JP2016516533A - 混合ペンニードル - Google Patents
混合ペンニードル Download PDFInfo
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- JP2016516533A JP2016516533A JP2016510775A JP2016510775A JP2016516533A JP 2016516533 A JP2016516533 A JP 2016516533A JP 2016510775 A JP2016510775 A JP 2016510775A JP 2016510775 A JP2016510775 A JP 2016510775A JP 2016516533 A JP2016516533 A JP 2016516533A
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- A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
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- A61M2205/00—General characteristics of the apparatus
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- A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw
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Abstract
Description
Claims (18)
- 遠位端および近位端と、第1の薬物コンパートメントおよび第2の薬物コンパートメントと、を有するペン本体と、
前記第1の薬物コンパートメントおよび前記第2の薬物コンパートメントのそれぞれに係合される第1の投薬機構および第2の投薬機構ならびに第1の投与プランジャおよび第2の投与プランジャと、
前記ペン本体の前記遠位端において受容され、前記ペン本体上の第1の位置および第2の位置に受容されるように適合される可動ハウジングと、
前記可動ハウジングの遠位端において受容され、患者端ニードル、フィラーニードル、ならびに前記患者端ニードルと前記フィラーニードルとの間にあって前記患者端ニードルと前記フィラーニードルとによってアクセスされる圧縮可能混合リザーバを備えるペンニードルアセンブリと、を備え、
前記可動ハウジングは、前記フィラーニードルが前記第1の薬物コンパートメントと流体連通する第1の位置と、前記フィラーニードルが前記第2の薬物コンパートメントと流体連通する第2の位置との間で可動であり、
前記混合リザーバを押圧することによって、注射中に前記患者端ニードルを通り抜けるように前記混合リザーバ内の薬物が押しやられることを特徴とする投薬ペン。 - 各薬物コンパートメントは薬物カートリッジを備え、各投与プランジャは各薬物カートリッジと係合することを特徴とする請求項1に記載の投薬ペン。
- 前記混合リザーバから前記第1の薬物コンパートメントおよび前記第2の薬物コンパートメントへの逆流を妨げる前記フィラーニードル上の逆止め弁を備えることを特徴とする請求項1に記載の投薬ペン。
- 前記第1の投薬機構および前記第2の投薬機構は、前記ペン本体の前記近位端から突出する第1の回転可能なノブおよび第2の回転可能なノブを備えることを特徴とする請求項1に記載の投薬ペン。
- 前記可動ハウジングは、長手方向の軸を有するシャフトによって前記ペン本体と接続され、前記可動ハウジングは、前記フィラーニードルが前記第1の薬物コンパートメントと軸方向に整合される第1の位置から、前記フィラーニードルが前記第2の薬物コンパートメントと軸方向に整合される第2の位置まで、前記シャフトの前記軸の周りを回転可能であることを特徴とする請求項1に記載の投薬ペン。
- 前記圧縮可能混合リザーバは、前記混合リザーバ内を移動し、前記混合リザーバを封止するストッパを含み、
前記患者端ニードルは、前記混合リザーバにアクセスするように前記ストッパを貫通して延び、
前記ペンニードルアセンブリの外側のスリーブは、近位方向に前記スリーブを移動することが、前記ストッパを移動させて前記混合リザーバを圧縮し、薬物を前記患者端ニードルから外へ押しやることになるように、前記ストッパに固定されることを特徴とする請求項1に記載の投薬ペン。 - 前記第1の薬物コンパートメントはインスリンを含み、前記第2の薬物コンパートメントはグルカゴン様ペプチドを含むことを特徴とする請求項1に記載の投薬ペン。
- 前記ペンニードルアセンブリの近位端を受容し、前記薬物コンパートメントへのアクセスを提供するように適合された前記可動ハウジングの前記遠位端における埋め込まれた開口を含むことを特徴とする請求項1に記載の投薬ペン。
- 前記ペンニードルアセンブリの近位端における内側にねじ切りされた開口を受容するように適合された前記可動ハウジングの前記遠位端から突出するねじ切りされた開口を含むことを特徴とする請求項1に記載の投薬ペン。
- 前記可動ハウジングと前記ペン本体とを接続するシャフトであって、前記可動ハウジングに取り付けられるペンニードルが、前記フィラーニードルが前記第1の薬物コンパートメントと流体連通する第1の位置から、前記フィラーニードルが前記第2の薬物コンパートメントと流体連通する第2の位置の間で移動するように、前記シャフトは、前記ペン本体を近位および遠位に摺動し、前記ペンニードルアセンブリの前記フィラーニードルが前記薬物コンパートメントに係合される近位位置から、前記ペンニードルアセンブリが前記ペン本体に対して回転する遠位位置の間で摺動する、シャフトを備えることを特徴とする請求項1に記載の投薬ペン。
- 前記ペンニードルアセンブリは、注射を投与する前に取り外される前記患者端ニードルに対する第1の取り外し可能カバーを備えることを特徴とする請求項1に記載の投薬ペン。
- 前記ペンニードルアセンブリは、前記可動ハウジングに前記ペンニードルアセンブリを取り付ける前に取り外される前記フィラーニードルを覆う第2の取り外し可能カバーを備えることを特徴とする請求項1に記載の投薬ペン。
- 薬剤を混合し、投薬ペンから前記薬剤を送達する方法であって、
第1の薬物コンパートメントに含まれる第1の薬剤の第1の投与を選択するステップと、
第2の薬物コンパートメントに含まれる第2の薬剤の第2の投与を選択するステップと、
可動ハウジングの遠位端において受容されるペンニードルアセンブリに前記第1の投与を送達する前記第1の薬物コンパートメントと係合される第1の投与プランジャの移動によって、第1の投与機構を作動するステップであって、前記ペンニードルアセンブリは、患者端ニードル、フィラーニードル、およびこれらの間にある圧縮可能混合リザーバを備え、前記圧縮可能混合リザーバは、前記フィラーニードルを介して前記第1の投与を受容する、第1の投与機構を作動するステップと、
前記圧縮可能混合リザーバから前記第1の薬物コンパートメントを解除するステップと、
前記圧縮可能混合リザーバと前記第2の薬物コンパートメントとを係合するステップと、
前記フィラーニードルを介して前記圧縮可能混合リザーバに前記第2の投与を送達する前記第2の薬物コンパートメントと係合される第2の投与プランジャの移動によって、第2の投与機構を作動するステップと、
前記混合リザーバを圧縮して、前記混合リザーバの前記第1の投与および前記第2の投与を、前記患者端ニードルを通り抜けるように押しやるステップと
を備えることを特徴とする方法。 - 前記第1の薬物コンパートメントおよび前記第2の薬物コンパートメントは、シャフトによって前記可動ハウジングと接続されたペン本体に位置し、
前記圧縮可能混合リザーバは、前記第1の投与プランジャから離れる方向に前記可動ハウジングおよび前記シャフトを移動することによって、前記第1の薬物コンパートメントから解除され、
前記可動ハウジングおよび前記シャフトは、前記第2の薬物コンパートメントと前記圧縮可能混合リザーバとが整合するように、回転され、
前記圧縮可能混合リザーバは、前記可動ハウジングおよび前記シャフトを前記第2の投与プランジャに向けて近位の方向に移動することによって、前記第2の薬物コンパートメントと係合されることを特徴とする請求項13に記載の方法。 - 前記ペンニードルアセンブリは、前記可動ハウジングの前記遠位端における内側または外側にねじ切りされた開口にねじ切りされることを特徴とする請求項14に記載の方法。
- 前記薬物ペンの近位端から突出する第1の用量ノブを回転して、前記第1の投薬機構を作動する前に前記第1の用量ノブを設定するステップと、
前記薬物ペンの近位端から突出する第2の用量ノブを回転して、前記第2の投薬機構を作動する前に前記第2の用量ノブを設定するステップと
を含むことを特徴とする請求項13に記載の方法。 - 前記圧縮可能混合リザーバは、前記混合リザーバ内を移動し、前記混合リザーバを封止するストッパを含み、前記ペンニードルアセンブリの外側のスリーブは、近位方向に前記スリーブを移動することが、前記ストッパを移動させて前記混合リザーバを圧縮し、薬物を前記患者端ニードルから外へ押しやることになるように、前記ストッパに固定されることを特徴とする請求項13に記載の方法。
- 前記第1の薬剤はインスリンであり、前記第2の薬剤はグルカゴン様ペプチドであることを特徴とする請求項13に記載の方法。
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US13/869,545 US9468725B2 (en) | 2013-04-24 | 2013-04-24 | Mixing pen needle |
US13/869,545 | 2013-04-24 | ||
PCT/US2014/035233 WO2014176393A2 (en) | 2013-04-24 | 2014-04-24 | Mixing pen needle |
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JP6426709B2 JP6426709B2 (ja) | 2018-11-21 |
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EP (1) | EP2988798B1 (ja) |
JP (1) | JP6426709B2 (ja) |
CN (1) | CN205460432U (ja) |
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DK3656421T3 (da) | 2018-11-20 | 2023-12-18 | Shl Medical Ag | Blandings- og udløsningsindretning til en lægemiddelindgivelsesanordning |
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WO2014176393A2 (en) | 2014-10-30 |
EP2988798A4 (en) | 2017-01-25 |
US20140323963A1 (en) | 2014-10-30 |
US10207054B2 (en) | 2019-02-19 |
ES2723358T3 (es) | 2019-08-26 |
JP6426709B2 (ja) | 2018-11-21 |
EP2988798B1 (en) | 2019-01-02 |
US9468725B2 (en) | 2016-10-18 |
EP2988798A2 (en) | 2016-03-02 |
CA2910321A1 (en) | 2014-10-30 |
CA2910321C (en) | 2021-05-18 |
WO2014176393A3 (en) | 2014-12-11 |
US20170000947A1 (en) | 2017-01-05 |
CN205460432U (zh) | 2016-08-17 |
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