CA2888759C - Autophagy-inducing peptide analogs - Google Patents

Autophagy-inducing peptide analogs Download PDF

Info

Publication number
CA2888759C
CA2888759C CA2888759A CA2888759A CA2888759C CA 2888759 C CA2888759 C CA 2888759C CA 2888759 A CA2888759 A CA 2888759A CA 2888759 A CA2888759 A CA 2888759A CA 2888759 C CA2888759 C CA 2888759C
Authority
CA
Canada
Prior art keywords
compound
peptide
beclin
autophagy
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2888759A
Other languages
English (en)
French (fr)
Other versions
CA2888759A1 (en
Inventor
Beth C. Levine
Sanae SHOJI-KAWATA
Nick V. Grishin
Lisa N. Kinch
Olivier Lichtarge
Angela D. Wilkins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
University of Texas System
Original Assignee
Baylor College of Medicine
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine, University of Texas System filed Critical Baylor College of Medicine
Publication of CA2888759A1 publication Critical patent/CA2888759A1/en
Application granted granted Critical
Publication of CA2888759C publication Critical patent/CA2888759C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CA2888759A 2013-03-18 2014-02-26 Autophagy-inducing peptide analogs Active CA2888759C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361803095P 2013-03-18 2013-03-18
US61/803,095 2013-03-18
PCT/US2014/018467 WO2014149440A1 (en) 2013-03-18 2014-02-26 Autophagy-inducing peptide analogs

Publications (2)

Publication Number Publication Date
CA2888759A1 CA2888759A1 (en) 2014-09-25
CA2888759C true CA2888759C (en) 2016-11-29

Family

ID=51267254

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2888759A Active CA2888759C (en) 2013-03-18 2014-02-26 Autophagy-inducing peptide analogs

Country Status (6)

Country Link
US (2) US8802633B1 (https=)
EP (1) EP2976353B1 (https=)
JP (1) JP2016516734A (https=)
AU (1) AU2014238163B2 (https=)
CA (1) CA2888759C (https=)
WO (1) WO2014149440A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108431033A (zh) 2015-09-28 2018-08-21 泰莱托恩基金会 骨生长病症的治疗
US10993983B2 (en) 2016-03-18 2021-05-04 Trustees Of Tufts College Cyclic peptide epitopes and small-molecule mimics for inducing autophagy
US20190183908A1 (en) 2016-05-13 2019-06-20 Case Western Reserve University Autophagy activators for treating or preventing skin injury
US10618939B2 (en) 2016-06-29 2020-04-14 The Hong Kong Polytechnic University Hydrocarbon-stapled polypeptides for enhancement of endosome-lysosomal degradation
US20180002381A1 (en) * 2016-06-29 2018-01-04 The Hong Kong Polytechnic University Hydrocarbon-stapled polypeptides for enhancement of endosome-lysosomal degradation
IL280101B2 (en) * 2018-07-11 2025-05-01 Immunity Pharma Ltd Peptide compounds and their therapeutic uses
WO2022038638A1 (en) * 2020-08-19 2022-02-24 Translational Health Science And Technology Institute Autophagy inducing peptides
WO2022111829A1 (en) 2020-11-30 2022-06-02 Symrise Ag Essential oils of citrus fruits for use as medicament for induced, increased and/or accelerated autophagy in human keratinocytes
CN117223676B (zh) * 2023-09-25 2024-08-20 武汉大学 面中部发育畸形动物选育方法、辅助选育试剂和预防药物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2881429B1 (fr) * 2005-02-01 2007-04-06 Servier Lab Motif de la proteine beclin interagissant avec les membres anti-apoptotiques de la famille de proteines bcl-2 et utilisations
US8999896B2 (en) * 2010-01-15 2015-04-07 California Institute Of Technology Discovery and applications of the proteolytic function of N-terminal acetylation of cellular proteins
WO2011106684A2 (en) * 2010-02-25 2011-09-01 San Diego State University Foundation Compositions and methods for modulating autophagy
AU2013217663B2 (en) * 2012-02-11 2016-09-22 Baylor College Of Medicine Autophagy-inducing peptide

Also Published As

Publication number Publication date
EP2976353A1 (en) 2016-01-27
EP2976353A4 (en) 2016-02-10
AU2014238163B2 (en) 2015-11-26
WO2014149440A1 (en) 2014-09-25
US10300106B2 (en) 2019-05-28
EP2976353B1 (en) 2018-12-26
CA2888759A1 (en) 2014-09-25
US20150359840A1 (en) 2015-12-17
US8802633B1 (en) 2014-08-12
JP2016516734A (ja) 2016-06-09
AU2014238163A1 (en) 2015-09-24

Similar Documents

Publication Publication Date Title
CA2888759C (en) Autophagy-inducing peptide analogs
Fischer et al. A quantitative validation of fluorophore-labelled cell-permeable peptide conjugates: fluorophore and cargo dependence of import
EP2812347B1 (en) Autophagy-inducing peptide
EP2320927A2 (en) Modified peptides as potent inhibitors of the psd-95/nmda receptor interaction
CA3086768C (en) Atf5 peptide variants and uses thereof
AU2020311873B2 (en) Modified BCL9 mimetic peptides
AU712327B2 (en) Two non-contiguous regions contribute to nidogen binding to a single EGF-like motif of the laminin gamma1 chain
US6849712B1 (en) Peptides with β1 integrin subunit dependent cell adhesion modulating activity
Berezowska et al. Dansylated analogues of the opioid peptide [Dmt1] DALDA: in vitro activity profiles and fluorescence parameters.
US12595289B2 (en) Therapeutic agent for breast cancer comprising BIG3-PHB2 interaction-inhibiting peptide derived from PHB2
CA2319207A1 (en) Peptides with .beta.1 integrin subunit dependent cell adhesion modulating activity
Jha Development of a New Cell Penetrating Peptide: Design, Synthesis and Applications
Class et al. Patent application title: ATF5 Peptide Variants and Uses Thereof
Greene et al. Synthesis of a C-Terminal Fluorescein-Labeled 36-mer Peptide
WO2022106951A1 (en) A process for producing egf
Wang et al. The effect of Glu position change on the opioid activity of deltorphin II

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150420

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 11TH ANNIV.) - STANDARD

Year of fee payment: 11

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250221

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20250221

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250221

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20260423