JP2016516792A - α−２アドレノレセプターおよびシグマレセプターリガンドの組み合わせ物 - Google Patents

α−２アドレノレセプターおよびシグマレセプターリガンドの組み合わせ物 Download PDF

Info

Publication number
JP2016516792A
JP2016516792A JP2016508133A JP2016508133A JP2016516792A JP 2016516792 A JP2016516792 A JP 2016516792A JP 2016508133 A JP2016508133 A JP 2016508133A JP 2016508133 A JP2016508133 A JP 2016508133A JP 2016516792 A JP2016516792 A JP 2016516792A
Authority
JP
Japan
Prior art keywords
dichlorophenyl
pyrazol
yloxy
substituted
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2016508133A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016516792A5 (OSRAM
Inventor
ザマニロ−カスタネド、ダニエル
ミゲル ベラ−エルナンデス、ホセ
ミゲル ベラ−エルナンデス、ホセ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Esteve Pharmaceuticals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Pharmaceuticals SA filed Critical Esteve Pharmaceuticals SA
Publication of JP2016516792A publication Critical patent/JP2016516792A/ja
Publication of JP2016516792A5 publication Critical patent/JP2016516792A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016508133A 2013-04-16 2014-04-15 α−２アドレノレセプターおよびシグマレセプターリガンドの組み合わせ物 Pending JP2016516792A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13382140.5A EP2792352A1 (en) 2013-04-16 2013-04-16 Alpha-2 adrenoreceptor and sigma receptor ligand combinations
EP13382140.5 2013-04-16
PCT/EP2014/057608 WO2014170319A1 (en) 2013-04-16 2014-04-15 Alpha-2 adrenoceptor and sigma receptor ligand combinations

Publications (2)

Publication Number Publication Date
JP2016516792A true JP2016516792A (ja) 2016-06-09
JP2016516792A5 JP2016516792A5 (OSRAM) 2017-06-01

Family

ID=48227118

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016508133A Pending JP2016516792A (ja) 2013-04-16 2014-04-15 α−２アドレノレセプターおよびシグマレセプターリガンドの組み合わせ物

Country Status (16)

Country Link
US (1) US20160058771A1 (OSRAM)
EP (2) EP2792352A1 (OSRAM)
JP (1) JP2016516792A (OSRAM)
KR (1) KR20150143754A (OSRAM)
CN (1) CN105228606A (OSRAM)
AR (1) AR095858A1 (OSRAM)
AU (1) AU2014255837A1 (OSRAM)
BR (1) BR112015026259A2 (OSRAM)
CA (1) CA2908926A1 (OSRAM)
HK (1) HK1219431A1 (OSRAM)
MX (1) MX2015014441A (OSRAM)
PH (1) PH12015502282A1 (OSRAM)
RU (1) RU2015148766A (OSRAM)
SG (1) SG11201508102XA (OSRAM)
TN (1) TN2015000440A1 (OSRAM)
WO (1) WO2014170319A1 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2116539A1 (en) 2008-04-25 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof
EP2353598A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for use in the prevention and/or treatment of postoperative pain
EP2353591A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof
EP2388005A1 (en) 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
EP2415471A1 (en) 2010-08-03 2012-02-08 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in opioid-induced hyperalgesia
EP2524694A1 (en) 2011-05-19 2012-11-21 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain
TW201607538A (zh) 2013-12-17 2016-03-01 以斯提夫博士實驗室股份有限公司 血清素－去甲腎上腺素再攝取抑制劑（ＳＮＲＩＳ）和σ受體配體組合物
EP3886854A4 (en) 2018-11-30 2022-07-06 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011510096A (ja) * 2008-04-18 2011-03-31 ウォーソー・オーソペディック・インコーポレーテッド 疼痛および／または炎症の治療のためのαアドレナリン作動性受容体アゴニスト
JP2012526854A (ja) * 2009-05-15 2012-11-01 レクロ・ファーマ・インコーポレイテッド デクスメデトミジンの舌下組成物およびその使用方法
WO2012156497A1 (en) * 2011-05-19 2012-11-22 Laboratorios Del Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050075001A (ko) * 2002-11-15 2005-07-19 이 아이 듀폰 디 네모아 앤드 캄파니 신규 안트라닐아미드 살충제
EP1781618B1 (en) 2004-08-27 2012-10-03 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
EP2116539A1 (en) 2008-04-25 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof
EP2292236A1 (en) 2009-08-14 2011-03-09 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention or treatment of pain induced by chemotherapy
EP2335688A1 (en) 2009-11-25 2011-06-22 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical compositions comprising sigma receptor ligands
RU2559325C2 (ru) 2009-11-25 2015-08-10 Лабораторьос Дель Др. Эстеве, С.А. Соли 4-[2-[[5-метил-1-(2-нафталинил)-1н-пиразол-3-ил]окси]этил]морфолина
HUE029738T2 (en) 2010-02-04 2017-04-28 Esteve Labor Dr 4- [2 - [[5-Methyl-1- (2-naphthalenyl) -1H-pyrazol-3-yl] oxy] ethyl] morpholine hydrochloride polymorphs and solvates
US20110269727A1 (en) * 2010-04-29 2011-11-03 Toledano Annette C Composition to reduce allodynic back pain and related method of use
EP2388005A1 (en) 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
EP2415471A1 (en) 2010-08-03 2012-02-08 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in opioid-induced hyperalgesia
EP2426111A1 (en) 2010-08-09 2012-03-07 Laboratorios Del. Dr. Esteve, S.A. 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride amorphous solid forms
EP2460519A1 (en) 2010-12-03 2012-06-06 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in bone cancer pain

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011510096A (ja) * 2008-04-18 2011-03-31 ウォーソー・オーソペディック・インコーポレーテッド 疼痛および／または炎症の治療のためのαアドレナリン作動性受容体アゴニスト
JP2012526854A (ja) * 2009-05-15 2012-11-01 レクロ・ファーマ・インコーポレイテッド デクスメデトミジンの舌下組成物およびその使用方法
WO2012156497A1 (en) * 2011-05-19 2012-11-22 Laboratorios Del Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BERNHARD WUNSCH, JOURNAL OF MEDICINAL CHEMISTRY, vol. V55 N19, JPN5016005370, 11 October 2012 (2012-10-11), pages 8209 - 8210, ISSN: 0004052005 *

Also Published As

Publication number Publication date
SG11201508102XA (en) 2015-11-27
PH12015502282A1 (en) 2016-02-01
WO2014170319A1 (en) 2014-10-23
HK1219431A1 (zh) 2017-04-07
CN105228606A (zh) 2016-01-06
MX2015014441A (es) 2016-06-21
US20160058771A1 (en) 2016-03-03
TN2015000440A1 (en) 2017-01-03
RU2015148766A3 (OSRAM) 2018-03-29
EP2986284A1 (en) 2016-02-24
BR112015026259A2 (pt) 2017-07-25
KR20150143754A (ko) 2015-12-23
RU2015148766A (ru) 2017-05-18
AR095858A1 (es) 2015-11-18
AU2014255837A1 (en) 2015-11-05
EP2792352A1 (en) 2014-10-22
CA2908926A1 (en) 2014-10-23

Similar Documents

Publication Publication Date Title
KR101855358B1 (ko) 골암통증에서의 시그마 리간드의 용도
KR101855357B1 (ko) 오피오이드 유도성 통각과민에서의 시그마 리간드의 용도
CN105873580B (zh) 加巴喷丁类化合物与σ受体配体的组合物
US20160058771A1 (en) Alpha-2 adrenoceptor and sigma receptor ligand combinations
JP2016523276A (ja) 間質性膀胱炎／膀胱痛症候群（ｉｃ／ｂｐｓ）に関連する疼痛の予防および治療のためのシグマリガンドの使用
US20160220574A1 (en) Nsaid and sigma receptor ligand combinations
CN105120868A (zh) 组合治疗
WO2012156497A1 (en) Use of sigma ligands in diabetes type-2 associated pain
TW201607538A (zh) 血清素－去甲腎上腺素再攝取抑制劑（ＳＮＲＩＳ）和σ受體配體組合物
KR20170096130A (ko) 골관절염에서 시그마 수용체 리간드의 용도
JP7308911B2 (ja) ニューロンヒスタミン受容体－３アンタゴニストとしての化合物およびその使用
TW201532605A (zh) α－２腎上腺素受體及σ受體配體組合
CN106146404A (zh) 哒嗪酮类衍生物及其应用
RU2667954C2 (ru) Фармацевтическая композиция для лечения функциональных психических расстройств

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170414

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170414

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171205

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180126

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180605

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20181113

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20190611