JP2016519939A - 多能性ヒト脂肪成体幹細胞：単離、キャラクタリゼーションおよび臨床的意味 - Google Patents

多能性ヒト脂肪成体幹細胞：単離、キャラクタリゼーションおよび臨床的意味 Download PDF

Info

Publication number
JP2016519939A
JP2016519939A JP2016515082A JP2016515082A JP2016519939A JP 2016519939 A JP2016519939 A JP 2016519939A JP 2016515082 A JP2016515082 A JP 2016515082A JP 2016515082 A JP2016515082 A JP 2016515082A JP 2016519939 A JP2016519939 A JP 2016519939A
Authority
JP
Japan
Prior art keywords
cells
cell
pasc
pascs
culture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016515082A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016519939A5 (enExample
Inventor
チャーゼンバルク，グレゴリオ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of JP2016519939A publication Critical patent/JP2016519939A/ja
Publication of JP2016519939A5 publication Critical patent/JP2016519939A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/73—Hydrolases (EC 3.)
    • C12N2501/734—Proteases (EC 3.4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1382—Adipose-derived stem cells [ADSC], adipose stromal stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
JP2016515082A 2013-05-22 2014-05-22 多能性ヒト脂肪成体幹細胞：単離、キャラクタリゼーションおよび臨床的意味 Pending JP2016519939A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361826417P 2013-05-22 2013-05-22
US61/826,417 2013-05-22
PCT/US2014/039137 WO2014190150A1 (en) 2013-05-22 2014-05-22 Pluripotent human adipose adult stem cells: isolation, characterization and clinical implications

Publications (2)

Publication Number Publication Date
JP2016519939A true JP2016519939A (ja) 2016-07-11
JP2016519939A5 JP2016519939A5 (enExample) 2017-06-29

Family

ID=51934148

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016515082A Pending JP2016519939A (ja) 2013-05-22 2014-05-22 多能性ヒト脂肪成体幹細胞：単離、キャラクタリゼーションおよび臨床的意味

Country Status (5)

Country Link
US (4) US10131880B2 (enExample)
EP (2) EP3613846A1 (enExample)
JP (1) JP2016519939A (enExample)
CL (1) CL2015003402A1 (enExample)
WO (1) WO2014190150A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022013072A (ja) * 2020-07-03 2022-01-18 富士フイルム株式会社 滑膜由来間葉系幹細胞の製造方法および関節治療用細胞製剤の製造方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016519939A (ja) * 2013-05-22 2016-07-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 多能性ヒト脂肪成体幹細胞：単離、キャラクタリゼーションおよび臨床的意味
JP6940101B2 (ja) * 2016-01-15 2021-09-22 国立大学法人富山大学 虚血性脳梗塞への多能性幹細胞の動員
US20190391147A1 (en) * 2016-04-07 2019-12-26 Rowan University Methods and kits for detecting myo/nog cells in human adipose tissue and methods of use thereof
SG11202011127WA (en) * 2018-05-09 2020-12-30 Life Science Institute Inc Therapeutic agent for spinal cord injury
US20230173065A1 (en) * 2020-05-15 2023-06-08 Seoul National University R&Db Foundation Composition for enhancing immune response by using activation function of dendritic cells of stromal vascular fractions isolated from adipose tissues
WO2022104069A1 (en) 2020-11-13 2022-05-19 Advanced Therapeutic Lab, Inc. Therapeutic methods and compositions utilizing stromal vascular fraction derived from adipose tissue
CN117187174B (zh) * 2023-11-08 2024-02-06 广州正源生物技术有限公司 一种Muse细胞培养基以及一种脂肪Muse细胞的提取方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012133942A1 (ja) * 2011-03-30 2012-10-04 株式会社Ｃｌｉｏ 生体の臍帯又は脂肪組織から単離できる多能性幹細胞

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030082152A1 (en) 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
EP1903107A1 (en) 1999-09-24 2008-03-26 Cybios LLC Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
EP1261694B1 (en) 2000-02-26 2008-01-16 Artecel, Inc. Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof
DE10326750B4 (de) * 2003-06-13 2006-07-27 Gerlach, Jörg, Dr.med. Verfahren zur Herstellung einer Zellpräparation und derart hergestellte Zellpräparationen
AU2005322873B2 (en) 2004-12-30 2011-09-01 Primegen Biotech, Llc Adipose-derived stem cells for tissue regeneration and wound healing
KR100679642B1 (ko) * 2005-11-16 2007-02-06 주식회사 알앤엘바이오 인간 지방조직 유래 다분화능 줄기세포 및 이를 함유하는세포치료제
US20090304644A1 (en) * 2006-05-30 2009-12-10 Cytori Therapeutics, Inc. Systems and methods for manipulation of regenerative cells separated and concentrated from adipose tissue
US20090317367A1 (en) 2007-02-21 2009-12-24 Cedars-Sinai Medical Center Methods of producing preadipocytes and increasing the proliferation of adult adipose stem/progenitor cells
WO2010069008A1 (en) 2008-12-19 2010-06-24 Griffith University A germline competent cell derived from adult tissue
EP2446024A1 (en) * 2009-06-26 2012-05-02 Life&Light Limited Mesenchymal stem cells grown under hypoxic conditions: compositions, methods and uses therefor
US9399758B2 (en) * 2009-07-15 2016-07-26 Mari Dezawa SSEA3(+) pluripotent stem cell that can be isolated from body tissue
US9550975B2 (en) 2009-07-15 2017-01-24 Mari Dezawa SSEA-3 pluripotent stem cell isolated from body tissue
US8501397B2 (en) * 2009-07-24 2013-08-06 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Enrichment of stem cells from adult tissues
US20120230966A1 (en) 2009-09-30 2012-09-13 Parcell Laboratories Llc Tissue transplant compositions and methods for use
JP5745533B2 (ja) 2009-12-18 2015-07-08 シャンハイ アイセル バイオテクノロジー カンパニー リミテッド 多能性幹細胞を製作するための材料と方法
KR20120002134A (ko) * 2010-06-30 2012-01-05 서울대학교산학협력단 지방 기질 세포의 역분화를 유도하는 방법
US20120028933A1 (en) * 2010-07-28 2012-02-02 Baust John M Cell Culture Media Supplement and Method of Molecular Stress Control
JP2016519939A (ja) * 2013-05-22 2016-07-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 多能性ヒト脂肪成体幹細胞：単離、キャラクタリゼーションおよび臨床的意味

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012133942A1 (ja) * 2011-03-30 2012-10-04 株式会社Ｃｌｉｏ 生体の臍帯又は脂肪組織から単離できる多能性幹細胞

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHAZENBALK G ET AL., NOVEL PATHWAY OF ADIPOGENESIS THROUGH CROSS-TALK BETWEEN ADIPOSE TISSUE MACROPH, JPN6018027867, ISSN: 0003842080 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022013072A (ja) * 2020-07-03 2022-01-18 富士フイルム株式会社 滑膜由来間葉系幹細胞の製造方法および関節治療用細胞製剤の製造方法

Also Published As

Publication number Publication date
US10131880B2 (en) 2018-11-20
US20240076623A1 (en) 2024-03-07
EP2999780B1 (en) 2019-10-09
EP2999780A4 (en) 2016-11-16
US20210403872A1 (en) 2021-12-30
EP2999780A1 (en) 2016-03-30
US20190136193A1 (en) 2019-05-09
US11066647B2 (en) 2021-07-20
WO2014190150A1 (en) 2014-11-27
US20160108364A1 (en) 2016-04-21
US11913027B2 (en) 2024-02-27
EP3613846A1 (en) 2020-02-26
CL2015003402A1 (es) 2016-07-22

Similar Documents

Publication Publication Date Title
US11913027B2 (en) Methods of treatment using pluripotent human adipose adult stem cells
Qiu et al. Human amniotic epithelial stem cells: a promising seed cell for clinical applications
Gimeno et al. Pluripotent nontumorigenic adipose tissue-derived muse cells have immunomodulatory capacity mediated by transforming growth factor-β1
US9982237B2 (en) Compositions and methods for reprograming non-pluripotent cells into pluripotent stem cells
US11155782B2 (en) Method for preparing pluripotent stem cells
US10449221B2 (en) Differentiation of stem cells into thyroid tissue
KR101874463B1 (ko) 세포의 재프로그램화 방법 및 이의 용도
Lovati et al. Comparison of equine bone marrow-, umbilical cord matrix and amniotic fluid-derived progenitor cells
WO2012133948A1 (ja) 生体組織から単離できるssea-3陽性の多能性幹細胞を含む他家移植用細胞治療用組成物
US20260117185A1 (en) Enhancement of fibroblast plasticity for treatment of disc degeneration
CN103620023B (zh) 睾丸体细胞来源的多能干细胞、其制备方法以及包含其的治疗勃起功能障碍的药物组合物
CN103459590A (zh) 可由机体的脐带或脂肪组织分离的多能干细胞
Cancedda et al. The Phoenix of stem cells: pluripotent cells in adult tissues and peripheral blood
CN120349967A (zh) 用于重编程细胞的方法
Lange-Consiglio et al. Isolation, molecular characterization, and in vitro differentiation of bovine Wharton jelly–derived multipotent mesenchymal cells
Chandravanshi et al. Reprogramming mouse embryo fibroblasts to functional islets without genetic manipulation
CN119173623A (zh) 诱导的全潜能干细胞、制备方法及使用方法
CN118234847A (zh) 胸腺细胞和制备方法
US20190359944A1 (en) Cell product of mammalian insulin-producing cells and methods for using the same
Somasundaram Endometrial stem cells and its potential applications
JP2018501189A (ja) 骨欠損を治療するための体性幹細胞
HK40013193A (en) Method for preparing pluripotent stem cells
Henning Identification and characterisation of a novel, multi-potent, skeletal muscle-derived stem cell with broad developmental plasticity
Redmond Hubbard A Comparison of Equine Adipose Tissue, Bone Marrow and Peripheral Blood as Sources of Mesenchymal Stem Cells
Cormack Studies on the cardiomyocytic potential of dermal stem cells

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170522

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170522

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180724

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180927

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181225

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20181225

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20190528