JP2016516028A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016516028A5 JP2016516028A5 JP2016500471A JP2016500471A JP2016516028A5 JP 2016516028 A5 JP2016516028 A5 JP 2016516028A5 JP 2016500471 A JP2016500471 A JP 2016500471A JP 2016500471 A JP2016500471 A JP 2016500471A JP 2016516028 A5 JP2016516028 A5 JP 2016516028A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- optionally substituted
- inden
- hydrogen
- hydroxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C[C@](CC1*)(C(*)CC1I)C(CC1)C(*)C(CC2*)C1(*)C2(*)N=* Chemical compound C[C@](CC1*)(C(*)CC1I)C(CC1)C(*)C(CC2*)C1(*)C2(*)N=* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361785860P | 2013-03-14 | 2013-03-14 | |
| US61/785,860 | 2013-03-14 | ||
| PCT/US2014/019125 WO2014143561A1 (en) | 2013-03-14 | 2014-02-27 | Ship1 modulators and methods related thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016516028A JP2016516028A (ja) | 2016-06-02 |
| JP2016516028A5 true JP2016516028A5 (OSRAM) | 2017-02-09 |
| JP6407950B2 JP6407950B2 (ja) | 2018-10-17 |
Family
ID=50288306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016500471A Expired - Fee Related JP6407950B2 (ja) | 2013-03-14 | 2014-02-27 | Ｓｈｉｐ１モジュレーターおよびそれに関連する組成物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10100056B2 (OSRAM) |
| EP (1) | EP2970100A1 (OSRAM) |
| JP (1) | JP6407950B2 (OSRAM) |
| KR (1) | KR20150130426A (OSRAM) |
| CN (1) | CN105209429B (OSRAM) |
| AU (1) | AU2014228574B2 (OSRAM) |
| BR (1) | BR112015022577A2 (OSRAM) |
| CA (1) | CA2902764A1 (OSRAM) |
| HK (1) | HK1220173A1 (OSRAM) |
| IL (1) | IL241168A0 (OSRAM) |
| MX (1) | MX2015011280A (OSRAM) |
| RU (1) | RU2015143675A (OSRAM) |
| WO (1) | WO2014143561A1 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9540353B2 (en) | 2013-01-09 | 2017-01-10 | Aquinox Pharmaceuticals (Canada) Inc. | SHIP1 modulators and methods related thereto |
| RU2015143675A (ru) | 2013-03-14 | 2017-04-27 | Экуинокс Фармасьютикалз (Кэнэда) Инк. | Ship1 модуляторы и относящиеся к ним способы |
| KR20220110337A (ko) | 2013-03-14 | 2022-08-05 | 에퀴녹스 파머수티칼스 (캐나다) 인코포레이티드 | Ship1 조절제 및 그와 관련된 방법 |
| US9944590B2 (en) | 2015-06-26 | 2018-04-17 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
| US10053415B2 (en) | 2016-01-20 | 2018-08-21 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
| WO2017149052A1 (en) | 2016-03-02 | 2017-09-08 | Patheon Austria Gmbh Co. & Kg | Process and intermediates for the production of 17(20)-ene b-seco steroids |
| WO2018126040A1 (en) | 2016-12-28 | 2018-07-05 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol |
| CN112533905A (zh) | 2018-04-06 | 2021-03-19 | 塔罗制药公司 | 可用于治疗疼痛和炎症的茚衍生物 |
| CN112654632A (zh) | 2018-04-06 | 2021-04-13 | 塔罗制药公司 | 可用于治疗疼痛和炎症的十六氢-1H-环戊二烯并[a]菲衍生物 |
| IL277904B2 (en) * | 2018-04-06 | 2024-05-01 | Aquinox Pharmaceuticals Canada Inc | History of indan for use in the treatment of pain and inflammation |
| CN111056962B (zh) * | 2019-11-28 | 2022-08-05 | 重庆爱旭龙科技有限公司 | 一种诺司普托及其醋酸盐的制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1084718B (de) | 1958-07-08 | 1960-07-07 | Bayer Ag | Verfahren zur Herstellung von Secosteroiden |
| SE345995B (OSRAM) | 1969-01-31 | 1972-06-19 | Bristol Myers Co | |
| US3682983A (en) | 1969-11-12 | 1972-08-08 | Klaus Prezewowsky | Preparation of {66 {11 {11 -17 ethinyl steroids |
| US3962275A (en) | 1972-06-05 | 1976-06-08 | Hoffmann-La Roche Inc. | 7-oxa steroids |
| US3869467A (en) | 1972-06-05 | 1975-03-04 | Hoffmann La Roche | 17-{62 -Hydroxy-17-{60 -methyl-5-{60 -androstano{9 3,2-c{9 or{8 2,3-d{9 isoxazoles |
| JPH01290624A (ja) | 1988-05-16 | 1989-11-22 | Shiono Chem Kk | ５，６―セコ―ステロール誘導体血清脂質低下剤 |
| WO1993013124A1 (en) | 1991-12-20 | 1993-07-08 | Glaxo Inc. | Inhibitors of 5-alpha-testosterone reductase |
| JPH05221901A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール誘導体 |
| JPH05221924A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール化合物 |
| US5464866A (en) | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
| AP459A (en) | 1992-12-18 | 1996-02-14 | Glaxo Wellcome Inc | Substituted 6-azaandrostenones. |
| DK0707566T3 (da) | 1993-07-09 | 2000-09-04 | Theramex | Hidtil ukendte strukturelle analoger til vitamin D |
| US5541322A (en) | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
| US6046185A (en) | 1996-07-11 | 2000-04-04 | Inflazyme Pharmaceuticals Ltd. | 6,7-oxygenated steroids and uses related thereto |
| EP1118654A4 (en) | 1999-04-16 | 2007-03-07 | Nippon Mitsubishi Oil Corp | TRACTION DRIVE FLUIDS |
| DK1278763T3 (da) | 2000-04-28 | 2007-06-11 | Inflazyme Pharm Ltd | 3-Nitrogen-6,7-dioxygensteroider og anvendelser relateret dertil |
| JP2004534042A (ja) | 2001-05-22 | 2004-11-11 | インフラジム ファーマシューティカルズ リミテッド | ステロイド−５−エン化合物のステロイド−５−エン−７−オン化合物へのアリル酸化、続くヒドロホウ素化および酸化による、６，７−ジヒドロキシステロイドの生成のための方法およびこの方法の中間体 |
| CA2463136A1 (en) | 2001-10-17 | 2003-04-24 | Raymond Andersen | Ship 1 modulators |
| WO2004035601A1 (en) | 2002-10-17 | 2004-04-29 | The University Of British Columbia | Ship 1 modulators |
| ES2359916T3 (es) | 2003-04-15 | 2011-05-30 | Aquinox Pharmaceuticals Inc. | Derivados de indeno como agentes farmacéuticos. |
| WO2007147251A1 (en) | 2006-06-21 | 2007-12-27 | The University Of British Columbia | Ship 1 modulator compounds |
| US8101605B2 (en) | 2009-12-04 | 2012-01-24 | Aquinox Pharmaceuticals Inc. | SHIP1 modulators and methods related thereto |
| KR20220110337A (ko) | 2013-03-14 | 2022-08-05 | 에퀴녹스 파머수티칼스 (캐나다) 인코포레이티드 | Ship1 조절제 및 그와 관련된 방법 |
| RU2015143675A (ru) | 2013-03-14 | 2017-04-27 | Экуинокс Фармасьютикалз (Кэнэда) Инк. | Ship1 модуляторы и относящиеся к ним способы |
| US9944590B2 (en) | 2015-06-26 | 2018-04-17 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
| US10053415B2 (en) | 2016-01-20 | 2018-08-21 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
-
2014
- 2014-02-27 RU RU2015143675A patent/RU2015143675A/ru not_active Application Discontinuation
- 2014-02-27 CN CN201480026640.8A patent/CN105209429B/zh not_active Expired - Fee Related
- 2014-02-27 KR KR1020157028155A patent/KR20150130426A/ko not_active Withdrawn
- 2014-02-27 WO PCT/US2014/019125 patent/WO2014143561A1/en not_active Ceased
- 2014-02-27 EP EP14710726.2A patent/EP2970100A1/en not_active Withdrawn
- 2014-02-27 BR BR112015022577A patent/BR112015022577A2/pt not_active IP Right Cessation
- 2014-02-27 HK HK16108135.1A patent/HK1220173A1/zh unknown
- 2014-02-27 CA CA2902764A patent/CA2902764A1/en not_active Abandoned
- 2014-02-27 US US14/772,737 patent/US10100056B2/en active Active
- 2014-02-27 AU AU2014228574A patent/AU2014228574B2/en not_active Ceased
- 2014-02-27 MX MX2015011280A patent/MX2015011280A/es unknown
- 2014-02-27 JP JP2016500471A patent/JP6407950B2/ja not_active Expired - Fee Related
-
2015
- 2015-09-03 IL IL241168A patent/IL241168A0/en unknown
-
2018
- 2018-09-12 US US16/129,586 patent/US20190023709A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016516028A5 (OSRAM) | ||
| RU2015143675A (ru) | Ship1 модуляторы и относящиеся к ним способы | |
| RU2457209C2 (ru) | Производные пурина, предназначенные для применения в качестве агонистов аденозинового рецептора а2а | |
| JP2014508128A5 (OSRAM) | ||
| RU2020108515A (ru) | Соединения и способы целевого расщепления андрогенного рецептора | |
| IL264982B (en) | (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors | |
| RU2017116197A (ru) | 2-амино-3,5-дифтор-3,6-диметил-6-фенил-3,4,5,6-тетрагидропиридины как ингибиторы васе1 для лечения болезни альцгеймера | |
| JP2010534654A5 (OSRAM) | ||
| RU2000126841A (ru) | Производные амида и антагонисты ноцицептина | |
| JP2012515166A5 (OSRAM) | ||
| JP2014511892A5 (OSRAM) | ||
| JP2017511794A5 (OSRAM) | ||
| JP2015502335A5 (OSRAM) | ||
| RU2018104868A (ru) | 2-амино-3-фтор-3-(фторметил)-6-метил-6-фенил-3,4,5,6-тетрагидропиридины в качестве ингибиторов bace1 | |
| JP2015509110A5 (OSRAM) | ||
| JP2016523923A5 (OSRAM) | ||
| RU2015144653A (ru) | Противовирусные соединения и их применения | |
| JP2005511508A5 (OSRAM) | ||
| JPWO2020033828A5 (OSRAM) | ||
| JP2016503786A5 (OSRAM) | ||
| RU2009118254A (ru) | Фенилацетамиды в качестве ингибиторов протеинкиназ | |
| RU2008123376A (ru) | Производные 4-(4-алкокси-3-гидроксифенил)-2-пирролидона в качестве ингибиторов pde-4 для лечения неврологических синдромов | |
| JP2008520645A5 (OSRAM) | ||
| JP2008500336A5 (OSRAM) | ||
| JP2013538198A5 (OSRAM) |