JP2016516734A - オートファジー誘導ペプチド類似体 - Google Patents

オートファジー誘導ペプチド類似体 Download PDF

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Publication number
JP2016516734A
JP2016516734A JP2016504295A JP2016504295A JP2016516734A JP 2016516734 A JP2016516734 A JP 2016516734A JP 2016504295 A JP2016504295 A JP 2016504295A JP 2016504295 A JP2016504295 A JP 2016504295A JP 2016516734 A JP2016516734 A JP 2016516734A
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Japan
Prior art keywords
peptide
compound
autophagy
substituted
residues
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JP2016504295A
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English (en)
Japanese (ja)
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JP2016516734A5 (https=
Inventor
レバイン，ベス・シー
ショージ−カワタ，サナエ
グリシン，ニック・ヴィー
キンチ，リサ・エヌ
リチタージ，オリビエ
ウィルキンス，アンジェラ・ディー
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Baylor College of Medicine
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Baylor College of Medicine
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Publication date
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Publication of JP2016516734A publication Critical patent/JP2016516734A/ja
Publication of JP2016516734A5 publication Critical patent/JP2016516734A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2016504295A 2013-03-18 2014-02-26 オートファジー誘導ペプチド類似体 Pending JP2016516734A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361803095P 2013-03-18 2013-03-18
US61/803,095 2013-03-18
PCT/US2014/018467 WO2014149440A1 (en) 2013-03-18 2014-02-26 Autophagy-inducing peptide analogs

Publications (2)

Publication Number Publication Date
JP2016516734A true JP2016516734A (ja) 2016-06-09
JP2016516734A5 JP2016516734A5 (https=) 2017-03-30

Family

ID=51267254

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016504295A Pending JP2016516734A (ja) 2013-03-18 2014-02-26 オートファジー誘導ペプチド類似体

Country Status (6)

Country Link
US (2) US8802633B1 (https=)
EP (1) EP2976353B1 (https=)
JP (1) JP2016516734A (https=)
AU (1) AU2014238163B2 (https=)
CA (1) CA2888759C (https=)
WO (1) WO2014149440A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021531246A (ja) * 2018-07-11 2021-11-18 イミュニティ ファルマ リミテッドImmunity Pharma Ltd. ペプチド化合物およびその治療的用途

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108431033A (zh) 2015-09-28 2018-08-21 泰莱托恩基金会 骨生长病症的治疗
US10993983B2 (en) 2016-03-18 2021-05-04 Trustees Of Tufts College Cyclic peptide epitopes and small-molecule mimics for inducing autophagy
US20190183908A1 (en) 2016-05-13 2019-06-20 Case Western Reserve University Autophagy activators for treating or preventing skin injury
US10618939B2 (en) 2016-06-29 2020-04-14 The Hong Kong Polytechnic University Hydrocarbon-stapled polypeptides for enhancement of endosome-lysosomal degradation
US20180002381A1 (en) * 2016-06-29 2018-01-04 The Hong Kong Polytechnic University Hydrocarbon-stapled polypeptides for enhancement of endosome-lysosomal degradation
WO2022038638A1 (en) * 2020-08-19 2022-02-24 Translational Health Science And Technology Institute Autophagy inducing peptides
WO2022111829A1 (en) 2020-11-30 2022-06-02 Symrise Ag Essential oils of citrus fruits for use as medicament for induced, increased and/or accelerated autophagy in human keratinocytes
CN117223676B (zh) * 2023-09-25 2024-08-20 武汉大学 面中部发育畸形动物选育方法、辅助选育试剂和预防药物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011088421A2 (en) * 2010-01-15 2011-07-21 California Institute Of Technology Discovery and applications of the proteolytic function of n-terminal acetylation of cellular proteins
WO2013119377A1 (en) * 2012-02-11 2013-08-15 Board Of Regents, The University Of Texas System Autophagy-inducing peptide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2881429B1 (fr) * 2005-02-01 2007-04-06 Servier Lab Motif de la proteine beclin interagissant avec les membres anti-apoptotiques de la famille de proteines bcl-2 et utilisations
WO2011106684A2 (en) * 2010-02-25 2011-09-01 San Diego State University Foundation Compositions and methods for modulating autophagy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011088421A2 (en) * 2010-01-15 2011-07-21 California Institute Of Technology Discovery and applications of the proteolytic function of n-terminal acetylation of cellular proteins
WO2013119377A1 (en) * 2012-02-11 2013-08-15 Board Of Regents, The University Of Texas System Autophagy-inducing peptide

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AUTOPHAGY, vol. 1, no. 1, JPN7014002200, 2005, pages 46 - 52, ISSN: 0003876136 *
S H JOO, BIOMOL THER., 2012, 20(1), PP19-26, JPN6018000191, ISSN: 0003876137 *
S PATTINGRE, ET AL., CELL, 2005, 122, PP927-939, JPN6018000194, ISSN: 0003715732 *
S S KAWATA, ET AL., NATURE, FEB.2013, 494, PP201-206, JPN6018000190, ISSN: 0003876135 *
T A AL-HILAL, ET AL., ADVANCED DRUG DELIVERY REVIEWS, 2013(AVAILABLE ONLINE 7 DEC 2012), 65, PP845-8, JPN6018000192, ISSN: 0003876138 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021531246A (ja) * 2018-07-11 2021-11-18 イミュニティ ファルマ リミテッドImmunity Pharma Ltd. ペプチド化合物およびその治療的用途
JP7395517B2 (ja) 2018-07-11 2023-12-11 イミュニティ ファルマ リミテッド ペプチド化合物およびその治療的用途
JP2024026217A (ja) * 2018-07-11 2024-02-28 イミュニティ ファルマ リミテッド ペプチド化合物およびその治療的用途
JP7682248B2 (ja) 2018-07-11 2025-05-23 イミュニティ ファルマ リミテッド ペプチド化合物およびその治療的用途

Also Published As

Publication number Publication date
EP2976353A1 (en) 2016-01-27
EP2976353A4 (en) 2016-02-10
AU2014238163B2 (en) 2015-11-26
CA2888759C (en) 2016-11-29
WO2014149440A1 (en) 2014-09-25
US10300106B2 (en) 2019-05-28
EP2976353B1 (en) 2018-12-26
CA2888759A1 (en) 2014-09-25
US20150359840A1 (en) 2015-12-17
US8802633B1 (en) 2014-08-12
AU2014238163A1 (en) 2015-09-24

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