN (1) | CN105473141A (https=) |
| AU (1) | AU2014237198A1 (https=) |
| BR (1) | BR112015023193A2 (https=) |
| CA (1) | CA2904662A1 (https=) |
| WO (1) | WO2014150395A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104471070B (zh) | 2012-05-17 | 2018-09-25 | 基因泰克公司 | 制备羟基化环戊并嘧啶化合物和其盐的方法 |
| MX350443B (es) | 2012-05-17 | 2017-09-06 | Genentech Inc | Proceso para hacer compuestos de aminoácidos. |
| AU2013262505B2 (en) | 2012-05-17 | 2017-09-21 | Array Biopharma Inc. | Process for making hydroxylated cyclopentylpyrimidine compounds |
| RU2014151017A (ru) | 2012-05-17 | 2016-07-10 | Аррэй Байофарма Инк. | Способ получения гидроксилированных циклопентилпиримидинов |
| HRP20200992T1 (hr) | 2012-05-17 | 2020-10-16 | Genentech, Inc. | Amorfni oblik pirimidinil-ciklopentanskog spoja koji inhibira akt, te njegovi pripravci i postupci |
| US10821106B2 (en) | 2015-08-21 | 2020-11-03 | Srx Cardio, Llc | Composition and methods of use of novel phenylalanine small organic compounds to directly modulate PCSK9 protein activity |
| HK1257102A1 (zh) | 2015-08-21 | 2019-10-11 | Portola Pharmaceuticals, Inc. | 苯基哌嗪前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)调节剂及其应用 |
| US10865185B2 (en) | 2015-08-21 | 2020-12-15 | Srx Cardio, Llc | Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate PCSK9 protein activity |
| CN105214087B (zh) | 2015-10-29 | 2017-12-26 | 陈敏 | Pcsk9单克隆抗体在制备治疗炎症免疫性疾病药物中的应用 |
| WO2017087885A1 (en) | 2015-11-19 | 2017-05-26 | Dana-Farber Cancer Institute, Inc. | Methods of identifying compounds that interfere with erg-driven misguidance of baf complexes in tmprss2-erg driven prostate cancers |
| US20190119236A1 (en) * | 2016-02-23 | 2019-04-25 | Portola Pharmaceuticals, Inc. | Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9) |
| BR112018076242A2 (pt) | 2016-06-24 | 2019-03-26 | Hoffmann La Roche | inibidores de pcsk9, pcsk9 inibido, composição farmacêutica, métodos para modular a atividade de pcsk9, para inibir a ligação de pcsk9 a ldlr, para aumentar a disponibilidade de ldlr, para reduzir um nível de ldl-c, para reduzir o nível sérico de ldl-c, para o tratamento de um distúrbio relacionado com colesterol, métodos para o tratamento de um distúrbio associado a um nível anormal de ldl-c, de uma condição associada a um nível elevado de ldl-c, de dislipidemia, de hipercolesterolemia, usos de um inibidor de pcsk9 e método para identificar um composto candidato como um inibidor de pcsk9 que liga um epítopo da seq id nº 1 |
| TW201823222A (zh) * | 2016-12-23 | 2018-07-01 | 財團法人生物技術開發中心 | 化合物、醫藥組成物及其用途 |
| WO2018165718A1 (en) | 2017-03-17 | 2018-09-20 | Cardio Therapeutics Pty Ltd | Heterocyclic inhibitors of pcsk9 |
| WO2019152437A1 (en) | 2018-01-30 | 2019-08-08 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| JP7217043B2 (ja) | 2018-06-25 | 2023-02-02 | デューク ユニバーシティ | Ｐｃｓｋ９発現を特徴とする癌の治療のための組成物および方法 |
| WO2020081588A1 (en) | 2018-10-17 | 2020-04-23 | Dana-Farber Cancer Institute, Inc. | Swi/snf family chromatin remodeling complexes and uses thereof |
| US20230089867A1 (en) * | 2018-11-27 | 2023-03-23 | Novartis Ag | Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder |
| UY38485A (es) | 2018-11-27 | 2020-06-30 | Novartis Ag | Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación |
| JP7657151B2 (ja) | 2018-11-27 | 2025-04-04 | ノバルティス アーゲー | 代謝性障害の処置のためのプロタンパク質コンバターゼスブチリシン／ケキシン９型（ｐｃｓｋ９）阻害剤としての環状ペプチド |
| SG11202107614PA (en) | 2019-01-18 | 2021-08-30 | Astrazeneca Ab | Pcsk9 inhibitors and methods of use thereof |
| US12384776B2 (en) | 2019-01-29 | 2025-08-12 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| WO2020160100A1 (en) | 2019-01-29 | 2020-08-06 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| EP3969620B1 (en) | 2019-05-17 | 2025-06-25 | Regeneron Pharmaceuticals, Inc. | Genome-based methods for reducing cardiovascular risk |
| CA3167275A1 (en) | 2020-01-29 | 2021-08-05 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| US12383555B2 (en) | 2020-05-20 | 2025-08-12 | Foghorn Therapeutics Inc. | Methods of treating cancers |
| US12115154B2 (en) | 2020-12-16 | 2024-10-15 | Srx Cardio, Llc | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) |
| JP2024509268A (ja) | 2021-03-09 | 2024-02-29 | フォグホーン セラピューティクス インコーポレイテッド | 結晶形、それらを含有する組成物、及びそれらの使用方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4017313A (en) | 1974-09-30 | 1977-04-12 | E. I. Du Pont De Nemours And Company | Photosensitive composition containing a leuco dye, a photosensitizer, an aromatic aldehyde and a secondary or tertiary amine and the use thereof in a direct-print process |
| DE3021590A1 (de) | 1980-06-09 | 1981-12-17 | Hoechst Ag, 6000 Frankfurt | 4-halogen-5-(halogenmethyl-phenyl)-oxazol-derivate, ein verfahren zu ihrer herstellung und sie enthaltenden strahlungsempfindliche massen |
| EP1185509A2 (en) * | 1999-05-24 | 2002-03-13 | Cor Therapeutics, Inc. | INHIBITORS OF FACTOR Xa |
| DE10063008A1 (de) * | 2000-12-16 | 2002-06-20 | Merck Patent Gmbh | Carbonsäureamidderivate |
| US20050288340A1 (en) | 2004-06-29 | 2005-12-29 | Pfizer Inc | Substituted heteroaryl- and phenylsulfamoyl compounds |
| CA2646917A1 (en) | 2006-04-11 | 2007-10-18 | Actelion Pharmaceuticals Ltd | Novel sulfonamide compounds |
| CN101679527A (zh) * | 2007-04-13 | 2010-03-24 | 诺瓦提斯公司 | 用于调节前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)的分子和方法 |
| US20090275053A1 (en) | 2008-04-30 | 2009-11-05 | Board Of Regents, The University Of Texas System | Cell-based pcsk9 screening assay |
| US9085527B2 (en) | 2008-07-08 | 2015-07-21 | Catabasis Pharmaceuticals, Inc. | Fatty acid acylated salicylates and their uses |
| WO2011006000A1 (en) * | 2009-07-08 | 2011-01-13 | Haiyan Liu | Berberine derivatives useful for modulating lipid levels and their methods of synthesis |
| BR112012007241A2 (pt) * | 2009-10-01 | 2019-09-24 | Cadila Healthcare Ltd Soc Indiana | compostos , composição farmacêutica, método para tratar desordens, uso dos compostos, medicamento, método para selecionar inibidores com pequenas moléculas de pcsk9 e pequenas moléculas |
| KR20130141500A (ko) * | 2010-09-29 | 2013-12-26 | 크리스탈지노믹스(주) | 단백질 키나제 억제 활성을 갖는 신규한 아미노퀴나졸린 화합물 |
| CA2874244A1 (en) | 2012-05-25 | 2013-11-28 | Catabasis Pharmaceuticals, Inc. | Methods of lowering proprotein convertase subtilisin/kexin type 9 (pcsk9) |
| AR092924A1 (es) | 2012-10-09 | 2015-05-06 | Sanofi Sa | Derivados de pirrolidinona como moduladores de gpr119 para el tratamiento de diabetes, obesidad, dislipidemia y trastornos relacionados |
-
2014
- 2014-03-11 WO PCT/US2014/023135 patent/WO2014150395A1/en not_active Ceased
- 2014-03-11 JP JP2016501157A patent/JP2016520515A/ja active Pending
- 2014-03-11 EP EP14768980.6A patent/EP2968318A4/en not_active Withdrawn
- 2014-03-11 US US14/767,126 patent/US10131637B2/en active Active
- 2014-03-11 AU AU2014237198A patent/AU2014237198A1/en not_active Abandoned
- 2014-03-11 CN CN201480016207.6A patent/CN105473141A/zh active Pending
- 2014-03-11 CA CA2904662A patent/CA2904662A1/en not_active Abandoned
- 2014-03-11 BR BR112015023193A patent/BR112015023193A2/pt active Search and Examination
-
2017
- 2017-12-01 US US15/829,028 patent/US20180079730A1/en not_active Abandoned
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